期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 25, 期 11, 页码 881-E700出版社
WILEY-BLACKWELL
DOI: 10.1111/nmo.12203
关键词
distal ileum; mucosal microfolds; peripheral mixing
BackgroundRecent work suggests that mixing in the small intestine takes place in central luminal and peripheral compartments. However, while movements of villi have been described, the mechanisms by which peripheral mixing are engendered remain unclear. MethodsWe examined the disposition and movement of mucosa and associated villi during contractions of the everted terminal ileum of the brushtail possum. We then simulated the effect of these movements on peripheral mixing. Key ResultsCompression of the intestinal mucosa by phasic longitudinal or radial contractions created short-lived microfolds, which were of similar scale to the attached villi. The packing density of the villous tips increased in the concavities and decreased on the crests of these microfolds. Simulations showed that these caused liquid digesta to be expelled from, or drawn into, intervillous spaces, significantly augmenting peripheral, but not bulk, luminal mixing. Conclusions & InferencesWe describe a mechanism by which peripheral mixing may be engendered by mucosal microfolds without requiring the coordinated contraction of individual villi or groups of villi.
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