Review
Otorhinolaryngology
Sebastian H. Doeltgen, Harsharan Kaur, Stephanie K. Daniels, Leila Mohammadi, Joanne Murray
Summary: The upper esophageal sphincter (UES) is crucial for safe swallowing, and there are various behavioral interventions available to improve UES opening. Different types of interventions have shown varying degrees of success in improving UES opening, with limited evidence base for their effectiveness.
Article
Medicine, General & Internal
Chul-Hyun Park, Kunwoo Kim, Jin-Tae Hwang, Jae-Hyung Choi, Yong-Taek Lee, Young Sook Park, Jung Ho Park, Kyung Jae Yoon
Summary: This study compared two methods of measuring upper esophageal sphincter (UES) relaxation and determined their diagnostic value in UES relaxation impairment. The results showed that VFSS and HRM have complementary ability in evaluating UES relaxation duration in patients with oropharyngeal dysphagia.
Article
Medicine, Research & Experimental
Dustin Romain, Lauran K. Evans, Yvette Diaz, Kathryn Allen, Kristine Galek
Summary: This study presented a rare case of hypotonic upper esophageal sphincter (UES), with the patient able to achieve a more normal swallow pressure pattern using biofeedback and a specific maneuver during manometry. It also highlighted the importance of combining manometry with other swallow imaging techniques for effective treatment planning and patient outcomes.
Article
Otorhinolaryngology
Katharina Winiker, Kristin Gozdzikowska, Esther Guiu Hernandez, Seh Ling Kwong, Phoebe Macrae, Maggie-Lee Huckabee
Summary: This study examined the ability of healthy adults to increase the period of pressure drop in the region of the upper oesophageal sphincter (UOS) during swallowing through volitional UOS pressure modulation. The findings suggest that healthy individuals can volitionally prolong UOS opening duration by modulating pressure at the region of the UOS. However, further training did not enhance performance, indicating a potential limitation in the extent to which the period of pressure drop may be prolonged in healthy individuals.
Article
Medicine, Research & Experimental
Michelle Florie, Walmari Pilz, Bernd Kremer, Femke Verhees, Ghislaine Waltman, Bjorn Winkens, Naomi Winter, Laura Baijens
Summary: This study found a relationship between patient-reported symptoms of oropharyngeal dysphagia using the EAT-10 questionnaire and swallowing function in HNC patients. The EAT-10 score was indicative of postswallow pharyngeal residue, particularly in the vallecular and pyriform sinus areas. A cutoff point of 19 points was useful for detecting pharyngeal residue in this population.
Review
Otorhinolaryngology
Yoko Inamoto, Marlis Gonzalez-Fernandez, Eiichi Saitoh
Summary: Videofluoroscopy and videoendoscopy have significantly changed the evaluation and management of swallowing disorders, while the advent of 320-row area detector CT has overcome previous limitations in instrumental evaluation techniques, allowing for more detailed studies of swallowing physiology and dysphagia.
Review
Food Science & Technology
Pengxu Wei
Summary: This article focuses on the treatment methods and effects of botulinum toxin injection for UES dysfunction. The research suggests that the entire UES should be targeted for injection rather than just the cricopharyngeal muscle. The article also discusses the therapeutic mechanisms of botulinum toxin and the strengths and weaknesses of guiding techniques.
Review
Medicine, Research & Experimental
Ayano Nagano, Keisuke Maeda, Akio Shimizu, Kenta Murotani, Naoharu Mori
Summary: Carbonation has favorable effects on swallowing function, preventing aspiration and increasing the duration of swallowing apnea.
Article
Clinical Neurology
Sonja Suntrup-Krueger, Paul Muhle, Isabella Kampe, Paula Egidi, Tobias Ruck, Frank Lenze, Michael Jungheim, Richard Gminski, Bendix Labeit, Inga Claus, Tobias Warnecke, Joachim Gross, Rainer Dziewas
Summary: The study evaluated the effect of capsaicin on swallowing function, finding that it improves swallowing efficacy and positively alters swallowing biomechanics in healthy subjects. Capsaicin mediates dose-dependent Substance P release and leads to a significant increase in salivary Substance P in healthy individuals.
Article
Otorhinolaryngology
Keiko Fukino, Masahiro Tsutsumi, Akimoto Nimura, Koh Miwa, Takashi Ono, Keiichi Akita
Summary: This study examined the connection between the palatopharyngeus and inferior constrictor, finding that the former interlaces with the cricopharyngeal part of the latter through dense connective tissues. This connection may play a role in directly affecting the upper esophageal sphincter and aiding in its opening.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Debora Freud, Anat Hamburger, Dafna Kaplan, Yael Henkin
Summary: The Sheba Blue Dye Test Protocol (SBDTP) is a swallowing bedside evaluation for tracheotomized patients that is more reliable than the traditional Modified Evans' Blue Dye Test (MEBDT). The study found that the SBDTP significantly increased the percentage of positive results, demonstrating its advantage in tracing aspiration among tracheotomized patients, particularly in cases where access to instrumental examination is limited.
Article
Medicine, General & Internal
Byung Joo Lee, Hyoshin Eo, Donghwi Park
Summary: This study found that in patients with ALS and dysphagia, the mVDS scores were statistically correlated with the selected feeding method and the presence of aspiration pneumonia. The ROC curve analysis also suggested that the mVDS score is accurate in predicting the severity of dysphagia in ALS patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
Karen B. Ng, Esther Guiu Hernandez, Kerstin L. C. Erfmann, Richard D. Jones, Phoebe Macrae, Maggie-Lee Huckabee
Summary: The study aimed to compare muscle activity during swallowing with different levels of effort. Results showed that maximum effort swallowing increased muscle activity, while minimum effort swallowing decreased muscle activity.
Article
Otorhinolaryngology
Hannah G. Kay, Benjamin Campbell, Jean-Nicolas Gallant, Catherine Carlile, Patty Wright, Byron Stephens, Sarah L. Rohde
Summary: Delayed upper aerodigestive tract (UADT) perforation is a rare complication of anterior cervical spinal hardware. Treatment approaches include primary repair and rotational flap, with patient smoking history being a potential risk factor for perforation development. Most patients demonstrated complete resolution of post-operative swallowing issues within a median of 31 days.
Article
Dentistry, Oral Surgery & Medicine
Juan Carlos de Vicente, Laura Rua-Gonzalvez, Jose Maria Barroso, Alvaro Fernandez del Valle-Fernandez, Lucas de Villalain, Ignacio Pena, Juan Luis Cobo
Summary: This study assessed functional swallowing outcomes in oral cancer patients treated with tumor resection and microvascular free flaps reconstruction. The study found that surgery combined with radiochemotherapy was associated with a higher prevalence of dysphagia, with dysphagia more frequent in the first year after treatment and less frequent after 24 months. Dysphagia was associated with laryngeal penetration and aspiration. The reconstruction method has a significant impact on swallowing, with a focus on minimizing dysphagia.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Audiology & Speech-Language Pathology
Sarah Rowland, Claire Mills, Margaret Walshe
Summary: This study aims to compare the clinical practices of SLPs working in adult CC units in Ireland and internationally in the areas of dysphagia, communication, and tracheostomy management, and explore their perspectives on training, skills, and resources. The survey results showed similarities and differences in clinical practices, as well as limitations in SLP input in CC settings.
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Review
Otorhinolaryngology
Jennifer Moloney, Margaret Walshe, Julie Regan
Summary: This study aimed to identify the range of PROMs commonly used in clinical trials for dysphagia following stroke and found that the SWAL-QOL and EAT-10 are commonly used PROMs. However, these tools do not directly assess the impact of 'Environmental Factors' and 'Role Functioning' on dysphagia.
Correction
Otorhinolaryngology
Jennifer Moloney, Julie Regan, Margaret Walshe
Letter
Gastroenterology & Hepatology
Lukas Michaja Balsiger, Karen Van den Houte, Tenghao Zheng, Joran Toth, Linde Besard, Andre Franke, Mauro D'Amato, Jan Tack, Florencia Carbone
Letter
Gastroenterology & Hepatology
Jan Tack, Karen Van den Houte, Florencia Carbone
Article
Gastroenterology & Hepatology
I-Hsuan Huang, Jolien Schol, Florencia Carbone, Yaozhu J. Chen, Karen Van den Houte, Lukas Michaja Balsiger, Bert Broeders, Tim Vanuytsel, Jan Tack
Summary: This study investigated the symptom patterns in distinguishing gastroparesis from functional dyspepsia. The results showed that patients with gastroparesis-like symptoms had a higher prevalence of delayed gastric emptying and higher symptom severity compared to patients with FD symptoms.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Chris Varghese, Gabriel Schamberg, Stefan Calder, Stephen Waite, Daniel Carson, Daphne Foong, William Jiaen Wang, Vincent Ho, Jonathan Woodhead, Charlotte Daker, William Xu, Peng Du, Thomas L. Abell, Henry P. Parkman, Jan Tack, Christopher N. Andrews, Gregory O'Grady, Armen A. Gharibans
Summary: This study aimed to define normative reference intervals for BSGM spectral metrics in healthy controls. The results showed the median and reference intervals for BSGM metrics, including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index, BMI-adjusted amplitude, and fed:fasted amplitude ratio. This study provides reference values for diagnostic interpretations of abnormal gastric function using BSGM spectral data.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Esther Colomier, Joost P. Algera, Karen Van den Houte, Magnus Simren, Jan Tack
Summary: A subgroup of patients with a disorder of gut-brain interaction (DGBI) experience various symptoms after eating, such as abdominal pain, gas-related symptoms, dyspeptic symptoms, and loose stool or urgency. Previous studies have examined the effects of dietary therapies, such as fiber-rich or restrictive diets, on patients with irritable bowel syndrome and other related disorders, but there is limited research on the underlying mechanisms of food-related symptoms. This review focuses on these potential mechanisms, including nutrient sensing and tasting, physical considerations, malabsorption, allergy-like reactions, and their interaction with the gut microbiota.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Lukas Michaja Balsiger, Florencia Carbone, Karlien Raymenants, Emidio Scarpellini, Jan Tack
Summary: Disorders of gut-brain interaction (DGBI) are common in clinical practice, and there are established recommendations for diagnosis and management. Patients with multiple DGBI diagnoses have more severe symptoms and impact, and the management approach for overlapping diagnoses is not well established. This Review aims to guide clinicians in understanding and managing overlapping DGBI through identifying causes, pitfalls, and practical approaches to diagnosis, treatment, and follow-up.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Emidio Scarpellini, Jan Tack
Summary: Background: Since the end of 2019, SARS-CoV-2 has caused the COVID-19 pandemic, and gastrointestinal (GI) symptoms during and after COVID-19 are receiving increasing attention. Methods: We review and comment on the prevalence, pathophysiology, and potential treatment options for GI disturbances in COVID-19. Results: Numerous reports show that a significant portion of COVID-19 patients experience GI symptoms both during and after the disease, with some experiencing symptoms for several months, even after vaccination. There is an ongoing debate regarding the association between GI symptoms and the outcome of COVID-19 patients. However, it is widely recognized that patients with chronic liver disease have a worse outcome. The similarities between GI symptoms and postinfectious functional dyspepsia and irritable bowel syndrome suggest that the gut microbiota may play a role. Preliminary reports and clinical trials have shown that modulating the gut microbiota could be an effective approach for treating and preventing COVID-19. Conclusion: GI symptoms have a significant impact on the natural course of both long-COVID-19 and non-long-COVID-19. Modulating the gut microbiota appears to be a promising target for disease treatment and prevention.
REVIEWS ON RECENT CLINICAL TRIALS
(2023)
Review
Otorhinolaryngology
Eileen Kelly, Julia Hirschwald, Julie Clemens, Julie Regan
Summary: This systematic review examined the prevalence, severity, and impact of persistent post-extubation laryngeal injury beyond hospital discharge and differences in injury between COVID-19 and non-COVID-19 populations. Six cohort studies were included, with a total of 436 participants. The review found that persistent laryngeal injury was associated with ICU length of stay, respiratory diagnosis, and tracheostomy.
Article
Gastroenterology & Hepatology
Caroline M. G. Saleh, Pietro Familiari, Barbara A. J. Bastiaansen, Paul Fockens, Jan Tack, Guy Boeckxstaens, Raf Bisschops, Aaltje Lei, Marlies P. Schijven, Jan Guido Costamagna, Albert J. Bredenoord
Summary: This study compares the efficacy of POEM and PD for patients with persistent or recurrent symptoms after LHM. The results show that POEM has a higher success rate than PD, with a higher incidence of reflux esophagitis in the POEM group.
Article
Gastroenterology & Hepatology
Navkiran Thind Tornkvist, Magnus Simren, Johann P. Hreinsson, Jan Tack, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Axel Josefsson, Hans Tornblom
Summary: This study aimed to define the prevalence and impact of disorders of gut-brain interaction (DGBI) in Sweden. The results showed that the prevalence of DGBI in Sweden is similar to global data, and patients often experience anxiety and/or depression, reduced quality of life, and frequent healthcare utilization. Prescription medication can provide relief for GI symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Serhat Bor, Xuicai Fang, Shrikant I. Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Murat Buyruk, Nalan Unal, Dan Huang, Jun Song, Johann P. Hreinsson, Olafur S. Palsson
Summary: The Rome Foundation Global Epidemiology Study (RFGES) assessed the prevalence, burden, and associated factors of Disorders of Gut-Brain Interaction (DGBI) in 33 countries. Two surveying methods (household interviews and Internet surveys) were used, and the findings showed that DGBI were only half as prevalent when assessed with household surveys compared to Internet surveys. The choice of survey method significantly affects symptom reporting and DGBI prevalence outcomes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Bert Broeders, Elise Devolder, Michael Jones, Magnus Simren, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Jan Tack
Summary: According to a study by the Rome Foundation in Belgium, the prevalence of DGBI is similar in the French and Dutch language groups, but the Dutch-speaking population has higher psychosocial well-being. French-speaking participants have higher scores for depression and non-gastrointestinal somatic symptoms, while the Dutch-speaking population has higher scores for overall physical and mental health quality of life.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
