Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Multidisciplinary Sciences
Pengchao Zhao, Xianfeng Xia, Xiayi Xu, Kevin Kai Chung Leung, Aliza Rai, Yingrui Deng, Boguang Yang, Huasheng Lai, Xin Peng, Peng Shi, Honglu Zhang, Philip Wai Yan Chiu, Liming Bian
Summary: The authors have developed a bio-adhesive liquid coacervate coating that can act as a flowable drug carrier in the intestinal tract, mediating sustained release of drugs and enhancing therapeutic efficacy. This system shows significant stability, forming a physically adhesive coating on a large area of the intestinal tract for extended drug release.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ines Silva, Joao Solas, Rui Pinto, Vanessa Mateus
Summary: This study successfully developed and validated a chronic TNBS-induced colitis mouse model. After week 4, clinical and inflammation signs remained stable, suggesting the model develops within 4 weeks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotomi
Summary: Olfactory disorders, closely related to cognitive deterioration, can be caused by infections, aging, and environmental chemicals. This study focused on the involvement of TRPV1 and TRPV4 channels in olfactory receptor neuron (ORN) regeneration, demonstrating that TRPV1 stimulates progenitor cell proliferation while TRPV4 regulates proliferation and maturation, suggesting their essential roles in ORN regeneration.
LABORATORY INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Magdalena Kurnik-Lucka, Pawel Pasieka, Patrycja Laczak, Marcin Wojnarski, Michal Jurczyk, Krzysztof Gil
Summary: The dopaminergic system may play a significant role in inflammatory bowel disease, but its impact is currently underestimated. Further in-depth observational studies are needed to support this notion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hideaki Yamada, Naoaki Sakata, Tomoko Tanaka, Hideaki Tagashira, Gumpei Yoshimatsu, Ryo Kawakami, Hideichi Wada, Takahiro Iwamoto, Shohta Kodama
Summary: This study showed that activating TRPV4 can improve blood flow in the ischemic hindlimb animal model by promoting both angiogenesis and lymphangiogenesis. It suggests that upregulating both lymphatic and blood vessels through TRPV4 activation could be a promising therapeutic strategy for peripheral artery disease.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Neurosciences
Meng-liu Zeng, Shuo Kong, Tao-xiang Chen, Bi-wen Peng
Summary: This review summarizes the known features of transient receptor potential vanilloid 4 (TRPV4) channel, including its expression, structure, and its physiological and pathological roles in the central nervous system (CNS), proposing an emerging therapeutic strategy for CNS diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jameson P. Holloman, Sophia H. Dimas, Angela S. Archambault, Fabia Filipello, Lixia Du, Jing Feng, Yonghui Zhao, Bryan Bollman, Laura Piccio, Andrew J. Steelman, Hongzhen Hu, Gregory F. Wu
Summary: This study investigates the role of TRPV4 in microglial activity and disease activity in a mouse model of multiple sclerosis (MS). The findings suggest that although TRPV4 modulates microglial activity, it does not impact disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
A. Quesada-Simo, A. Garrido-Marin, P. Nos, S. Gil-Perotin
Summary: Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are autoimmune disorders that cause inflammation in the brain and gastrointestinal (GI) tract, respectively. While they share common pathogenic mechanisms, their immune responses to treatment differ. Anti-CD20 therapies effectively control inflammation in MS but may cause bowel inflammation in susceptible individuals. This review explores the association between immunity in MS and IBD, the impact of anti-CD20 therapies on the gut microenvironment, and recommendations for early detection and management of GI toxicities in MS patients undergoing B-cell depletion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Unal Atas, Nuray Erin, Gokhan Tazegul, Gulsum Ozlem Elpek, Bulent Yildirim
Summary: TRPV1 expression is higher in the stomach than in the duodenum, predominantly found in specific cell types. Levels of TRPV1 expression in obese and healthy individuals were similar in different cell types of gastric and duodenal tissues. TRPV1 expression was higher in older patients and those with diabetes and hypertension.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Picchianti-Diamanti, Francesca Romana Spinelli, Maria Manuela Rosado, Fabrizio Conti, Bruno Lagana
Summary: Phosphodiesterases (PDEs) are a diverse family of enzymes that regulate intracellular second messengers, with PDE4 being the most studied isoenzyme known for its role in down-regulating inflammatory responses. Inhibition of PDE4 can increase levels of cAMP, leading to decreased expression of inflammatory factors and increased regulatory cytokines, making it a potential therapeutic target for chronic inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Koji Kuronuma, Mitsuo Otsuka, Masato Wakabayashi, Takeshi Yoshioka, Tomofumi Kobayashi, Masami Kameda, Yasuhide Morioka, Hirofumi Chiba, Hiroki Takahashi
Summary: The study suggests that pirfenidone exerts its antifibrotic effects in IPF partly by inhibiting TRPV4. The levels of TRPV4 endogenous ligands in bronchoalveolar lavage fluid may serve as biomarkers for predicting the effectiveness of pirfenidone treatment in IPF patients.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Physiology
Kenichi Goto, Takanari Kitazono
Summary: Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors, while myoendothelial gap junctions facilitate endothelium-dependent hyperpolarization for vasodilation. Increased intracellular Ca2+ concentration in endothelial cells is essential for the production of factors and generation of hyperpolarization, with TRPV4 ion channel playing a critical role. Dysregulation of endothelial TRPV4 channels is linked to endothelial dysfunction associated with cardiovascular disease risk factors, indicating potential for novel therapeutic strategies in CVD prevention.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Alexa R. Weingarden, Amuel J. S. Rubin, John Gubatan
Summary: ICI therapy has revolutionized cancer treatment by boosting the immune system against tumors, but it can also lead to autoimmune-like side effects such as IMC. Patients with GI malignancies and pre-existing inflammatory bowel disease are at increased risk of developing IMC.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Neurosciences
Mohammad Zakir Hossain, Hiroshi Ando, Shumpei Unno, Rita Rani Roy, Junichi Kitagawa
Summary: The swallowing reflex is a crucial physiological process for the passage of food or liquid into the esophagus. Recent studies have found that the transient receptor potential vanilloid 4 (TRPV4) may play a role in facilitating the swallowing reflex. This study demonstrated that TRPV4 is expressed in sensory nerves innervating the swallowing-related regions and its activation by an agonist can enhance swallowing. This suggests that TRPV4 could be a potential pharmacological target for managing oropharyngeal dysphagia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Marek Pajak, Magdalena Wozniczka, Miroslawa Swiatek, Bartlomiej Czerwinski, Jakub Wlodarczyk, Jakub Fichna
Summary: The complexation properties of two synthetic nucleosides, beta-D-ribofuranoside-4-pyrimidinone (ribo) and beta-D-deoxyribofuranoside-4-pyrimidinone (deoxy), with Ag(I) ions in aqueous solution were investigated. The stability constants of the coordination entities formed were calculated and the percentage of each entity in solution was estimated. The results suggest that these coordination entities have potential antiviral, antibacterial, and antitumor properties, as well as potential applications in nanobiotechnology.
ACTA POLONIAE PHARMACEUTICA
(2023)
Review
Pharmacology & Pharmacy
Karolina Merecz, Mikolaj Hirsa, Olga Biniszewska, Jakub Fichna, Aleksandra Tarasiuk
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that affects approximately 10% of the global population. Recent studies have shown that antagonism of the serotonin 5-HT3 receptor is an effective treatment for IBS-D. The modulation of serotonin function plays a crucial role in maintaining intestinal homeostasis.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jakub Wlodarczyk, Julia Krajewska, Lukasz Szeleszczuk, Patrycja Szalwinska, Agata Gurba, Szymon Lipiec, Przemyslaw Taciak, Remigiusz Szczepaniak, Izabela Mlynarczuk-Bialy, Jakub Fichna
Summary: Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are global health problems with increasing frequency and unclear pathogenesis. Current treatment involves drugs like corticosteroids and derivative compounds, but more specific and effective therapies are desired. In this study, novel gold complexes were tested and found to have anti-inflammatory potential both in vitro and in vivo, particularly TGS 703, which was able to alleviate inflammation in a mouse model of colitis and showed a link to antioxidant systems. These findings suggest that gold(III) complexes may have therapeutic applications in the treatment of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jacek Burzynski, Jakub Fichna, Aleksandra Tarasiuk
Summary: Acute pancreatitis (AP) and chronic pancreatitis (CP) are severe diseases that pose a great threat to human health in high-income countries. Oxidative stress plays a significant role in the development of AP and CP, and there is growing interest in the use of antioxidant therapy to manage these conditions. Vitamin A, a well-known antioxidant, has been understudied in relation to its impact on oxidative stress in AP and CP. This review aims to evaluate the molecular targets of vitamin A and its potential role in attenuating oxidative stress in AP and CP. The findings suggest that vitamin A may influence several molecular pathways involved in antioxidative defense and cytoprotection, indicating its potential to alter the disease course of AP and CP.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Toxicology
Szymon Lipiec, Agata Gurba, Izabela M. Agnieszczak, Andrzej Antoni Szczepankiewicz, Przemyslaw Szymanski, Przemyslaw Taciak, Remigiusz Szczepaniak, Lukasz Szeleszczuk, Hanna Nieznanska, Jakub Wlodarczyk, Jakub Fichna, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Metal-based agents in cancer therapy, like cisplatin and its derivates, have established clinical applications but also can induce serious side effects. Thus, metallotherapeutic alternatives for platinum derivatives are developed and intensively studied. Platinum is replaced by several transition metals including gold. Especially gold (III) complexes can have the same square-planar structure and are isoelectric with platinum (II).
TOXICOLOGY IN VITRO
(2023)
Article
Immunology
Adam Makaro, Mikolaj Swierczynski, Kacper Pokora, Barbara Sarniak, Radzislaw Kordek, Jakub Fichna, Maciej Salaga
Summary: Inflammatory bowel diseases (IBD) is a chronic and relapsing inflammation in the gastrointestinal tract. The incidence and prevalence of IBD are high and increasing, and current therapeutic strategies are suboptimal. This study focused on gliflozins, a group of anti-diabetic drugs, and found that they have anti-inflammatory properties. In vitro experiments showed that two gliflozins, EMPA and DAPA, suppressed nitric oxide production in macrophages, and in vivo experiments demonstrated that EMPA alleviated colitis in mice. Our findings suggest that SGLT-2 inhibitors have anti-inflammatory effects independent of their hypoglycemic effects.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Barbara Wlodarczyk, Lukasz Durko, Przemyslaw Wlodarczyk, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: Differentiating between pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) poses a challenge. This study assessed the usability of IGF-1, IGFBP-2, and IGF-1/IGFBP-2 ratio in differentiating PDAC and CP. The results indicate that CA 19-9 demonstrates high potential as a marker for PDAC and CP differentiation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jakub Wasik, Ewa Malecka-Wojciesko
Summary: Eosinophilic esophagitis is a Th-2 antigen-mediated disease that causes inflammation in the esophagus with an influx of eosinophils. It leads to esophageal remodeling and difficulties in swallowing. While the disease has a relatively short history, its incidenc e and prevalence are increasing rapidly, especially in Western countries. The diagnosis requires the presence of at least 15 eosinophils per high-power field in esophageal biopsies, along with relevant symptoms and exclusion of other causes of esophageal eosinophilia. Treatment options for eosinophilic esophagitis are challenging, but the combination of proton pump inhibitors, topical corticosteroids, elimination diet, and biological treatment has shown promise. New methods for disease diagnosis and clinical assessment are also available.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Marcin Sochal, Marta Ditmer, Agata Binienda, Agata Gabryelska, Piotr Bialasiewicz, Renata Talar-Wojnarowska, Jakub Fichna, Ewa Malecka-Wojciesko
Summary: Inflammatory bowel disease (IBD) patients often experience sleep and mood disorders which may be related to the disruption of the brain-gut axis. This study found that IBD patients had lower expression of BDNF mRNA but higher concentrations of proBDNF and BDNF protein compared to healthy controls. BDNF protein levels were positively correlated with sleep efficiency in the IBD group and depression severity was associated with BDNF mRNA and protein levels in the remission group.
Article
Nutrition & Dietetics
Malgorzata Godala, Ewelina Gaszynska, Konrad Walczak, Ewa Malecka-Wojciesko
Summary: This study evaluated the utility of albumin, transferrin, and transthyretin levels in assessing nutritional status and activity of inflammatory bowel disease (IBD). The results found significantly lower albumin levels in IBD patients compared to controls and in Crohn's disease (CD) patients compared to ulcerative colitis (UC) patients. Higher transthyretin levels were found in IBD patients compared to healthy subjects. Albumin levels in IBD patients were associated with disease activity and nutritional status, while further studies are needed to assess the utility of transferrin and transthyretin as markers.
Article
Medicine, General & Internal
Malgorzata Godala, Ewelina Gaszynska, Lukasz Durko, Ewa Malecka-Wojciesko
Summary: This study investigated dietary perceptions and behaviors in patients with inflammatory bowel disease (IBD). Most patients believed that diet can trigger IBD relapses and imposed food restrictions to prevent relapses. However, these behaviors may not align with current scientific knowledge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jagoda Oliwia Rogowska, Lukasz Durko, Ewa Malecka-Wojciesko
Summary: Endosonography, a minimally invasive imaging technique, has revolutionized the diagnosis and management of pancreatic diseases. This review highlights the latest advancements in endosonography of the pancreas, including key technological developments, procedural techniques, clinical applications and additional techniques. EUS is well established for T-staging and N-staging of pancreaticobiliary malignancies, for pancreatic cyst discovery, for identifying subepithelial lesions (SEL), for differentiation of benign pancreaticobiliary disorders or for acquisition of tissue by EUS-guided fine-needle aspiration or EUS-guided fine-needle biopsy. This review briefly describes principles and application of EUS and its related techniques.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Bialasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: The study investigates the impact of the serotonergic pathway on the pathogenesis and course of inflammatory bowel diseases (IBDs), and its relationship with sleep and mood disorders. The results show that patients with active IBD have higher levels of 5-HT and SERT protein expression, which are positively correlated with insomnia severity. After treatment, only 5-HT levels are decreased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Malgorzata Wozniak, Anna Borkowska, Marta Jastrzebska, Marcin Sochal, Ewa Malecka-Wojciesko, Renata Talar-Wojnarowska
Summary: This study aimed to evaluate the usefulness of laboratory parameters, including hepcidin, in the differential diagnosis of anaemia in hospitalized patients with inflammatory bowel disease (IBD). The study included 118 adult patients with IBD – 55 with ulcerative colitis (UC) and 63 with Crohn's disease (CD). Anaemia was more prevalent in CD patients compared to UC patients, and its prevalence increased with the severity of IBD and inflammatory changes. Comprehensive laboratory assessment, including hepcidin levels, is necessary for the full picture of anaemia in IBD.
JOURNAL OF CLINICAL MEDICINE
(2023)
