Article
Cardiac & Cardiovascular Systems
Aviram Akuka, Niv Ben-Shabat, Abdulla Watad, Avishai M. Tsur, Scott Ehrenberg, Dennis McGonagle, Doron Comaneshter, Roy Beinart, Arnon D. Cohen, Howard Amital
Summary: This study is the first large population-based study conducted on seropositive adults, and it found a positive association between anti-Ro seropositivity and adult cardiac conduction disturbances and, to a lesser extent, cardiac rhythm disturbances.
EUROPEAN HEART JOURNAL
(2022)
Review
Rheumatology
Jessica L. Fairley, Laura Ross, Alannah Quinlivan, Dylan Hansen, Elizabeth Paratz, Wendy Stevens, Peter M. Kistler, Alex McLellan, Andre La Gerche, Mandana Nikpour
Summary: This study aimed to investigate the occurrence rate of sudden cardiac death (SCD), arrhythmia, and conduction defects in SSc patients. The findings showed that the annual incidence of SCD in SSc patients ranged from 1.0% to 3.3%, which is at least 10 times higher than the general population. Additionally, arrhythmias were common even in SSc patients without known or suspected SSc-associated heart involvement.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Immunology
Man Li, Xintao Li, Hongwei Gao, Peng Li, Li Zhang, Xiaoling Zhang, Peipei Liu, Xuemei Yang, Lili Wu, Jiangwei Zeng, Shouling Wu, Lixia Sun
Summary: This study found a significant association between monocyte-lymphocyte ratio (MLR) and increased risk of new-onset cardiac conduction block (CCB). Assessing MLR may have clinical relevance for predicting CCB risk and providing insights for preventive strategies and patient management.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Medicinal
Francesco Pettini, Carmen Domene, Simone Furini
Summary: The study of the inactivation mechanism of hERG is crucial due to its association with cardiac arrhythmias. Two models, namely, the closure of the selectivity filter and the widening of the extracellular portion of the selectivity filter, have been proposed to describe C-type inactivation in potassium channels. Molecular dynamics simulations revealed that the extracellular entrance of hERG widens during inactivation, supporting the hypothesis of widening of the extracellular entrance rather than closure of the selectivity filter.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Francesco Pettini, Carmen Domene, Simone Furini
Summary: Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, but its mechanism and association with cardiac arrythmias are of paramount importance. Two models have been proposed for C-type inactivation in K+ channels, and this study used molecular dynamics simulations to investigate the mechanism in hERG. The findings suggest that C-type inactivation in hERG involves a widening of the extracellular entrance of the channel rather than a closure of the selectivity filter.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Biochemistry & Molecular Biology
Yaopeng Hu, Qin Li, Yanghua Shen, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Summary: The E7K mutation leads to an increased open state of the TRPM4 channel, resulting in conduction disorders due to its pathologically enhanced activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rongrong Shen, Dongchuan Zuo, Kuihao Chen, Yiheng Yin, Kai Tang, Shangwei Hou, Bo Han, Yawei Xu, Zheng Liu, Haijun Chen
Summary: Hypokalemia causes ectopic heartbeats, and this study demonstrates the critical role of K2P1 leak cation channels in ventricular ectopic beats and sudden death in a mouse model. These findings contribute to a better understanding of cardiac issues associated with hypokalemia.
Article
Physiology
Radek Halfar, Brodie A. J. Lawson, Rodrigo Weber dos Santos, Kevin Burrage
Summary: In this study, machine learning is used to accurately predict the arrhythmic risk caused by cardiac fibrosis. The research explores the initiation sites of re-entry activation patterns and their sensitivity to activation sequence, as well as the range of structural information required to predict re-entry initiation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Kirstine Calloe, Helena B. D. Magnusson, Dorte Launholt Lildballe, Morten Krogh Christiansen, Henrik Kjaerulf Jensen
Summary: In the past 20 years, genetic variants in SCN5A encoding the cardiac voltage-gated sodium channel Na(v)1.5 have been associated with a range of inherited cardiac arrhythmias. Loss-of-function variants have been linked to sick sinus syndrome, atrial stand still, atrial fibrillation, impaired pulse generation, conduction defects, the Brugada syndrome, and sudden cardiac death. Gain-of-function variants have been associated with Long QT syndrome type 3, Torsade de Pointes ventricular tachycardia and SCD, as well as the Multifocal Ectopic Purkinje-related Premature Contractions (MEPPC) syndrome. MEPPC is a rare condition characterized by a high burden of premature contractions and dilation of the heart muscle. The link between SCN5A variants, MEPPC and DCM is not yet fully understood.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Latoya A. Stewart, Gabrielle K. Steinl, Bernice L. Huang, Catherine McManus, James A. Lee, Jennifer H. Kuo, Marcella D. Walker
Summary: In a retrospective cross-sectional study comparing cardiac conduction in patients with primary hyperparathyroidism (PHPT) or thyroid disease (TD), it was found that PHPT patients had shorter QTc intervals compared to TD controls. However, there was no significant difference in the prevalence of arrhythmia between the two groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cardiac & Cardiovascular Systems
Gary Tse, Ka Hou Christien Li, Chloe Kwong Yee Cheung, Konstantinos P. Letsas, Aishwarya Bhardwaj, Abhishek C. Sawant, Tong Liu, Gan-Xin Yan, Henggui Zhang, Kamalan Jeevaratnam, Nazish Sayed, Shuk Han Cheng, Wing Tak Wong
Summary: This review consolidates pre-clinical findings on the electrophysiological mechanisms underlying hypokalaemia-induced arrhythmogenicity, discussing triggers and substrates, as well as the characteristics of static and dynamic substrates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Erika Mejia, Abigail Lynch, Patrick Hearle, Oluwatimilehin Okunowo, Heather Griffis, Maully Shah, David Lynch, Kimberly Y. Lin
Summary: Friedreich ataxia patients have a high risk of cardiac rhythm abnormalities, with the incidence of atrial ectopy increasing as disease duration lengthens.
PEDIATRIC NEUROLOGY
(2021)
Review
Medicine, General & Internal
Michal Szotek, Lukasz Druzbicki, Karol Sabatowski, Gisella R. Amoroso, Koen De Schouwer, Pawel T. Matusik
Summary: Transcatheter aortic valve implantation (TAVI) has become a widely accepted treatment method for aortic stenosis in patients who are at high surgical risk or disqualified from surgery. However, TAVI is associated with a high incidence of conduction abnormalities, such as heart block, which may require permanent pacemaker implantation. Understanding the risk factors for these complications and providing optimal care is crucial for improving patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yuxiao Chen, Lian Lou, Xuan Zhang, Luyang Jin, Yao Chen, Lele Chen, Zhihang Li, Fen Zhang, Ting Fu, Shenjiang Hu, Jian Yang
Summary: This study used genetic evidence to analyze the relationship between leukocyte counts and the risk of different types of arrhythmia. The results showed that an increase in lymphocyte count is associated with a higher risk of atrioventricular block, but there is uncertain evidence on the relationship between neutrophil and basophil counts and the risk of atrial fibrillation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Seppe Maris, Michiel Brands, Daniele Lenskens, Geert Braeken, Stefan Kemnitz, Herbert Vanhove, Myles Mc Laughlin, Raf Meesen, Bert Brone, Bjorn Stessel
Summary: This study aimed to evaluate the effects of transcutaneous medium-frequency alternating electrical current stimulation on sensory perception and force production in the index and middle finger. The results showed that stimulation at 2 kHz and 10 kHz could inhibit tactile sensory nerve activity in the fingers, while motor nerve activity was not significantly affected.
SCIENTIFIC REPORTS
(2022)
Letter
Nutrition & Dietetics
Varsha M. Asrani, Colin McArthur, Ian Bissett, John A. Windsor
CLINICAL NUTRITION
(2022)
Letter
Gastroenterology & Hepatology
Manu Nayar, Chris Varghese, Aditya Kanwar, Ajith K. Siriwardena, Ali Raza Haque, Altaf Awan, Anita Balakrishnan, Arab Rawashdeh, Bogdan Ivanov, Chetan Parmar, Christopher M. Halloran, Clifford Caruana, Cynthia-Michelle Borg, Dhanny Gomez, Dimitrios Damaskos, Dimitrios Karavias, Guy Finch, Husam Ebied, James K. Pine, James R. A. Skipworth, James Milburn, Javed Latif, Jeyakumar Apollos, Jihene El Kafsi, John A. Windsor, Keith Roberts, Kelvin Wang, Krish Ravi, Maria Coats, Marianne Hollyman, Mary Phillips, Michael Okocha, Michael S. J. Wilson, Nadeem A. Ameer, Nagappan Kumar, Nehal Shah, Pierfrancesco Lapolla, Connor Magee, Bilal Al-Sarireh, Raimundas Lunevicius, Rami Benhmida, Rishi Singhal, Srinivasan Balachandra, Semra Demirli Atici, Shameen Jaunoo, Simon Dwerryhouse, Tamsin Boyce, Vasileios Charalampakis, Venkat Kanakala, Zaigham Abbas, Nilanjana Tewari, Sanjay Pandanaboyana
Letter
Gastroenterology & Hepatology
Feng Yang, Yuting Huang, Tian Li, Yunting Fu, Chenyu Sun, Yecheng Xu, John Windsor, Deliang Fu
Article
Medicine, Research & Experimental
Alistair Brian James Escott, Jiwon Hong, Brigid Nancy Connor, Kian Liun Phang, Andrew Hugh Holden, Anthony Ronald John Phillips, John Albert Windsor
Summary: This study successfully developed a technique for measuring thoracic duct lymph pressure, flow, and composition in surgical patients, demonstrating profound changes in the composition of thoracic duct lymph over time and in response to enteral feeding and vasopressor treatment.
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Editorial Material
Surgery
John A. Windsor, Natalie L. Trevaskis, Anthony J. Phillips
Summary: This article examines the use of the gut-lymph model for treating organ failure and provides strategies for its clinical translation.
Article
Health Care Sciences & Services
Na Shi, Lan Lan, Jiawei Luo, Ping Zhu, Thomas R. W. Ward, Peter Szatmary, Robert Sutton, Wei Huang, John A. Windsor, Xiaobo Zhou, Qing Xia
Summary: This study used machine learning to predict the therapeutic intervention needs and mortality in patients with acute pancreatitis, achieving high accuracy. The results showed that using admission clinical predictors, it is possible to accurately predict the intervention needs and mortality in AP patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Sanjay Pandanaboyana, Wei Huang, John A. Windsor, Asbjorn Mohr Drewes
Summary: This review discusses the available analgesic options for acute pancreatitis and emphasizes the evidence specific to this condition. Nonsteroidal anti-inflammatory drugs and paracetamol are effective alternatives to opioids for pain relief in acute pancreatitis. Epidural analgesia provides optimal pain relief in the first 24 hours after onset, and experimental analgesics and acupuncture may potentially reduce opioid use. Tailoring treatment to the individual patient, assessing pain intensity and pancreatitis severity, and using opioid sparing strategies whenever possible are important principles in pain management for acute pancreatitis.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Article
Critical Care Medicine
Lu Ke, Jing Zhou, Wenjian Mao, Tao Chen, Yin Zhu, Xinting Pan, Hong Mei, Vikesh Singh, James Buxbaum, Gordon Doig, Chengjian He, Weili Gu, Weihua Lu, Shumin Tu, Haibin Ni, Guoxiu Zhang, Xiangyang Zhao, Junli Sun, Weiwei Chen, Jingchun Song, Min Shao, Jianfeng Tu, Liang Xia, Wenhua He, Qingyun Zhu, Kang Li, Hongyi Yao, Jingyi Wu, Long Fu, Wendi Jiang, He Zhang, Jiajia Lin, Baiqiang Li, Zhihui Tong, John Windsor, Yuxiu Liu, Weiqin Li
Summary: This study aimed to evaluate whether early immune-enhancing Thymosin alpha 1 (T alpha 1) treatment reduces the incidence of infected pancreatic necrosis in patients with predicted severe acute necrotising pancreatitis, but the results showed that this treatment did not reduce the incidence of IPN during the index admission.
INTENSIVE CARE MEDICINE
(2022)
Review
Surgery
Daniel Joh, Mathew Morreau, Angela Lee, Sayali Pendharkar, Bruce Stokes, Roger Warren, Anthony Hickey, Anthony J. Phillips, John A. Windsor
Summary: Acute Mesenteric Ischaemic (AMI) is a rare and serious condition, and current treatments have limitations. This systematic review of experimental studies suggests that intraluminal oxygen delivery may be an effective treatment for AMI, but further research is needed to determine the optimal timing and formulation before clinical translation.
ANZ JOURNAL OF SURGERY
(2023)
Letter
Gastroenterology & Hepatology
Lin Gao, Xiaojia Xiao, Lu Ke, Jiwon Hong, Lisa Brown, Anthony Phillips, John A. Windsor
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Tiago Bouca-Machado, Stefan A. W. Bouwense, Martin Brand, Ihsan Ekin Demir, Jens Brondum Frokjaer, Pramod Garg, Peter Hegyi, J. -Matthias Lohr, Enrique de-Madaria, Soren Schou Olesen, Sanjay Pandanaboyana, Jan Bech Pedersen, Vinciane Rebours, Andrea Sheel, Vikesh Singh, Martin Smith, John A. Windsor, Dhiraj Yadav, Asbjorn Mohr Drewes
Summary: Acute on chronic pancreatitis (ACP) is a common condition, but there are significant gaps in our knowledge about it. Through a systematic review and expert consensus, a new definition of ACP was reached. Despite the poor evidence base, this position statement provides a foundation for the management of ACP.
Article
Gastroenterology & Hepatology
Linqian Li, Xiaoying Zhang, Guilan Cheng, Dingxi Wang, Shiyu Liu, Lan Li, Na Shi, Tao Jin, Ziqi Lin, Lihui Deng, Wei Huang, John A. Windsor, Guixiang Li, Qing Xia
Summary: This study aimed to optimize the technique for measuring intra-bladder pressure in patients with predicted severe acute pancreatitis. The results showed that measuring intra-bladder pressure at the iliac crest with a head of bed elevation of 15 degrees and instilling 25 mL of normal saline can be appropriate for monitoring intra-abdominal pressure in predicted severe acute pancreatitis patients. A bed elevation of 30 degrees significantly increased intra-bladder pressure.
Review
Gastroenterology & Hepatology
Dhya Al-Leswas, Nesta Baxter, Wei B. Lim, Francis Robertson, Bathiya Ratnayake, Jayanta Samanta, Gabriele Capurso, Enrique de-Madaria, Asbjorn M. Drewes, John Windsor, Sanjay Pandanaboyana
Summary: This systematic review and meta-analysis found that epidural anesthesia (EA) is safe and effective in managing pain in acute pancreatitis (AP). EA can reduce pain severity, improve pancreatic perfusion, and decrease mortality in AP patients. The use of EA is associated with lower need for ventilatory support.
Article
Gastroenterology & Hepatology
Wenjian Mao, Kang Li, Jing Zhou, Miao Chen, Bo Ye, Gang Li, Vikesh Singh, James Buxbaum, Xiaoyun Fu, Zhihui Tong, Yuxiu Liu, John Windsor, Weiqin Li, Lu Ke, CAPCTG
Summary: This study aimed to assess the performance of the Pancreatitis Activity Scoring System (PASS) and its modifications in predicting infected pancreatic necrosis (IPN) in patients with acute necrotizing pancreatitis. The mPASS-4 model had the best predictive performance and simplified the original PASS, increasing the likelihood of clinical implementation.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Johanes K. Kasim, Jiwon Hong, Anthony J. R. Hickey, Anthony R. J. Phillips, John A. Windsor, Paul W. R. Harris, Margaret A. Brimble, Iman Kavianinia
Summary: Pancreatic ductal adenocarcinoma is a debilitating disease with no effective treatments. Trichoderin A, a natural product, shows promise as an anticancer agent. It selectively kills pancreatic cancer cells under glucose deprivation, which is significant given the nutrient-deprived nature of the disease.
