Review
Endocrinology & Metabolism
Xintong Hou, Dan Yang, Guimei Yang, Mengnan Li, Jian Zhang, Jiaxin Zhang, Yi Zhang, Yunfeng Liu
Summary: This review summarizes the physiological significance of vasoactive intestinal peptide (VIP) in glucose homeostasis and the potential therapeutic value of VPAC2-selective agonists in type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Charlotte Helfrich-Foerster
Summary: The circadian clock serves as an internal time reference for organisms to anticipate seasonal changes. A recent study reveals the neural connection between the circadian clock and seasonal timing.
Article
Multidisciplinary Sciences
Maha S. A. Al-Keilani, Samah M. Awad, Hanan M. Hammouri, Tala Al Shalakhti, Basima A. Almomani, Muna M. Dahabreh, Mohammad-Jaafar Ajlony
Summary: The study aimed to investigate the serum levels of vasoactive intestinal peptide (VIP) and alpha calcitonin gene related peptide (aCGRP) in cystic fibrosis pediatric patients during pulmonary exacerbation and post-antibiotic therapy, and their associations with different clinicopathological parameters. The results showed significant changes in serum aCGRP levels following treatment of pulmonary exacerbations, but no significant changes in serum VIP levels. Serum VIP was associated with diabetes mellitus, other comorbidities, and type of antibiotic therapy, while serum aCGRP level was associated with type of antibiotic therapy and positive Staphylococcus aureus microbiology test.
Article
Immunology
Xiaofan Song, Shanyao Pi, Yueming Gao, Fengxia Zhou, Shuqi Yan, Yue Chen, Lei Qiao, Xina Dou, Dongyan Shao, Chunlan Xu
Summary: The study demonstrated that VIP pretreatment inhibited the activation of mast cells and the release of certain enzymes. The protective effect of L. casei ATCC 393 on ETEC K88-induced intestinal mucosal immune barrier dysfunction was abolished by aVIP.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raul Villanueva-Romero, Alicia Cabrera-Martin, Emigdio alvarez-Corrales, Mar Carrion, Selene Perez-Garcia, Amalia Lamana, David Castro-Vazquez, Carmen Martinez, Rosa P. Gomariz, Irene Gutierrez-Canas, Yasmina Juarranz
Summary: This study investigates the behavior of human CD4(+)CD45RA(+) T cells after in vitro activation and the role of the VIP system in this process. The findings show that without polarizing conditions, these T cells mainly differentiate into pathogenic Th17 subset and an unpaired Treg subset. The study also confirms the important immunomodulatory role of VIP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xin Zhao, Lijiao Deng, Lele Ren, Huanhuan Yang, Bin Wang, Xiaochan Zhu, Xiaoli Zhang, Chao Guo, Yi Zhang, Yunfeng Liu
Summary: VIP functions as a neuro-modulator with insulinotropic effect on pancreatic beta cells. It stimulates insulin secretion by inhibiting Kv channels, activating Ca2+ channels, and increasing [Ca2+]i through the VPAC2-R and AC/PKA signaling pathway. These findings provide a theoretical basis for VPAC2-R as a novel therapeutic target.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biology
Evgeny Privalov, Matthias Zenkel, Ursula Schloetzer-Schrehardt, Stefanie Kuerten, Antonio Bergua, Bettina Hohberger
Summary: The purpose of this study was to investigate the level of choroidal VIP (VIPchor) in the presence of an increased atmospheric pressure in a chicken model. The results showed that VIPchor level was significantly increased at 40 mmHg compared to the ambient pressure. This finding suggests that the accumulation of VIP within the neurons would decrease vasodilation and choroidal thickness.
Article
Immunology
Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jiang
Summary: Targeting inflammatory pathways is important in treating osteoarthritis (OA), however, the role and mechanism of VIP in OA is unclear. This study found that the p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop modulates various phenotypes in OA chondrocytes, including cell apoptosis, ROS accumulation, extracellular matrix deposition, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Developmental Biology
Kevin M. Goff, Ethan M. Goldberg
Summary: VIP-INs in the cerebral cortex play a crucial role in regulating network dynamics and normal circuit development, with implications in sensory input, development, and behavior. Underexplored disease-associated genes highly expressed in VIP-INs may broadly implicate them in autism spectrum disorder and intellectual disability. Further cell type-specific investigations and targeted therapeutics are discussed in the context of genomic diagnosis.
DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Liu Shi, Yang Liu, Zhengmeng Yang, Tianyi Wu, Hiu Tung Lo, Jia Xu, Jiajun Zhang, Weiping Lin, Jinfang Zhang, Lu Feng, Gang Li
Summary: Vasoactive intestinal peptide (VIP) plays a significant role in modulating bone homeostasis and promoting fracture healing. Study on sympathectomized mice models showed that VIP treatment can rescue the inhibitory effects of sympathetic nervous system disorder on bone structure and fracture healing, leading to improved bone quality and mechanical properties. VIP administration inhibits bone resorption and enhances osteogenesis marker expression, suggesting VIP as a potential alternative treatment for fracture healing.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hatice Deniz Ilhan, Betul Unal, Yusuf Ayaz, Nuray Erin
Summary: This study found a close association between the recurrence of pterygium and increased levels of Substance P and Vasoactive Intestinal Peptide (VIP) in TRPV1-positive nerve fibers. Changes in TRPV1 expression were also observed in recurrent cases. These findings suggest a potential role of TRPV1 in pterygium recurrence and indicate that inhibiting TRPV1 activity may help prevent pterygium recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jia-Xi Duan, Xin-Xin Guan, Hui-Hui Yang, Wen-Xiu Mei, Ping Chen, Jia-Hao Tao, Qing Li, Yong Zhou
Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Neurosciences
Ellen Merrick Schill, Alexandria N. Floyd, Rodney D. Newberry
Summary: This article explores the interactions between the enteric nervous system, immune system, and gut microbiota in maintaining intestinal homeostasis in adults, with a focus on their development and roles in early life, as well as the potential impact of early-life antibiotic exposure on gut health.
TRENDS IN NEUROSCIENCES
(2022)
Article
Immunology
Yixi Li, Wen Zhu, Rui Lin, Junjie Zhao, Yue Wang
Summary: Sjogren's disease is a chronic autoimmune disease characterized by the loss of exocrine gland function, and drugs that can correct immune imbalance and improve gland function are needed. Vasoactive intestinal peptide (VIP) has been identified as a potential therapeutic candidate with anti-inflammatory and immunoregulatory properties for treating autoimmune diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Karen J. Tonsfeldt, Laura J. Cui, Jinkwon Lee, Thijs J. Walbeek, Liza E. Brusman, Ye Jin, Michihiro Mieda, Michael R. Gorman, Pamela L. Mellon
Summary: This study examines the effects of disruptions to the circadian system on reproductive capacity, particularly in females. The loss of the Bmal1 gene in specific neuron populations affects circadian activity and temperature rhythms, but does not disrupt estrus cycles, fecundity, kisspeptin responsiveness, or inducible LH surge in female mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rachel M. McQuade, Vanesa Stojanovska, Rhian Stavely, Cara Timpani, Aaron C. Petersen, Raquel Abalo, Joel C. Bornstein, Emma Rybalka, Kulmira Nurgali
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Gastroenterology & Hepatology
R. T. Filippone, A. M. Robinson, V. Jovanovska, R. Stavely, V. Apostolopoulos, J. C. Bornstein, K. Nurgali
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Physiology
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C. Bornstein, Jaime P. P. Foong
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M. Allen, Joel C. Bornstein, Jaime P. P. Foong
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Pharmacology & Pharmacy
Rachel M. McQuade, Vanesa Stojanovska, Joel C. Bornstein, Kulmira Nurgali
PHARMACOLOGICAL RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Lin Y. Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C. Bornstein, Tor C. Savidge, Jaime P. P. Foong
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Rhiannon T. Filippone, Narges Dargahi, Rajaraman Eri, Jose A. Uranga, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Summary: Targeting eosinophils through the CCR3 axis can alleviate inflammatory bowel disease and contribute to understanding the role of eosinophils as potential targets for IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Sabrina S. B. Poon, Lin Y. Hung, Qinglong Wu, Pavitha Parathan, Nazli Yalcinkaya, Anthony Haag, Ruth Ann Luna, Joel C. Bornstein, Tor C. Savidge, Jaime P. P. Foong
Summary: Infants and young children have the highest exposure to antibiotics globally. Early life exposure to antibiotics increases susceptibility to various diseases, especially gut disorders. This study on mice found that neonatal antibiotic treatment has long-term effects on gut function, the enteric nervous system, gut microbiota, and mucosal serotonin levels in young adulthood.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Anita J. L. Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony J. J. Hannan, Lincon A. A. Stamp, Marlene M. M. Hao, Joel C. C. Bornstein
Summary: Glutamate is a major neurotransmitter in the central nervous system that plays a role in excitatory neurotransmission and synaptic plasticity. While it has a smaller role in neurotransmission in the enteric nervous system, this study found that Group-I metabotropic glutamate receptors (mGlu1 and mGlu5) have complex roles in gastrointestinal function. mGlu5 was found to affect excitatory enteric neurotransmission, while mGlu1 affected colonic motor complexes.
Article
Biochemistry & Molecular Biology
Rhian Stavely, Lauren Sahakian, Rhiannon T. T. Filippone, Vanesa Stojanovska, Joel C. C. Bornstein, Samy Sakkal, Kulmira Nurgali
Summary: This study investigates the expression of HMGB1 in the enteric nervous system and its relevance to intestinal neuroinflammation. The results suggest that oxidative stimuli induce cytoplasmic translocation of HMGB1 and neuronal loss, which can be ameliorated by inhibiting HMGB1.
Article
Biochemistry & Molecular Biology
Madushani Herath, Ellie Cho, Ulrika Marklund, Ashley E. Franks, Joel C. Bornstein, Elisa L. Hill-Yardin
Summary: Mutations in the Nlgn3 gene are associated with autism spectrum disorder (ASD) and gastrointestinal (GI) dysfunction. This study characterizes the expression of Nlgn3 in the enteric nervous system using RNA in situ hybridization and immunofluorescence. The results show that Nlgn3 mRNA is expressed in cholinergic and VIP-expressing submucosal neurons, nitrergic and calretinin-containing myenteric neurons, and glial cells. The autism-associated R451C mutation reduces Nlgn3 mRNA expression in cholinergic submucosal neurons and certain myenteric neurons and glial cells. These findings contribute to the understanding of the role of Nlgn3 in GI dysfunction in ASD.
Article
Gastroenterology & Hepatology
Jaime P. P. Foong, Lin Y. Hung, Sabrina Poon, Tor C. Savidge, Joel C. Bornstein
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
K. Nurgali, V. Stojanovska, R. M. McQuade, A. A. Rahman, E. Donald, A. Robinson, D. Myers, J. Bornstein
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
J. P. P. Foong, L. Y. Hung, P. Unterweger, P. Parathan, B. Prapaporn, A. Haag, R. A. Luna, J. C. Bornstein, T. C. Savidge
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
L. -Y. Hung, P. Parathan, P. Boonma, A. Haag, R. A. Luna, J. C. Bornstein, T. Savidge, J. P. P. Foong
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)