Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshiki Kaneoke, Tomohiro Donishi, Masaki Terada
Summary: The study demonstrates that parasagittal gastric cine MRI can measure gastric oscillatory contractions around 0.05 Hz and is correlated with EGG recordings, making it a valuable tool for detecting and quantifying gastric motility abnormalities.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Gastroenterology & Hepatology
Stefan Calder, Leo K. Cheng, Christopher N. Andrews, Niranchan Paskaranandavadivel, Stephen Waite, Saeed Alighaleh, Jonathan C. Erickson, Armen Gharibans, Gregory O'Grady, Peng Du
Summary: Gastric disorders are common, but current noninvasive tools to assess gastric function are lacking. This study successfully used high-resolution electrode arrays to capture slow waves from the stomach and epigastrium in pigs, validating BSGM as a suitable method for accurately detecting gastric slow-wave spatiotemporal profiles from the body surface.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dariusz Komorowski, Barbara Mika
Summary: A new method for identifying EGG rhythm has been proposed in this study, which calculates the normogastric index values consistent with those obtained using classical spectral analysis.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Chris Varghese, Gabriel Schamberg, Stefan Calder, Stephen Waite, Daniel Carson, Daphne Foong, William Jiaen Wang, Vincent Ho, Jonathan Woodhead, Charlotte Daker, William Xu, Peng Du, Thomas L. Abell, Henry P. Parkman, Jan Tack, Christopher N. Andrews, Gregory O'Grady, Armen A. Gharibans
Summary: This study aimed to define normative reference intervals for BSGM spectral metrics in healthy controls. The results showed the median and reference intervals for BSGM metrics, including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index, BMI-adjusted amplitude, and fed:fasted amplitude ratio. This study provides reference values for diagnostic interpretations of abnormal gastric function using BSGM spectral data.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Engineering, Multidisciplinary
Y. Ye-Lin, J. L. Martinez-De-Juan, A. Jareno-Silvestre, G. Prats-Boluda
Summary: This study explored the potential of using concentric ring electrodes (CRE) to improve the spatial resolution of electrogastrogram (EGG) recordings for detecting gastric myoelectric activity. The results showed that the BC EGG records with CRE had a lower signal amplitude than bipolar recordings, but were less affected by cardiac interference, with a high slow wave (SW) detectability rate above 80%. Additionally, both fasting and postprandial EGG records using CRE exhibited similar gastric SW frequency and postprandial/fasting power ratio, suggesting the feasibility of using CRE for identifying gastric myoelectric activity.
Article
Instruments & Instrumentation
Xinyu Wu, Jianshe Liu, Wei Chen
Summary: This paper proposes a SQUID readout circuit with tunable feedback polarity, which enhances the performance of SQUID by integrating feedback circuits and superconducting switches to achieve the switching of feedback polarity. Additionally, a two-stage scheme is introduced to address the degraded noise performance caused by negative feedback.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Engineering, Biomedical
Chad E. Drake, Leo K. Cheng, Niranchan Paskaranandavadivel, Saeed Alighaleh, Timothy R. Angeli-Gordon, Peng Du, Leonard A. Bradshaw, Recep Avci
Summary: Bioelectric slow waves regulate gastrointestinal motility, and disordered activity is linked to motility disorders. A method for reconstructing 3D stomach geometry from coil localization was developed and validated using anatomically realistic models and in-vivo pig studies. The proposed method could enable investigation of novel analysis techniques.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Neurosciences
Gidon Levakov, Shira Ganor, Galia Avidan
Summary: Recent studies have found that various brain regions, mainly sensory, unimodal regions, are synchronized with the stomach's myoelectrical rhythm. These interactions have implications for feeding behavior and gastrointestinal disorders. However, little is known about the reliability of these interactions and their susceptibility to artifacts. In this study, the researchers examined the reliability of these interactions and found that there was substantial reliability in both the brain and gastric signals, but not in measures of gastric-brain synchrony.
HUMAN BRAIN MAPPING
(2023)
Review
Chemistry, Analytical
Bradley J. Roth
Summary: Biomagnetism involves measuring weak magnetic fields generated by nerves and muscles. The first measured biomagnetic signal was the magnetocardiogram (MCG) of the heart, which has the largest magnetic field. Magnetic fields have also been detected from isolated tissues like peripheral nerves and cardiac muscle, providing insights into the properties of biomagnetism. The magnetoencephalogram (MEG) of the brain is of great interest and has potential clinical applications for epilepsy, migraine, and psychiatric disorders. Solving the biomagnetic inverse problem, which calculates electrical sources within the brain from magnetic field recordings outside the head, is challenging but various techniques have been introduced. Superconducting quantum interference device (SQUID) magnetometers were traditionally used to record biomagnetic fields, but new sensors have been developed that eliminate the need for cryogenic technology required by SQUIDs.
Article
Chemistry, Multidisciplinary
Katrijn Everaert, Tilmann Sander, Rainer Koerber, Norbert Loewa, Bartel Van Waeyenberge, Jonathan Leliaert, Frank Wiekhorst
Summary: Thermal noise magnetometry (TNM) is a magnetic characterization technique that measures thermally induced fluctuations in magnetization to understand nanomagnetic structures. A tabletop setup using optically pumped magnetometers (OPMs) is proposed as a flexible alternative to the traditional superconducting quantum interference device (SQUID) setup. The OPM setup offers high sensitivity in lower frequencies, making it suitable for monitoring aggregation processes. Results show that the tabletop setup is a versatile tool for studying MNPs for various applications.
NANOSCALE ADVANCES
(2023)
Article
Physics, Applied
Jay C. LeFebvre, Ethan Cho, Hao Li, Han Cai, Shane A. Cybart
Summary: In this study, the flux focusing effect in series arrays of planar Josephson junctions is investigated, and the characteristics of these arrays in magnetic field sensing are presented. By tuning and scaling the geometry of the devices, their sensitivity to magnetic fields can be improved and linear voltage responses can be generated. Experimental results confirm the performance of the arrays, demonstrating their superior performance in cryogenic environments.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Harshita Kumari, Cindi L. Dennis, Steven R. Kline, Andrew Mossine, Carol A. Deakyne, Jerry L. Atwood
Summary: The magnetic properties of nickel-seamed C-pyrogallol[4]arene (PgC(3)Ni) hexamers and dimers are studied for the first time in solution. The study reveals the presence of an unprecedented 13 angstrom-radius species and confirms the existence of two additional new species. Select parameters that shift the equilibrium towards desired species are identified.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Computer Science, Interdisciplinary Applications
Hamza Hassan, Surosree Ganguli, Hani Rashed, William Johnson, Bikash Bhandari, Thomas Abell
Summary: This study aimed to predict disordered gastric emptying by combining autonomic nervous system testing and electrogastrography, and found that factors such as RRI, VC, PAR, and EGG better described gastric emptying in patients with diabetic gastropathy.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Cell Biology
Armen A. Gharibans, Stefan Calder, Chris Varghese, Stephen Waite, Gabriel Schamberg, Charlotte Daker, Peng Du, Saeed Alighaleh, Daniel Carson, Jonathan Woodhead, Gianrico Farrugia, John A. Windsor, Christopher N. Andrews, Greg O'Grady
Summary: Chronic nausea and vomiting syndromes (NVSs) are prevalent and debilitating disorders. A medical device enabling noninvasive body surface gastric mapping (BSGM) was developed and applied to evaluate NVS pathophysiology. The study found that patients with NVS have impaired meal responses and can be divided into two distinct subgroups based on gastric motor abnormalities and psychological comorbidities.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Analytical
Antonio Vettoliere, Carmine Granata
Summary: In this article, experimental results are presented on fully integrated superconducting quantum interference devices (SQUID), which include a circuit for tuning and optimizing the main sensor device characteristics. It is shown that the critical current of a SQUID magnetometer in liquid helium can be modified using a suitable heating circuit. This allows for the improvement of SQUID sensor characteristics, such as the voltage-magnetic flux characteristic, responsivity, as well as flux and magnetic field noise. Additionally, the SQUID sensor can be reset in case of magnetic flux entrapment without removing it from the helium bath. These findings are valuable for optimizing and resetting magnetic sensors in large multichannel systems.
Article
Geriatrics & Gerontology
David J. Robles, Ammar Dharani, Kenneth A. Rostowsky, Nikhil N. Chaudhari, Van Ngo, Fan Zhang, Lauren J. O'Donnell, Lauren Green, Nasim Sheikh-Bahaei, Helena C. Chui, Andrei Irimia
Summary: Age is linearly associated with white matter degradation, likely not only due to injury but also to cumulative effects of other pathologies and their interactions with injury. As time passes, the degradation of brain white matter will result in age-dependent deficits in information processing speed, interhemispheric communication, motor coordination, visual acuity, sensory integration, reading speed/comprehension, executive function, personality, and memory.
Article
Clinical Neurology
Margaret Gatz, Wendy J. Mack, Helena C. Chui, E. Meng Law, Giuseppe Barisano, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, Amy R. Borenstein, Ellen E. Walters, Andrei Irimia, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, Michael Miyamoto, David E. Michalik, Daniel K. Cummings, Edmond Seabright, Angela R. Garcia, Paul L. Hooper, Thomas S. Kraft, Caleb E. Finch, Gregory S. Thomas, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, Hillard Kaplan
Summary: This study evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten populations who lead a subsistence lifestyle. The results showed a low prevalence of dementia in both populations, and widespread intracranial arterial calcification was observed.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
H. Akrami, R. M. Leahy, A. Irimia, P. E. Kim, C. N. Heck, A. A. Joshi
Summary: This study used an MR imaging data set to identify imaging biomarkers that predict posttraumatic epilepsy. The findings suggest that lesions in the temporal lobes, occipital lobe, and cerebellum are associated with an increased incidence of posttraumatic epilepsy.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Neurosciences
Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. McAllister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Summary: Mild traumatic brain injury (mTBI) is common in military personnel and is associated with age-related neurodegenerative disorders affecting white matter in the brain. Non-negative matrix factorization (NMF) was used to detect covarying patterns of fractional anisotropy (FA) associated with mTBI in a large dataset of military Veterans. The study showed significant age-dependent differences in WM alterations between Veterans with and without TBI, highlighting the importance of considering age in assessing the effects of mTBI.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Clinical
Tricia L. Merkley, Carrie Esopenko, Vanessa S. Zizak, Robert M. Bilder, Adriana M. Strutt, David F. Tate, Andrei Irimia
Summary: This article emphasizes the importance of considering cultural and linguistic variables in neuropsychological test performance. It highlights the impact of cultural and language differences on test outcomes, and raises concerns about the misinterpretation of results if norms are applied universally.
Article
Geriatrics & Gerontology
Anar Amgalan, Alexander S. Maher, Phoebe Imms, Michelle Y. Ha, Timothy A. Fanelle, Andrei Irimia
Summary: Neural and cognitive deficits after mild traumatic brain injury (mTBI) are accompanied by changes in resting state functional correlation networks. These changes are sex-dependent and associated with specific functional recovery patterns across cognitive domains. Age and sex also influence the changes in functional connectivity between different brain networks, which in turn affect cognitive recovery. This study provides insight into the impact of mTBI on functional connectivity and its correlation with cognitive deficits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Jess A. Holguin, John L. Margetis, Anisha Narayan, Grant M. Yoneoka, Andrei Irimia
Summary: Contemporary stroke assessment protocols have limited ability to detect vascular cognitive impairment (VCI), especially in cases of mild stroke (MiS) with subtle deficits. Processing speed is a valuable proxy for complex neurocognitive operations and can be used as a more sensitive and specific metric for screening VCI. This knowledge can inform rehabilitation approaches and enhance patient recovery.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sean O. Mahoney, Nahian F. Chowdhury, Van Ngo, Phoebe Imms, Andrei Irimia
Summary: This study reveals that intracortical demyelination after mild traumatic brain injury is significantly more severe than in typical aging, with different regions of the brain affected differently. Occipital regions may be more susceptible to primary injury, while temporal, cingulate, and insular regions are more vulnerable to later manifestations of injury sequelae.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Anar Amgalan, Alexander S. Maher, Satyaki Ghosh, Helena C. Chui, Paul Bogdan, Andrei Irimia
Summary: Adults aged 60 and over who suffer from mild traumatic brain injury (mTBI) experience accelerated brain aging, with the extent of aging being influenced by their age at the time of injury.
Article
Geriatrics & Gerontology
Roy J. Massett, Alexander S. Maher, Phoebe E. Imms, Anar Amgalan, Nikhil N. Chaudhari, Nahian F. Chowdhury, Andrei Irimia, Alzheimers Dis Neuroimaging Initiat
Summary: The biological age of the brain, different from its chronological age, can be used as a biomarker for neural/cognitive diseases and mortality prediction. An ML-based ridge regression model was developed to quantify the contribution of each brain region to brain age using MRI data. The model's performance was evaluated and important brain structures were identified.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Andrei Irimia, Van Ngo, Nikhil N. Chaudhari, Fan Zhang, Shantanu H. Joshi, Anita N. Penkova, Lauren J. O'Donnell, Nasim Sheikh-Bahaei, Xiaoyu Zheng, Helena C. Chui
Summary: This study found that cerebral microbleeds in mTBI patients are associated with white matter degradation and cognitive decline, with male sex and older age as significant risk factors for larger reductions. The findings indicate a significant positive correlation between CMBs and changes in cognitive functions, suggesting the need for long-term cognitive assessment in mTBI patients.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Alexander F. Shida, Roy J. Massett, Phoebe Imms, Ramanand V. Vegesna, Anar Amgalan, Andrei Irimia
Summary: This study compares the rates of regional gray matter volume loss between individuals with recent mild traumatic brain injury (mTBI) and healthy controls (HCs). The results show that mTBI patients have significantly steeper rates of volume loss in various brain regions, particularly in the prefrontal and temporal structures.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Meeting Abstract
Critical Care Medicine
Emily Dennis, Alexander Olsen, Maheen Adamson, Houshang Amiri, Erin Bigler, Karen Caeyenberghs, Kristen Dams-O'Connor, Evelyn Deutscher, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta Haberg, Cooper Hodges, Andrei Irimia, Neda Jahanshad, Ruchira Jha, Hannah Lindsey, Abdalla Mohamed, Martin Monti, Mary Newsome, Gershon Spitz, Paul Thompson, David Tate, Elisabeth Wilde, Frank Hillary
JOURNAL OF NEUROTRAUMA
(2022)
Meeting Abstract
Critical Care Medicine
Alexander Maher, Anar Amgalan, Roy Massett, Andrei Irimia
JOURNAL OF NEUROTRAUMA
(2022)
Meeting Abstract
Critical Care Medicine
Nahian Chowdhury, Sean Mahoney, Shania Wang, Andrei Irimia
JOURNAL OF NEUROTRAUMA
(2021)