Review
Psychology, Multidisciplinary
Julian Koenig, Julian F. Thayer, Michael Kaess
Summary: Psychophysiological research methods provide important insights into the normal and pathological functioning of the human organism. Existing studies on the psychophysiological concomitants of personality pathology are mixed, with a focus on borderline personality disorder. Findings suggest robust alterations in ANS function related to severe early maltreatment and trauma, as well as symptoms of dissociation, although lifestyle and secondary health factors are often overlooked.
CURRENT OPINION IN PSYCHOLOGY
(2021)
Article
Surgery
Jorge Daes, David J. Morrell, Andres Hanssen, Melissa Caballero, Elika Luque, Rafael Pantoja, Jorge Luquetta, Eric M. Pauli
Summary: Laparoscopic paragastric autonomic neural blockade (PG-ANB) can safely and effectively reduce early visceral pain (VP) symptoms, decrease the occurrence of autonomic symptoms, and reduce the use of analgesics after sleeve gastrectomy.
Article
Biochemistry & Molecular Biology
Jonathon L. Mcclain, Wilmarie Morales-Soto, Jacques Gonzales, Visha Parmar, Elena Y. Demireva, Brian D. Gulbransen
Summary: Enteric glia contribute to histamine clearance in the enteric nervous system through HNMT expression. Deleting glial Hnmt increases glial histamine levels and alters visceromotor responses. However, the effects are sex-dependent.
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Behavioral Sciences
Valentin Magnon, Guillaume T. Vallet, Amanda Benson, Martial Mermillod, Pierre Chausse, Adeline Lacroix, Jean-Baptiste Bouillon-Minois, Frederic Dutheil
Summary: This systematic review and meta-analysis examined the association between vagally-mediated heart rate variability (HRV) and executive functioning. The results showed a small positive association between the two, with vagally-mediated HRV predicting cognitive inhibition and cognitive flexibility more than working memory.
Article
Psychology, Biological
Fenghua Li, Todd Jackson
Summary: This study investigated psychophysiological differences between individuals with high, moderate, and low pain resilience during the anticipation, experience, and recovery from laboratory-induced pain. Results showed that individuals with high pain resilience displayed significantly lower skin conductance level during anticipation and experience of pain compared to those with moderate and low resilience. Additionally, individuals with high pain resilience maintained lower skin conductance level during the recovery period as well. Differences were also found in self-reported anticipatory anxiety and expected pain levels, with the low resilience group reporting higher levels in these aspects.
Article
Clinical Neurology
Mansoureh Togha, Fahimeh Martami, Elham Jafari, Shadi Ariyanfar, Seyedeh Melika Hashemi
Summary: Visceral symptoms are common in migraine sufferers not only during attacks but also in the premonitory and postdrome phases; Participants with visceral symptoms experience longer and more severe migraine attacks compared to those without symptoms.
Article
Psychology, Experimental
Kieran McVeigh, Ian R. Kleckner, Karen S. Quigley, Ajay B. Satpute
Summary: Psychologists, philosophers, and neuroscientists have long debated whether there is a universal mapping of physiology to emotion or if these mappings vary by person or situation. This study explored the relationship between subjective experience and autonomic reactivity in instances of fear across three different situations. The results showed that the relationship between fear experience and autonomic reactivity is situation-dependent, with individual variance constrained by the situation.
Review
Food Science & Technology
Ana Campos-Rios, Lola Rueda-Ruzafa, Salvador Herrera-Perez, Paula Rivas-Ramirez, Jose Antonio Lamas
Summary: Visceral pain is a common symptom in functional gastrointestinal disorders, with the involvement of both the central and peripheral nervous systems in visceral hypersensitivity. Current treatments often involve opioids, but their side effects and decreasing effectiveness have led to a search for new therapies, with tetrodotoxin being a promising option.
Article
Psychology, Multidisciplinary
Kelly E. Faig, Karen E. Smith, Stephanie J. Dimitroff
Summary: Frameworks of emotional development have traditionally focused on the influence of environmental factors on children's emotion understanding. However, individual experiences of emotion are influenced by a complex interplay of external inputs and internal bodily signals. This article highlights the importance of incorporating somatovisceral theories of emotions into frameworks of emotional development to enhance children's understanding of emotions in themselves and others. It discusses potential future research directions, including afferent cardiac processing and interoception, immune activation, physiological synchrony, and social touch.
Article
Neurosciences
Lennard Geiss, Beate Beck, Wolfgang Hitzl, Thomas Hillemacher, Katharina M. Hoesl
Summary: This study found reduced cardiovascular autonomic modulation in patients with Borderline Personality Disorder (BPD) compared to controls, particularly during resting state and stress exposure. This indicates a deficit in vagal modulation in BPD patients. Breathing techniques, such as metronomic breathing, may be helpful in reducing stress and increasing vagal tone in BPD patients.
NEUROPSYCHOBIOLOGY
(2021)
Article
Psychiatry
Carter E. Bedford, Yoshio Nakamura, William R. Marchand, Eric L. Garland
Summary: The study revealed that active duty soldiers with comorbid chronic pain and PTSD exhibited heightened sympathetic nervous system reactivity when viewing negative affective images, highlighting the importance of intervening on potential risk factors for these conditions.
PSYCHIATRY RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Yanzhen Li, Hong Zhang, Jingwen Yang, Muouyang Zhan, Xuefei Hu, Yongmin Liu, Lingling Yu, Xiaochen Yan, Shangdong Liang, Ruyue Zhang, Ying Lu, Beining Li, Cunzhi Liu, Man Li
Summary: The study found that increased expression of P2Y12 in the mPFC is associated with visceral pain and depression in IBD mice, and interfering with P2Y12 expression in the mPFC or performing EA treatment can significantly alleviate visceral pain and depression in IBD mice. EA treatment can also downregulate P2Y12 expression, weaken microglial activation, and inhibit IL-1 beta expression in the mPFC, thereby relieving visceral pain and depression in IBD mice.
Article
Psychology, Multidisciplinary
Isabel Neumann, Ivo Kaethner, Daniel Gromer, Paul Pauli
Summary: Virtual verbal support in virtual reality can positively influence physiological pain responses, but has no effect on pain ratings. The perceived agency of virtual characters does not significantly affect pain responses.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Rodger A. Liddle
Summary: Visceral pain associated with irritable bowel syndrome affects 15% of the US population. Recent studies have discovered a new pathway for gut signal communication to the nervous system through synaptic connections between guanylyl cyclase C (GUCY2C)-promoting neurons and submucosal neurons. Selective deletion of GUCY2C in mouse models indicates that defective GUCY2C neuropod-cell signaling is responsible for visceral pain. Unveiling the role of neuropod cells is a significant step in understanding and potentially treating visceral pain.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Gastroenterology & Hepatology
James K. Ruffle, Adam D. Farmer, Qasim Aziz
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Simon Eaton, Stamatiki Kritas, Stephen J. Kentish, Eduardo J. A. Araujo, Cristiano Bacarin, Amanda J. Page, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
James K. Ruffle, Anya Patel, Vincent Giampietro, Matthew A. Howard, Gareth J. Sanger, Paul L. R. Andrews, Steven C. R. Williams, Qasim Aziz, Adam D. Farmer
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Gastroenterology & Hepatology
Fabienne G. M. Smeets, Daniel Keszthelyi, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Jose M. Conchillo, Joanna W. Kruimel, Jim Van Os, A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Editorial Material
Gastroenterology & Hepatology
James K. Ruffle, Niall Power, Qasim Aziz
Article
Gastroenterology & Hepatology
Kenichiro Nakagawa, Ken Hara, Asma Fikree, Shahab Siddiqi, Philip Woodland, Atsushi Masamune, Qasim Aziz, Daniel Sifrim, Etsuro Yazaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, Research & Experimental
David Gunn, Ron Fried, Rabia Lalani, Amanda Farrin, Ivana Holloway, Tom Morris, Catherine Olivier, Rachael Kearns, Maura Corsetti, Mark Scott, Adam Farmer, Anton Emmanuel, Peter Whorwell, Yan Yiannakou, David Sanders, John Mclaughlin, Kapil Kapur, Maria Eugenicos, Ayesha Akbar, Nigel Trudgill, Lesley Houghton, Phil G. Dinning, Alexander C. Ford, Qasim Aziz, Robin Spiller
Article
Gastroenterology & Hepatology
Adam D. Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K. Ruffle, Heather E. Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Florencia Carbone, Nick Goelen, Asma Fikree, Qasim Aziz, Jan Tack
Summary: Functional dyspepsia (FD) often co-exists with joint hypermobility syndrome (JHS), characterized by decreased gastric accommodation and lower nutrient tolerance compared to FD patients with JHS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.