Review
Biochemistry & Molecular Biology
Tibor Docsa, Adam Sipos, Charles S. Cox, Karen Uray
Summary: Feeding intolerance and ileus are common complications in critically ill, surgical, and trauma patients, leading to longer hospital stays, increased infections, readmission rates, and medical costs. Current medical treatment for ileus is ineffective and has serious side effects. Inflammatory mediators play a critical role in the development of ileus, but their direct effects on gastrointestinal cells are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
P. Viannay, J. F. Hamel, M. Bougard, J. Barbieux, A. Hamy, A. Venara
Summary: The study showed that the majority of patients undergoing colorectal surgery regained their preoperative autonomy before discharge and maintained it in the days leading up to discharge. Postoperative recovery of autonomy was found to be progressive, with the day of gastrointestinal transit recovery being significantly associated with increased autonomy.
JOURNAL OF VISCERAL SURGERY
(2021)
Article
Clinical Neurology
Eric Feuchtbaum, James P. Wondra II, David B. Bumpass, Lukas P. Zebala, Lawrence G. Lenke, Michael P. Kelly
Summary: This study evaluated the efficacy of alvimopan in adult patients undergoing posterior spinal fusion. The results showed that alvimopan did not accelerate the recovery of bowel function compared to placebo, and favored placebo in all outcome measures. The study suggests that alvimopan may not have a clinically relevant effect in these patients.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Medicine, Research & Experimental
TianRong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, JunKe Wang, ZhiWen Zhao, MingFei Wang, JiYuan Song, RenXiang Feng, Leping Li, Changqing Jing, Feng Tian
Summary: Gut microbiota plays a vital role in maintaining normal intestinal peristalsis, and disruptions caused by antibiotics or opioid anesthetics during surgical procedures can impact intestinal motility. However, the precise mechanisms behind this dysbiosis are still not fully understood. This review focuses on the effects of gut microbiota and their metabolites on postoperative intestinal motility, specifically the regulation of the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andreea Firut, Dragos Nicolae Margaritescu, Adina Turcu-Stiolica, Marius Bica, Ionela Rotaru, Ana-Maria Patrascu, Razvan Ilie Radu, Daniela Marinescu, Stefan Patrascu, Costin Teodor Streba, Valeriu Surlin
Summary: This study aimed to assess the role of immunocyte-derived ratios (IDRs) as markers for postoperative recovery of gastrointestinal function following colorectal cancer surgery. The results showed that certain IDRs may have potential as predictive determinants for postoperative gastrointestinal functional recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Federica Canzan, Arianna Caliaro, Maria Luisa Cavada, Elisabetta Mezzalira, Salvatore Paiella, Elisa Ambrosi
Summary: The effectiveness of early postoperative feeding in reducing the duration of postoperative ileus after gastrointestinal surgery is still debated.
Article
Veterinary Sciences
Helene Deflers, Frederic Gandar, Geraldine Bolen, Johann Detilleux, Charlotte Sandersen, Didier Marlier
Summary: The aim of this study was to evaluate and compare the effects of single doses of butorphanol, morphine, and tramadol on gastrointestinal motility in rabbits using non-invasive imaging methods. The results showed that butorphanol and morphine can temporarily slow gastrointestinal transit, while tramadol does not have such effects.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Eglantina Idrizaj, Chiara Traini, Maria Giuliana Vannucchi, Maria Caterina Baccari
Summary: This article focuses on the influence of nitric oxide (NO) on gastric motility, highlighting its importance in both physiological and pathological conditions. The main role of NO in regulating gastric smooth muscle motor responses, including NO synthases expression and signaling pathways, is discussed. Understanding nitrergic mechanisms is crucial for addressing gastric pathophysiological conditions and developing potential therapeutic approaches for GI motility disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Shaoqiang Zheng, Li Xu, Yan Zhou, Wenchao Zhang, Yaoping Zhao, Lin Hu, Shan Zheng, Geng Wang, Tianlong Wang
Summary: This randomized controlled trial investigated the effects of bilateral 2-level erector spinae plane block on postoperative gastrointestinal function and rehabilitation in patients undergoing posterior lumbar surgery. The results showed that patients who received the block had shorter time to first flatus, earlier food and liquid intake, earlier off-bed activity, shorter hospital stay, and lower pain levels and opioid consumption. This technique may also have anti-inflammatory effects. Therefore, bilateral 2-level erector spinae plane block can expedite recovery and improve postoperative outcomes in these patients.
Review
Biochemistry & Molecular Biology
Maria Caterina Baccari, Maria Giuliana Vannucchi, Eglantina Idrizaj
Summary: This mini-review summarizes the literature on the control of gastrointestinal motility by GLP-2, the mechanism through which it occurs, and the physiological implications of these effects. A better understanding of the role of GLP-2 in gastrointestinal motor responses may be important for the development of new therapeutic approaches in gastrointestinal dysmotility.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Elvio Mazzotta, Iveta Grants, Egina Villalobos-Hernandez, Samhita Chaudhuri, Jonathon L. McClain, Luisa Seguella, Derek M. Kendig, Bryan A. Blakeney, Srinivasa K. Murthy, Reiner Schneider, Patrick Leven, Sven Wehner, Alan Harzman, John R. Grider, Brian D. Gulbransen, Fedias L. Christofi
Summary: The ETB receptor signaling in enteric glia plays a role in the modulation of intestinal motility and inflammation. ET-1 release regulates glial responses through the ETB receptor, and its upregulation in inflammation may contribute to the pathogenesis of postoperative ileus.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Physiology
Stephanie K. Gaskell, Christopher E. Rauch, Ricardo J. S. Costa
Summary: This translational research case series describes the implementation of a gastrointestinal assessment protocol during exercise (GastroAxEx) to inform individualised therapeutic intervention of endurance athletes affected by exercise-induced gastrointestinal syndrome (EIGS) and associated gastrointestinal symptoms (GIS). A four-phase approach was applied, focusing on clinical assessment, laboratory simulation of exercise stress, therapeutic intervention, and monitoring. The results showed individualised interventions based on the identified causal factors of EIGS and GIS during exercise led to improvements in symptoms and work output for athletes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yu Wu, Zenghua Cai, Lishuang Liu, Jinbao Wang, Yanli Li, Yuling Kang, Ni An
Summary: Dexmedetomidine can improve gastrointestinal function recovery after laparoscopic hysteromyomectomy, reducing the time to first flatus, oral feeding, and defecation.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Martina Brandlhuber, Petra Benhaqi, Bernhard Brandlhuber, Vanessa Koliogiannis, Michael S. Kasparek, Mario H. Mueller, Martin E. Kreis
Summary: The study suggests that afferent nerve signaling to the central nervous system during early POI development is mainly mediated by the vagus nerve and to a lesser extent via systemic circulation. Vagal modulation may attenuate the intestinal immune response during the early hours of POI, indicating interactions between the central nervous system and the intestine.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Surgery
N. N. Dudi-Venkata, H. M. Kroon, S. Bedrikovetski, M. Lewis, M. J. Lawrence, R. A. Hunter, J. W. Moore, M. L. Thomas, T. Sammour
Summary: The routine use of multi-modal laxatives after elective colorectal surgery can result in earlier recovery of gastrointestinal function and reduce the incidence of prolonged postoperative ileus.
BRITISH JOURNAL OF SURGERY
(2021)