Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Medicine, General & Internal
Ruixi Zhou, Junjie Ying, Xia Qiu, Luting Yu, Yan Yue, Qian Liu, Jing Shi, Xihong Li, Yi Qu, Dezhi Mu
Summary: This study revealed that PANoptosis programs are activated concurrently in SAE rats. TLR9 activates PANoptosis through the p38 MAPK signaling pathway. TLR9 may serve as a potential target for SAE treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Vikram Jeet Singh, Bharti Sharma, Pooja A. Chawla
Summary: The article focuses on the MAPK signaling pathway and the role of different heterocyclic compounds with nitrogen, sulfur, and oxygen in blocking the MAPK signaling pathway. Heterocyclic compounds are important due to their high potency and selectivity against various targets involved in the MAPK signaling pathway for cancer management. The potential of these compounds in inhibiting MAPK cascade and recent advancements in developing MAPK signaling pathway inhibitors are discussed in detail.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Agriculture, Multidisciplinary
Kai-yuan Ji, Ru-jun Wen, Zheng-zhou Wang, Qian-qian Tian, Wei Zhang, Yun-hai Zhang
Summary: In mammals, miRNAs regulate the expression of target genes and play crucial roles in various biological processes. The expression levels of miR-370-5p differ significantly in sheep with different hair colors, but its function is not clear. This study investigated the roles of miR-370-5p in sheep melanocytes and found that its overexpression significantly inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001), and melanin production (P<0.001).
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Liu, Jing Hu, Weiwei Wang, Qian Wang
Summary: This study explored the effect of miR-145 on cardiac fibrosis in heart failure mice and its target gene MAP3K3. The levels of miR-145 were decreased in heart failure mice and Ang II-treated cardiac fibroblasts. Upregulation of miR-145 improved cardiac dysfunction and inhibited fibrosis by suppressing MAP3K3 expression. Blocking MAP3K3 or upregulating miR-145 can be potential treatments for heart failure and cardiac fibrosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Plant Sciences
Xiangyu Guo, Xiangdan Li, Yanru Dong, Wei Xie, Toufeng Jin, Dongyuan Xu, Lan Liu
Summary: This study aimed to investigate the preventive and protective effect of cod skin collagen peptide powder (CP) on mice with ulcerative colitis (UC) and explore the underlying mechanism. The results showed that CP reduced inflammation by upregulating mitogen-activated protein kinase phosphatase-1 (MKP-1) and polarizing macrophages toward the M2 phenotype. It also inhibited the development of fibrosis complicating UC by regulating the expression of ZO-1, Occludin, α-SMA, Vimentin, Snail, and Slug.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Jong Hee Im, Jae-Heung Ko, Won-Chan Kim, Brent Crain, Daniel Keathley, Kyung-Hwan Han
Summary: MYB46 acts as a master switch for secondary cell wall biosynthesis, ensuring precise gene expression in critical tissues but being suppressed where secondary wall formation is not desired. The negative regulation of MYB46 by MPK6 during salt stress reveals a novel mechanism for plants to incorporate environmental signals into differential regulation of secondary wall biosynthesis.
Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lijuan Wei, Li Feng, Yayu Liu, Weibiao Liao
Summary: Salt stress impairs the growth and development of tomato seedlings, affecting various physiological and biochemical parameters. Transcriptome analysis revealed that multiple metabolic pathways, especially photosynthesis, carbon metabolism, biosynthesis of amino acids, and MAPK signaling pathway, are involved in the response of tomato seedlings to salt stress. Further investigation showed that MAPK might regulate hormone balance, ROS metabolism, antioxidant capacity, and plant immunity under salt stress condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anita Alexa, Orsolya Ember, Ildiko Szabo, Yousef Mo'ath, Adam L. Poti, Attila Remenyi, Zoltan Banoczi
Summary: This study optimized a linear binding motif to increase cellular uptake while maintaining low binding affinity, resulting in improved inhibition of specific kinases. However, the modulation of MAPK phosphorylation levels in cells by these peptides was complex, indicating the need for a better quantitative understanding of MAPK-mediated protein-protein interactions.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)