Review
Biochemistry & Molecular Biology
Arpad Szallasi
Summary: Today's sedentary lifestyle and poor dietary habits contribute to the increasing prevalence of hypertension, a major risk factor for stroke. Recent research suggests that the activation of TRPV1 receptor by capsaicin, a compound found in chili peppers, can lower blood pressure and potentially be a therapeutic target for hypertensive patients. However, the mechanism of action of capsaicin on blood pressure regulation is more complex than previously understood. Further studies are needed to explore the potential benefits of TRPV1-targeting drugs in treating hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tina Blazevic, Cosmin I. Ciotu, Markus Gold-Binder, Elke H. Heiss, Michael J. M. Fischer, Verena M. Dirsch
Summary: Capsaicin, an active compound of chili peppers, can inhibit platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle cells (VSMCs), possibly through a role of TRPV1. However, commercially available antibodies were ineffective in detecting TRPV1 expression. Moreover, TRPV1 agonists did not increase intracellular calcium levels in VSMCs. RT-qPCR results showed low TRPV1 expression in VSMCs, suggesting the absence of canonical TRPV1 channel activity.
Article
Medicine, Research & Experimental
Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke
Summary: This study provides direct evidence in humans for pain-related functional changes linked to TRPV1, a potential target in the development of pain relievers. Two individuals carrying a homozygous missense mutation in TRPV1 demonstrated insensitivity to heat stimulation, elevated pain thresholds, and abnormal responses to a TRPA1 channel activator. These findings highlight the importance of TRPV1 in pain modulation and may contribute to the development of novel pain therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Katherine Sattler, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Summary: Recent evidence shows the important role of the TRPV1 channel in the cardiovascular system and its association with inflammation. Experimental results demonstrate that TRPV1 mediates LPS-induced inflammation in cardiomyocytes, leading to changes in cellular electrophysiology. Further studies are needed to investigate the underlying pathways and clinical applications of these findings.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Article
Pharmacology & Pharmacy
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu
Summary: Autophagy plays a crucial role in regulating the ageing process and neurodegeneration. Dysfunction of autophagy is implicated in Alzheimer's disease pathogenesis. The activation of TRPV1 using capsaicin induces autophagy, which could potentially be a therapeutic target for Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Gargi Mishra, Kristy L. Townsend
Summary: The homeostatic regulation of adipose tissue is crucial for maintaining energy balance and overall metabolism. While most research has focused on sympathetic nerves and norepinephrine, recent studies have shed light on the contributions of sensory nerves and neuropeptides to adipose tissue functions. This article provides an overview of the regulation, function, and plasticity of adipose tissue sensory nerves, highlighting their roles in important metabolic processes such as lipolysis and vascular control.
Review
Endocrinology & Metabolism
Gargi Mishra, Kristy L. Townsend
Summary: Homeostatic regulation of adipose tissue is crucial for maintaining energy balance and overall metabolism, and the peripheral nervous system plays a key role in this regulation. Sensory nerves contribute to the regulation of adipose functions, but their specific roles and contributions are still understudied.
Article
Biochemistry & Molecular Biology
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu
Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.
Article
Pharmacology & Pharmacy
Mircea Iftinca, Manon Defaye, Christophe Altier
Summary: TRPV1 is a significant channel in pain perception and its agonists are being studied for chronic pain management. While TRPV1 antagonists have limited clinical use due to side effects, capsaicin offers a potential avenue for long-lasting pain relief by defunctionalising nociceptors. The development of TRPV1-targeted drugs could provide a new generation of analgesics for various pain conditions.
Article
Multidisciplinary Sciences
Xiuping Gao, Jianguo Zhuang, Lei Zhao, Wan Wei, Fadi Xu
Summary: The study shows that TRPV1 plays a modulating role in cough responses to PGE(2) through the vagal sensory nerve. There may be a cross-effect of TRPV1 and EP3 receptor in vagal pulmonary C-neurons, influencing cough responses.
Article
Biochemistry & Molecular Biology
Suo Zou, Takahiro Shimizu, Atsushi Kurabayashi, Masaki Yamamoto, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: In this study, it was found that hydrogen sulfide pretreatment can prevent bladder dysfunction caused by cyclophosphamide treatment by suppressing the activity of bladder afferent nerves, rather than by inhibiting bladder inflammation. Therefore, hydrogen sulfide may be a new candidate as a protective drug for bladder dysfunction induced by cyclophosphamide chemotherapy.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Isabella Romeo, Antonella Brizzi, Federica Pessina, Francesca Alessandra Ambrosio, Francesca Aiello, Carmela Belardo, Gabriele Carullo, Giosue Costa, Luciano De Petrocellis, Maria Frosini, Livio Luongo, Samuele Maramai, Marco Paolino, Aniello Schiano Moriello, Claudia Mugnaini, Francesco Scorzelli, Sabatino Maione, Federico Corelli, Vincenzo Di Marzo, Stefano Alcaro, Anna Artese
Summary: We developed a rational drug design strategy and synthesized ligands to improve the binding properties and potency of a previously identified TRPV1 agonist. Molecular modeling and simulations guided the design towards introducing a lipophilic iodine and a flat pyridine/benzene at a specific position in the ligand. Most synthesized compounds showed high TRPV1 efficacy, selectivity, and protective properties against oxidative stress-induced ROS formation. The compounds also exhibited neuroprotective and antinociceptive effects in biological evaluations.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Ahsen Ustaoglu, Akinari Sawada, Chung Lee, Wei-Yi Lei, Chien-Lin Chen, Richard Hackett, Daniel Sifrim, Madusha Peiris, Philip Woodland
Summary: This study demonstrates that increased pain perception in patients with nonerosive reflux disease may result from the expression of acid-sensitive channels on superficial mucosal afferents and esophageal epithelial cells. This raises the potential for topical therapy as a treatment option.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tom Breugelmans, Wout Arras, Lauren-Emma Boen, Eliah Borms, Lisa Kamperdijk, Joris De Man, Els Van de Vijver, Ann Van Gils, Benedicte Y. De Winter, Nicolette Moes, Annemieke Smet
Summary: This study found that colonic mucin expression is disturbed in pediatric IBD patients and is associated with disease activity and presentation. These findings suggest that mucin expression can serve as a molecular marker to aid in the diagnosis and management of the disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pathology
Cedric Peleman, Winnok H. De Vos, Isabel Pintelon, Ann Driessen, Annelies Van Eyck, Christophe Van Steenkiste, Luisa Vonghia, Joris De Man, Benedicte Y. De Winter, Tom Vanden Berghe, Sven M. Francque, Wilhelmus J. Kwanten
Summary: A new image analysis method was used to quantify the differences between liver lobule zones in NAFLD. The results showed that this method accurately measured the distribution of hypoxia markers in the steatotic liver and overcame the impact of steatosis on pathologists' interpretation.
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Nikita Hanning, Rosanne Verboven, Joris G. De Man, Hannah Ceuleers, Heiko U. De Schepper, Annemieke Smet, Benedicte Y. De Winter
Summary: This study showed that single-day or multi-day orogastric gavages do not have a significant effect on gut physiology in mice. However, multi-day gavages result in a slight increase in stress levels and altered gastrointestinal motor function. Despite this, the intestinal barrier function remains unaffected.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Cell Biology
Samuel Van Remoortel, Lana Lambeets, Heiko De Schepper, Jean-Pierre Timmermans
Summary: In recent years, it has been discovered that the family of Mas-related G protein-coupled receptors (MRGPRs) plays a crucial role in neuro-immune communication in the skin. However, the expression of MRGPRs at other mucosal surfaces remains poorly understood. This study aimed to investigate the expression of MRGPRs in mucosal biopsies of the human gastrointestinal (GI) tract. The results showed that MRGPRF mRNA was the only detectable member of the MRGPR family expressed in human mucosal biopsies of the terminal ileum and sigmoid colon. Immunohistochemical analysis revealed that MRGPRF was specifically expressed in mucosal entero-endocrine cells (EECs).
CELL AND TISSUE RESEARCH
(2023)
Review
Obstetrics & Gynecology
Sylvie van den Broeck, Sara Nullens, Yves Jacquemyn, Heiko De Schepper, Alexandra Vermandel, Niels Komen
Summary: The objective of this study is to review available devices for perineal support during defecation in patients with obstructive defecation syndrome (ODS) and posterior pelvic organ prolapse (POP). A total of 10 studies were included for review. The devices can be categorized into three groups: pessaries, vaginal stent, and external support device. The meta-analysis showed that the pessaries significantly improved Colorectal-Anal Distress Inventory (CRADI-8) and Impact Questionnaire (CRAI-Q-7), while the vaginal stent decreased ODS significantly.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Kristien J. Ledeganck, Annelies Van Eyck, Kristien Wouters, Eline Vermeiren, Benedicte Y. De Winter, Stijn Verhulst, Kim Van Hoorenbeeck, Annick France, Hilde Dotremont, Marieke den Brinker, Dominique Trouet
Summary: This study investigated the relationship between urinary EGF, serum renin, and blood pressure in children with obesity or T1DM. The results showed that the urinary EGF/urinary creatinine ratio is correlated with SBP and MAP in boys with obesity as well as boys with T1DM. Multiple regression analysis revealed that sex and pulse pressure were independently associated with renin in obese males. Sex, the presence of diabetes, age, the glomerular filtration rate, and both pulse pressure and mean arterial pressure were independently associated with urinary EGF/urinary creatinine in male subjects. In conclusion, pulse pressure and mean arterial pressure are negatively associated with the functional integrity of the nephron, as reflected by a decreased expression of urinary EGF, in boys with either obesity or diabetes.
Article
Microbiology
Baptiste Oosterlinck, Hannah Ceuleers, Wout Arras, Joris G. De Man, Karen Geboes, Heiko De Schepper, Marc Peeters, Sarah Lebeer, Jurgita Skieceviciene, Georgina L. Hold, Juozas Kupcinskas, Alexander Link, Benedicte Y. De Winter, Annemieke Smet
Summary: This study identified the mucin-microbiome signatures in gastric adenocarcinomas and their impact on clinical outcomes. The findings showed that intestinal mucin phenotype and high-level MUC13 expression were associated with poor survival, while gastric MUC5AC or MUC6 abundance was associated with a more favorable outcome. Furthermore, oral bacteria such as Neisseria, Prevotella, and Veillonella were found to play a potential role in MUC13 signaling and were associated with intestinal and mixed mucin phenotype tumors.
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Review
Gastroenterology & Hepatology
H. Ruymbeke, J. Geldof, D. De Looze, M. A. Denis, H. De Schepper, P. Dewint, I. Gijsen, M. Surmont, J. Wyndaele, P. Roelandt
Summary: An anal fissure is a painful tear in the sensitive skin of the anus, typically located below the dentate line. It is a common condition that significantly affects quality of life. Primary fissures are usually associated with constipation and found at the posterior midline, while secondary fissures, which account for about 1% of cases, can have atypical appearances and may be caused by underlying conditions such as Crohn's disease, malignancy, trauma or venereal infections. This manuscript aims to provide a comprehensive review of the clinical aspects, evaluation, and treatment of secondary anal fissures. (Acta gastroenterol. belg., 2023, 86, 58-67).
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
K. Van Malderen, J. G. De Man, B. Y. De Winter, H. U. De Schepper
Summary: This study aimed to evaluate the characteristics of a population visiting a patient-centered informative website about IBS. The study found that red flag symptoms and psychological comorbidities were common, and despite seeking medical help and receiving therapy, most patients still experienced moderate to severe symptoms with a significant impact on their quality of life. Furthermore, there was an urgent need for high-quality information and education for both healthcare professionals and patients.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Editorial Material
Gastroenterology & Hepatology
N. Lanthier, S. Lefere, H. De Schepper, C. Reenaers
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
