Article
Clinical Neurology
Bernice J. A. Gulpers, Frans R. J. Verhey, Simone J. P. M. Eussen, Miranda T. Schram, Bastiaan E. de Galan, Martin P. J. van Boxtel, Coen D. A. Stehouwer, S. Kohler
Summary: This study investigates the relationship between individual anxiety disorders, generalized anxiety symptoms, and multiple cognitive domains. The results show that agoraphobia is associated with worse scores on all cognitive domains and higher odds of cognitive impairment. High scores on the Generalized Anxiety Disorder 7-item scale (GAD-7) are associated with worse scores on processing speed and higher odds of cognitive impairment. Panic disorder is significantly associated with worse scores on memory tasks. These associations are stronger in younger participants and in those with type 2 diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Tobin J. Ehrlich, Hanjoo Kim, Kelly A. Ryan, Scott A. Langenecker, Elizabeth R. Duval, Anastasia K. Yocum, Claudia Diaz-Byrd, Anna L. Wrobel, Olivia M. Dean, Sue M. Cotton, Michael Berk, Melvin G. McInnis, David F. Marshall
Summary: This study evaluated the relationship between childhood trauma and cognition in individuals diagnosed with bipolar disorder. It found that higher childhood trauma was associated with worse memory functioning in bipolar disorder patients. The study emphasizes the importance of understanding the long-term cognitive outcomes of childhood trauma in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Naoise Mac Giollabhui, Lauren B. Alloy, Lizanne J. S. Schweren, Catharina A. Hartman
Summary: Many depressed individuals experience difficulties in executive functioning, especially those with chronic inflammation. This study found that depression and higher CRP levels are associated with worse executive functioning, with this association being more pronounced in older adults.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychology, Multidisciplinary
Judit Catalan-Aguilar, Esperanza Gonzalez-Bono, Alejandro Lozano-Garcia, Paula Tormos-Pons, Kevin G. Hampel, Vicente Villanueva, Irene Cano-Lopez
Summary: This study aims to establish phenotypes according to how patients face a stressful condition (epilepsy) and examine differences in cognition and quality of life depending on these phenotypes. The results suggest that dealing with stress in patients with epilepsy is related to cognitive performance and quality of life. These findings underline the relevance of considering comorbidities in epilepsy and may be useful for detecting vulnerable or resilient profiles as risk or protective factors for cognitive and quality of life decline.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Oncology
Annelise A. Madison, Rebecca Andridge, Anthony H. Kantaras, Megan E. Renna, Jeanette M. Bennett, Catherine M. Alfano, Stephen P. Povoski, Doreen M. Agnese, Maryam Lustberg, Robert Wesolowski, William E. Carson III, Nicole O. Williams, Raquel E. Reinbolt, Sagar D. Sardesai, Anne M. Noonan, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Depression combined with inflammation or intestinal permeability may contribute to poorer subjective and objective cognitive function in breast cancer survivors. These findings suggest that survivors with depression accompanied by immune dysregulation may be more aware of depression-related cognitive deficits compared to other depressed survivors.
Article
Endocrinology & Metabolism
Xavier Caldu, Xavier Prats-Soteras, Isabel Garcia-Garcia, Anna Prunell-Castane, Consuelo Sanchez-Garre, Neus Cano, Encarnacio Tor, Maria-Jose Sender-Palacios, Jonatan Ottino-Gonzalez, Maite Garolera, Maria Angeles Jurado
Summary: This cross-sectional study found that excessive body weight, as indicated by BMI, and levels of inflammatory biomarkers are negatively associated with cognitive performance. The study suggests that inflammation may be one of the mechanisms through which excess body weight affects cognition.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Mirjam Stieger, Margie E. Lachman
Summary: Increasing cognitive activity is important for reducing declines in executive functioning, especially among individuals with lower educational attainment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Robert-Jan Alers, Chahinda Ghossein-Doha, Lisanne P. W. Canjels, Eva S. H. Muijtjens, Yentl Brandt, M. Eline Kooi, Suzanne C. Gerretsen, Jacobus F. A. Jansen, Walter H. Backes, Petra P. M. Hurks, Vincent van de Ven, Marc E. A. Spaanderman
Summary: This study investigates the impact of preeclampsia on maternal cognitive functioning decades after pregnancy. The results show that women who had preeclampsia are 9 times more likely to experience clinical attenuation of higher-order cognitive functions compared to women who had a normotensive pregnancy. These differences persist for at least 19 years postpartum. Women with lower educational attainment, mood or anxiety disorders, or obesity are particularly at risk.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Helen J. Burgess, Isabel Carley, David F. Marshall, Scott A. Langenecker, Melvin G. McInnis, Patricia J. Deldin, Kelly A. Ryan
Summary: Individuals with bipolar I disorder (BD-I) have poorer sleep quality and neuropsychological functioning compared to healthy controls, and poor sleep quality is associated with learning, memory, and executive functioning impairments, with similar effects across groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
George K. Georgiou, Li Zhang
Summary: This study examined the predictive role of executive functioning in reading and mathematics, and compared the overlapping or complementary effects of behavioral ratings and performance-based measures. The results showed that only working memory among the performance-based measures predicted reading and mathematics. Additionally, none of the behavioral ratings made a significant contribution to academic achievement after controlling for mother's education and processing speed.
BEHAVIORAL SCIENCES
(2023)
Article
Clinical Neurology
Eileen E. Moran, Susan B. Bressman, Roberto A. Ortega, Deborah Raymond, William C. Nichols, Christina A. Palmese, Sonya Elango, Matthew Swan, Vicki Shanker, Imali Perera, Cuiling Wang, Molly E. Zimmerman, Rachel Saunders-Pullman
Summary: Mutations and variants in the glucocerebrosidase (GBA) gene are common genetic risk factors for Parkinson's disease (PD), but carriers without PD show poorer performance in executive functioning while no significant differences are observed in other domains. This suggests that most GBA mutation carriers may not present pre-manifest non-motor or motor features associated with PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Prathima A. A. Raghavendra, Shantala Hegde, Mariamma Philip, Muralidharan Kesavan
Summary: This study explored musical and neuro-cognitive deficits in patients with mild-moderate major depressive disorder (MDD). The results showed that these patients had significant deficits in working memory, verbal learning, and memory, but no differences in music cognition. The study also found a significant relationship between music cognition and attention.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Katarzyna Wachowska, Janusz Szemraj, Janusz Smigielski, Piotr Galecki
Summary: This study found that levels of IL-1 and IL-6 in the serum were increased in depressed patients, and their episodic memory was impaired. However, these two dysfunctions do not seem to covary in the present study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Veronica Cian, Alessandro De Laurenzis, Chiara Siri, Anna Gusmeroli, Margherita Canesi
Summary: This study aims to assess the prevalence of neuropsychological and neuropsychiatric impairment in patients after hospitalization due to COVID-19. The results showed that COVID+ patients exhibited vulnerability in memory and executive functions, while the control group showed higher levels of anxiety.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Martino Ceroni, Stefania Rossi, Giorgia Zerboni, Elena Biglia, Emiliano Soldini, Alessia Izzo, Lucia Morellini, Leonardo Sacco
Summary: This study analyzed the neuropsychological performance of adults with ADHD and found that attention and executive deficits may be influenced by age and education level. Gender did not show statistically significant differences in cognitive performance.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Clinical
Patricia S. Andrews, Jennifer Thompson, Rameela Raman, Chelsea Rick, Amy Kiehl, Pratik Pandharipande, James C. Jackson, Warren D. Taylor, E. W. Ely, Jo E. Wilson
Summary: This study found that patients with a history of depression before admission to the intensive care unit (ICU) exhibit more severe depressive symptoms in the year following hospitalization. However, this history of depression is not associated with cognitive performance.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Daniel E. Gustavson, Chandra A. Reynolds, Timothy J. Hohman, Angela L. Jefferson, Jeremy A. Elman, Matthew S. Panizzon, Michael C. Neale, Mark W. Logue, Michael J. Lyons, Carol E. Franz, William S. Kremen
Summary: The study demonstrated that AD-PRSs were associated with declines in episodic memory and executive function in cognitively normal middle-aged men, with these declines potentially driven by a combination of APOE and non-APOE genetic influences.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Jesse D. Moreira, Adam C. Gower, Liying Xue, Yuriy Alekseyev, Karan K. Smith, Seung H. Choi, Nir Ayalon, Melissa G. Farb, Kenneth Tenan, Ashley LeClerc, Daniel Levy, Emelia J. Benjamin, Marc E. Lenburg, Richard N. Mitchell, Robert F. Padera, Jessica L. Fetterman, Deepa M. Gopal
Summary: Current cardiac biobanking practices are insufficient to capture the diverse array of phenotypes present in cardiovascular diseases (CVDs) and the spatial heterogeneity across cardiac tissue sites. We have developed a rigorous and systematic protocol for the dissection and preservation of human cardiac biospecimens to enhance the availability of whole organ tissue for multiple applications. When combined with longitudinal clinical phenotyping, our protocol will enable multiomics in hearts to deepen our understanding of CVDs.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine S. S. Takvorian, Dongyu Wang, Paul Courchesne, Ramachandran S. S. Vasan, Emelia J. J. Benjamin, Susan Cheng, Martin G. G. Larson, Daniel Levy, Jennifer E. E. Ho
Summary: We identified 5 protein biomarkers associated with incident HFpEF, including NT-proBNP, growth differentiation factor-15, adrenomedullin, uncarboxylated matrix Gla protein, and C-reactive protein. We also found 14 biomarkers associated with incident HFrEF, including myeloperoxidase, resistin, and paraoxanase-1. These findings provide insights into similarities and differences in the development of HF subtypes.
CIRCULATION-HEART FAILURE
(2023)
Article
Gastroenterology & Hepatology
Heidi S. Ahmed, Na Wang, J. Jeffrey Carr, Jingzhong Ding, James G. Terry, Lisa B. VanWagner, Lifang Hou, Yuankai Huo, Joseph Palmisano, Yinan Zheng, Emelia J. Benjamin, Michelle T. Long
Summary: This study aimed to investigate the association between NAFLD and cardiovascular disease, cancer, and all-cause mortality. The results showed that hepatic steatosis was associated with overall mortality, but the association was weakened when considering time-varying covariates. There was no significant association between hepatic steatosis and cardiovascular disease or cancer. The study highlights the importance of considering concurrent cardiometabolic disease in studying the association between NAFLD and cardiovascular outcomes.
Article
Medicine, General & Internal
Ellen Childs, Korede Yoloye, Robina M. Bhasin, Emelia J. Benjamin, Sabrina A. Assoumou
Summary: Academic medical centers can improve care quality and address health inequities by recruiting and retaining faculty from underrepresented in medicine (URiM) groups. However, the retention of URiM faculty is a barrier to achieving equity-related goals. This study aimed to identify factors influencing the retention of URiM faculty at large academic centers.
SOUTHERN MEDICAL JOURNAL
(2023)
Article
Peripheral Vascular Disease
Alok R. Amraotkar, Ugochukwu S. Owolabi, Marina Malovichko, Sana Majid, Robert M. Weisbrod, Emelia J. Benjamin, Jessica L. Fetterman, Glenn A. Hirsch, Sanjay Srivastava, Ram Poudel, Rose Marie Robertson, Aruni Bhatnagar, Naomi M. Hamburg, Rachel J. Keith
Summary: This study aimed to assess the association between e-cigarette use and vascular health. The results showed that dual use of e-cigarettes and combustible cigarettes was associated with higher levels of endothelial origin circulating angiogenic cells (CACs), indicating vascular injury. Sole use of e-cigarettes was associated with higher levels of endothelial and inflammatory CACs, suggesting ongoing systemic injury. Therefore, CACs may serve as informative biomarkers for evaluating the effects of tobacco product use on vascular health.
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Christina Catherine Dahm, Henrik Kjaerulf Jensen
Summary: Increasing alcohol intake over a 5-year period is associated with a higher risk of atrial fibrillation (AF), while reducing alcohol intake does not significantly affect AF risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Dana Shulman, Serafima Dubnov, Tamara Zorbaz, Nimrod Madrer, Iddo Paldor, David A. Bennett, Sudha Seshadri, Elliott J. Mufson, David S. Greenberg, Yonatan Loewenstein, Hermona Soreq
Summary: Females with Alzheimer's disease (AD) experience accelerated dementia and loss of cholinergic neurons compared to males, and the underlying mechanisms may involve changes in transfer RNA fragments (tRFs) targeting cholinergic transcripts (CholinotRFs). The study found that NAc CholinotRFs of mitochondrial genome origin had reduced levels, which correlated with elevations in their predicted cholinergic-associated mRNA targets. Single-cell RNA sequencing in AD temporal cortices also indicated altered sex-specific levels of cholinergic transcripts in diverse cell types and sex-specific CholinotRF elevations in neuroblastoma cells under cholinergic differentiation. These findings suggest the involvement of CholinotRFs in cholinergic regulation and their potential role in AD sex-specific cholinergic loss and dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Public, Environmental & Occupational Health
Mara E. Murray Horwitz, Camille V. Edwards, Priyanka Athavale, Lois Mccloskey, Howard J. Cabral, Emelia J. Benjamin, Margaret A. Handley
Summary: This study aimed to explore the effectiveness of a postpartum health coaching intervention for reducing postpartum weight gain in Latina populations. The results showed that the intervention did not significantly reduce postpartum weight gain. However, stratified analyses revealed that the intervention had more favorable effects among English speakers and those with higher perceived diabetes risk.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
John Erhabor, Ellen Boakye, Ngozi Osuji, Olufunmilayo Obisesan, Albert D. Osei, Hassan Mirbolouk, Andrew C. Stokes, Omar Dzaye, Omar El-Shahawy, Carlos J. Rodriguez, Glenn A. Hirsch, Emelia J. Benjamin, Andrew P. DeFilippis, Rose Marie Robertson, Aruni Bhatnagar, Michael J. Blaha
Summary: This study examines the association between psychosocial stressors and current e-cigarette use among adolescents in the United States. The results show that adolescents who experience psychosocial stressors are more likely to use e-cigarettes, similar to the association between stressors and combustible cigarette use. These findings highlight the importance of targeted school-based interventions to reduce adolescent e-cigarette use.
Article
Medicine, General & Internal
Yao Lu, Sophia J. Kiechl, Jie Wang, Qingbo Xu, Stefan Kiechl, Raimund Pechlaner, Global Pulse Wave Velocity Study Grp
Summary: This study investigated the age and sex trajectories, regional differences, and global reference values of arterial stiffness. The results showed that the global age-standardized means of pulse wave velocity were 12.5 m/s for brachial-ankle PWV and 7.45 m/s for carotid-femoral PWV. Males had higher levels than females, and there were regional differences across different countries.
Review
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Ahmed Mustafa Rashid, Ahmed Kamal Siddiqi, Anusha Anwer, Muhammad Shariq Usman, Hifza Sakhi, Aruni Bhatnagar, Naomi M. Hamburg, Glenn A. Hirsch, Carlos J. Rodriguez, Michael J. Blaha, Andrew P. DeFilippis, Emelia J. Benjamin, Michael E. Hall
Summary: Despite their perceived safety, electronic cigarette (EC) usage may have adverse clinical cardiovascular effects, especially among young people. A systematic review of 27 studies found that smoking EC was associated with significant increases in cardiovascular hemodynamic measures and biomarkers. The findings of this study are important for policymakers to make informed decisions regarding the regulation of EC.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Oluchi Ekenze, Adlin Pinheiro, Serkalem Demissie, Andreas Charidimou, Alexa S. Beiser, Ramachandran S. Vasan, Emelia J. Benjamin, Charles DeCarli, Sudha Seshadri, Jose R. Romero
Summary: This study investigated the relationship between inflammatory biomarkers and magnetic resonance imaging-visible perivascular spaces (PVS) in participants without stroke and dementia. The study found significant associations between certain biomarkers and PVS burden in the basal ganglia and centrum semiovale. The findings suggest that inflammation may play a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different biomarkers depending on PVS topography.
NEUROBIOLOGY OF AGING
(2023)
Article
Cell Biology
Jason Cunha, Melissa V. Chan, Bongani B. Nkambule, Florian Thibord, Amber Lachapelle, Robin E. Pashek, Ramachandran S. Vasan, Jian Rong, Emelia J. Benjamin, Naomi M. Hamburg, Ming-Huei Chen, Gary F. Mitchell, Andrew D. Johnson
Summary: Arterial tonometry and vascular calcification measures are valuable in assessing cardiovascular disease (CVD) risk. This study examined the relationship between arterial tonometry, platelet function, arterial calcium, and aortic diameter. The results suggest that higher arterial calcium may be associated with increased platelet reactivity, while larger aortic diameter may be linked to lower platelet reactivity. These findings indicate the potential interplay between subclinical atherosclerosis, platelet activation, and vascular structure.
