Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sergi Olvera-Maneu, Anais Carbajal, Jaume Gardela, Manel Lopez-Bejar
Summary: Monitoring the endocrine status of horses through hair samples can provide valuable information on their welfare and reproductive health. This study found that cortisol, testosterone, and dehydroepiandrosterone sulphate levels in horse hair were significantly influenced by season, with varying hormone ratios between seasons. Seasonality should be considered when analyzing sexual and stress hormones in stallion hair to avoid misinterpretations.
Review
Cell Biology
Kristen N. Krolick, Haifei Shi
Summary: Estrogens play a crucial role in the neuroendocrine regulation of energy homeostasis, contributing to sex differences induced by chronic stress. Females are more susceptible to the psychological consequences of stress, while males are more vulnerable to metabolic consequences. Researchers hypothesize that gonadal hormones are key factors in stress studies, with estrogens recognized for their protective effects on metabolic dysregulation.
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Min Hsia, Yi-Fen Chiang, Hsin-Yuan Chen, Mohamed Ali, Paulus S. Wang, Kai-Lee Wang
Summary: The study found that a high-fructose diet can lead to decreased plasma testosterone levels in rats, affecting the responsiveness of Leydig cells to hormones and the activity of the hypothalamus-pituitary-gonadal (HPG) axis.
Article
Environmental Sciences
Yue Yang, Zhicai Zuo, Zhuangzhi Yang, Heng Yin, Ling Wei, Jing Fang, Hongrui Guo, Hengmin Cui, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Zhengli Chen, Chao Huang, Yanqiu Zhu, Wentao Liu
Summary: Nickel chloride has adverse effects on reproductive function in male mice, including reducing sperm concentration and motility while increasing sperm malformation rates. It also causes damage to testis and epididymis tissues, decreases serum testosterone levels, and down-regulates the expression of certain testis-related genes. These findings suggest that nickel chloride disrupts spermatogenesis through testicular damage and disturbance of the hypothalamic-pituitary-testis axis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Review
Endocrinology & Metabolism
Chang Shan, Jiang Yue, Wei Liu
Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ozlem Atli Eklioglu, Sinem Ilgin
Summary: The HPG axis plays a crucial role in male reproductive function, with neurotransmitters regulating the release of GnRH by affecting GnRH-releasing neurons. Patients with epilepsy often experience decreased fertility potential and lower sperm quality, which may be related to the impact of antiepileptic drugs on the HPG axis. Antiepileptic drugs can act as endocrine-disrupting chemicals, affecting fertility and exacerbating adverse effects on sperm quality in individuals with epilepsy. Investigating the reproductive effects of antiepileptic drugs and understanding the role of the HPG axis in potential reproductive pathologies is essential.
Article
Fisheries
Jiamin Pi, Huan Zhong, Yi Zhou, Tao Dai, Weiling Qin, Hui Liu, Yi Zhang, Yuling Zhou
Summary: This study aimed to investigate the regulatory role of ghrelin on ovarian development in grass carp and its mechanism on key hormonal receptors. The results showed high expression of ghrelin and ghrelin O-acyltransferase in the ovary, and stimulation of folliclestimulating hormone receptor expression by ghrelin treatment. Furthermore, acyl-ghrelin inhibited estrogen receptor-alpha expression, while octanoic acid treatment inhibited ER beta 1 and ER beta 2 expression in the ovary.
AQUACULTURE REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Hwan-Deuk Kim, Young-Jong Kim, Min Jang, Seul-Gi Bae, Sung-Ho Yun, Mi-Ree Lee, Yong-Ryul Seo, Jae-Keun Cho, Seung-Joon Kim, Won-Jae Lee
Summary: This study investigated the effect of heat stress on reproductive performance in domestic sows and found that heat stress in summer reduced the expression of hypothalamic kisspeptin, resulting in decreased levels of reproductive hormones and fewer large ovarian follicles, leading to summer infertility in sows.
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mavis A. Tenkorang, Brina Snyder, Rebecca L. Cunningham
Article
Physiology
Brent Shell, George E. Farmer, T. Prashant Nedungadi, Lei A. Wang, Alexandria B. Marciante, Brina Snyder, Rebecca L. Cunningham, J. Thomas Cunningham
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Charity Smith, Jo Contreras-Garza, Rebecca L. Cunningham, Jessica M. Wong, Philip H. Vann, Daniel Metzger, Ella Kasanga, Anthony Oppong-Gyebi, Nathalie Sumien, Derek A. Schreihofer
NEUROENDOCRINOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Juhi Singhal, Oluwatobiloba Osikoya, Elizabeth Wilson, Steve Mabry, Spencer Cushen, Rebecca Cunningham, Styliani Goulopoulou
Article
Endocrinology & Metabolism
Kirthikaa Balapattabi, Joel T. Little, Martha E. Bachelor, Rebecca L. Cunningham, J. Thomas Cunningham
Summary: This study found that unlike male bile duct-ligated (BDL) rats, female and ovariectomized (OVX) BDL rats did not develop hyponatremia, supraoptic vasopressin (AVP) neuron activation, or increased copeptin secretion compared to female controls. Adrenal estradiol may have compensated for the lack of ovarian estrogens in OVX BDL rats.
NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Phong Duong, Mavis A. A. Tenkorang, Jenny Trieu, Clayton McCuisto, Nataliya Rybalchenko, Rebecca L. Cunningham
BIOLOGY OF SEX DIFFERENCES
(2020)
Review
Neurosciences
Michael F. Salvatore, Isabel Soto, Helene Alphonso, Rebecca Cunningham, Rachael James, Vicki A. Nejtek
Summary: Research suggests that individuals with Parkinson's disease may experience deficits in executive functioning early in the disease process, prior to motor decline. The use of the Iowa Gambling Task (IGT) to evaluate executive functioning in non-strategic decision-making could help identify PD pathology and detect the disease in its premotor stages.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Endocrinology & Metabolism
Nathalie Sumien, J. Thomas Cunningham, Delaney L. Davis, Rachel Engelland, Oluwadarasimi Fadeyibi, George E. Farmer, Steve Mabry, Paapa Mensah-Kane, Oanh T. P. Trinh, Philip H. Vann, E. Nicole Wilson, Rebecca L. Cunningham
Summary: Neurodegenerative diseases have severe impacts on cognitive and motor function, with age and longevity being the main risk factors and sex also playing an important role. Sex hormone receptors play a crucial role in cell health, with oxidative stress associated with aging influencing this health status. Understanding these signaling cascades could lead to therapeutic targets for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Paulina Escandon, Sarah E. Nicholas, Rebecca L. Cunningham, David A. Murphy, Kamran M. Riaz, Dimitrios Karamichos
Summary: This study aims to determine the role of corneal stroma sex hormone receptors in keratoconus and their interaction with estrone and estriol. The findings suggest that the human cornea is a hormone-responsive tissue significantly influenced by estrone and estriol, indicating their potential involvement in the pathobiology of keratoconus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Dimitrios Karamichos, Paulina Escandon, Brenda Vasini, Sarah E. Nicholas, Lyly Van, Deanna H. Dang, Rebecca L. Cunningham, Kamran M. Riaz
Summary: Keratoconus, a progressive and multifactorial corneal disorder, has a devastating impact on vision and the socioeconomic status of patients. Corneal transplant remains the primary surgical intervention for treatment, despite advances in medical therapy and visual rehabilitation. The role of hormones, especially gonadotropins, in keratoconus is still unclear, but hormonal imbalances have been linked to the disease. The existence of a new axis called the Hypothalamic-Pituitary-Adrenal-Corneal (HPAC) axis is proposed to further understand the pathobiology of keratoconus.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Pathology
Paulina Escandon, Sarah E. Nicholas, Brenda Vasini, Rebecca L. Cunningham, David A. Murphy, Kamran M. Riaz, Dimitrios Karamichos
Summary: Keratoconus (KC) is a corneal disease characterized by thinning and bulging of the corneal structure. The cause of KC is multifactorial and not well understood. This study investigated the role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in KC using an in vitro model. The results showed that LH stimulation significantly increased cell proliferation in human KC cells and led to changes in sex hormone receptors, fibrotic markers, and gonadotropin signaling pathway proteins. These findings highlight the importance of further studying the role of FSH/LH in KC and corneal homeostasis.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Oluwadarasimi Fadeyibi, Nataliya Rybalchenko, Steve Mabry, Dianna H. Nguyen, Rebecca L. Cunningham
Summary: This study shows that interfering with the localization of the membrane androgen receptor (mAR) to cholesterol-rich lipid rafts can reduce androgen-induced neurotoxicity under oxidative stress environments.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Mavis Akosua Asantewaa Tenkorang, Phong Duong, Elizabeth Nicole Wilson, Rebecca Lynn Cunningham
Meeting Abstract
Biochemistry & Molecular Biology
Kirthikaa Balapattabi, Joel T. Little, Martha E. Bachelor, Rebecca L. Cunningham, J. Thomas Cunningham
Article
Endocrinology & Metabolism
Mavis A. A. Tenkorang, Phong Duong, Rebecca L. Cunningham
