Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Julia Martins de Oliveira, Patricia Medici Dualib, Alexandre Archanjo Ferraro, Camila Rodrigues de Souza Carvalho, Rosiane Mattar, Sergio Atala Dib, Bianca de Almeida-Pititto
Summary: Breastfeeding is associated with improvement in glucose metabolism and insulin resistance markers in overweight and obese women 60 to 180 days after birth. Prolactin levels do not mediate this association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sarah J. Blackwood, Oscar Horwath, Marcus Moberg, Marjan Ponten, William Apro, Maria M. Ekblom, Filip J. Larsen, Abram Katz
Summary: Muscle fiber composition differences are associated with alterations in peripheral insulin action and secretion, which can be used to predict insulin resistance and glucose-stimulated insulin secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Tanicia Daley, Benjamin Cousineau, Paula-Dene Nesbeth, Elizabeth Ivie, Moriah Bellissimo, Kirk Easley, Priyathama Vellanki, Miriam Vos, William Hunt, Arlene Stecenko, Thomas Ziegler, Jessica Alvarez
Summary: This study aimed to investigate the relationship between dietary macronutrient quality and glucose homeostasis in adults with cystic fibrosis (CF). The results showed that individuals with cystic fibrosis-related diabetes (CFRD) consumed less total fat and monounsaturated fatty acids (MUFA), and higher unsaturated dietary fat, higher plant protein, and higher carbohydrate quality were associated with better glucose tolerance indicators in adults with CF.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Hematology
Fahim Abbasi, Cindy Lamendola, Chelsea S. Harris, Vander Harris, Ming-Shian Tsai, Pragya Tripathi, Fakhar Abbas, Gerald M. Reaven, Peter D. Reaven, Michael P. Snyder, Sun H. Kim, Joshua W. Knowles
Summary: The study showed that high-intensity atorvastatin for 10 weeks increased insulin resistance and insulin secretion in individuals without type 2 diabetes, potentially leading to an increased risk of developing diabetes over time.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jun Bae Bang, Chang-Kwon Oh, Yu Seun Kim, Sung Hoon Kim, Hee Chul Yu, Chan-Duck Kim, Man Ki Ju, Byung Jun So, Sang Ho Lee, Sang Youb Han, Cheol Woong Jung, Joong Kyung Kim, Hyung Joon Ahn, Su Hyung Lee, Ja Young Jeon
Summary: In this study, the changes in glucose metabolism after kidney transplantation were investigated. It was found that some patients with pre-transplant diabetes experienced diabetes remission one year after transplantation. The newly diagnosed diabetes before transplantation and baseline insulinogenic index (IGI(30)) were associated with diabetes remission.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Alvaro Gonzalez-Dominguez, Maria Millan-Martinez, Jesus Dominguez-Riscart, Alfonso Maria Lechuga-Sancho, Raul Gonzalez-Dominguez
Summary: Trace elements and heavy metals play pivotal roles in childhood obesity and insulin resistance. This study found that insulin resistance may have distinct phenotypic subtypes. By analyzing plasma samples, it was discovered that delayed glucose-induced hyperinsulinemia was associated with worsened insulin resistance and lipid profile, as well as disturbed levels of chromium, cobalt, lead, and arsenic. These findings highlight the crucial involvement of altered metal homeostasis in regulating insulin signaling, glucose metabolism, and dyslipidemia in childhood obesity.
Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Medicine, Research & Experimental
Etienne Delangre, Gaelle Pommier, Stefania Tolu, Benjamin Uzan, Danielle Bailbe, Jamileh Movassat
Summary: In this study, the effects of lithium chloride (LiCl) on glucocorticoid-induced metabolic disorders were investigated using rat models. The results showed that lithium significantly reduced insulin resistance and improved glucose tolerance, accompanied by decreased hepatic gluconeogenesis. In addition, lithium enhanced insulin secretion. These findings demonstrate the beneficial effects of lithium in mitigating the adverse metabolic effects of chronic glucocorticoid therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Camila Pires Mendes, Barbara Graziela Postal, Marisa Jadna Silva Frederico, Rui Goncalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patricia Devantier Neuenfeldt, Ricardo Jose Nunes, Fatima Regina Mena Barreto Silva
Summary: A new library of hybrid compounds was developed to optimize the pharmacological activities of two drugs for the treatment of type 2 diabetes, potentially minimizing adverse effects. Among the screened compounds, PTEBS was identified to effectively regulate glucose and lipid homeostasis.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Amy Darukhanavala, Filia Van Dessel, Jannifer Ho, Megan Hansen, Ted Kremer, David Alfego
Summary: This study aimed to evaluate whether HbA1c is suitable for screening patients with pre-CFRD dysglycemia, and the results showed a lack of association between HbA1c and glycemic states. Further studies are needed to explore more efficient screening methods to reduce the burden of annual OGTTs.
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Integrative & Complementary Medicine
Lin Ang, Hye Won Lee, Jun Yong Choi, Junhua Zhang, Myeong Soo Lee
INTEGRATIVE MEDICINE RESEARCH
(2020)
Review
Integrative & Complementary Medicine
Lin Ang, Hye Won Lee, Anna Kim, Myeong Soo Lee
INTEGRATIVE MEDICINE RESEARCH
(2020)
Review
Nutrition & Dietetics
Ji Hee Jun, Tae Young Choi, Hye Won Lee, Lin Ang, Myeong Soo Lee
Summary: RCT studies on herbal medicine decoctions for treating Behcet's disease showed significant effects on the total response rate and erythrocyte sedimentation rate, but not on C-reactive protein level. Herbal medicine also significantly decreased the recurrence rate after three months of follow-up.
Article
Integrative & Complementary Medicine
Hye Won Lee, Tae-Young Choi, Myeong Soo Lee, Ju Ah Lee, Ji Hee Jun, Jiae Choi, Lin Ang, Chang-Hoon Lee, Jin-Moo Lee, Kyoung Sun Park, Dong Chul Kim, Se-Ran Jang, Jeong-Eun Yoo, Dong-Il Kim, Seong-Hee Cho, Seung-Jeong Yang, In Seon Lee, In-Suk Ahn, Dong-Nyung Lee, Chang-Min Choi, Mi-Hwa Song, Eunseop Kim
Summary: The study aimed to obtain the symptom, prescription, and therapeutic patterns for the treatment of patients with menopausal syndrome in major Korean medicine hospitals. The main symptoms of patients with menopausal disorders included hot flush, hyperhidrosis, fatigue, insomnia, and chest tightness, with commonly prescribed treatments being herbal medicines such as Guipi decoction and Si-wu guipi decoction, along with acupuncture. Further research on the objectivity of efficacy assessment is warranted.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Ji Hee Jun, Lin Ang, Tae Young Choi, Hye Won Lee, Myeong Soo Lee
Summary: The study found that integrative medicine, combining herbal medicine with drug therapy, is more effective in treating Behcet's disease, reducing recurrence rate and improving inflammatory markers.
Article
Chemistry, Multidisciplinary
Hyun Yang, Hye Jin Kim, Hye Won Lee
Summary: The study showed that Ecklonia cava extract can inhibit bone loss and depressive symptoms in a menopausal mouse model by modulating bone metabolism markers and serotonin levels.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Jung-Hyo Cho, Jong-Suk Lee, Hyeong-Geug Kim, Hye Won Lee, Zhigang Fang, Hyeok-Hee Kwon, Dong Woon Kim, Chang-Min Lee, Jin-Woo Jeong
Summary: The ethyl acetate fraction of Amomum villosum var. xanthioides (AXEF) showed significant antioxidant and anti-inflammatory effects in a NASH mouse model, alleviating fatty liver induced by ER stress. It reduced lipid droplet accumulations, liver enzymes, hepatic inflammations, and cell death signals.
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong
Summary: Letrozole, an aromatase inhibitor used in breast cancer treatment, has been reported to cause metabolic changes and structural remodeling in the heart. Our study found that letrozole exposure in female rats resulted in decreased fatty acid oxidation, increased glycolysis, and left ventricular hypertrophy. This shift in cardiac metabolism may lead to reduced energy supply and increased risk of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Sang R. Lee, Jun H. Heo, Hye-Won Lee, Eui-Ju Hong
Summary: This study focuses on the relationship between neurodegenerative diseases and energy metabolism, using Curcumae radix extract in cells and animal models. The results show that Curcumae radix can reduce neurodegenerative markers and influence cellular glycolysis and mitochondrial function.
Review
Integrative & Complementary Medicine
Sae-Rom Jeon, Jung Won Kang, Lin Ang, Hye Won Lee, Myeong Soo Lee, Tae-Hun Kim
Summary: This article provides an overview of the evidence for complementary and alternative medicines (CAMs) interventions in the treatment of COVID-19 patients. The study found that Traditional Chinese Medicine (TCM) herbal medications showed positive results in reducing disease progression, shortening fever resolution time, and decreasing the risk of severe COVID-19 cases. However, the effectiveness of other interventions still needs further evaluation. Gastric disturbance was a main adverse event of TCM medications.
INTEGRATIVE MEDICINE RESEARCH
(2022)
Article
Chemistry, Medicinal
Chan-young Kim, Hyeong-Geug Kim, Hye Won Lee, In-Chan Seol, Yoon-Sik Kim, Hyung Il Choi, Miso S. Park, Ho-Ryong Yoo
Summary: This study evaluated the pharmacological properties of Jaeumgeonbi-Tang (JGT) in chronic subjective dizziness (CSD) patients. The results showed that JGT can improve redox status and balance psycho-emotional stress hormones, which is beneficial for CSD patients.
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee, Eui-Ju Hong
Summary: Inflammation is a natural defense mechanism, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system is important in the development of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava, have anti-inflammatory and antioxidant properties and can be used to control neuroinflammation in the treatment of neurodegenerative diseases. In this study, we found that Ecklonia cava extract can reduce the levels of pro-inflammatory cytokines and markers of inflammation and neurodegeneration in mice with chronic inflammation induced by lipopolysaccharide.
Article
Biochemistry & Molecular Biology
Seong-Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong
Summary: Endoplasmic reticulum (ER) stress is caused by impaired protein-folding machinery, leading to accumulation of misfolded proteins and triggering unfolded-protein response. Excessive ER stress leads to cell death and chronic disease development. Curcumin regulates ER stress and inflammation, exerting neuroprotective effects. Investigating the effects of curcumin on ER stress, inflammation, and neurodegeneration is therefore important.
Review
Medicine, General & Internal
Hye Won Lee, Lin Ang, Jung Tae Kim, Myeong Soo Lee
Summary: This updated review provides a detailed understanding of the potential application of aromatherapy for relieving pain and anxiety in burn patients. The meta-analyses show that inhaled aromatherapy plus routine care has beneficial effects in relieving pain after dressing and calming anxiety.
MEDICINA-LITHUANIA
(2022)
Review
Andrology
Hye Won Lee, Myeong Soo Lee, Tae-Hun Kim, Terje Alraek, Chris Zaslawski, Jong Wook Kim, Du Geon Moon
Summary: Ginseng has minimal impact on erectile dysfunction, adverse events, and satisfaction, but may improve self-reported sexual performance in men.
WORLD JOURNAL OF MENS HEALTH
(2022)