Article
Cell Biology
Christian Ulrich von Linstow, Sofie Mozart Hindkjaer, Pernille Vinther Nielsen, Matilda Degn, Kate Lykke Lambertsen, Bente Finsen, Bettina Hjelm Clausen
Summary: The study found that bone marrow cells can modulate the poststroke inflammation, benefiting poststroke outcomes, with TNF and IL-1Ra identified as key players in the defense response after tMCAo.
Article
Neurosciences
Xiaoyan Huang, Mingyan Guo, Yangfan Zhang, Jiatian Xie, Rong Huang, Zhiyi Zuo, Phei Er Saw, Minghui Cao
Summary: Acute ischemic stroke (AIS) is a major cause of death globally, and is characterized by rapid inflammatory responses that worsen the brain injury caused by lack of blood supply. Microglia, the first responders of the immune system, play a role in this process. However, the specific role of microglial activity in ischemic brain injury is not fully understood. This study used genetically modified mice to remove microglia and found that their absence exacerbated ischemic brain injury. The study also uncovered the mechanism behind this worsening of brain injury, involving increased recruitment of neutrophils, blockage of microvessels, and impaired blood flow, as well as upregulation of a chemokine called CXCL1. The researchers demonstrated that microglial interleukin-1 receptor antagonist (IL-1RA) can suppress the expression of CXCL1 in astrocytes, reducing neutrophil recruitment and microvessel occlusion. Treatment with antibodies against CXCL1 or administration of recombinant IL-1RA protein improved the outcomes of mice after ischemic stroke. This study highlights the importance of microglia and their secretion of IL-1RA in protecting against acute ischemic brain injury.
Article
Nutrition & Dietetics
Kari Luotola
Summary: Low-grade inflammation plays a major role in obesity, metabolic syndrome, and the development of type 2 diabetes. The interleukin-1 receptor antagonist (IL-1Ra) is an important natural anti-inflammatory factor involved in glucose homeostasis disturbances. IL-1Ra levels can be used as a potential biomarker for metabolic dysregulation, particularly in prediabetes. Further research is needed to understand the role of IL-1Ra in metabolic abnormalities and its relationship with other lifestyle and metabolic parameters.
Article
Immunology
Binxin Wu, Furong Gao, Jianhua Lin, Lixia Lu, Huiming Xu, Guo-Tong Xu
Summary: The study found that human amniotic epithelial cell-conditioned medium (AECM) significantly alleviated symptoms of allergic conjunctivitis, reduced infiltration of immune cells and levels of inflammatory factors in the conjunctiva, and increased levels of anti-inflammatory factors IL-1 receptor antagonist (IL-1ra) and IL-10. The anti-allergic effects of AECM were mainly mediated by IL-1ra and IL-10, showing promise as a novel therapeutic strategy for treating allergic conjunctivitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Article
Immunology
Alba Llibre, Nikaia Smith, Vincent Rouilly, Munyaradzi Musvosvi, Elisa Nemes, Celine Posseme, Simbarashe Mabwe, Bruno Charbit, Stanley Kimbung Mbandi, Elizabeth Filander, Hadn Africa, Violaine Saint-Andre, Vincent Bondet, Pierre Bost, Humphrey Mulenga, Nicole Bilek, Matthew L. Albert, Thomas J. Scriba, Darragh Duffy
Summary: This study reveals the differences in immune responses at the transcriptomic, proteomic, and metabolomic levels between tuberculosis and latent tuberculosis infection. Dysregulated IL-1 responses were observed in tuberculosis patients after BCG stimulation, while differences in IL-1 alpha/IL-1 beta secretion were associated with downstream differences in granzyme mediated cleavage in latent tuberculosis infection/tuberculosis after BCG stimulation. Furthermore, IL-1 beta driven signalling was significantly perturbed in tuberculosis disease but was completely restored after successful treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Chintana Chirathaworn, Jira Chansaenroj, Watchadaporn Chaisuriyong, Somrat Lertmaharit, Yong Poovorawan
Summary: This study investigates the biomarkers of inflammation regulation in CHIKV infection-induced joint pain. The levels of sVCAM-1 were found to be significantly higher in patients with joint pain, while the levels of IL-1Ra and sVCAM-1 were not associated with age.
Article
Virology
Bugra Kerget, Ferhan Kerget, Alperen Aksakal, Seda Askin, Leyla Saglam, Metin Akgun
Summary: The study revealed a correlation between serum levels of alpha defensin, IL-1Ra, and IL-18 with the clinical course and prognosis of COVID-19, showing potential for their utility in treatment and follow-up of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yue Liu, Chang Liu, Chang Wang, Qian Zhang, Xingyuan Qu, Chen Liang, Chao Si, Lei Wang
Summary: Periodontitis is a major cause of adult tooth loss, and it has a bidirectional relationship with diabetes. IL-1 beta plays a significant role in the pathophysiology of periodontitis and diabetes, while IL-1ra acts as a natural inhibitor of IL-1. This study developed a temperature-sensitive hydrogel loaded with IL-1ra and demonstrated its potential for treating periodontitis with diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pio Conti, Fabrizio E. Pregliasco, Rosa G. Bellomo, Carla E. Gallenga, Alessandro Caraffa, Spyros K. Kritas, Dorina Lauritano, Gianpaolo Ronconi
Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Damian Mikulski, Pawel Robak, Ewelina Perdas, Edyta Weglowska, Aleksandra Losiewicz, Izabela Drozdz, Dariusz Jarych, Malgorzata Misiewicz, Janusz Szemraj, Wojciech Fendler, Tadeusz Robak
Summary: Multiple myeloma is a disease characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. Cytokines, such as IL-13 and IL-4, play an important role in the growth and survival of multiple myeloma. This study found that pretreatment levels of IL-13 and IL-4 are predictors of better progression-free survival and overall survival, while IL-1Ra levels negatively impact overall survival in patients treated with bortezomib-based chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Abi G. Yates, Trisha Jogia, Ellen R. Gillespie, Yvonne Couch, Marc J. Ruitenberg, Daniel C. Anthony
Summary: The study found that exogenous administration of IL-1RA can attenuate the acute phase response (APR) in traumatic spinal cord injury, reducing immune cell infiltration at the spinal cord lesion site.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Public, Environmental & Occupational Health
Hajnal Zsuzsanna Balla, Yang Cao, Jakob O. Strom
Summary: The meta-analysis did not find significant association between beta-blocker treatment and mortality, functional outcome, and post-stroke infections in acute stroke patients, suggesting that the proposed beneficial effects of beta-blockers in the acute phase of stroke are not supported by the current findings.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Microbiology
Cesar Sanchez, Luis Jaramillo-Valverde, Silvia Capristano, Gilmer Solis, Alonso Soto, Julio Valdivia-Silva, Julio A. Poterico, Heinner Guio
Summary: The IGRA test is the standard specific test for Mycobacterium tuberculosis infection status. However, it cannot distinguish between active tuberculosis disease (ATBD) and latent tuberculosis infection (LTBI). In this study, we conducted longitudinal studies to identify a combination of antigen peptides and cytokines that can discriminate between ATBD and LTBI. Our results indicate that in vitro cell stimulation with a novel combination of peptides and IL-1RA detection in culture supernatants can effectively distinguish between LTBI and ATBD.
Article
Orthopedics
Ganesh Swamy, Paul Salo, Neil Duncan, Frank Jirik, John Matyas
Summary: This study investigates the effect of increased IL-1 beta activity on intervertebral discs (IVDs) through examining mice with an IL-1Ra gene deletion. The results show that IL-1Ra-/- mice have worse histopathology and mechanical properties of IVDs compared to wild-type mice. Inflammatory gene expression is downregulated in IL-1Ra-/- IVDs, suggesting a role of IL-1 beta-driven inflammation in IVD degeneration. The study also suggests that response to injury involves pathways other than inflammation.
Correction
Clinical Neurology
Ashley McDonough, Jonathan R. Weinstein
Article
Clinical Neurology
Marie Suesse, Malte Johannes Hannich, Christine Holbe, Johanna Ruhnau, Bettina von Sarnowski, Alexander Dressel
ACTA NEUROLOGICA SCANDINAVICA
(2019)
Article
Clinical Neurology
Antje Vogelgesang, Grazyna Domanska, Johanna Ruhnau, Alexander Dressel, Michael Kirsch, Juliane Schulze
Article
Neurosciences
Ashley McDonough, Shahani Noor, Richard V. Lee, Ryan Dodge, James S. Strosnider, Jasmine Shen, Stephanie Davidson, Thomas Moller, Gwenn A. Garden, Jonathan R. Weinstein
Review
Neurosciences
Ashley McDonoug, Jonathan R. Weinstein
Article
Medicine, General & Internal
Sylvia Stracke, Sandra Lange, Sarah Bornmann, Holger Kock, Lara Schulze, Johanna Klinger-Koenig, Susanne Boehm, Antje Vogelgesang, Felix von Podewils, Agnes Foeel, Stefan Gross, Katrin Wenzel, Gerd Wallukat, Harald Pruess, Alexander Dressel, Rudolf Kunze, Hans J. Grabe, Soenke Langner, Marcus Doerr
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Cell Biology
Malte Johannes Hannich, Alexander Dressel, Kathrin Budde, Astrid Petersmann, Matthias Nauck, Marie Suesse
Summary: In this study, researchers investigated the synthesis of intrathecal FLC-k in cerebrospinal fluid samples from 296 patients. They found that FLC-k synthesis can occur independently of the antibody class produced, and can help distinguish between an inflammatory process and blood contamination. This suggests that additional determination of FLC-k in quotient diagrams may aid in clinical diagnostics.
Article
Neurosciences
Katherine E. Prater, Macarena S. Aloi, Jasmine L. Pathan, Chloe N. Winston, Rachel A. Chernoff, Stephanie Davidson, Matthew Sadgrove, Ashley McDonough, Dannielle Zierath, Wei Su, Jonathan R. Weinstein, Gwenn A. Garden
Summary: The research revealed that Prom1-expressing myeloid progenitor cells can contribute to the generation of new microglia both in vitro and in vivo, specifically in the uninjured brain. However, in response to ischemia/reperfusion, little proliferation was observed from these Prom1-expressing progenitors, with the majority of new microglia derived from Prom1-negative cells.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Juliane Schulze, Juliane Gellrich, Michael Kirsch, Alexander Dressel, Antje Vogelgesang
Summary: The experiment demonstrates antigen-specific activation of T lymphocytes infiltrating ischemic brain lesions after stroke. Activated T lymphocytes in the brain show high expression of inhibitory PD-1 and low expression of CD25, indicating immunosuppressive mechanisms.
Article
Neurosciences
Margaret A. Hamner, Ashley McDonough, Davin C. Gong, Levi J. Todd, German Rojas, Sibylle Hodecker, Christopher B. Ransom, Thomas A. Reh, Bruce R. Ransom, Jonathan R. Weinstein
Summary: Ischemic preconditioning (IPC) is a phenomenon where exposure to non-injurious ischemia enhances tolerance to subsequent ischemic challenges. In a study testing the hypothesis that microglia are necessary for IPC in white matter (WM), researchers found that depletion of microglia eliminated IPC-mediated protection, highlighting the critical role of preconditioned microglia in WM IPC.
Article
Nanoscience & Nanotechnology
Richard Lee, Hadi M. Zareie, Mehmet Sarikaya
Summary: This study designed a bifunctional chimeric biomolecule for nucleic acid detection on solid sensor surfaces, demonstrating the effect of steric hindrance on probe assembly. The dual nature of the construct allows specific recognition and probe immobilization on sensor surfaces, providing facile functionalization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Malte Johannes Hannich, Mohammed R. Abdullah, Kathrin Budde, Astrid Petersmann, Matthias Nauck, Alexander Dressel, Marie Suesse
Summary: This cohort study aimed to investigate whether further analysis of intrathecal inflammation can be omitted if the free light chain kappa (FLC kappa) quotient is within the reference range in the corresponding quotient diagram. The results showed that using FLC kappa-IF as a first line analysis can significantly reduce the workload of detecting immune responses in cerebrospinal fluid with high negative predictive value.
Article
Biophysics
Oliver Nakano-Baker, Hanson Fong, Shalabh Shukla, Richard Lee, Le Cai, Dennis Godin, Tatum Hennig, Siddharth Rath, Igor Novosselov, Sami Dogan, Mehmet Sarikaya, Devin MacKenzie
Summary: Using simulated odorant-binding proteins (OBPs) and machine learning methods, a sensor array was designed to detect a characteristic VOC fingerprint associated with COVID-19. The sensor array directly transduces vapor composition into multi-channel electrical signals, allowing for rapid and non-invasive monitoring, disease diagnostics, and environmental exposure assessment. The use of chimeric VOC- and solid-binding peptides and carbon nanotube transistors demonstrated selective peptide binding and VOC sensing.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Behavioral Sciences
Matthias Grothe, Michael Opolka, Julia Berneiser, Alexander Dressel
Summary: This study compared two social cognition tests in multiple sclerosis patients and found that emotion recognition had better accuracy compared to theory of mind. Cognitive factors were associated with both social cognition tasks, with emotion recognition being more influenced. However, no relationship was found between social cognition and quality of life.
BRAIN AND BEHAVIOR
(2021)