Article
Biochemistry & Molecular Biology
Ethel A. Wilhelm, Paola S. Soares, Angelica S. Reis, Ketlyn P. Motta, Briana B. Lemos, William B. Domingues, Eduardo B. Blodorn, Daniela R. Araujo, Angelita M. Barcellos, Gelson Perin, Mauro P. Soares, Vinicius F. Campos, Cristiane Luchese
Summary: This study evaluated the potential of Se-DMC in a CFA-induced arthritis model in mice, showing its anti-inflammatory, analgesic, and neurobehavioral correction effects. Se-DMC reduced paw edema, decreased expression of inflammatory molecules, restored neurobehavioral deficits induced by CFA, indicating potential therapeutic benefits.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Flavio A. R. Barbosa, Romulo F. S. Canto, Kerolain F. Teixeira, Anacleto S. de Souza, Aldo S. de Oliveira, Antonio L. Braga
Summary: Alzheimer's disease (AD) is a prevalent type of dementia that affects millions of older people worldwide. Selenium-containing compounds have shown potential as multi-targeted drugs for the treatment of AD due to their antioxidant and anticholinesterase properties. These compounds can decrease the aggregation of amyloid-beta (A beta), a key feature of AD. Some selenium-derived compounds have molecular features similar to FDA-approved drugs, suggesting that they may have optimized pharmacokinetic properties.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ryosuke Masuda, Ryutaro Kimura, Takafumi Karasaki, Shohei Sase, Kei Goto
Summary: This study provides the first direct spectroscopic evidence for the formation of Sec-SeOH in small-molecule selenocysteine and selenopeptide model systems. The catalytic cycle of glutathione peroxidase was investigated using NMR-observable Sec-SeOH models, examining various chemical processes including intramolecular cyclization.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Applied
Yang-Tong Ma, Miao-Chang Liu, Yun-Bing Zhou, Hua-Yue Wu
Summary: In the past decade, there has been a growing focus on using elemental selenium as a selenium source in organic synthesis. Compared to previous selenium reagents that were unstable, smelly, and toxic, elemental selenium is more readily available, cheaper, bench-stable, and easier to handle. This review mainly discusses strategies for activating elemental selenium and synthesizing organoselenium compounds, such as monoselenides, diselenides, selenium-containing heterocycles, and more.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Food Science & Technology
Lourdes Santiago-Lopez, Arantxa Almada-Corral, Hugo S. Garcia, Veronica Mata-Haro, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba, Adrian Hernandez-Mendoza
Summary: This study aimed to assess the potential antidepressant- and anxiolytic-like effects of huauzontle fermented by Lactiplantibacillus plantarum Lp22. The results showed that mice receiving both fermented and unfermented huauzontle exhibited more brave and active behaviors in the behavioral tests, and had lower oxidative stress index. These findings suggest the potential therapeutic applications of fermented huauzontle on depression and anxiety-like behaviors, possibly mediated by antioxidant and anti-inflammatory mechanisms.
Article
Chemistry, Multidisciplinary
Rui-Li Guo, Xing-Long Zhang, Xian-Pan Bu, Meng-Yue Wang, Bao-Yin Zhao, Ya-Ru Gao, Qiong Jia, Yong-Qiang Wang
Summary: A new class of electrophilic monofluoromethylselenolation reagents have been developed, which can be easily prepared in one step under mild reaction conditions. These reagents exhibit efficient electrophilic monofluoromethylselenolation reactions towards various nucleophiles, with mild and environmentally friendly reaction conditions, good tolerance of functional groups, and broad substrate scope.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Kauane Nayara Bahr Ledebuhr, Gustavo D. 'Avila Nunes, Evelyn Mianes Besckow, Maira Regina Giehl, Benhur Godoi, Cristiani Folharini Bortolatto, Cesar Augusto Bruning
Summary: This study evaluated the antinociceptive effect of the compound SePB and found that it demonstrated analgesic properties without affecting the locomotor activity of the mice. The antinociceptive effect of SePB was shown to involve the serotonin receptors. Further research is needed to assess its efficacy and toxicity in chronic pain models.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Organic
Mingyu Zhang, Zhenyu Luo, Xinye Tang, Linmin Yu, Jinglin Pei, Junlei Wang, Caicai Lu, Binbin Huang
Summary: An efficient electrochemical selenocyclization strategy has been developed for the construction of 3-selenylindoles. This strategy exhibits excellent functional group compatibility and shows potential in the late-stage functionalization of bioactive molecules.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Tao Guo, Zhonghui Li, Lei Bi, Lulu Fan, Panke Zhang
Summary: The synthesis of organoselenium compounds has attracted significant attention for their biological values and pharmaceutical applications. Over the years, various selenating reagents, including elemental selenium, have been developed. Elemental selenium, in particular, has shown great potential for the direct incorporation of selenium atoms into target molecules. Additionally, direct C-H bond selenation with elemental selenium is considered an atom-efficient method. This review highlights the recent advances in organic synthesis involving elemental selenium since 2002, providing useful information for researchers studying selenium in organic reactions.
Article
Chemistry, Organic
Matteo Tironi, Stefan Dix, Matthew N. Hopkinson
Summary: The benzothiazolium salt BT-SeCF2H serves as an efficient nucleophilic reagent for transferring difluoromethylselenyl groups onto organic molecules, allowing for the synthesis of valuable fluorinated compounds through deoxygenative reactions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Multidisciplinary
Juan M. M. Sonego, Sheila I. I. de Diego, Sergio H. H. Szajnman, Carola Gallo-Rodriguez, Juan B. B. Rodriguez
Summary: Originally described as a toxin, selenium is now recognized as a crucial trace element for life. Selenium-containing drugs have advantages over sulfur and oxygen isosteres, as the presence of selenium confers antioxidant properties and high lipophilicity, improving oral bioavailability. This article focuses on the features of selenium atom and synthetic approaches to various organoselenium compounds, as well as their proposed reaction mechanisms. The preparation and biological properties of selenosugars, including selenoglycosides, selenonucleosides, selenopeptides, and other selenium-containing compounds are discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Marwa Sak, Yasair S. Al-Faiyz, Hany Elsawy, Saad Shaaban
Summary: Novel organic selenides were synthesized and characterized. Their anticancer, antimicrobial, and antioxidant activities were evaluated, showing selective cytotoxicity against cancer cells, antimicrobial potential comparable to reference drugs, and comparable antioxidant activity to vitamin C.
Review
Biochemistry & Molecular Biology
Kainat Ahmed, Delawar Ashraf, Ghayoor Abbas Chotana, Amir Faisal, Khalid Mohammed Khan, Rahman Shah Zaib Saleem
Summary: Selenium, as a trace element, plays important biological roles, including neuroprotection, anti-inflammatory, anticancer, antioxidant, hepatoprotective, and immunomodulatory activities. Selenium-containing peptides, such as selenoproteins, offer more health benefits compared to traditional selenium supplements.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Estevan Sonego Zimmermann, Luana Mota Ferreira, Laura Bedin Denardi, Marcel Henrique Marcondes Sari, Veronica Ferrari Cervi, Cristina Wayne Nogueira, Sydney Hartz Alves, Leticia Cruz
Summary: This study evaluated the in vitro antifungal action of a diphenyl diselenide-loaded poly(e-caprolactone) nanocapsules suspension and its in vivo efficacy in an animal model of vulvovaginal candidiasis. Results showed that the nano-based formulation had superior pharmacological action compared to the hydrogel containing non-encapsulated diphenyl diselenide, indicating it as a promising approach against vulvovaginal candidiasis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Organic
Raquel G. Jacob, Daniela Hartwig, Jose Edmilson R. Nascimento, Paola B. Abib, Camila P. Ebersol, Pamela P. P. Nunes, Paloma T. Birmann, Angela M. Casaril, Lucielli Savegnago, Ricardo F. Schumacher
Summary: This study presents a simple and efficient method for the one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy. The obtained compounds showed promising antioxidant effects in various in vitro trials, indicating their potential in protecting against oxidative diseases.
TETRAHEDRON LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Paloma T. Birmann, Angela M. Casaril, Laura Abenante, Filipe Penteado, Cesar A. Bruning, Lucielli Savegnago, Eder J. Lenardao
Summary: This review summarizes recent preclinical studies on organoselenium compounds as therapeutic agents for the treatment of mental and neurodegenerative diseases. Diaryl diselenides, Ebselen-derivatives, and Se-containing heterocycles are identified as the most representative organoselenium molecules. The review aims to provide disease-oriented information that can be useful for the development of novel bioactive molecules with potential clinical viability.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Joelma M. M. Sarturi, Luciano Dornelles, Natalia V. V. Segatto, Tiago Collares, Fabiana K. K. Seixas, Bruna Candia Piccoli, Fernanda D'Avila da Silva, Folorunsho Bright Omage, Joao Batista Teixeira da Rocha, Renata A. A. Balaguez, Diego Alves, Eder J. J. Lenardao, Eric F. F. Lopes, Anna Kula-Pacurar, Krzysztof Pyrc, Luca Sancineto, Oscar E. D. Rodrigues
Summary: This study synthesized and evaluated the multi-target behavior of new 5'-hydroxy-3-(chalcogenyl-triazoyl)-thymidine derivatives as antioxidant and anti-HIV agents. The compounds showed good activity and no apparent toxicity in mice. The design strategy of modifying the AZT nucleus via the 1,3-dipolar Huisgen cycloaddition reaction proved effective in achieving the desired biological activities.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Mikaela Peglow Pinz, Renata Leivas de Oliveira, Caren Aline Ramson da Fonseca, Guilherme Teixeira Voss, Beatriz Pereira da Silva, Luis Fernando Barbosa Duarte, William Borges Domingues, Hadassa Gabriela Ortiz, Anne Suely Pinto Savall, Flavia Carla Meotti, Diego Alves, Vinicius Farias Campos, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luchese
Summary: In this study, the researchers found that treatment with FSP can alleviate memory impairment and sensitivity to pain caused by Aβ, by exerting its effects against oxidative stress and neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Mariana G. Fronza, Manoela Sacramento, Diego Alves, Domenico Pratico, Lucielli Savegnago
Summary: This study demonstrates that QTC-4-MeOBnE has a moderate effect in a transgenic model of AD, preventing memory impairment and depressive-like behavior, and modulating multiple pathways involved in the onset and progression of AD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcelo Heinemann Presa, Marcia Juciele da Rocha, Camila Simoes Pires, Kauane Nayara Bahr Ledebuhr, Gabriel Pereira da Costa, Diego Alves, Cristiani Folharini Bortolatto, Ceisar Augusto Bruning
Summary: This study evaluated the antidepressant-like effect of a hybrid compound containing triazole and acetophenone, demonstrating that it modulates the serotonergic system through 5-HT2A/2C and 5-HT4 receptors and inhibits monoamine oxidase A activity in the hippocampus. The compound showed penetration into the central nervous system and low toxicity at a high dose, making it an interesting candidate for the development of a new therapeutic strategy for major depressive disorder (MDD).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Organic
Gabriel P. P. Da Costa, Gustavo B. B. Blodorn, Thiago Barcellos, Marcio S. Silva, Rafael Luque, Diego Alves
Summary: We described a simple and metal-free protocol for the synthesis of [1,2,3]triazolo[1,5-a]quinoline 3-carboxamides. The synthesis involves two steps, with the first step utilizing organocatalysis and the second step involving the use of an inorganic base. The reactions were performed in dimethylsulfoxide as solvent at 70°C for 2 hours. The synthetic protocol yielded a variety of [1,2,3]triazolo[1,5-a]quinoline 3-carboxamides in good to excellent yields (63-96%) for secondary compounds and moderate to good yields (48-76%) for tertiary compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Neurosciences
Paloma T. Birmann, Angela M. Casaril, Ana Paula Pesarico, Rafael R. Rodrigues, Fabricio R. Conceicao, Fernanda Severo Sabedra Sousa, Tiago Collares, Fabiana K. Seixas, Lucielli Savegnago
Summary: This study evaluated the antidepressant-like effects of Komagataella pastoris KM71H in a model of antibiotic-induced intestinal dysbiosis in mice. The results showed that KM71H administration reduced immobility time and increased grooming activity, accompanied by the modulation of the intestinal microbiota and preservation of intestinal barrier integrity. These findings suggest the potential of KM71H as a new probiotic with antidepressant-like effects.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tais da Silva Teixeira Rech, Dianer Nornberg Strelow, Leticia Devantier Kruger, Jose Sebastiao Santos Neto, Gustavo Bierhals Blodorn, Diego Alves, Cesar Augusto Bruning, Cristiani Folharini Bortolatto
Summary: This study aimed to evaluate the relationship between the antidepressant-like effect of 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) and the glutamate pathway. The results showed that pretreatment of mice with drugs targeting glutamate receptors inhibited the antidepressant-like effect of SeBZF1. These findings contribute to a better understanding of the pharmacological effects of SeBZF1.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Thiago Angelo Smaniotto, Angela Maria Casaril, Darling de Andrade Lourenco, Fernanda S. Sousa, Fabiana K. Seixas, Tiago Collares, Rafael Woloski, Luciano da Silva Pinto, Diego Alves, Lucielli Savegnago
Summary: Our study investigated the effects of intranasal administration of interleukin-4 (IL-4) on mice with depressive-like behavior induced by chronic unpredictable mild stress (CUMS). We found that IL-4 reversed the depressive behavior and regulated oxidative stress markers in the brain structures, suggesting its potential as an innovative strategy for major depression (MD) treatment.
PSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Organic
Emilay B. T. Diogo, Fabio G. Delolo, Gabriela A. P. Graca, Esther R. S. Paz, icaro A. O. Bozzi, Renata Diniz, Juliano P. Passos, Tulio Matencio, Liane K. Soares, Diego Alves, Pedro M. S. Costa, Claudia Pessoa, Cynthia L. M. Pereira, Lutz Ackermann, Eufranio N. da Silva Junior
Summary: Undivided electrochemical cells are used to economically prepare sulphur-containing naphthoquinones through electrochemical sulphenylation of quinoidal compounds. This environmentally friendly and efficient protocol eliminates the need for chemical oxidants and enables the synthesis of desired molecules. It offers an efficient and versatile method for synthesizing cytotoxic quinones against cancer cell lines.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Gabriel Pereira da Costa, Gustavo Bierhals Blodorn, Angelita Manke Barcellos, Diego Alves
Summary: The importance of organoselenium compounds has been increasing in synthetic chemistry. They can serve as electrophiles, nucleophiles, and catalysts for organic transformations. The combination of inorganic and organic oxidants with organoselenium catalysts enables efficient, mild, and selective reactions.
Article
Neurosciences
Ana Claudia Funguetto-Ribeiro, Kelly Ayumi Nakama, Mikaela Peglow Pinz, Renata Leivas de Oliveira, Manoela do Sacramento, Flavia S. Oliveira Pereira, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luchese, Diego Alves, Daiana Silva avila, Sandra Elisa Haas
Summary: This study developed and investigated the effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model, showing low toxicity and the potential to improve memory impairment.
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)