Article
Cell Biology
Honglin Yan, Wenxian Huang, Jie Rao, Jingping Yuan
Summary: miR-21 exhibits anti-apoptotic and pro-survival effects in ischemia by regulating the p53/Bcl-2/Bax signaling pathway, suggesting it as an attractive therapeutic molecule for ischemic stroke treatment.
Review
Biochemistry & Molecular Biology
Masoumeh Amirian, Amir Masoud Jafari-Nozad, Majid Darroudi, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Accumulating evidence has shown the significant role of miR-29 in human malignancies, particularly breast cancer (BC). MiR-29 acts as a tumor suppressor by targeting multiple signaling pathways and transcripts, but it can also promote BC progression through gene and transcription factor targeting. The conflicting roles of miR-29 in BC may be attributed to its regulatory roles dependent on the environment and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Yulin Zhu, Huatang Zhao, Wenshan Zhang, Xingang Ma, Ye Liu
Summary: The study confirmed the neuroprotective effect of dexmedetomidine in cerebral ischemia-reperfusion rats may be associated with miR-199a. By inhibiting miR-199a expression, it reduced neurological dysfunction and pathological damage to the cerebral cortex, while also inhibiting autophagy process and related protein expression, thus decreasing neuronal injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Multidisciplinary Sciences
Hye Youn Sung, Eun Nam Choi, Jihye Han, Yun Ju Chae, Sun-Wha Im, Hee-Sun Kim, Eun-Mi Park, Jung-Hyuck Ahn
Summary: Research suggests that ischemic preconditioning reduces brain ischemia-reperfusion injury by downregulating the expression of miR-33-5p and miR-135b-5p, which in turn protects neurons from apoptosis induced by oxygen-glucose deprivation. Inhibition of these two miRNAs significantly increases mRNA and protein levels of ABCA1 and reduces activation of the mitochondria-dependent apoptosis pathway.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Yangjie Zhou, Wei Wei, Julian Shen, Lu Lu, Taotao Lu, Hong Wang, Xiehua Xue
Summary: Alisol A 24-acetate exhibits antiapoptotic effects on OGD-induced BMECs by inhibiting miR-92a-3p targeting the Bcl-2 gene, indicating its potential as a novel therapeutic agent for cerebrovascular disease treatment.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meng-Nan Liu, Gang Luo, Wan-Jiao Gao, Si-Jin Yang, Hua Zhou
Summary: miR-29 plays a crucial role in cardiovascular disease (CVD), particularly in maintaining arterial integrity and regulating atherosclerosis. Studies have shown the potential of miR-29 as a potential marker for prevention, treatment, and prognostic observation in CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Rui Huang, Wei Zhang, Weishuai Li, Yan Gao, Dongming Zheng, Guorong Bi
Summary: Circular RNA circ_0000831 may serve as a biomarker for ischemic stroke and play a role in regulating inflammation and cell apoptosis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qasim M. Alhadidi, Lijun Xu, Xiaoyun Sun, Yusuf S. Althobaiti, Atiah Almalki, Hashem O. Alsaab, Creed M. Stary
Summary: Ischemic stroke is a devastating cerebrovascular disease, and research suggests that miR-182 plays a crucial role in stroke injury and recovery. Inhibition of miR-182 has been found to protect mitochondrial structure, mitigate neuroinflammation, and reduce cell death.
NEUROCHEMICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Maurizio Chioccioli, Subhadeep Roy, Rachel Newell, Linda Pestano, Brent Dickinson, Kevin Rigby, Jose Herazo-Maya, Gisli Jenkins, Steward Ian, Gauri Saini, Simon R. Johnson, Rebecca Braybrooke, Guying Yu, Maor Sauler, Farida Ahangari, Shuizi Ding, Joseph DeIuliis, Nachelle Aurelien, Rusty L. Montgomery, Naftali Kaminski
Summary: The study demonstrated the potential therapeutic effect of the peptide-conjugated MRG-229 mimic on IPF, reducing expression of fibrotic genes and collagen production. Positive results were observed in animal models and patient cohorts, indicating a promising treatment approach for IPF.
Article
Neurosciences
Lixiao Xu, Gen Li, Xiaojuan Tang, Chenxi Feng, Mei Li, Xiaolu Jiang, Yan Gu, Yajing Yun, Lianghua Lu, Xing Feng, Xin Ding, Bin Sun
Summary: The study revealed that the upregulation of miR-375-3p in the pineal gland during hypoxic-ischemic brain damage (HIBD) exacerbated the damage, leading to reduced melatonin secretion, cognitive impairment, and disturbances in emotion and circadian rhythm.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Masahiro Horita, Colin Farquharson, Louise A. Stephen
Summary: This review summarizes the differential expression patterns and functional roles of the miR-29 family in diseases such as osteoarthritis, osteoporosis, cardiorenal, and immune disease, highlighting their therapeutic potential. Further research is needed to identify the precise mechanisms of the miR-29 family in these diseases and their potential in therapeutics.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Neurosciences
Naixin Liu, Yan Fan, Yilin Li, Yingxuan Zhang, Jiayi Li, Yinglei Wang, Zhuo Wang, Yixiang Liu, Yuansheng Li, Zijian Kang, Ying Peng, Zeqiong Ru, Meifeng Yang, Chengan Feng, Ying Wang, Xinwang Yang
Summary: This study found that OL-FS13 could alleviate cerebral ischemia-reperfusion (CI/R) injury by inhibiting miR-21-3p to activate the CAMKK2/AMPK/Nrf-2 signaling pathway.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Bin Zhu, Wei Liu, Qiang Xu, Hong-liang Liu
Summary: This study investigated the expression pattern and clinical significance of serum miR-455-5p in the onset and development of carotid artery stenosis (CAS) and its potential protective role in endothelial cell injury. The findings suggest that down-regulated expression of miR-455-5p may serve as a biomarker for the early diagnosis of CAS and has predictive value for the development of cerebral ischemia events (CIEs) in CAS patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)
