Review
Biochemistry & Molecular Biology
Florian J. Bock, Joel S. Riley
Summary: Apoptosis is a cellular pathway that controls structured cell death but can also lead to inflammation under certain conditions. This review discusses how apoptosis through death receptor and mitochondrial pathways can activate inflammation, and highlights the unique case of cell death due to mitotic stress and its relationship with inflammation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Immunology
Zhen-Hua Ying, Hui-Min Li, Wen-Ying Yu, Chen-Huan Yu
Summary: IRD exerts protective effects against LPS-induced inflammation by suppressing the PKM2-mediated pathway, reducing inflammatory cytokine release, and alleviating oxidative stress, as demonstrated in both murine macrophage and mouse models.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasmina M. Abd-Elhakim, Attia A. A. Moselhy, Adil Aldhahrani, Rasha R. Beheiry, Wafaa A. M. Mohamed, Mohamed Mohamed Soliman, Bayan A. Saffaf, Maha M. El Deib
Summary: The study examined the effects of sodium salicylates (SS) on kidney function and structure in rats, showing nephrotoxic activity and hematological alterations. Curcumin (CUR) effectively mitigated the harmful impacts of SS on the kidneys, although co-administration of SS+CUR induced an anemic condition. Careful consideration should be taken with their combined use.
Article
Biochemistry & Molecular Biology
Nathan P. P. Mirtallo Ezzone, Gerardo D. D. Anaya-Eugenio, Ermias Mekuria Addo, Yulin Ren, A. Douglas Kinghorn, Esperanza J. J. Carcache de Blanco
Summary: The present study investigated the potential anticancer properties of corchorusoside C (1), a cardenolide from Streptocaulon juventas, using a zebrafish model and DU-145 prostate cancer cells. The results showed that compound 1 selectively inhibited the expression of NF-kappa B pathway elements in TNF-alpha induced zebrafish and cell lines. Molecular docking studies revealed the binding interactions of 1 with various proteins involved in cancer pathways. Furthermore, the toxicity profile of 1 in zebrafish was found to be favorable compared to other anticancer drugs. Overall, these findings suggest that compound 1 may be a promising treatment option for prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Dalia H. El-Kashef, Randa A. Zaghloul
Summary: This study demonstrated that montelukast exerts hepatoprotective effects against CCl4-induced hepatotoxicity through antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic mechanisms.
Article
Cell Biology
Savita Devi, Mohanalaxmi Indramohan, Elisabeth Jager, Jessica Carriere, Lan H. Chu, Lucia de Almeida, David R. Greaves, Christian Stehlik, Andrea Dorfleutner
Summary: Inflammatory responses are important for controlling infections and tissue repair, but excessive inflammation can cause inflammatory disease. Pro-inflammatory cytokines IL-1b and IL-18 depend on caspase-1 activation within inflammasomes. Higher primates have evolved small proteins (POPs and COPs) to limit inflammation by targeting crucial interactions. This study shows that COPs can regulate inflammasome activation by modulating CARD interactions and ameliorate inflammatory disease.
Article
Immunology
Yaodong Wang, Xiaorong Zhou, Kejian Zou, Guanhua Chen, Ling Huang, Fangying Yang, Wenxu Pan, Hongwei Xu, Zhaohui Xu, Huan Chen, Jiayu Chen, Sitang Gong, Xuan Zhou, Wanfu Xu, Junhong Zhao
Summary: This study revealed that MCT4 exacerbates intestinal inflammation in inflammatory bowel disease by promoting Caspase-1-mediated canonical cell pyroptosis through the ERK1/2-NF-kappa B pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaixin Ding, Xinzhi Li, Xiaomeng Ren, Na Ding, Li Tao, Xue Dong, Zheng Chen
Summary: GBP5 is identified as a major factor causing liver injury and inflammation. Its expression is regulated by the NIK signaling pathway and it induces hepatocyte apoptosis through the activation of multiple apoptotic signaling pathways, leading to liver injury and inflammation.
Article
Oncology
Rashmi Mallya, Milind J. Bhitre
Summary: The study found that the methanol extract of Zanthoxylum rhetsa leaves has selective cytotoxic activity against Jurkat cell lines, primarily through an apoptotic mechanism. It alters the cell cycle, increases the expression of pro-apoptotic markers, and decreases the expression of anti-apoptotic markers.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Plant Sciences
Tao-yang Wang, Yong-jian Hu, Xia Wang, Yu-feng Li, Fan Zhang, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu
Summary: OB can intervene in radiation injury by regulating p65/Cas3, indicating its potential as a treatment.
Review
Biochemistry & Molecular Biology
Abdulkareem Olarewaju Babamale, Szu-Ting Chen
Summary: Cell death is essential for host defense, but dysregulation of NLRs can pose severe threats during microbial and parasitic infections. NLRs play a crucial role in innate immunity and anti-bacterial defense, and their functions need to be tightly regulated. Recent research shows that NLRs are involved in various signaling pathways and their exploration in controlling cell death during infections is promising.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Wei Kong, Zhen Xie, Xiaokang Shang, Yoshinori Hayashi, Fei Lan, Shuxuan Narengaowa, Shuxuan Zhao, Hui Li, Zhenzhen Quan, Zhou Wu, Hiroshi Nakanishi, Hong Qing, Junjun Ni
Summary: Zfp335 is a transcription factor that regulates neurogenesis and neuronal differentiation in mammals. Knockdown of Zfp335 expression significantly ameliorated microglia activation after LPS challenge, resulting in reduced inflammation and neurodegeneration. Zfp335 affects neuronal activity through transcriptional regulation of Ly6M, suggesting that inhibiting microglial Zfp335 could be a potential strategy for preventing brain diseases induced by microglia activation.
Article
Biochemistry & Molecular Biology
Siyu Li, Hongmei Huang, Yan Zhang, Ling Li, Ziyu Hua
Summary: This study investigated the neuroinflammation type of A1-like astrocytes induced by unconjugated bilirubin (UCB) and its underlying regulatory mechanisms. The results showed that UCB stimulation activated A1-like astrocytes, and the inhibition of NF-Kappa B and caspase-1 alleviated A1-like astrocytes and exerted anti-inflammatory protective effects.
NEUROCHEMICAL RESEARCH
(2023)
Article
Microbiology
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothee Fettrelet, Alexandra A. DeLaney, Opher S. Kornfeld, Bettina L. Lee, Eric M. Rodriguez Lopez, Daniel Grubaugh, Meghan A. Wynosky-Dolfi, Naomi H. Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P. Beiting, Jorge Henao-Mejia, Brian C. Schaefer, Kaiwen W. Chen, Petr Broz, Igor E. Brodsky
Summary: Programmed cell death is crucial for tissue homeostasis and host defense, with pyroptosis being an inflammatory form involving cell lysis and release of cytokines. Genetic targeting of Card19 impacts adjacent gene Ninj1, regulating processes of cell lysis downstream of gasdermin cleavage and influencing susceptibility to bacterial infections.
Article
Gastroenterology & Hepatology
Menghao Huang, Hyeong Geug Kim, Xiaolin Zhong, Chuanpeng Dong, Brian Zhang, Zhigang Fang, Yang Zhang, Xiaoyu Lu, Romil Saxena, Yunlong Liu, Chi Zhang, Suthat Liangpunsakul, X. Charlie Dong
Article
Biochemistry & Molecular Biology
Xiaocheng Charlie Dong, Kushan Chowdhury, Menghao Huang, Hyeong Geug Kim
Summary: Fatty liver disease is a major liver disorder in modern societies, requiring comprehensive understanding of its pathophysiology and molecular mechanisms. Remarkable progress has been made in basic and translational research, but critical issues such as reliable biomarkers, molecular targets, and prevention strategies still need to be addressed. As more data are generated, integrative approaches are needed to understand the disease at various levels and investigate gene-environment interactions for personalized treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Li Wei, X. Charlie Dong
Summary: The study identified that the lack of Sirt6 in the liver leads to more severe fatty liver disease and affects the activities of carbohydrate response element binding protein and sterol regulatory element binding protein 1. It was found that Sirt6 can suppress metabolic regulators in the liver through direct deacetylation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Austin M. Reilly, Shijun Yan, Menghao Huang, Surabhi D. Abhyankar, Jason M. Conley, Robert N. Bone, Natalie D. Stull, Daniel J. Horan, Hyun C. Roh, Alexander G. Robling, Aaron C. Ericsson, Xiaocheng C. Dong, Carmella Evans-Molina, Hongxia Ren
Summary: This study characterizes the metabolic phenotypes of adult GIRKO mice switched to a high-fat diet, revealing important gene-diet interactions contributing to the progression of diabetes. The findings suggest that the development of insulin resistance, dyslipidemia, and gut inflammation are key factors in driving the onset and progression of diabetes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Yanping Song, Ruitong Chu, Fuyang Cao, Yanfeng Wang, Yanhong Liu, Jiangbei Cao, Yongxin Guo, Weidong Mi, Li Tong
Summary: The study found that the dopaminergic system in the VTA promotes emergence from anesthesia in rats under sevoflurane, and the VTA(DA)-PrL pathway facilitates emergence from sevoflurane anesthesia.
NEUROSCIENCE BULLETIN
(2022)
Article
Oncology
Yanping Song, Jingjing Liu, Mingxing Lei, Yanfeng Wang, Qiang Fu, Bailin Wang, Yongxin Guo, Weidong Mi, Li Tong
Summary: The study developed an algorithm to predict postoperative pneumonia in elderly lung cancer patients undergoing video-assisted thoracoscopic surgery. The algorithm, consisting of seven variables, was internally and externally validated to be effective in predicting the risk of postoperative pneumonia. The algorithm showed a C-index of 0.70 in the training group, 0.67 in the internal validation group, and 0.71 in the external validation dataset.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Analytical
Rujin Zhang, Chaowei Zhuang, Zilin Wang, Guihua Xiao, Kunsha Chen, Hao Li, Li Tong, Weidong Mi, Hao Xie, Jiangbei Cao
Summary: The study combined extended-field-of-view microscopy with a novel prism-based cranial window to achieve simultaneous imaging of deep-brain regions and the superficial cortex in mouse brains, providing promising results for dynamic imaging in both layers.
Article
Biochemistry & Molecular Biology
Kushan Chowdhury, Menghao Huang, Hyeong-Geug Kim, X. Charlie Dong
Summary: Hepatic fibrosis is a response to liver tissue injury, and SIRT6 and HSCs play important roles in this process. This study found that SIRT6-deficient HSCs are prone to induce hepatic fibrosis, and the Hippo pathway proteins YAP and TAZ are highly activated in SIRT6-deficient HSCs. Further research revealed that SIRT6 regulates YAP and TAZ through deacetylation, thereby suppressing fibrosis-related genes.
Editorial Material
Pharmacology & Pharmacy
Wenji Zhang, Menghao Huang, Runping Liu
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physics, Applied
Jian Wang, Yudong Zhang, Zhaohu Wang, Wenjing Jiang, Mengdie Yang, Menghao Huang, Junseok Kim
Summary: In this paper, we propose an improved algorithm that involves increasing the number of cumulative summations in the computational steps of 2D MF-DFA. The proposed method aims to modify the distribution of the generalized Hurst exponent to enhance the extraction of skin lesion image features. The computation shows that the process involving two cumulative summations achieves better performance than with 0 and 1 cumulative summations.
MODERN PHYSICS LETTERS B
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Menghao Huang, Hyeonggeug Kim, Yang Zhang, Kushan Chowdhury, Jiazhi Xu, Liqing Yu, X. Charlie Dong
Meeting Abstract
Gastroenterology & Hepatology
Hyeonggeug Kim, Junghyo Cho, Zhang Yang, Menghao Huang, Chang-Hyun Gil, Kushan Chowdhury, X. Charlie Dong
Article
Chemistry, Multidisciplinary
Xican Ma, Bing Han, Aoyu Wang, Lu Yang, Menghao Huang, Kushan Chowdhury, Jian Gu, Kai Zhang, Kai Lv
Article
Gastroenterology & Hepatology
Xiaolin Zhong, Menghao Huang, Hyeong-Geug Kim, Yang Zhang, Kushan Chowdhury, Wenjie Cai, Romil Saxena, Robert F. Schwabe, Suthat Liangpunsakul, X. Charlie Dong
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)