Article
Plant Sciences
Yu-Ying Sun, Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study found that nitric oxide (NO) can enhance thermotolerance in maize seedlings by triggering the LCD/H2S signaling pathway. Additionally, NO also improves the adaptability of maize seedlings to heat stress by regulating the activity of the ROS scavenging system.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Biomedical
Andre J. van der Vlies, Masoud Ghasemi, Bernadette M. Adair, James H. Adair, Enrique D. Gomez, Urara Hasegawa
Summary: Hydrogen sulfide (H2S) is a gaseous signaling molecule with regulatory roles in cancer cell proliferation and migration, making it of interest in cancer therapy. Controlled delivery of H2S has been a challenge, but polymeric micelles containing H2S donating groups offer a solution. These micelles release H2S upon oxidation by reactive oxygen species (ROS) present inside cancer cells, with the release profiles controlled by changing the polymer design. In vitro and in vivo experiments demonstrate that micelles with moderate H2S release rates have the strongest anti-proliferative effect in human colon cancer cells and the chick chorioallantoic membrane cancer model, while not affecting human umbilical vein endothelial cell proliferation. This study highlights the importance of fine-tuning H2S release profiles using a micelle approach for maximizing the therapeutic potential of H2S in cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Kavitej Samra, Mathun Kuganesan, William Smith, Anna Kleyman, Robert Tidswell, Nishkantha Arulkumaran, Mervyn Singer, Alex Dyson
Summary: Metabolically active gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide are important signalling molecules with therapeutic potential in oxidative pathologies. Sodium hydroselenide (NaHSe), a simple selenide salt, has shown significant metabolic activity by inhibiting cytochrome C oxidase and impacting selenoprotein expression. The oxidation status of selenium plays a crucial role in protein expression and the use of NaHSe as a potential therapeutic agent warrants further research and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Dandan Huang, Guangqin Jing, Lili Zhang, Changbao Chen, Shuhua Zhu
Summary: NO, H2S, and ROS play essential signaling roles in cells through oxidative post-translational modification within suitable ranges of concentration to maintain redox balance and regulate DNA repair pathways, including mtDNA. The interactions among them are intricate, influencing their generation, elimination, and signaling actions. Additionally, NO and H2S may be involved in epigenetic variations in DNA damage repair of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Chemistry, Analytical
Ryan E. Johnson, Joshua M. van der Zalm, Aicheng Chen, Ian J. Bell, Terence J. Van Raay, M. Sameer Al-Abdul-Wahid, Richard A. Manderville
Summary: This article describes a hemicyanine hybrid probe containing 7-(diethylamino)coumarin (ACou) donor and cationic indolenium (Ind) acceptor, which is used for detecting nucleophilic analytes such as cyanide and reactive sulfur species (RSS). The study reveals that thiolates react with ACou-Ind through conjugate addition to form C4-SR adducts, and ACou-Ind serves as a turn-off probe by losing red ICT fluorescence upon RSS addition. Moreover, the article discusses that the blue coumarin emission of thiolate adducts does not enhance in the presence of reactive oxygen species (ROS), but undergoes oxidative deconjugation in the presence of ROS H2O2. The relevance of the chemosensing mechanism for ACou-Ind is assessed in live zebrafish, and the implications for the interplay between RSS and ROS are discussed.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Quan Gu, Qingqing Xiao, Ziping Chen, Yi Han
Summary: Melatonin acts as a multifunctional molecule in plants, particularly in protecting against abiotic stresses. It interacts with signaling molecules such as reactive oxygen species (ROS), nitric oxide (NO), and hydrogen sulfide (H2S) to modulate plant responses to abiotic stresses and enhance plant tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tajammul Husain, Mohammad Suhel, Sheo Mohan Prasad, Vijay Pratap Singh
Summary: Research has shown that both ethylene and hydrogen sulfide have the potential to alleviate the toxicity of hexavalent chromium in crop plants, with endogenous H2S playing a crucial role in the ET-mediated mitigation of Cr(VI) stress.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Andrea Doman, Eva Doka, Dorottya Garai, Virag Bogdandi, Gyorgy Balla, Jozsef Balla, Peter Nagy
Summary: Reactive sulfur species, including H2S, have emerged as important effector molecules in biological events. They interact with metalloproteins to exert their biological roles, altering fundamental cellular functions and contributing to immune defense, cellular protection against oxidative stress, and redox signaling. Understanding the interactions between RSS and metal centers is crucial for drug development and advancements in redox medicine.
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Deepti Singh, Nathi Lal Sharma, Dharmendra Singh, Manzer H. Siddiqui, Jyoti Taunk, Susheel Kumar Sarkar, Abhishek Rathore, Chandan Kumar Singh, Abdullah A. Al-amri, Saleh Alansi, Hayssam M. Ali, Md Atikur Rahman
Summary: This study investigated the effects of highly toxic chromium ions on the growth and physio-biochemical performance of mungbeans. It was found that the exogenous application of hydrogen sulfide promoted plant growth, improved antioxidant activities, and reduced cell death by suppressing chromium accumulation and translocation. These findings highlight the importance of hydrogen sulfide application in protecting crops against chromium toxicity.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Chemistry, Multidisciplinary
Weirun Li, Peier Chen, Yuxuan Pan, Ling Lu, Xiaodong Ning, Jiamin Liu, Jintao Wei, Minsheng Chen, Peng Zhao, Caiwen Ou
Summary: By using a complex scaffold and nanocomposite scaffold, a band-aid like patch can slowly release H2S and attach to the myocardium, relieving inflammation and promoting angiogenesis after myocardial infarction and recovering heart function.
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Review
Pharmacology & Pharmacy
Heng Liu, Miles N. Radford, Chun-tao Yang, Wei Chen, Ming Xian
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Obstetrics & Gynecology
Yixing Wu, Chuntao Yang, Fuhui Meng, Fenglian Que, Wenxia Xiao, Huying Rao, Yan Wan, Hugh S. Taylor, Lingeng Lu
REPRODUCTIVE SCIENCES
(2019)
Review
Chemistry, Multidisciplinary
Shi Xu, Akil Hamsath, Deshka L. Neill, Yingying Wang, Chun-tao Yang, Ming Xian
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Analytical
Huiling Wang, Yulin Xu, Li Rao, Chuntao Yang, Hong Yuan, Tingjuan Gao, Xin Chen, Hongyan Sun, Ming Xian, Chunrong Liu, Changlin Liu
ANALYTICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Chun-tao Yang, Nelmi O. Devarie-Baez, Akil Hamsath, Xiao-dong Fu, Ming Xian
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Chemistry, Organic
Yingying Wang, Chun-tao Yang, Shi Xu, Wei Chen, Ming Xian
Article
Chemistry, Multidisciplinary
Wei Chen, Tetsuro Matsunaga, Deshka L. Neill, Chun-tao Yang, Takaaki Akaike, Ming Xian
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Cell Biology
Qingzi Chen, Yubo Zhou, Lifen Zhou, Zhaodi Fu, Chuntao Yang, Lei Zhao, Shuni Li, Yan Chen, Yousen Wu, Zhenwei Ling, Yufeng Wang, Jianrong Huang, Jianhua Li
CELL DEATH & DISEASE
(2020)
Article
Oncology
Xiang Li, Na Li, Li Huang, Shi Xu, Xue Zheng, Akil Hamsath, Mei Zhang, Lijun Dai, Hui Zhang, Justin Jong-Leong Wong, Ming Xian, Chun-tao Yang, Jinbao Liu
FRONTIERS IN ONCOLOGY
(2020)
Article
Endocrinology & Metabolism
Yi-Xing Wu, Chun-Tao Yang, Na Li, Xue Zheng, Xiang Li, Hui Zhang, Jie Shen
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Endocrinology & Metabolism
Yupin Tan, Lili Zou, Na Li, Li Huang, Meiji Chen, Xuexiang Li, Xue Zheng, Wenkai Li, Yun Li, Chun-Tao Yang
Summary: This study revealed the effects of mast cells on gene expression in asthmatic lungs and the therapeutic effects of inhaled budesonide. Mast cell engraftment enhanced inflammation/immune response, while BUD treatment reduced serum IL-6 content and pulmonary inflammation, inhibiting mast cell degranulation. The study suggests that mast cell-induced pulmonary gene profile can be reversed through mast cell blockade or inhaled BUD.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Pharmacology & Pharmacy
Ximing Zhang, Mianrong Chen, Xiang Ni, Yingying Wang, Xue Zheng, Hui Zhang, Shi Xu, Chun-tao Yang
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Neurosciences
Kun-Li Yang, Wen-Hong Li, Ya-Jie Liu, Ying-Juan Wei, Yan-Kai Ren, Chen-Di Mai, Si-Yu Zhang, Yue Zuo, Zhen-Zhou Sun, Dong-Liang Li, Chih-Huang Yang
Summary: This study found that hydrogen sulfide can protect the central nervous system, alleviate neuroinflammation caused by stroke, and improve brain and retinal injuries by blocking the NLRP3 inflammasome pathway. The findings suggest that hydrogen sulfide compounds could be a potential therapeutic strategy for ischemic stroke.
Article
Clinical Neurology
Manli Li, Xiaoli Ma, Chendi Mai, Zhiru Fan, Yangyang Wang, Yankai Ren
Summary: This study used VOSviewer and CiteSpace to assess the current state of insular epilepsy research and determine research hotspots and prospective directions. The findings identified surgical treatment, functional network connectivity, and the application of neuroimaging methods as hot topics and research frontiers in the field of insular epilepsy.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Pharmacology & Pharmacy
Kunli Yang, Hu Luo, Yajie Liu, Yankai Ren, Meixia Guo, Bin Wang, Chih-huang Yang, Dongliang Li
Summary: This study found that hydrogen sulfide (H2S) can protect neural cells from damage induced by high concentrations of ATP. ATP induces cytotoxicity in PC12 cells through the endogenous H2S/CBS system, and supplementation with exogenous H2S can mitigate this damage.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)