Editorial Material
Neurosciences
Sarah Mondoloni, Manuel Mameli
Summary: This study examines the characteristics of co-release of GABA and glutamate at synapses from basal ganglia to habenula, shedding light on the packaging and release mechanisms of multiple neurotransmitters.
Article
Biochemical Research Methods
Jaskaran Singh, Yingzhou Edward Pan, Shunmoogum A. Patten
Summary: This study developed an ImageJ macro called NMJ Analyser to automatically and unbiasedly analyze the structural morphology of neuromuscular junctions in zebrafish. The macro can extract and quantify terminal structures from zebrafish images, providing valuable insights for the study of neuromuscular diseases and developmental neurobiology.
Article
Multidisciplinary Sciences
Eri Tabuchi, Takeshi Sakaba, Yuki Hashimotodani
Summary: Recent evidence suggests that glutamate and GABA can be coreleased from the same presynaptic terminals in certain adult brain regions, such as the SuM-DG pathway. The LTP of glutamatergic transmission selectively increases excitatory drive, contributing to network activity in the DG region.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Aditya Nair, Yue Yang Teo, George J. Augustine, Martin Graf, Hee - Sup Shin
Summary: The cholinergic system in the basal forebrain has a crucial role in various behaviors such as attention and learning, by modifying the impact of noise in neural populations. The confounding release of acetylcholine (ACh) and GABA by cholinergic inputs to the claustrum, a structure involved in attention control, has opposing effects on the electrical activity of claustrum neurons projecting to cortical and subcortical targets. This cholinergic switching between subcircuits offers a potential mechanism for neurotransmitter corelease in behaviorally relevant computations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Frederic Knoflach, Daniel Bertrand
Summary: GABA(A) receptors are key inhibitory ligand-gated ion channels that are targeted by therapeutic compounds, attracting attention for drug discovery efforts. Recent advances in understanding the molecular structure of these receptors have provided insights into allosteric modulation and its relevance for drug development.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arnaud L. Lalive, Mauro Congiu, Christopher Lewis, Dominik Groos, Joseph A. Clerke, Anna Tchenio, Yuan Ge, Fritjof Helmchen, Manuel Mameli
Summary: Through experiments with mice, it was found that the activity of lateral habenula neurons decreases with the decrease of reward-related stimuli, and this phenomenon can guide reward-driven behavior through synaptic inhibition.
Article
Biochemistry & Molecular Biology
Jason R. Borgus, Ying Wang, Dana J. DiScenza, B. Jill Venton
Summary: The study found that most dopamine transients in mice were coincident with adenosine, indicating a simultaneous release pattern. Adenosine receptors were identified as potential targets for modulating simultaneous release of adenosine and dopamine. Regulating adenosine and dopamine cotransmission could be crucial for developing treatments for dopamine-related diseases like Parkinson's or addiction.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Xin-Yue Wang, Xiang Xu, Rui Chen, Wen-Bin Jia, Peng-Fei Xu, Xiao-Qing Liu, Ying Zhang, Xin-Feng Liu, Yan Zhang
Summary: Chronic stress and chronic pain are major factors leading to depression. This study reveals the role of an inhibitory circuit from the sensory thalamic reticular nucleus to the lateral habenula in the development and modulation of depression.
Article
Cell Biology
Riccardo Melani, Nicolas X. Tritsch
Summary: This study reveals that GABA synthesis in SNc(DA) neurons is not mediated by Aldh1a1 enzyme, but is obtained through presynaptic uptake by Gat1 protein and then packaged into synaptic vesicles for release by Vmat2 protein. This finding expands the range of molecular mechanisms available to neurons to support inhibitory synaptic communication.
Article
Cell Biology
Abhilash Sawant, Briana N. Ebbinghaus, Adam Bleckert, Clare Gamlin, Wan-Qing Yu, David Berson, Uwe Rudolph, Raunak Sinha, Mrinalini Hoon
Summary: This study used a combination of techniques to determine the composition and organization of inhibitory synapses in a well-characterized RGC type in the mouse retina. The researchers found the presence of mixed GABA-glycine receptor synapses, as well as the sequence of postsynaptic assembly for these synapses. These findings reveal the characteristics of an additional motif of inhibition in the mammalian retina.
Article
Medicine, Research & Experimental
Margarida Beatriz, Ricardo J. Rodrigues, Rita Vilaca, Conceicao Egas, Paulo S. Pinheiro, George Q. Daley, Thorsten M. Schlaeger, Nuno Raimundo, A. Cristina Rego, Carla Lopes
Summary: The study focused on EVs and their role in reversing the abnormal GABAergic phenotype in Huntington's disease-derived neurons. It was found that EVs from control fibroblasts reversed the deficits in GABAergic synaptic transmission, while EVs from HD-derived fibroblasts had the opposite effects on control neurons. Analysis of miRNAs in EVs identified differentially expressed miRNAs between HD and control lines with predicted synaptic targets.
Review
Biochemistry & Molecular Biology
Kaiyu Xu, Ying Zhang, Jiali Li
Summary: The mammalian brain exhibits extraordinary complexity in structure, function, and diverse biological and physiological processes. CircRNAs, a novel class of transcripts with a covalently closed-loop structure, are highly enriched in the brain and are produced through alternative back-splicing of genes associated with synaptogenesis and neural activities. Despite the unclear biological functions of most circRNAs in the brain, emerging evidence suggests that dynamic changes in circRNA expression play a critical role in brain function and maintaining physiological homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onesia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabricio Simao, Friederike Klempin, Marcel Leist, Mauro Cunha Xavier Pinto
Summary: Astrocytes play a crucial role in providing trophic and metabolic support for neurons, and they can transform into reactive astrocytes during injuries and infections to release signaling molecules for cerebral defense. Understanding the signaling pathways of reactive astrocytes can help control neuroinflammation and identify new targets for neurorepair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ya Wen, Zhifang Dong, Jun Liu, Peter Axerio-Cilies, Yehong Du, Junjie Li, Long Chen, Lu Zhang, Lidong Liu, Jie Lu, Ning Zhou, Dong Chuan Wu, Yu Tian Wang
Summary: Maintaining a proper balance between neuronal excitation and inhibition is crucial for brain function. This study reveals a novel interaction between glutamate and GABA(A) receptors, where glutamate can enhance the function of GABA(A) receptors by directly binding to them. Disruption of this interaction leads to increased neuronal excitability, suggesting its importance in maintaining the excitation-inhibition balance in the brain.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Rahul S. Guda, Katherine E. Odegaard, Chengxi Tan, Victoria L. Schaal, Sowmya Yelamanchili, Gurudutt Pendyala
Summary: This study investigated the impact of oxycodone on mixed neuroglial cultures, revealing its disruption of key pathways associated with synaptic function, particularly those related to GDP binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mark Zuchner, Joel C. Glover, Jean-Luc Boulland
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Neurosciences
Mark Zuchner, Elena Kondratskaya, Camilla B. Sylte, Joel C. Glover, Jean-Luc Boulland
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Anatomy & Morphology
Rabia Soussi, Jean-Luc Boulland, Emilie Bassot, Helene Bras, Patrice Coulon, Farrukh Abbas Chaudhry, Jon Storm-Mathisen, Lotfi Ferhat, Monique Esclapez
BRAIN STRUCTURE & FUNCTION
(2015)
Article
Anatomy & Morphology
Mrinal Joel, Cecilie J. Sandberg, Jean-Luc Boulland, Einar O. Vik-Mo, Iver A. Langmoen, Joel C. Glover
DEVELOPMENTAL DYNAMICS
(2013)
Article
Multidisciplinary Sciences
Jean-Luc Boulland, Francois M. Lambert, Mark Zuchner, Susanne Strom, Joel C. Glover
Article
Cell & Tissue Engineering
Jean-Luc Boulland, Maria Mastrangelopoulou, Andrew C. Boquest, Rune Jakobsen, Agate Noer, Joel C. Glover, Philippe Collas
STEM CELLS AND DEVELOPMENT
(2013)
Article
Clinical Neurology
Mark Zuchner, Andreas Lervik, Elena Kondratskaya, Vanessa Bettembourg, Lili Zhang, Henning A. Haga, Jean-Luc Boulland
FRONTIERS IN NEUROLOGY
(2019)
Article
Neurosciences
Elena Kondratskaya, Oleksandr Ievglevskyi, Mark Zuchner, Athina Samara, Joel C. Glover, Jean-Luc Boulland
Review
Radiology, Nuclear Medicine & Medical Imaging
Joel C. Glover, Markus Aswendt, Jean-Luc Boulland, Jasna Lojk, Stefan Stamenkovic, Pavle Andjus, Fabrizio Fiori, Mathias Hoehn, Dinko Mitrecic, Mojca Pavlin, Stefano Cavalli, Caterina Frati, Federico Quaini
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Mathilde Toch, Audrey Harris, Olivier Schakman, Elena Kondratskaya, Jean-Luc Boulland, Nicolas Dauguet, Stephanie Debrulle, Charlotte Baudouin, Maria Hidalgo-Figueroa, Alexander Gow, Joel C. Glover, Fadel Tissir, Frederic Clotman
SCIENTIFIC REPORTS
(2020)
Correction
Multidisciplinary Sciences
Mathilde Toch, Audrey Harris, Olivier Schakman, Elena Kondratskaya, Jean-Luc Boulland, Nicolas Dauguet, Stephanie Debrulle, Charlotte Baudouin, Maria Hidalgo-Figueroa, Xiuqian Mu, Alexander Gow, Joel C. Glover, Fadel Tissir, Frederic Clotman
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Mark Zuchner, Manuel J. Escalona, Lena Hammerlund Teige, Evangelos Balafas, Lili Zhang, Nikolaos Kostomitsopoulos, Jean-Luc Boulland
Summary: Researchers have developed a multimodal SCI apparatus for large animals to generate biomechanically reproducible impacts. They found a correlation between the biomechanical characteristics of the impact, functional outcomes, and tissue damage, providing detailed procedures in the hopes to facilitate the adoption of the swine model by other research groups.
DISEASE MODELS & MECHANISMS
(2021)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Joel C. Glover, Markus Aswendt, Jean-Luc Boulland, Jasna Lojk, Stefan Stamenkovic, Pavle Andjus, Fabrizio Fiori, Mathias Hoehn, Dinko Mitrecic, Mojca Pavlin, Stefano Cavalli, Caterina Frati, Federico Quaini
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Developmental Biology
Rishab S. Chawla, Mark Zuchner, Maria Mastrangelopoulou, Francois M. Lambert, Joel C. Glover, Jean-Luc Boulland
DEVELOPMENTAL NEUROBIOLOGY
(2017)
Article
Neurosciences
Maria Di Bonito, Jean-Luc Boulland, Wojciech Krezel, Eya Setti, Michele Studer, Joel C. Glover
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)