期刊
NEUROCHEMISTRY INTERNATIONAL
卷 61, 期 8, 页码 1397-1403出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2012.10.002
关键词
Electro-acupuncture; Calcitonin gene-related peptide; Neuroprotection; Spinal cord injury; Cerebellar granule neurons
资金
- Natural Science Foundation of Guangdong Province [07001682, S2011040004895]
- Social Developmental Foundation of Guangdong Province [2010B030700008]
- Chinese National Natural Science Foundation [30973721, 81102646]
- National 863 Project [2011A030300004]
Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically. (C) 2012 Elsevier Ltd. All rights reserved.
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