期刊
NEUROCHEMISTRY INTERNATIONAL
卷 59, 期 5, 页码 551-558出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2011.06.009
关键词
MicroRNA; BDNF; Synaptic plasticity
资金
- Core Research for Evolutional Science and Technology Program (CREST), Japan Science and Technology Agency (JST)
- Takeda Science Foundation
- Japan Health Sciences Foundation
- NCNP [20-3, 21-9]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [20390318, 21680034]
- Health and Labor Sciences Research Grants
- Grants-in-Aid for Scientific Research [20390318, 21680034] Funding Source: KAKEN
MicroRNAs (miRs), endogenous small RNAs, regulate gene expression through repression of translational activity after binding to target mRNAs. miRs are involved in various cellular processes including differentiation, metabolism, and apoptosis. Furthermore, possible involvement of miRs in neuronal function have been proposed. For example, miR-132 is closely related to neuronal outgrowth while miR-134 plays a role in postsynaptic regulation, suggesting that brain-specific miRs are critical for synaptic plasticity. On the other hand, numerous studies indicate that BDNF (brain-derived neurotrophic factor), one of the neurotrophins, is essential for a variety of neuronal aspects such as cell differentiation, survival, and synaptic plasticity in the central nervous system (CNS). Interestingly, recent studies, including ours, suggest that BDNF exerts its beneficial effects on CNS neurons via up-regulation of miR-132. Here, we present a broad overview of the current knowledge concerning the association between neurotrophins and various miRs. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据