Article
Biochemistry & Molecular Biology
Minjie Shen, Yu Guo, Qiping Dong, Yu Gao, Michael E. Stockton, Meng Li, Sudharsan Kannan, Tomer Korabelnikov, Keegan A. Schoeller, Carissa L. Sirois, Chen Zhou, Jonathan Le, Daifeng Wang, Qiang Chang, Qian-Quan Sun, Xinyu Zhao
Summary: Parvalbumin interneurons (PVIs) are influenced by the regulation of the FXR1 gene, impacting behaviors and oscillations related to schizophrenia. This reveals a potential mechanism of action for FXR1 in schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Sarah E. Canetta, Emma S. Holt, Laura J. Benoit, Eric Teboul, Gabriella M. Sahyoun, R. Todd Ogden, Alexander Z. Harris, Christoph Kellendonk
Summary: In their study, Hubel and Wiesel identified sensitive periods where experience can have long-lasting effects on adult visual cortical functioning and behavior through changes in neuronal activity. They investigated whether similar sensitive periods exist for non-sensory cortices and found that inhibition of prefrontal parvalbumin (PV)-expressing interneurons during the juvenile and adolescent period leads to persistent impairments in adult prefrontal circuit connectivity, in vivo network function, and behavioral flexibility, which can be reversed by targeted activation of PV interneurons in adulthood.
Article
Multidisciplinary Sciences
Eunee Lee, Seungjoon Lee, Jae Jin Shin, Woochul Choi, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park, Min Whan Jung, Se-Bum Paik, Eunjoon Kim
Summary: The NMDARs and gap junctions in cortical PV interneurons are involved in modulating burst firing, which ultimately affects social behavior.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Annalise N. Binette, Jianfeng Liu, Hugo Bayer, Kennedi L. Crayton, Laila Melissari, Samantha O. Sweck, Stephen Maren
Summary: Stress has a significant impact on fear extinction and affects the activity of PV interneurons in the mPFC. PV interneurons regulate extinction learning under stress in a sex-dependent manner, and this effect is mediated by amygdaloprefrontal projections.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Sara Sabihi, Caitlin Goodpaster, Skyler Maurer, Benedetta Leuner
Summary: Mother-offspring interactions reduce postpartum anxiety-like behavior through GABAA neurotransmission in the mPFC. Activation of GABAA receptors in the mPFC restores anxiolysis in mothers separated from their pups, while an increased anxiety-like behavior in pup-separated mothers is associated with a lower number and percentage of activated GABAergic neurons in the mPFC.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Kevin M. Manz, Benjamin C. Coleman, Carrie A. Grueter, Brenda C. Shields, Michael R. Tadross, Brad A. Grueter
Summary: In the NAcSh, NE modulates glutamatergic synaptic transmission onto PV-INs by recruiting postsynaptically-localized alpha(2)-adrenergic receptors, decreasing PV-IN-dependent feedforward inhibition onto MSNs via optogenetic stimulation from cortical afferents.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Stefano Delli Pizzi, Raffaella Franciotti, Piero Chiacchiaretta, Antonio Ferretti, Richard A. Edden, Carlo Sestieri, Mirella Russo, Stefano L. Sensi, Marco Onofrj
Summary: This study aims to investigate the neural mechanisms of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients. The results showed that patients with SSD exhibited higher gamma-aminobutyric acid (GABA) levels and connectivity in the medial prefrontal cortex (mPFC), indicating both shared and individual effects of PD and SSD on mPFC neurotransmission and connectivity patterns.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Paul J. Harrison, David M. Bannerman
Summary: The involvement of the glutamate system, particularly the NMDA receptor hypofunction, is considered to be part of the pathophysiology of schizophrenia. Recent data strongly implicate the gene GRIN2A, encoding the NR2A NMDA receptor subunit, in the development of schizophrenia. Both rare and common variants of this gene are associated with genetic risk for the disorder, and they are likely to result in reduced gene expression.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Zhoulong Yu, Ying Han, Die Hu, Na Chen, Zhongyu Zhang, Wenxi Chen, Yanxue Xue, Shiqiu Meng, Lin Lu, Wen Zhang, Jie Shi
Summary: The study reveals the important role of Neurocan in adolescent depression, as well as a novel mechanism for the antidepressant effect of ketamine.
MOLECULAR PSYCHIATRY
(2022)
Article
Anatomy & Morphology
John H. Harkness, Angela E. Gonzalez, Priyanka N. Bushana, Emily T. Jorgensen, Deborah M. Hegarty, Ariel A. Di Nardo, Alain Prochiantz, Jonathan P. Wisor, Sue A. Aicher, Travis E. Brown, Barbara A. Sorg
Summary: The study found diurnal fluctuations in perineuronal nets (PNNs) surrounding parvalbumin (PV) interneurons and PV cells, impacting the excitatory:inhibitory balance in the cortex and providing new insights into treatments for diseases affected by disruptions in sleep and circadian rhythms.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Psychiatry
Larissa Allgauer, Jan-Harry Cabungcal, Catherine Yzydorczyk, Kim Quang Do, Daniella Dwir
Summary: A large body of evidence suggests that intrauterine growth restriction (IUGR) can cause long-term cognitive and behavioral deficits, as well as increasing the risk of schizophrenia (SZ). Oxidative stress and neuroinflammation play important roles in the pathophysiology of SZ and can affect the development of parvalbumin interneurons (PVI) and their perineuronal nets (PNN). However, these pathways have not been explored in IUGR models. New research has proposed the MMP9-RAGE pathway as a potential mechanism for persistent damage to PVIs. Maternal protein deficiency during gestation can induce oxidative stress and neuroinflammation in adolescent rats with IUGR, leading to decreased PVIs and PNNs and increased levels of MMP9 and RAGE shedding. Maternal diet is an important factor for proper neurodevelopment and may have implications for SZ.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Ellen P. Woon, Laura M. Butkovich, Arianna A. Peluso, Aziz Elbasheir, Kian Taylor, Shannon L. Gourley
Summary: We have discovered a connection between the ventral hippocampus and the medial orbitofrontal cortex that plays an important role in the updating of value memories, and this connection is mediated by the neuroplasticity-associated neurotrophin receptor TrkB.
Article
Neurosciences
Robert Kim, Terrence J. Sejnowski
Summary: By analyzing computational models and neural data, the authors demonstrate that inhibitory-to-inhibitory signaling is crucial for maintaining stable temporal dynamics and working memory in the primate prefrontal cortex.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Mykhailo Y. Batiuk, Teadora Tyler, Katarina Dragicevic, Shenglin Mei, Rasmus Rydbirk, Viktor Petukhov, Ruslan Deviatiiarov, Dora Sedmak, Erzsebet Frank, Virginia Feher, Nikola Habek, Qiwen Hu, Anna Igolkina, Lilla Roszik, Ulrich Pfisterer, Diego Garcia-Gonzalez, Zdravko Petanjek, Istvan Adorjan, Peter V. Kharchenko, Konstantin Khodosevich
Summary: Schizophrenia is a widespread and complex mental disorder characterized by a reduction in abundance of GABAergic neurons and an increase in principal neurons, especially in the upper cortical layers. Many neuronal subtypes show extensive transcriptomic changes, particularly in upper-layer GABAergic neurons. Transcription factor network analysis reveals the developmental origin of these transcriptomic changes.
Article
Multidisciplinary Sciences
Christoph Metzner, Volker Steuber
Summary: The mechanisms underlying circuit dysfunctions in schizophrenia are still poorly understood. Studies on auditory steady-state responses (ASSRs) in schizophrenia patients show inconsistent results regarding changes in power at 20 Hz during 40 Hz stimulation. Factors such as differences in recording modalities, stimulus types, and stimulus amplitudes may contribute to these inconsistencies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)