Article
Cell Biology
Rupali Vohra, Berta Sanz-Morello, Anna Luna Molgaard Tams, Zaynab Ahmad Mouhammad, Kristine Karla Freude, Jens Hannibal, Blanca Irene Aldana, Linda Hildegaard Bergersen, Miriam Kolko
Summary: The present study demonstrates that activation of HCA(1)R with 3,5-DHBA treatment can improve RGC survival and mitigate glutamate-induced retinal degeneration. Thus, HCA(1)R agonist administration may serve as a potential new strategy for rescuing RGCs and preventing visual disability.
Article
Multidisciplinary Sciences
Nange Jin, Lian-Ming Tian, Iris Fahrenfort, Zhijing Zhang, Friso Postma, David L. Paul, Stephen C. Massey, Christophe P. Ribelayga
Summary: This study utilized rod- or cone-specific gene knockout mice to investigate the functionality of the secondary rod pathway and the additive contribution of different pathways to retinal output.
Article
Biology
Michael W. Country, Michael G. Jonz
Summary: By studying the responses of goldfish and rainbow trout retinal cells to hypoxia, it was found that goldfish maintain [Ca2+](i) stably by using mitochondrial ATP-dependent K+ channels (mK(ATP)) to resist excitotoxicity, while rainbow trout experience a rapid increase in [Ca2+](i) during hypoxia, which can be life-threatening.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Yanhao Chu, Yaqi Wu, Shilin Jia, Ke Xu, Jinyue Liu, Lijia Mai, Wenguo Fan, Fang Huang
Summary: In this study, the distribution and expression of core clock genes, pain-related genes, melatonin-related genes, and opioid-related genes in different cell types and neuron subtypes within the mouse and human trigeminal ganglion were analyzed. Species differences were investigated by comparing these genes between human and mouse trigeminal ganglion. The results of this study provide a valuable resource for exploring the molecular mechanisms underlying oral facial pain and pain rhythms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Erika M. Ellis, Antonio E. Paniagua, Miranda L. Scalabrino, Mishek Thapa, Jay Rathinavelu, Yuekan Jiao, David S. Williams, Greg D. Field, Gordon L. Fain, Alapakkam P. Sampath
Summary: Most defects causing RP are rod-specific mutations, but the degeneration of cones is the most debilitating feature. Researchers made single-cell recordings of light responses from degenerating cones and retinal interneurons, finding that degenerating cones can still give light responses through opsin localized in specific membrane areas or distributed throughout the inner segment. The findings show that cones and their retinal pathways can remain functional during degeneration, providing hope for enhancing the light sensitivity of residual cones in restoring vision in RP patients.
Article
Biochemistry & Molecular Biology
Chun-Lei Deng, Cheng-Biao Hu, Sheng-Tao Ling, Na Zhao, Li-Hui Bao, Feng Zhou, Ye-Cheng Xiong, Tao Chen, Bing-Dong Sui, Xiao-Rui Yu, Cheng-Hu Hu
Summary: The study revealed the therapeutic effects and mechanisms of mesenchymal stem cell transplantation and exosomal transplantation on photoreceptor injuries, with a focus on miR-21 mediation for photoreceptor viability. These methods demonstrated long-lasting efficacy in treating retinal degenerative diseases, highlighting their potential as a therapeutic approach.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Emma R. West, Sylvain W. Lapan, ChangHee Lee, Kathrin M. Kajderowicz, Xihao Li, Constance L. Cepko
Summary: This study provides a comprehensive analysis of bipolar subtypes in the mouse retina, revealing the ordered birthdates and spatial distribution patterns of these subtypes. The study also suggests clonal restriction on the production of homotypic subtypes. These findings shed light on the development of neuronal subtypes and establish a framework for studying subtype diversification.
Article
Chemistry, Analytical
Alberto Esteban-Linares, Lauren K. Wareham, Thayer S. Walmsley, Joseph M. Holden, Matthew L. Fitzgerald, Zhiliang Pan, Ya-Qiong Xu, Deyu Li
Summary: In this study, a microfluidic platform capable of maintaining stable operating pressures while limiting shear stress was developed. The platform was demonstrated to be effective in measuring the change in intracellular Ca2+ levels of retinal ganglion cells in response to pressure. This microfluidic platform has potential for studying cell and tissue responses to elevated pressure.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Dorsa Haji Ghaffari, Akwasi Darkwah Akwaboah, Ehsan Mirzakhalili, James D. Weiland
Summary: Retinal prostheses aim to improve visual perception in patients with photoreceptor degeneration-induced blindness, but the current limitations in shape and letter perception are due to low spatial resolution. Research has shown that better patient outcomes are correlated with spatially separate phosphenes. By using an optimization algorithm to find optimal stimulation parameters for focal RGC activation, the time required for optimizing implant operation can be reduced.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Neurosciences
Hanna Dumanska, Mariia Telka, Nikolai Veselovsky
Summary: The study aims to evaluate the initial effect of acute hypoxia on HVA calcium currents in cultured retinal ganglion cells (RGCs). The results demonstrate that acute hypoxia strongly inhibits HVA calcium channel activity in RGCs, with a correlation between the level of inhibition and the duration of hypoxia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jie Yan, Alexander Guenter, Soumyaparna Das, Regine Muehlfriedel, Stylianos Michalakis, Kangwei Jiao, Mathias W. Seeliger, Francois Paquet-Durand
Summary: Inherited retinal degenerations (IRDs) are blinding diseases characterized by progressive loss of photoreceptors. The excessive activation of calpain and poly (ADP-ribose) polymerase (PARP) is associated with the pathology of IRDs. Inhibitors of these enzymes have shown promise in preventing photoreceptor cell death. However, the relationship between calpain and PARP in IRDs is still unclear. In this study, organotypic retinal explant cultures were used to investigate the effects of calpain inhibitors, PARP inhibitors, and voltage-gated Ca2+ channel (VGCC) inhibitors on cell death in IRD mice models. The results suggest that PARP acts upstream of calpain and both enzymes are part of the same degenerative pathway in Pde6b-dependent photoreceptor degeneration. Our findings highlight the potential of targeting PARP for therapeutic interventions in IRD-type diseases.
Article
Neurosciences
Yvonne Koelsch, Joshua Hahn, Anna Sappington, Manuel Stemmer, Antonio M. Fernandes, Thomas O. Helmbrecht, Shriya Lele, Salwan Butrus, Eva Laurell, Irene Arnold-Ammer, Karthik Shekhar, Joshua R. Sanes, Herwig Baier
Summary: This study systematically classified RGCs in adult and larval zebra fish using single-cell transcriptomics, identifying marker genes for various mature types and developmental intermediates. The research also engineered transgenic driver lines based on this dataset, enabling specific experimental access to a subset of RGC types. Furthermore, molecularly defined RGCs were shown to exhibit specific functional tuning through in vivo calcium imaging.
Article
Neurosciences
Alessio Canovai, James R. Tribble, Melissa Joe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Summary: Retinal ganglion cells require regulated metabolism and functional mitochondria to maintain ATP levels and cell viability. Alterations in metabolism and mitochondrial processes are early indicators of optic neuropathies. PQQ, a quinone cofactor, has potential neuroprotective effects and can affect cellular and mitochondrial metabolism, but its mechanisms need to be further studied.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M. Williams, Takaaki Kuwajima, Kun-Che Chang
Summary: Retinal ganglion cells (RGCs) and their axons are important for transmitting visual signals from the eye to the brain, but they cannot regenerate in mammals. In this study, researchers investigated the effects of inhibiting aldose reductase (AR), an inflammatory response mediator, on ocular inflammation and RGC survival after optic nerve crush (ONC). The results showed that AR inhibition attenuated inflammation, promoted RGC survival, and delayed axon degeneration, suggesting it as a potential therapeutic strategy for optic neuropathies.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sailee S. Lavekar, Jade Harkin, Melody Hernandez, Catia Gomes, Shruti Patil, Kang-Chieh Huang, Shweta S. Puntambekar, Bruce T. Lamb, Jason S. Meyer
Summary: This study demonstrates the capacity of retinal organoids differentiated from human pluripotent stem cells to effectively model early Alzheimer's disease-related alterations, including the accumulation of A beta plaques and neurofibrillary tangles as well as synaptic dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Diego J. Valdez, Paula S. Nieto, Natalia S. Della Costa, Clemar Schurrer, Mario E. Guido
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Multidisciplinary Sciences
Diego Javier Valdez, Santiago Miguel Benitez-Vieyra
Article
Immunology
Lei Sun, Zhengfan Jiang, Victoria A. Acosta-Rodriguez, Michael Berger, Xin Du, Jin Huk Choi, Jianhui Wang, Kuan-wen Wang, Gokhul K. Kilaru, Jennifer A. Mohawk, Jiexia Quan, Lindsay Scott, Sara Hildebrand, Xiaohong Li, Miao Tang, Xiaoming Zhan, Anne R. Murray, Diantha La Vine, Eva Marie Y. Moresco, Joseph S. Takahashi, Bruce Beutler
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Zoology
Tobias Nicolas Rojas, David Lautaro Vergara-Tabares, Diego Javier Valdez, Marina Flavia Ponzio, Susana Ines Peluc
INTEGRATIVE ZOOLOGY
(2019)
Article
Behavioral Sciences
Marilina Vera Cortez, Diego J. Valdez, Joaquin L. Navarro, Mnica B. Martella
Article
Biology
Lucas D. Gorne, Victoria A. Acosta-Rodriguez, Susana J. Pasquare, Gabriela A. Salvador, Norma M. Giusto, Mario Eduardo Guido
CHRONOBIOLOGY INTERNATIONAL
(2015)
Article
Multidisciplinary Sciences
Diego J. Valdez, Marilina Vera Cortez, Natalia S. Della Costa, Alvina Leche, Cristian Hansen, Joaquin L. Navarro, Monica B. Martella
Article
Multidisciplinary Sciences
Filipa Rijo-Ferreira, Victoria A. Acosta-Rodriguez, John H. Abel, Izabela Kornblum, Ines Bento, Gokhul Kilaru, Elizabeth B. Klerman, Maria M. Mota, Joseph S. Takahashi
Article
Zoology
Ludmila Maldonado, Tomas C. Tempesti, Gustavo M. Somoza, Susana Peluc, Diego J. Valdez
Article
Ornithology
Macarena Morales, Deysi J. Gigena, Santiago M. Benitez-Vieyra, Diego J. Valdez
Review
Multidisciplinary Sciences
Victoria A. Acosta-Rodriguez, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi
Summary: Dietary restriction, along with drug interventions targeting nutrient-sensing gene pathways, influences energy intake and circadian rhythms to promote a healthy lifespan and mitigate negative effects of a mismatch between internal and external rhythms on organismal health.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Victoria Acosta-Rodriguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi
Summary: Research shows that the interval of fasting and circadian alignment of feeding are important factors in extending lifespan under CR; nighttime CR can alleviate inflammation and metabolic pathway damage caused by aging; circadian interventions promote longevity.
Article
Endocrinology & Metabolism
Diego J. Valdez
Summary: This article reviews the reproductive biology of ratites, specifically focusing on the Challenge Hypotheses and the Challenge Hypothesis 2.0. Ratites, which are flightless and have promiscuous mating systems with male-only parental care, provide a unique perspective for studying the role of androgens in reproductive behavior. The lack of experimental approaches in behavioral endocrinology across ratites is also discussed. The review aims to inspire further research on this basal group of birds and enhance our understanding of the evolution of reproductive behavior in birds.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Diego Valdez, Santiago Benitez-Vieyra
Summary: Molting is the process of replacing old feathers with new ones, and plumage color is determined by pigments and feather structure. However, there is limited research on the change in plumage color over time and its relationship to reproductive tasks. This study focuses on the Eared Dove and found a molting period of 6 months (January to June) with changes in feather coloration from July to December. The color variation in the crown feathers during the breeding season suggests a possible link to reproductive behaviors.
Article
Cell Biology
Victoria A. Acosta-Rodriguez, Marleen H. M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)