Article
Multidisciplinary Sciences
Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Shahram Ejtemaei-Mehr, Mohammad Sharifzadeh, Ahmad Reza Dehpour
Summary: This study demonstrates that Ivermectin has anticonvulsant effects against PTZ- and MES-induced seizures in mice, possibly mediated by its action on GABAA receptors and KATP channels.
Article
Biochemistry & Molecular Biology
Adrian Bartoszek, Alicja Trzpil, Anna Kozub, Emilia Fornal
Summary: This study aimed to optimize the zebrafish larvae pentylenetetrazol-induced seizure model to investigate the interaction between caffeine and topiramate. An analytical method was developed to measure the levels of caffeine, topiramate, and its metabolite paraxanthine in zebrafish larvae. The results showed that caffeine and topiramate separately reduced the locomotor activity of zebrafish larvae but could not lower it to the control level. Co-administration of caffeine and topiramate at specific doses suppressed the activity to the control level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Lars Stumpp, Hugo Smets, Simone Vespa, Joaquin Cury, Pascal Doguet, Jean Delbeke, Antoine Nonclercq, Riem El Tahry
Summary: The study demonstrates the possibility of using vagus nerve electroneurogram for seizure detection, with successful development of metrics and a classifier for this purpose.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2021)
Review
Biochemistry & Molecular Biology
Ricardo Mario Arida
Summary: The review discusses the significant contribution of the ketogenic diet and physical exercise in reducing seizure susceptibility and improving the condition of epilepsy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Neurosciences
Nathan Byers, Eu-Teum Hahm, Susan Tsunoda
Summary: The study found that dSlo2/K-Na channels in Drosophila are selectively expressed in specific neurons in the adult brain and play a role in inhibiting global hyperactivity and seizure-like behavior. Additionally, the absence of these channels increased susceptibility to seizures and led to spontaneous seizures in both genetic and pharmacologically induced seizure models.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Article
Pharmacology & Pharmacy
Patrick C. Milder, Agnes S. Zybura, Theodore R. Cummins, James A. Marrs
Summary: Approximately 30% of patients with epilepsy do not achieve adequate seizure control with current drugs and treatments, highlighting the need for more efficient screening methods. This study presents an optimized method using a zebrafish seizure model to screen anti-seizure drugs, comparing behavior and neural activity. The results show that EEG and GCaMP measurements largely correlate with behavior, providing a more comprehensive assessment of drug efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mari Carmen Gomez-Cabrera, Aitor Carretero, Fernando Millan-Domingo, Esther Garcia-Dominguez, Angela G. Correas, Gloria Olaso-Gonzalez, Jose Vina
Summary: This review highlights the major research findings and advancements in the field of exercise redox biology, as well as discusses the biomarkers for assessing health, performance, and recovery in the sport population during exercise training. The focus is on four categories of redox biomarkers and their methodological considerations.
Article
Cell Biology
Debora Melissa Petry Moecke, Gisele Henrique Cardoso Martins, Thaine Cristina Garlet, Kelly Cattelan Bonorino, Marilia Gabriela Luciani, Monique Bion, Barbara dos Santos, Monique da Silva Gevaerd, Jamil Assreuy Filho, Adair Roberto Soares dos Santos, Daniella Serafin Couto Vieira, Alcir Luiz Dafre, Deborah de Camargo Hizume Kunzler
Summary: The study found that aerobic exercise can improve lung function in CKD patients, reduce kidney damage, and enhance antioxidant defenses. Although aerobic exercise did not significantly affect pulmonary damage, it significantly improved physical performance in CKD patients.
Article
Cell Biology
Debora Melissa Petry Moecke, Gisele Henrique Cardoso Martins, Thaine Cristina Garlet, Kelly Cattelan Bonorino, Marilia Gabriela Luciani, Monique Bion, Barbara dos Santos, Monique da Silva Gevaerd, Jamil Assreuy Filho, Adair Roberto Soares dos Santos, Daniella Serafin Couto Vieira, Alcir Luiz Dafre, Deborah de Camargo Hizume Kunzler
Summary: The effects of aerobic exercise (AE) on lungs of chronic kidney disease (CKD) were investigated in this study. The results showed that AE improved kidney injury and enhanced antioxidant defenses in the lungs. However, there were no significant changes in pulmonary damage.
Article
Endocrinology & Metabolism
Zenat Fatima Khattak, Bushra Ansari, Muhammad Jamal, Abdul Aleem Awan, Muhammad Azhar Sherkheli, Rizwan ul Haq
Summary: People from different cultures prefer to use medicinal plants for treatment due to their affordability, cost-effectiveness, and accessibility. Mentions the anti-seizure activity of Withania coagulans in different seizure models, indicating its potential as an anticonvulsant.
METABOLIC BRAIN DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Abrar Alhebshi, Nehal Alsharif, Josh Thorley, Lewis J. James, Tom Clifford
Summary: This systematic review examined the effects of dietary protein/amino acid interventions on exercise-induced oxidative stress and inflammation and found weak and inconsistent evidence, calling for further research.
Article
Endocrinology & Metabolism
Chia-Chi Liu, YunJia Zhang, Angela Makris, Helge H. Rasmussen, Annemarie Hennessy
Summary: The study compared the glutathionylation of the beta(1) subunit of the Na+-K+ pump in placentas from healthy pregnancies and preeclampsia. The results showed a significant increase in GSS-beta(1) levels in preeclamptic placentas, providing new insights into the mechanism of Na+-K+ pump dysfunction in preeclampsia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Ghorbannejad Hadi, Tofighi Asghar, Tolouei Azar Javad, Razi Mazdak
Summary: Long-term consumption of tramadol negatively affects spermatogenesis development, while exercise training protocols (ETPs) can reduce the damage caused by tramadol on antioxidant and endocrine capacities, with low-intensity training showing the best results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, General & Internal
David S. Kim, Tobias Weber, Ulrich Straube, Christine E. Hellweg, Mona Nasser, David A. Green, Anna Fogtman
Summary: Physical exercise can decrease radiation-induced DNA damage, oxidative stress, and inflammation, while increasing antioxidant activity. Despite high heterogeneity in results, there is evidence for a beneficial effect of exercise in cellular, clinical, and functional outcomes.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Erika Da Guedes, Leandro Rodrigo Ribeiro, Cesar Alves Carneiro, Aline Matilde Ferreira Santos, Alefe Brito Monteiro, Humberto Hugo Nunes De Andrade, Ricardo Dias Castro, Flavio Freitas Barbosa, Jose Maria Barbosa Filho, Reinaldo Nobrega De Almeida, Mirian Graciela Stiebbe Salvadori
Summary: trans-Anethole (TAN) showed anticonvulsant effects in classic seizure models by increasing the time for the onset of spasms and convulsions, and reducing the duration of seizures.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
P. C. Stibbe, L. B. Ianiski, C. Weiblen, A. F. Maciel, M. L. Machado, T. L. da Silveira, F. A. A. Soares, J. M. Santurio, M. P. Soares, D. I. B. Pereira, L. A. Sangioni, S. de Avila Botton
Summary: The objective of this study was to evaluate the inhibitory effects and toxicity of agricultural fungicides mefenoxam and pyraclostrobin against Pythium insidiosum. The results showed that both compounds had inhibitory effects on the pathogenic oomycete without causing toxicity in vitro and in vivo models. Further studies on pharmacokinetics, toxicity, and pharmacological interactions are necessary for evaluating their potential use in the clinical management of pythiosis.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thayanara Cruz da Silva, Tassia Limana da Silveira, Luiza Venturini dos Santos, Leticia Priscila Arantes, Rodrigo Pereira Martins, Felix Alexandre Antunes Soares, Cristiane Lenz Dalla Corte
Summary: This study aimed to investigate the effects of adenosine on the behaviors, morphology, survival after stress conditions, and oxidative stress response pathways in Caenorhabditis elegans. The results showed that adenosine modulated the defecation rate, pharyngeal pumping rate, locomotion, and stress response pathways in the worms. Furthermore, adenosine had modulatory effects on oxidative stress response signaling.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tamie Duarte, Monica de Medeiros Silva, Paula Michelotti, Nilda Berenice de Vargas Barbosa, Bruno Cesar Feltes, Marcio Dorn, Joao Batista Teixeira da Rocha, Cristiane Lenz Dalla Corte
Summary: This study investigated the effects of two hypercaloric diets and aging on the expression levels of ACE2 genes in fruit flies, and analyzed the binding affinity between fruit fly ACE2 and the Spike protein. The results showed that the expression of Ance and Acer genes in adult fruit flies is influenced by diet and age, and that Ance and Acer proteins can interact with the Spike protein in different regions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Toxicology
Luiz Eduardo Ben Pilissao, Cristiane Freitas Rodrigues, Douglas Porto, Gabriela Rossi Brabo, Andressa Tassinari da Silva, Robson Luiz Puntel, Clesio Soldatelli Paim, Cristiane Casagrande Denardin, Daiana Silva Avila
Summary: This study investigated the effects and mechanisms by which maca affects the reproductive system using an in vivo model. It was found that maca extract caused a significant decrease in total number of eggs and in the number of eggs per worm in nematodes, and was associated with increased lipid peroxidation, reduced triacylglycerol levels, impaired vitellogenin expression, and an increase in apoptotic germline cells. This maca extract also contained quantifiable levels of alkaloids.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Biophysics
Debora F. Goncalves, Leahn R. Senger, Joao V. P. Foletto, Paula Michelotti, Felix A. A. Soares, Cristiane L. Dalla Corte
Summary: Caffeine may improve mitochondrial function by increasing mitochondrial respiration in a Parkinson's disease model.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2023)
Article
Biochemistry & Molecular Biology
Paula Michelotti, Debora F. Goncalves, Tamie Duarte, Joelma M. Sarturi, Rafael S. Da Silva, Oscar E. D. Rodrigues, Joao B. T. Rocha, Cristiane L. Dalla Corte
Summary: This study aimed to evaluate the toxicity of AZT and its derivative compounds on adult Drosophila melanogaster. The results showed that AZT and its derivative 7K impaired locomotion and induced mitochondrial dysfunction in the flies. Based on the data, 7K had the highest toxicity while other compounds showed lower toxicity compared to AZT.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Food Science & Technology
Naieli Schiefelbein Souto, Micheli Dassi, Ana Claudia Monteiro Braga, Erica Vanessa Furlan Rosa, Michele Rechia Fighera, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari, Ana Flavia Furian
Summary: Several studies have demonstrated the toxicity of both aspartame (ASP) and aflatoxin B-1 (AFB(1)) separately, but little is known about their concomitant exposure and hazardous consequences. In this study, male rats were exposed to AFB(1), ASP, or both substances for 14 days. The results showed that the combination of ASP and AFB(1) had greater behavioral impairments and oxidative status imbalance compared to the groups treated with only ASP or AFB(1). These findings suggest that the co-exposure to ASP and AFB(1) disrupts brain homeostasis.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Neurosciences
Bruna Neuberger, Fernanda Kulinski Mello, Michele Pereira Mallmann, Karine Gabriela da Costa Sobral, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flavia Furian, Tuane Bazanella Sampaio, Mauro Schneider Oliveira
Summary: Epilepsy is a common neurological disorder characterized by recurrent seizures. In this study, the beneficial effects of rosmarinic acid (RA) on epileptic activity were evaluated using in vitro and in vivo models. The results showed that RA could attenuate seizure-induced neuromotor impairment and reduce protein oxidation levels in the brain cortex. These findings suggest that RA may be a potential add-on therapy for epilepsy.
Article
Neurosciences
Ana Claudia Monteiro Braga, Naieli Schiefelbein Souto, Fernanda Licker Cabral, Micheli Dassi, Erica Vanessa Furlan Rosa, Naiara dos Santos Guarda, Luiz Fernando Freire Royes, Michele Rechia Fighera, Rafael Noal Moresco, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari, Ana Flavia Furian
Summary: This study investigated the effects of intermittent exposure to Aflatoxin B-1 (AFB(1)) on biochemical and behavioral parameters. The results showed that intermittent exposure did not cause any impairment in body weight, organ weight, behavior, antioxidant defenses, and markers of oxidation in various tissues. Moreover, hepatic and renal functions were not affected. Further studies are needed to explore the effects of AFB(1) exposure in order to better understand its potential hazards.
Article
Endocrinology & Metabolism
Eduarda Monteiro Fidelis, Anne Suely P. Savall, Jhuly Dornelles Mello, Caroline Brandao Quines, Antonio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de avila, Suzan Goncalves Rosa, Simone Pinton
Summary: This study investigated the antioxidant and neuroprotective effects of purple pitanga extract (PPE) against early oxidative stress induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropypiridine (MPTP) administration. The findings showed that PPE prevented the increase in reactive oxygen species (ROS) levels and protected against lipid peroxidation caused by MPTP. Furthermore, PPE enhanced the activity of Na+/K+ ATPase, indicating its neuroprotective capacity.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell & Tissue Engineering
Micheli Mainardi Pillat, Ana Carolina Ayupe, Guilherme Juvenal, Carine Meinerz, Talita Glaser, Diogo Vieira da Silva Pellegrina, Daisylea Souza Paiva, Carlos Fernando Mello, Beatriz Monteiro Longo, Eduardo Moraes Reis, Henning Ulrich
Summary: Proteins involved in AD, such as APP and PS1, have a critical role in CNS development and immune response. Mutations in these proteins lead to abnormal expression in NPCs and resemble the brain pathology in adult AD patients.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)