Article
Neurosciences
Yue Li, Edmund Hollis
Summary: Motor control relies on precise encoding and modulation across various motor centers, refined through learning repetition. The baso-cortical cholinergic pathway plays a critical role in the acquisition of coordinated motor skills in mice, with depletion of cholinergic neurons leading to significant impairments in training. Cholinergic neuromodulation during training is essential for task acquisition, specifically influencing corticostriatal neurons in the prefrontal and motor cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Biological
Eduarda G. Nachtigall, Julia D. R. de Freitas, Lucas Aschidamini Marcondes, Cristiane R. G. Furini
Summary: The research found that environmental enrichment has a facilitating effect on memory persistence in rats, with 5 weeks of exposure having a positive impact. However, a two-week exposure did not affect memory persistence. Additionally, specific brain regions, such as the basolateral amygdala, medial prefrontal cortex, and CA1 region of the hippocampus, play important roles in mediating the effect of environmental enrichment on memory persistence.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Amir Mohammad Ghorbanpour, Meysam Saboor, Reza Panahizadeh, Hakimeh Saadati, Masoomeh Dadkhah
Summary: This study aimed to investigate the protective effects of royal jelly (RJ) and environmental enrichment (EE) on anxiety-like behaviors, cognitive functions, and levels of brain-derived neurotrophic factor (BDNF) in stressed rats. The results showed that EE and RJ improved cognitive deficits, reduced anxiety-like behaviors, and increased BDNF levels, demonstrating their potential in protecting susceptible brain areas against chronic stress.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huang
Summary: This study found that environmental enrichment can ameliorate methamphetamine-induced behavioral sensitization and anxiety symptoms. The various components of environmental enrichment play a crucial role in reducing behavioral sensitization, and no individual component is able to effectively reduce behavioral sensitization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Leandro A. Oliveira, Ivy I. Carvalho, Renata Y. Kurokawa, Josiane de O. Duarte, Cristiane Busnardo, Carlos C. Crestani
Summary: The study found that depletion of acetylcholine within the PL decreased the tachycardia response to restraint stress, while depletion within the IL reduced the restraint-evoked pressor response and cutaneous vasoconstriction.
BRAIN RESEARCH BULLETIN
(2022)
Review
Neurosciences
Saravanan Subramaniam, David T. Blake, Christos Constantinidis
Summary: DBS has emerged as a potential treatment for memory and cognitive impairment in neurodegenerative diseases. Stimulating specific brain structures, such as the nucleus basalis of Meynert, can enhance cortical activity and potentially ameliorate neuropathological mechanisms associated with Alzheimer's disease. High-frequency, continuous stimulation may not be suitable for Alzheimer's disease, and lower stimulation frequency or intermittent patterns of stimulation may be more effective when targeting the cholinergic forebrain.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Pharmacology & Pharmacy
Maria Serena Paladini, Vittoria Spero, Veronica Begni, Francesca Marchisella, Alice Guidi, Piotr Gruca, Magdalena Lason, Ewa Litwa, Maurisz Papp, Marco A. Riva, Raffaella Molteni
Summary: The study suggests that the second-generation antipsychotic blonanserin may normalize emotionality deficits induced by Chronic Mild Stress in rats by modulating redox mechanisms in the prefrontal cortex, providing new insights into its therapeutic properties and potential use as a treatment for psychiatric disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Neurosciences
Veronica Pastor, Jorge H. Medina
Summary: Information storage in the brain involves different memory types and stages, and cholinergic pathways through acetylcholine receptors play an active role in memory modulation. The alpha 7 subtype of nicotinic acetylcholine receptors has been studied in relation to memory processing, but there is still limited information available. This review aims to identify the brain regions where alpha 7 nicotinic receptors are essential for different memory types and stages, and discuss their potential as pharmacological targets for memory impairment in neurological disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Jamshid Faraji, Hamid Lotfi, Alireza Moharrerie, S. Yaghoob Jafari, Nasrin Soltanpour, Rosa Tamannaiee, Kameran Marjani, Shabnam Roudaki, Farhad Naseri, Reza Moeeini, Gerlinde A. S. Metz
Summary: The early environment plays a critical role in brain development, and the type of stimulation (physical or social) can have different effects. In this study, male and female rats were subjected to physical and social environmental enrichment, and it was found that physical stimulation improved motor and cognitive functions, as well as the expression of BDNF in the hippocampus and medial prefrontal cortex (mPFC). However, the combination of physical and social enrichment had better effects on females, with increased functional and structural changes, as well as elevated levels of oxytocin and BDNF expression in the mPFC.
Article
Anatomy & Morphology
Michael R. Duggan, Surbhi Joshi, Jacob Strupp, Vinay Parikh
Summary: The study investigated changes in the prefrontal cortex in attention control during aging, finding that aged rats exhibit a more significant decline in attention performance in tasks. By silencing PFC output neurons and examining their effects on young and aged rats, it was discovered that young animals showed impaired attention capacities, while aged animals were relatively unaffected.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Wen-Jing Ren, Ya-Fei Zhao, Jie Li, Patrizia Rubini, Zeng-Qiang Yuan, Yong Tang, Peter Illes
Summary: This study found that in a mouse model of major depressive disorder, depression-like behavior can be aggravated by microinjecting the P2X7R agonist ATP or its analog dibenzoyl-ATP into the medial prefrontal cortex, and this effect can be reversed by the P2X7R antagonist JNJ-47965567.
Article
Anatomy & Morphology
Rudieri Souza, Debora Bueno, Leandro B. Lima, Maria J. Muchon, Luciano Goncalves, Jose Donato, Sara J. Shammah-Lagnado, Martin Metzger
Summary: This study compares the cortical inputs to the ventral tegmental area (VTA), laterodorsal tegmental nucleus (LDTg), and median raphe nucleus (MnR) in rats, revealing a similar set of prefrontal afferents. These findings further support the important role of the prefrontal cortex in controlling major state-setting mesopontine modulatory transmitter systems.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Shefali Chaudhary, Sheng Zhang, Simon Zhornitsky, Yu Chen, Herta H. Chao, Chiang-Shan R. Li
Summary: Trait anxiety tends to decrease with age, possibly due to reduced ability to process emotional stimuli and improved regulation of emotions. In a study of 88 adults aged 21 to 85 using fMRI, it was found that anxiety was negatively correlated with age. While there was no evidence supporting the hypotheses of delayed reaction time or diminished limbic/emotional circuit, the findings indicated that higher automaticity in processing negative emotions may contribute to decreased anxiety with age.
Article
Neurosciences
Shulan Hsieh, Meng-Heng Yang, Zai-Fu Yao
Summary: This study employed a mixed design task for functional magnetic resonance imaging (fMRI) to investigate the differences in task-related brain activity patterns in the prefrontal cortex (PFC) under different task conditions. The results showed that both low episodic and low abstraction conditions evoked more brain activity in the anterior PFC, regardless of age group.
Article
Neurosciences
Gabriella Margetts-Smith, Anastasia I. Macnaghten, Leonie S. Brebner, Joseph J. Ziminski, Meike C. Sieburg, Jeffrey W. Grimm, Hans S. Crombag, Eisuke Koya
Summary: Acute exposure to environmental enrichment reduces the impact of motivationally relevant stimuli on sucrose-seeking behavior by decreasing specific brain region activity, while chronic exposure does not have the same effect. This highlights the significant impact of environmental enrichment on reward-seeking behavior in animals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Giacomo Ronzoni, Maria Anton, Francisco Mora, Gregorio Segovia, Alberto Del Arco
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Endocrinology & Metabolism
Giacomo Ronzoni, Alberto del Arco, Francisco Mora, Gregorio Segovia
PSYCHONEUROENDOCRINOLOGY
(2016)
Article
Behavioral Sciences
Gregorio Segovia, Alberto Del Arco, Marta de Blas, Pedro Garrido, Francisco Mora
BEHAVIOURAL BRAIN RESEARCH
(2008)
Article
Behavioral Sciences
Alberto Del Arco, Gregorio Segovia, Marta de Blas, Pedro Garrido, Dario Acuna-Castroviejo, Reinald Pamplona, Francisco Mora
BEHAVIOURAL BRAIN RESEARCH
(2011)
Review
Neurosciences
Francisco Mora, Gregorio Segovia, Alberto del Arco, Marta de Blas, Pedro Garrido
Review
Neurosciences
Francisco Mora, Gregorio Segovia, Alberto del Arco
BRAIN RESEARCH REVIEWS
(2008)
Article
Clinical Neurology
Gregorio Segovia, Alberto del Arco, Francisco Mora
JOURNAL OF NEURAL TRANSMISSION
(2009)
Article
Clinical Neurology
Gregorio Segovia, Alberto Del Arco, Marta De Blas, Pedro Garrido, Francisco Mora
JOURNAL OF NEURAL TRANSMISSION
(2010)
Article
Clinical Neurology
P. Garrido, M. De Blas, G. Ronzoni, I. Cordero, M. Anton, E. Gine, A. Santos, A. Del Arco, G. Segovia, F. Mora
JOURNAL OF NEURAL TRANSMISSION
(2013)
Article
Geriatrics & Gerontology
Pedro Garrido, Marta de Blas, Alberto Del Arco, Gregorio Segovia, Francisco Mora
NEUROBIOLOGY OF AGING
(2012)
Article
Biochemistry & Molecular Biology
L. F. Hernandez, G. Segovia, F. Mora
NEUROCHEMISTRY INTERNATIONAL
(2008)
Article
Neurosciences
Alberto Del Arco, Gregorio Segovia, Francisco Mora
PSYCHOPHARMACOLOGY
(2008)
Article
Public, Environmental & Occupational Health
Gregorio Segovia, Belen Sanz-Barbero
Summary: Pseudotherapy use in Spain is associated with confidence in its effectiveness, regardless of users' assessment of its scientific validity. The probability of pseudotherapy use is higher in women compared to men, and attitudes towards medicine, health, and the public health system also influence the use of pseudotherapies.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Clinical Neurology
A. Del Arco, G. Segovia, J. J. Canales, P. Garrido, M. de Blas, J. M. Garcia-Verdugo, F. Mora
JOURNAL OF NEURAL TRANSMISSION
(2007)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)
