Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Fengqing Zhu, Guanglei Chang, Xiaoqiong Tang, Lingyun Gao, Nan Zhang
Summary: Doxorubicin (DOX) is used for cancer treatment but can cause cardiovascular toxicity. This study examined whether DOX promotes atherosclerosis by impairing cardiac function. The results showed that DOX increased miR-33 expression and reduced the protein level of ATP binding cassette transporter A1 (ABCA1). DOX also suppressed cholesterol efflux, especially under high-cholesterol conditions. Transfection of miR-33 mimics or inhibitors into cells respectively decreased or increased ABCA1 protein expression and regulated intracellular lipid accumulation. Overall, DOX upregulates miR-33 to suppress ABCA1 expression, leading to intracellular lipid deposition in macrophages, which is an early sign of atherosclerosis. This study provides new insights for the clinical observation and evaluation of DOX side effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao
Summary: In this study, a scavenger receptors AI (SR-AI) targeted theranostic nanoparticles were constructed to target foam cells and atherosclerotic plaques via ABCA1 activation. The SAU-NPs showed more active targeting to plaque lesions compared to non-SR-AI targeted nanoparticles. SAU-NPs carrying 5242331 inhibited the transformation to foam cells and effectively reduced cholesterol deposition through activating the LXR & alpha;-ABCA1/ABCG1/SR-BI pathway.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yu-Ting Wu, Jiang-Bin Li, Hui-Qin Lin, Guo-Xin Zhang, Cong-Min Hong, Ming Li, Zhi-Jun Guo, Yan-Bing Yang
Summary: The study demonstrated that overexpression of miR-200b-3p and downregulation of ABCA1 can promote lipid accumulation and inhibit cholesterol efflux, while inhibiting miR-200b-3p may alleviate these effects.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Cell Biology
Jie Zhang, Jiayou Liu, Fubin Zheng, Min Yu, Sergey Shabala, Won-Yong Song
Summary: Arsenic is toxic to all organisms, but different organisms have evolved mechanisms to reduce cytosolic arsenic concentration and alleviate arsenic toxicity. These mechanisms include arsenite extrusion and arsenic sequestration into vacuoles. In addition, a special arsenate resistance mechanism has been found in certain bacterial systems.
Article
Microbiology
Jie Chen, Shan Han, Shujiang Li, Ming Wang, Hanmingyue Zhu, Tianmin Qiao, Tiantian Lin, Tianhui Zhu
Summary: The ABC1 gene in the N. parvum strain plays a crucial role in stress response and virulence, and may be associated with heavy metal resistance.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Rui Lu, Takahiro Ishikawa, Mamoru Tanaka, Tomoe Tsuboi, Shinji Yokoyama
Summary: This study demonstrates that Zn++ can increase ABCA1 stability by enhancing calmodulin binding to ABCA1, leading to increased HDL biogenesis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Biochemistry & Molecular Biology
Shangming Liu, Jiahui Gao, Linhao He, Zhenwang Zhao, Gang Wang, Jin Zou, Li Zhou, Xiangjun Wan, Shilin Tang, Chaoke Tang
Summary: Myristica fragrans has been shown to promote cholesterol efflux from macrophages, reduce intracellular cholesterol accumulation, and modulate lipid metabolism and inflammation through the GATA3, LXR alpha, and ABCA1 pathways, indicating its potential therapeutic efficacy in atherosclerotic cardiovascular disease.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Genetics & Heredity
Joana Ferreira, Manuel Bicho, Fatima Serejo
Summary: This study aimed to investigate the influence of ABCA1 gene polymorphism on the severity of liver disease and found that this polymorphism varies according to gender. In patients with chronic hepatitis C, ABCA1 gene polymorphism is associated with serum lipid levels and liver function parameters. In terms of gender differences, females carrying the ABCA1 mutation are associated with higher viral serum levels, while males carrying the ABCA1 mutation are associated with higher liver enzymes, lower total cholesterol, and increased disease severity.
Article
Oncology
Zhijuan Liang, Wei Jiao, Liping Wang, Yuanbin Chen, Dan Li, Zhao Zhang, Zhilei Zhang, Ye Liang, Haitao Niu
Summary: CYP27A1 plays a regulatory role in the proliferation and migration of ccRCC, by activating LXRs/ABCA1 to regulate cholesterol homeostasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang, Weihua Li
Summary: The study revealed a positive association between circulating sPLA2-IIA and HDL-C levels, suggesting that sPLA2-IIA may enhance cholesterol efflux through regulation of PPAR-gamma/LXR-alpha/ABCA1.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Keisuke Ikegami, Masayuki Hashiguchi, Hayato Kizaki, Osamu Yasumuro, Ryohkan Funakoshi, Satoko Hori
Summary: This study aimed to develop a risk prediction model for denosumab-induced hypocalcemia in patients with bone metastases receiving natural vitamin D/calcium supplementation. A risk prediction model was developed using a large database and showed good discriminant and predictive performance. This model could be useful for risk management of denosumab treatment in patients with bone metastases.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Immunology
Kazuhisa Ishida, Kaoru Yamada, Risa Nishiyama, Tadafumi Hashimoto, Itaru Nishida, Yoichiro Abe, Masato Yasui, Takeshi Iwatsubo
Summary: This study reveals the role of aquaporin-4 (AQP4) in the clearance of extracellular tau from the brain to cerebrospinal fluid and deep cervical lymph nodes, with the deletion of AQP4 exacerbating tau deposition and neurodegeneration. The findings identify a novel regulatory mechanism of glymphatic clearance in the central nervous system for extracellular tau, which may contribute to tau aggregation and neurodegeneration.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Multidisciplinary Sciences
Haru Iino, Masayuki Hashiguchi, Satoko Hori
Summary: This study aimed to compare WTP/QALY and GDP per capita, and to develop a new CE threshold range based on WTP using GDP per capita. The results showed that a CE threshold range of 0.5-1.5 times GDP per capita is appropriate, and there is a positive correlation between WTP/QALY and healthy life expectancy.
Article
Multidisciplinary Sciences
Satoshi Nishioka, Tomomi Watanabe, Masaki Asano, Tatsunori Yamamoto, Kazuyoshi Kawakami, Shuntaro Yada, Eiji Aramaki, Hiroshi Yajima, Hayato Kizaki, Satoko Hori
Summary: Early detection and management of adverse drug reactions (ADRs) is crucial for improving patients' quality of life. A recent study used natural language processing (NLP) deep-learning methods to identify potential ADRs, particularly Hand-foot syndrome (HFS), from cancer patients' internet blogs. The study successfully demonstrated the effectiveness of this approach and its potential to enhance ADR management for individual patients.
Article
Multidisciplinary Sciences
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Summary: This study investigates the pathological mechanisms of vesicular traffic impairment in Alzheimer's disease and proposes a therapeutic target for AD.
Article
Oncology
Tomomi Watanabe, Shuntaro Yada, Eiji Aramaki, Hiroshi Yajima, Hayato Kizaki, Satoko Hori
Summary: This study used the BERT model to extract and classify multiple worries from text generated by patients with breast cancer, and the results showed that the model was able to effectively identify various concerns of breast cancer patients.
Article
Biochemistry & Molecular Biology
Yuya Kishino, Koji Matsukawa, Taisei Matsumoto, Ryota Miyazaki, Tomoko Wakabayashi, Takashi Nonaka, Fuyuki Kametani, Masato Hasegawa, Tadafumi Hashimoto, Takeshi Iwatsubo
Summary: This study revealed that casein kinase 1 delta phosphorylates FUS and increases its solubility. Coexpression of CK1 delta in Drosophila models ameliorated retinal degeneration and extended lifespan. These findings highlight the regulatory role of CK1 delta in the assembly and toxicity of FUS.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ayano Mori, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki
Summary: This study comprehensively assessed the digestion efficiency and stability of tryptic peptides, identified optimal signature peptides for human hepatic transporters and membrane marker proteins, and provided reliable quantification of human hepatic transporters for integrated pharmacokinetic studies.
PHARMACEUTICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yuki Yamasaki, Takashi Moriwaki, Seiryo Ogata, Shingo Ito, Sumio Ohtsuki, Genki Minegishi, Satoshi Abe, Yumi Ohta, Kanako Kazuki, Kaoru Kobayashi, Yasuhiro Kazuki
Summary: This study developed a novel P-glycoprotein humanized mouse line carrying the 2677G>T mutation and evaluated its influence on the expression and function of P-glycoprotein at the blood-brain barrier. The results showed that the mutation did not alter the expression levels of P-glycoprotein but increased the brain penetration of P-glycoprotein substrates. This mutant mouse line provides a useful model for studying the impact of MDR1 gene mutations on P-glycoprotein at the blood-brain barrier.
PHARMACOGENETICS AND GENOMICS
(2022)
Article
Cell Biology
Takayuki Hoshii, Sarah Perlee, Sota Kikuchi, Bahityar Rahmutulla, Masaki Fukuyo, Takeshi Masuda, Sumio Ohtsuki, Tomoyoshi Soga, Behnam Nabet, Atsushi Kaneda
Summary: The protein degrader technology was used in this study to degrade SETD1A and investigate its role in acute myeloid leukemia (AML) cells. The results showed that SETD1A degradation led to downregulation of DNA repair and heme biosynthesis pathways, and SETD1A was also found to be essential for maintaining mitochondrial respiration in AML cells. Furthermore, the study revealed a non-enzymatic role of SETD1A in transcriptional pause release, providing insight into the mechanism of RNA polymerase II (RNAPII) pausing and its function in cancer.
Article
Multidisciplinary Sciences
Ryota Futamata, Masato Kinoshita, Katsueki Ogiwara, Noriyuki Kioka, Kazumitsu Ueda
Summary: In this study, the researchers found that ABCA1 deficiency in the Japanese medaka fish inhibits successful ovulation through cholesterol accumulation in the ovarian follicle. ABCA1A in the theca cells regulates cholesterol content in the ovarian follicles.
Review
Biochemistry & Molecular Biology
Kaoru Yamada
Summary: The central nervous system relies heavily on water, and disruptions in water balance can significantly affect its normal functions. Specialized water channels known as aquaporins, specifically AQP1 and AQP4, have been implicated in various brain disorders including brain edema and Neuromyelitis optica. Additionally, recent research focuses on the role of AQPs in waste removal in Alzheimer's disease, suggesting that targeting fluid homeostasis may be a promising approach for AD treatment. This review aims to provide an overview of the pathological implications of AQPs in AD, addressing unresolved questions and future prospects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tsubasa Takizawa, Keiko Ihara, Shunsuke Uno, Seiya Ohtani, Narumi Watanabe, Noboru Imai, Jin Nakahara, Satoko Hori, David Garcia-Azorin, Paolo Martelletti
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shungo Imai, Natsumi Aoki, Keisuke Ikegami, Hayato Kizaki, Satoko Hori
Summary: The dosage conversion of methadone remains challenging in Japan, with over 30% of patients requiring high-dose methadone switching and a longer completion period. Factors such as age, outpatient status, and concomitant use of medication influence the need for high-dose methadone switching.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Takeshi Masuda, Yuma Inamori, Arisu Furukawa, Maki Yamahiro, Kazuki Momosaki, Chih-Hsiang Chang, Daiki Kobayashi, Hiroto Ohguchi, Yawara Kawano, Shingo Ito, Norie Araki, Shao-En Ong, Sumio Ohtsuki
Summary: Recent advances in single-cell proteomics have shown the potential of sensitive analysis in limited cell populations. This study introduces a water droplet-in-oil digestion method that minimizes sample loss and increases protein and peptide recovery. The method is widely applicable for single-cell proteomics.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)
