Article
Plant Sciences
Xin Liu, Yuan Huang, Xu Liang, Qiong Wu, Nan Wang, Li-jun Zhou, Wen-wu Liu, Qun Ma, Bei Hu, Huan Gao, Ya-ling Cui, Xiang Li, Qing-chun Zhao
Summary: AE and AIII were found to improve the thermogenic capacity of mice, thus alleviating the symptoms of hypothermia in low-temperature environment. Mechanistically, this effect may be achieved by activating the SIRT1/PGC-1 alpha pathway to enhance the function of BAT and promote the browning of WAT.
Article
Biochemistry & Molecular Biology
Yulei Zhou, Xiaofang Lu, Lei Chen, Peifeng Zhang, Jingqi Zhou, Qianwen Xiong, Yirui Shen, Wei Tian
Summary: Stimulating Atractylodes macrocephala Koidz. with Chrysanthemun indicum L. polysaccharide can significantly enhance biomass and bioactive compound accumulation, with 2 mg/mL concentration being determined as the most effective during field experiments. The polysaccharide induction of terpenoid synthesis in Atractylodes macrocephala Koidz. is mainly dependent on the mevalonate pathway, showing potential for agricultural production.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Fisheries
Zongyi Sun, Dejun Li, Haibin Wang, Yu Ding, Chun Zhang, Shuyue Wang, Xuejiao Wang, Bingxin Li, Danning Xu
Summary: This study discovered that DEHP, a new environmental pollutant, poses a threat to the survival of fish. Furthermore, the researchers found that the use of PAMK can alleviate DEHP-induced apoptosis in fish cells. This study explored the application of traditional Chinese medicine in mitigating the damage caused by DEHP for the first time.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Tianqi Chen, Xiuqin Zheng, Limin Ouyang, Zhuzhen Han, Yingbo Yang, Lihua Gu, Li Yang, Zhengtao Wang
Summary: Six new polyacetylenes (1-6) and three known ones (7-9) were isolated from Atractylodes macrocephala. The structures and absolute configurations were determined by NMR, HR-ESI-MS, DP4+ calculations, and ECD calculations. The cytotoxicity and apoptosis of the compounds (1-9) were evaluated on CT-26 cell lines. Compounds 5 and 7 showed significant cytotoxicity, while compounds 3-6 promoted apoptosis in CT-26 cells. These findings suggest the potential use of polyacetylenes from Atractylodes macrocephala in colorectal cancer treatment.
Article
Chemistry, Medicinal
Haixin Zhang, Chunyu Lin, Luying Yin, Jinguang Si, Meng Yu, Jingrong Li, Lingyu Li, Tao Zhang, Zhongmei Zou
Summary: Twelve unknown compounds were isolated from the rhizomes of Atractylodes macro-cephala, including five sesquiterpenes, one monoterpene, and four lignans. The structures and absolute configurations of these compounds were determined by spectroscopic data analysis and electronic circular dichroism calculations. Among them, compound 2 exhibited weak cytotoxicity against SGC-7901 cells, and compound 4 significantly promoted the proliferation of LPS-induced IEC-6 cells.
Review
Plant Sciences
Xiangyu Li, Zhili Rao, Zhiqiang Xie, Hu Qi, Nan Zeng
Summary: This review summarizes the extraction and purification methods, structural characteristics, and pharmacological activities of polysaccharides from A. macrocephala, and explores their potential applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Congying Liu, Shengguang Wang, Zedong Xiang, Tong Xu, Mengyuan He, Qing Xue, Huaying Song, Peng Gao, Zhufeng Cong
Summary: This review summarizes the chemical compositions, biological activities, and applications of polysaccharides from Atractylodes macrocephala Koidz. Polysaccharides from Atractylodes macrocephala Koidz are important medicinal components with various activities such as immunomodulatory, antitumor, gastroprotective, hepatoprotective, and hypoglycemic effects. Its special structure and pharmacological activity also make it suitable for use as an immune adjuvant, natural plant supplement, and vaccine adjuvant.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Multidisciplinary
Zhenyang Li, Yingying Zhang, Pan Zhao, Huifen Li, Fang Fang, Wei Li, Jiangting Liu
Summary: Electrochemically deposited sensors and DNA biosensors are widely used in the food industry and various fields due to their high sensitivity, fast response, easy operation, no pollution, and low price. A study reported the use of a rare earth electrochemically deposited gadolinium ferricyanide thin film modified glassy carbon electrode, and investigated the electrocatalytic oxidation of guanine. Additionally, a rare earth terbium ferricyanide thin film modified glassy carbon electrode was also deposited and studied for its catalytic properties.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Xiangying Zhou, Nan Cao, Danning Xu, Yunbo Tian, Xu Shen, Danli Jiang, Yunmao Huang, Wanyan Li, Bingxin Li
Summary: This study aimed to explore the mechanism by which Atractylodes macrocephala Koidz (PAMK) alleviates cyclophosphamide (CTX)-induced ferroptosis in thymocytes. The results showed that PAMK had a significant alleviating effect on thymus damage and thymocyte ferroptosis in goslings. Therefore, PAMK can be used as a natural alternative to antibiotics as a feed additive for immunomodulatory effects on goslings.
Article
Biochemistry & Molecular Biology
Hai-Xin Zhang, Jin-Guang Si, Jing-Rong Li, Meng Yu, Chen-Xu Zhao, Tao Zhang, Zhong-Mei Zou
Summary: Fifteen undescribed eudesmane-type sesquiterpenes were isolated from the rhizomes of Atractylodes macrocephala, along with fourteen known analogues. The structures of the undescribed compounds were determined through spectroscopic analysis, Snatzke's rule, ECD calculations, and X-ray crystallographic analysis. Two of the undescribed isolates, atramacronoids D and E, represent novel eudesmanolactam-phenol and eudesmanolactam-ethyl hybrids obtained from plants, respectively. One of the isolates, atramacronoid D, showed weak cytotoxicity against SGC-7901 cells, while atramacronoid E significantly promoted the proliferation of LPS-induced IEC-6 cells.
Article
Chemistry, Medicinal
Cao Thanh Hai, Nguyen Thi Luyen, Do Hoang Giang, Bui Quang Minh, Nguyen Quang Trung, Pham The Chinh, Dang Viet Hau, Nguyen Tien Dat
Summary: Two new compounds (1 and 2) and three known sesquiterpene lactones (3, 4, and 5) were isolated from Atractylodes macrocephala. Compound 5 exhibited the most active anti-inflammatory activity with an IC50 value of 27.5 µM in inhibiting nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biotechnology & Applied Microbiology
Zhijuan Zheng, Junqing Wang
Summary: This study aimed to explore the effects of BMSCs combined with AMP on ulcerative colitis. The results showed that BMSCs treatment could alleviate tissue injury and regulate inflammatory cytokine production, while AMP enhanced the effects of BMSCs, promoting their homing to injured tissue and regulating cytokine levels.
Article
Biochemistry & Molecular Biology
Bo Dong, Liyun Wu, Qiaozhen Chen, Wenjie Xu, Dinggang Li, Dong Han, Xiaoming Zhu, Haokun Liu, Yunxia Yang, Shouqi Xie, Junyan Jin
Summary: Atractylodes macrocephala polysaccharide (AMP) can enhance antioxidant defense and anti-inflammation, and the safe tolerance margin of AMP supplement for largemouth bass was found to be between 400-4000 mg/kg.
Article
Biochemistry & Molecular Biology
Ling Li, Yihao He, Nan Wang, Yuting Li, Yaoyao Du, Ning He, Bing Wang, Tong Zhang
Summary: This study aimed to evaluate the therapeutic compounds in Atractylodes macrocephala rhizoma essential oil (AO) and investigate its mechanism in the treatment of ulcerative colitis (UC). Atractylone (ATR) was identified as the primary active compound in AO and was found to regulate multiple signaling pathways to alleviate UC symptoms. ATR also exhibited anti-inflammatory, antioxidative stress, and intestinal injury reduction effects.
Article
Chemistry, Applied
Rui Wang, Hailing Shan, Guanjun Zhang, Qiao Li, Jinpeng Wang, Qiuxin Yan, Erzhuo Li, Yan Diao, Lijun Wei
Summary: In this study, a neutral polysaccharide fragment named AMP1-1 was isolated and purified, which showed anti-weightlessness-induced bone loss (WIBL) activity. AMP1-1 promoted bone formation and inhibited bone resorption by remodeling bone homeostasis, as demonstrated through mechanical properties and enzyme activities. These findings suggest that AMP1-1 has potential applications in preventing WIBL.
CARBOHYDRATE POLYMERS
(2022)
