Article
Biochemistry & Molecular Biology
Teresa Ponce-Lopez, Jose Antonio Gonzalez Alvarez Tostado, Fernando Dias, Keren Happuck Montiel Maltez
Summary: N-nitrosodiethylamine (NDEA) is a potential carcinogen that causes liver tumors, chronic inflammation, diabetes, cognitive problems, and Alzheimer's disease-like symptoms in animals. Metformin may protect against memory issues and brain inflammation triggered by NDEA.
Article
Clinical Neurology
Giacomo Stroffolini, Giulia Guastamacchia, Sabrina Audagnotto, Cristiana Atzori, Mattia Trunfio, Marco Nigra, Alessandro Di Stefano, Giovanni Di Perri, Andrea Calcagno
Summary: Cerebrospinal fluid biomarkers in patients with Tuberculous meningitis (TBM) are indicative of inflammation, blood brain barrier damage, and impairment in amyloid-beta metabolism. A beta may serve as a prognostic marker in TBM, supporting the routine use of available neuromarkers. This study is the first to demonstrate such low levels of A beta 1-42 in TBM.
Article
Biochemistry & Molecular Biology
Alice Filippini, Valentina Salvi, Vincenzo Dattilo, Chiara Magri, Stefania Castrezzati, Robert Veerhuis, Daniela Bosisio, Massimo Gennarelli, Isabella Russo
Summary: The accumulation of amyloid-beta in Alzheimer's disease (AD) brains causes reactive astrogliosis and neuroinflammatory response. This study investigates the role of leucine-rich repeat kinase 2 (LRRK2) in regulating astrocytic activation in response to amyloid-beta(1-42) (A beta(1-42)). The results demonstrate that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of A beta(1-42) deposits, suggesting a potential contribution of PD-linked LRRK2 to AD-related neuroinflammation and pathogenesis.
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Clinical Neurology
Lei Liu, Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe, David A. Bennett, Celeste M. Karch, Tracy Young-Pearse, Dennis J. Selkoe
Summary: This study aims to identify biomarkers for Alzheimer's disease (AD) and finds that the A beta 37/42 ratio can be used to distinguish AD from normal aging. Experimental results show that this ratio outperforms the traditional ratio in differentiating physiological and pathological states in cell culture, brain tissue, and cerebrospinal fluid. The findings may provide a new indicator for early diagnosis of AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, Research & Experimental
Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, Yongtian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Kuettner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunovic, Leonie Mikolasch, Daiana N. Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J. Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J. Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike-Nora Voegtle, Joern Dengjel, Chris Meisinger, Adrian Keller, Stephan J. Sigrist, Tobias Eisenberg, Frank Madeo
Summary: In this study, the researchers used yeast and fruit fly models to investigate the role of HSP40 family member Ydj1 in Alzheimer's disease. They found that Ydj1 physically interacts with Abeta42, stabilizes Abeta42 oligomers, and facilitates their translocation to mitochondria, resulting in cell death and memory impairment.
EMBO MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bartlomiej Stanczykiewicz, Tomasz M. Goszczynski, Pawel Migdal, Marta Piksa, Krzysztof Pawlik, Jakub Gburek, Krzysztof Golab, Boguslawa Konopska, Agnieszka Zablocka
Summary: The research aims to determine the inhibitory activity of ovocystatin, a cysteine protease inhibitor isolated from egg white, on A beta 42 fibril formation in vitro. The results show that ovocystatin possesses A beta 42 anti-aggregation activity and inhibits A beta 42 oligomer toxicity in PC12 cells. This research may contribute to the development of potential substances to prevent or delay beta-amyloid aggregation, a major cause of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Review
Immunology
Zachary Valiukas, Ramya Ephraim, Kathy Tangalakis, Majid Davidson, Vasso Apostolopoulos, Jack Feehan
Summary: Alzheimer's disease is a chronic neurodegenerative disorder characterized by the presence of toxic substances in the brain. Traditional drug treatments have limitations, leading to the exploration of immunotherapies, which target the production and deposition of these substances.
Article
Geriatrics & Gerontology
Chih-Yuan Ko, Jian-Hua Xu, Yu-Wei Chang, Yangming Martin Lo, James Swi-Bea Wu, Wen-Chung Huang, Szu-Chuan Shen
Summary: This study demonstrated that ALA enhances the phagocytosis of oA beta(1-42) in BV-2 cells by upregulating the COX-2/15-deoxy-(& UDelta;12,14)-prostaglandin J2/PPAR-gamma/CD36 pathway. Future studies should validate these findings with in vivo studies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Bibiana C. Mota, Magdalena Sastre
Summary: PGC1 alpha plays a crucial role in neurodegenerative disorders, especially in Alzheimer's disease. Overexpression of PGC1 alpha can reduce A beta generation, potentially serving as a novel therapeutic avenue for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Ali Yildirim, Fatih Ozgen, Birsen Ucar, Ozkan Alatas, Neslihan Tekin, Zubeyir Kilic
FETAL AND PEDIATRIC PATHOLOGY
(2016)
Article
Dermatology
Hilal Kaya Erdogan, Isil Bulur, Evin Kocaturk, Bahadir Yildiz, Zeynep Nurhan Saracoglu, Ozkan Alatas
JOURNAL OF COSMETIC DERMATOLOGY
(2017)
Article
Allergy
Hilal Kaya Erdogan, Isil Bulur, Evin Kocaturk, Zeynep Nurhan Saracoglu, Ozkan Alatas, Muzaffer Bilgin
POSTEPY DERMATOLOGII I ALERGOLOGII
(2018)
Article
Dermatology
Ersoy Acer, Hilal Kaya Erdogan, Evin Kocaturk, Zeynep Nurhan Saracoglu, Ozkan Alatas, Muzaffer Bilgin
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Hematology
Evin Kocaturk, Zeynep Kusku Kiraz, Hava Uskudar Teke, Sukru Saygin Demir, Ibrahim Ozkan Alatas
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Article
Urology & Nephrology
Nadide Melike Sav, Pelin Kosger, Betul Can, Nuran Cetin, Birsen Ucar, Ozkan Alatas, Fahrettin Akyuz, Bilal Yildiz
Summary: This study found that patients with a solitary kidney are at a higher risk of developing cardiovascular disease, as their kidney function and blood pressure are abnormal. Therefore, close monitoring of these patients should be conducted to prevent severe kidney impairment.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Oncology
Gozde Nur Yurttas, Zeynep Canan Ozdemir, Cihan Tanrikut, Ezgi Kar, Zeynep Kusku Kiraz, Ozkan Alatas, Dilek Burukoglu Donmez, Ozcan Bor
Summary: This study investigates the effects of N-acetylcysteine (NAC) on liver and pancreatic damage induced by L-asparaginase (L-ASP) in rats. The results indicate that NAC can reduce the damage caused by L-ASP.
LEUKEMIA & LYMPHOMA
(2022)
Article
Chemistry, Medicinal
Mehlika D. Altintop, Belgin Sever, Gulsen Akalin Ciftci, Ipek Ertorun, Ozkan Alastas, Ahmet Ozdemir
Summary: New thiosemicarbazones were synthesized and tested as potential anti-inflammatory agents. Compound 4-[4-(piperidin-1-ylsulfonyl)phenyl]-1-[4-(4-cyanophenoxy)benzylidene]thiosemicarbazide showed the highest potency as a selective COX-1 inhibitor. These compounds exhibited low cytotoxic activity and favorable pharmacokinetic properties, suggesting they could serve as oral anti-inflammatory and antioxidant agents.
ARCHIV DER PHARMAZIE
(2022)
Article
Surgery
Zeynep Kusku Kiraz, Ezgi Kar, Fatih Kar, Evin Kocaturk, Medine Nur Kebapci, I. Ozkan Alatas, Sema Uslu
Summary: Oral glucose loading during OGTT may affect oxidative status, leading to decreased TAS and increased TOS levels with increasing glucose and insulin levels. Within five hours of OGTT, oxidative stress parameters and thiol/disulfide balance were found to deteriorate in all groups.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Pediatrics
Nuran Cetin, Evin Kocaturk, Asli Kavaz Tufan, Zeynep Kusku Kiraz, Ozkan Alatas
Summary: Immature granulocytes may serve as a biomarker for inflammation in children with predialysis CKD.
PEDIATRIC NEPHROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nevin Aydin, Pinar Yildiz, Dondu Uskudar Cansu, Elif Gundogdu, Ruya Mutluay, Goknur Yorulmaz, Melisa Sahin Tekin, Evin Kocaturk, I. Ozkan Alatas, Elif Doyuk Kartal, Nurettin Erben, Gul Durmaz, Nilgun Kasifoglu, Tercan Us, Garip Sahin, Cengiz Bal, Senay Yilmaz, Cengiz Korkmaz
Summary: This study investigated the correlation between CO-RADS classification, CT patterns of the lung, and laboratory data in patients with a positive RT-PCR test. The results showed that creatinine can be considered an important marker for lung involvement, while LDH can be considered an important marker for parenchymal involvement. The structured total CT scoring system was proposed as an alternative method for evaluation.
BMC MEDICAL IMAGING
(2022)
Article
Ophthalmology
Omer Sozer, Onur Ozalp, Eray Atalay, Sukru Saygin Demir, Ibrahim Ozkan Alatas, Nilgun Yildirim
Summary: This study evaluated the blood levels of vitamin B12, folic acid, riboflavin, and homocysteine in KC patients and healthy subjects. The results showed no differences in homocysteine, vitamin B12, and folic acid levels between the KC group and control group. However, the riboflavin levels were significantly lower in the KC group, suggesting a possible risk factor in the pathogenesis of KC.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Onur Ozalp, Eray Atalay, Ibrahim Ozkan Alata, Zeynep Kusku Kiraz, Nilgun Yildirim
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ferzane Mercan, Muhittin A. Serdar, Mehmet Senes, Dildar Konukoglu, Tamer Cevat Inal, Ozkan Alatas, Asli Pinar, Ozlem Savci, Muhammet Guven, Mehmet Gunduz, Ertugrul Egin, Yasal Onder Tipioglu, Ahmet Tekin, Dogan Yucel
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2019)
Article
Dermatology
Isil Bulur, Hilal K. Erdogan, Evin Kocaturk, Zeynep N. Saracoglu, Ozkan Alatas, Pinar Yildiz, Muzaffer Bilgin
GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
(2018)