Article
Biochemistry & Molecular Biology
Mingxin Ye, Hui Li, Hongjun Luo, Yongyin Zhou, Wenhong Luo, Zhexuan Lin
Summary: This study found that erythrocytes metabolize methionine to homocysteine, which enhances the antioxidative capability of erythrocytes and protects them against damage from reactive oxygen species.
Article
Medicine, General & Internal
Aleksander Nobis, Daniel Zalewski, Eliza Samaryn, Mateusz Maciejczyk, Anna Zalewska, Napoleon Waszkiewicz
Summary: Depression is a prevalent psychiatric disorder that significantly impacts individuals and public health worldwide. Recent research has focused on identifying biological markers to better understand the underlying mechanisms of depression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Phillip Zhu, Kyle T. Nguyen, Aidan B. Estelle, Nikolai N. Sluchanko, Ryan A. Mehl, Richard B. Cooley
Summary: 14-3-3 proteins are key regulators of phosphorylated client proteins. Nitration of tyrosine residues in 14-3-3 alters its structure and function, affecting downstream signaling pathways.
Review
Biochemistry & Molecular Biology
Rita Moretti, Mauro Giuffre, Paola Caruso, Silvia Gazzin, Claudio Tiribelli
Summary: Homocysteine plays a crucial role in various diseases, particularly in cardiovascular diseases. However, there is limited research on its association with small vessel disease, despite evidence suggesting its potential key role in pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Anna Maria Czarnecka, Marta Obara-Michlewska, Dorota Wesol-Kucharska, Milena Greczan, Magdalena Kaczor, Janusz Ksiazyk, Dariusz Rokicki, Magdalena Zielinska
Summary: From the results, we found that the plasma level of S100B is positively correlated with ammonia level, while the plasma level of 3-NT does not correlate with ammonia concentration. This offers a unique perspective for future identification and monitoring of neurological deficits risk-linked with hyperammonemia episodes in patients with inherited hyperammonemias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cornelia G. Bala, Adriana Rusu, Dana Ciobanu, Camelia Bucsa, Gabriela Roman
Summary: The study aims to identify distinct metabolic changes associated with increased oxidative stress in patients with type 2 diabetes. It found that certain amino acids showed significantly different levels between patients with high oxidative stress and those with lower levels. The disrupted metabolic pathways in patients with high oxidative stress include phenylalanine, tyrosine and tryptophan biosynthesis, among others.
Article
Chemistry, Multidisciplinary
Kun Wang, Jinjin Li, Yan Yi, Bin Lv, Yelin Wu, Chaochao Wang, Huiyan Li, Yanli Li, Yang Liu, Xuechao Cai, Xianfu Meng, Xingwu Jiang, Xiangpeng Zheng, Zhaocai Zhou, Wenbo Bu
Summary: The innovative polyamine-activated carbonyl stress strategy based on the MPP nanoplatform successfully overcomes the drawbacks of oxidative damage therapy and achieves excellent chemodynamic therapy-induced oxidative damage efficacy. It depletes polyamines in tumor cells to produce toxic byproducts, enhancing the efficiency of oxidative damage therapy.
Article
Chemistry, Multidisciplinary
Debraj Ghorai, Kanak Kanti Das, Santanu Panda
Summary: In this study, a transition metal-free carbonyl-directed boron-Wittig reaction method was used to synthesize alkenyl oxindoles using alpha-bis(boryl)carbanions as substrates. The reaction showed high selectivity and allowed for specific substitution patterns. This method has significant research and application value.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Milosz Nesterowicz, Malgorzata Zendzian-Piotrowska, Jerzy Robert Ladny, Anna Zalewska, Mateusz Maciejczyk
Summary: Amantadine does not significantly affect protein glycoxidation, lacks antioxidant and antiglycation effects, and may even have some glycoxidant, proglycation, and prooxidant properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Kamil Karolczak, Cezary Watala
Summary: The antioxidant properties of melatonin can effectively reduce oxidative stress induced by homocysteine, potentially providing clinical benefits in patients with high homocysteine levels. However, current research findings mainly come from in vitro models, and there is still a significant lack of clinical evidence supporting the use of melatonin as an attenuator of homocysteine-induced oxidative stress.
Article
Chemistry, Inorganic & Nuclear
Balasubramanian Sriram, Jeena N. Baby, Mary George, Yung-Fu Hsu, Sea-Fue Wang
Summary: This study develops a highly sensitive electrode material for the detection of NO2-Tyr by integrating the unique features of BiVO4 and MoS2. The MoS2@BiVO4 heterojunction exhibits excellent electrochemical behavior, allowing for the measurement of NO2-Tyr in biological media without time-consuming pretreatments. The synergistic interactions between BiVO4 and MoS2 contribute to low resistance charge transfer, a good response range, and a lower limit of detection for NO2-Tyr.
INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Jan Spaas, Lieve van Veggel, Melissa Schepers, Assia Tiane, Jack van Horssen, David M. Wilson, Pablo R. Moya, Elisabeth Piccart, Niels Hellings, Bert O. Eijnde, Wim Derave, Rudy Schreiber, Tim Vanmierlo
Summary: Oligodendrocyte precursor cells (OPCs) play a crucial role in various neurodegenerative disorders, with oxidative/carbonyl stress potentially impacting their differentiation and function, contributing to disease progression. Investigating how oxidative/carbonyl stress disrupts OPC differentiation may offer new directions for therapeutic strategies in neurodegenerative disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Nutrition & Dietetics
Karolina Rak, Karolina Lozna, Marzena Styczynska, Lukasz Bobak, Monika Bronkowska
Summary: The study revealed a positive correlation between maternal serum Fe concentration and UCS 3 ' NT in male newborns, as well as a negative correlation between maternal serum Cu concentration and UCS 3 ' NT in male newborns. Strategies to optimize the nutritional status of pregnant women are needed to reduce the risk of oxidative stress during pregnancy and in newborns, and its adverse effects on offspring's health.
Review
Medicine, General & Internal
Panagiotis Charalampidis, Eleftherios Teperikidis, Aristi Boulmpou, Christodoulos E. Papadopoulos, Victoria Potoupni, Konstantina Tsioni, Pantelitsa Rakitzi, Theodoros Karamitsos, Vassilios Vassilikos
Summary: Research on the potential value of homocysteine (Hcy) levels in predicting atrial fibrillation (AF) revealed that Hcy levels seem to hold predictive value in paroxysmal atrial fibrillation (PAF), along with potential mechanisms of action and special considerations for clinically relevant diagnostic procedures. Gaps of evidence were identified and considerations for future clinical trial design were presented.
Article
Cell Biology
Dusan Todorovic, Marija Stojanovic, Kristina Gopcevic, Ana Medic, Sanja Stankovic, Boba Kotlica, Milica Labudovic Borovic, Dragan Djuric
Summary: This study aimed to investigate the effects of hyperhomocysteinemia and aerobic physical activity on cardiovascular biomarkers, oxidative stress, and histomorphometric parameters in the heart and aorta of rats. The results showed that aerobic physical activity in hyperhomocysteinemic rats led to increased oxidative stress in cardiac tissue, changes in histomorphometric parameters, and elevated lipid parameters and cardiac damage biomarkers in sera.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Microbiology
Magdalena Ulanowska, Beata Olas
Summary: COVID-19, caused by SARS-CoV-2 virus, affects respiratory function and disrupts the coagulation system, leading to clotting and thrombotic events. Inflammation and cytokine storms are major causes of hemostasis disorders, with the use of anticoagulants such as heparin recommended to prevent and treat thrombosis. The relationship between blood platelets and COVID-19, as well as the potential use of antiplatelet drugs in COVID-19 cases, are also areas of focus in research.
Article
Medicine, Research & Experimental
Bartosz Skalski, Sylwia Pawelec, Dariusz Jedrejek, Agata Rolnik, Rostyslav Pietukhov, Renata Piwowarczyk, Anna Stochmal, Beata Olas
Summary: The phenylpropanoid glycosides in European broomrapes have antioxidant and anticoagulant properties, indicating potential for treating cardiovascular diseases. The structure of the compounds, particularly the presence of acyl and catechol moieties, is closely related to their bioactivity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Mariusz Kowalczyk, Agata Rolnik, Weronika Adach, Magdalena Kluska, Michal Juszczak, Lukasz Grabarczyk, Katarzyna Wozniak, Beata Olas, Anna Stochmal
Summary: The study investigated the phytochemical profile of field bean extract and its potential to prevent oxidative damage. The extract showed protective effects on plasma lipids and proteins, as well as DNA, but had differing effects on coagulation and MAO activity. More research is needed to fully understand the biological properties of the extract.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Justyna Piechocka, Natalia Litwicka, Rafal Glowacki
Summary: This study provides evidence for the formation of the adduct 1,3-thiazinane-4-carboxylic acid (TCA) in humans through the reaction of homocysteine/thiolactone (Hcy/HTL) and formaldehyde (FA). A GC-MS method has been developed and successfully applied for the quantification of TCA in human urine samples. This method may serve as a new analytical tool for the investigation of TCA's role in living systems in routine clinical analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Beata Olas
Summary: Apitherapy, a form of alternative therapy that uses bee products, shows potential in preventing and treating cardiovascular diseases. Bee pollen, royal jelly, bee venom, propolis, and bee bread have been found to possess new bioactivities, making them interesting natural products for the prevention and treatment of common cardiovascular diseases.
Review
Nutrition & Dietetics
Beata Olas
Summary: Cardiovascular diseases (CVDs) are a leading cause of death, and traditional treatments often have side effects. The European Society of Cardiology recommends a preventative strategy based on a varied diet. Dandelion, a medicinal plant rich in secondary metabolites, has multidirectional health-promoting effects and potential to protect the heart. This review summarizes the effects of dandelion on the cardiovascular system and CVDs and highlights its cardioprotective potential.
Article
Nutrition & Dietetics
Beata Olas
Summary: Patients with COVID-19 often experience various hemostasis dysfunctions, including coagulation dysfunction and changes in blood platelet function, which are a major cause of death. Recent research suggests that dietary phenolic compounds may play an important role in the treatment of COVID-19, but recommendations regarding their use to prevent or reduce the risk of cardiovascular diseases during COVID-19 infection remain uncertain.
Article
Nutrition & Dietetics
Beata Olas, Bartosz Skalski
Summary: Sea buckthorn is a plant rich in vitamins, phenolic compounds, amino acids, fatty acids, and micro- and macro-elements. Numerous studies have found that preparations from various organs of sea buckthorn have anti-cancer, anti-ulcer, and hepatoprotective properties, as well as antibacterial and antiviral activities. This paper reviews the positive role of sea buckthorn preparations in the treatment and prevention of cardiovascular diseases, focusing on their effect on hemostasis.
Article
Biochemistry & Molecular Biology
Dominika Szczerbiec, Justyna Piechocka, Rafal Glowacki, Agnieszka Torzewska
Summary: This study investigates the antibacterial effect of organic acids secreted by Lactobacillus strains on urinary tract infections caused by P. mirabilis. The results show that these acids have a high inhibitory effect on the growth and biofilm formation of P. mirabilis and could be used as novel agents for the treatment of urinary tract infections.
Review
Nutrition & Dietetics
Beata Olas
Summary: The caper, derived from the Latin word capra meaning goat, refers to the salt-fermented floral buds of the perennial shrubs from the Capparis genus. C. spinosa is one of the most popular species, and its aromatic floral buds are collected before blooming, dried, and pickled. Capers are commonly marinated and enjoyed in vinegar, brine, or oil. They have potential as dietary supplements due to their low calorie content and abundance of bioactive phytochemicals. Research has shown that C. spinosa possesses various nutritional and biological properties, including antioxidant activity from its phenolic compounds. This paper reviews the biological properties, including toxicity, of the fruits, buds, seeds, roots, and leaves of C. spinosa.
Article
Nutrition & Dietetics
Natalia Slawinska, Jerzy Zuchowski, Anna Stochmal, Beata Olas
Summary: Sea buckthorn, a small tree, has been valued for its medicinal properties. Its berries and leaves are known to contain phytochemicals and have been used in folk medicine for the treatment of various conditions. This study examined the phytochemical content and biological activity of sea buckthorn seeds. The results showed that sea buckthorn seeds contain various flavonoids and have antioxidant and anticoagulant potential. However, further research is needed to identify the specific compounds responsible for these effects, especially in vivo models.
Review
Nutrition & Dietetics
Natalia Slawinska, Beata Olas
Summary: Seeds contain various phytochemicals with diverse biological activities. This review summarizes the chemical content and biological activity of seeds from eight plant species. Studies have shown that these seeds have health-promoting effects and could be used in drug development and functional food preparation. However, further animal studies and clinical trials are needed to determine their potential application in disease prevention and treatment.
Review
Nutrition & Dietetics
Beata Olas
Summary: Schisandra chinensis berries are valuable agents in modern phototherapy with anti-cancer, hepatoprotective, anti-inflammatory, and antioxidant properties. The unique chemical composition of these berries, particularly their lignan content, contributes to their therapeutic potential. The selected lignans, including schisandrin, schisandrin B, schisantherin A, schisantherin B, schisanhenol, deoxyschisandrin, and gomisin A, possess cardioprotective properties.
Review
Biochemistry & Molecular Biology
Magdalena Brys, Karina Urbanska, Beata Olas
Summary: Genipin, an important compound isolated from Gardenia jasminoides and Genipa americana fruits, has various potential therapeutic properties and industrial applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Anna Dietrich-Muszalska, Joanna Kolodziejczyk-Czepas, Pawel Nowak
Summary: The study shows that patients with schizophrenia have higher levels of oxidative stress compared to healthy subjects, but a 4-week treatment with atypical antipsychotics can reduce lipid peroxidation and increase total plasma antioxidant activity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)