Article
Biochemistry & Molecular Biology
Lei Zhang, Zhuo Wang, Xueling Yuan, Rubo Sui, Mojtaba Falahati
Summary: Heptelidic acid inhibits tau fibrillization in a concentration-dependent manner and reduces neurotoxicity associated with tau amyloid, making it a potential candidate for preventive care studies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Physiology
Haomiao Yu, Yili Chen, Huimin Ma, Zihan Wang, Rui Zhang, Jundong Jiao
Summary: This study revealed the important role of TRPC6 in regulating high glucose-induced mitochondrial fragmentation and apoptosis in human podocytes through the calpain-1/CDK5 pathway.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xueling Yuan, Zhuo Wang, Lei Zhang, Rubo Sui, Suliman Khan
Summary: Liquiritigenin was found to be an efficient inhibitor of tau amyloid fibril formation, reducing ROS and caspase-3 activity, and increasing CAT activity to alleviate neurotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jie Ai, Hongyan Wang, Peng Chu, Abdullah Shopit, Mengyue Niu, Nisar Ahmad, Tsehaye Tesfaldet, Fu Han Wang, Jia Ni Fang, Xiaodong Li, Shi Jie Tang, Qing Ju Han, Guozhu Han, Jinyong Peng, Zeyao Tang
Summary: The study demonstrates that phosphocreatine (PCr) can protect neuronal cells from A beta protein-induced injury through various pathways, such as reducing oxidative stress and apoptotic pathway activities, as well as modulating Tau protein phosphorylation and other key signaling pathways.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Margarita O. Shedenkova, Elena Stelmashook, Sergey A. Golyshev, Elizaveta E. Genrikhs, Nickolay K. Isaev
Summary: This study investigates the effect of extracellular alkalosis on the neurotoxicity of zinc ions in rat cerebellar granule neurons. The results suggest that zinc ions can cause neuronal death, while extracellular alkalosis can reduce the toxic effect of zinc ions and promote neuronal survival.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Anuradha Urati, Mangaldeep Dey, Avtar Singh Gautam, Rakesh Kumar Singh
Summary: Iron is a necessary metal for normal brain function and is involved in many vital pathways. However, excessive accumulation of iron in the brain can lead to neurodegenerative and neurotoxic effects. This study found that exposure to ferrous sulphate may induce neuronal inflammation, apoptotic cell death, and elevated levels of amyloid-beta and hyperphosphorylated tau. These findings provide insights into the mechanism of iron-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Neurosciences
Nazhakaiti Palihati, Yuanhong Tang, Yajuan Yin, Ding Yu, Gang Liu, Zhenzhen Quan, Junjun Ni, Yan Yan, Hong Qing
Summary: In recent years, the glycosylated protein Clusterin has attracted extensive research attention, especially in Alzheimer's disease. It is closely associated with the occurrence and progression of AD and may affect the pathogenesis through mechanisms such as regulating inflammation, controlling cell apoptosis, and clearing pathological proteins. Further research on the relationship between Clusterin and AD is essential for a deeper understanding of the etiology and developing early diagnostic and therapeutic strategies.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Mengru Zhang, Cheng Chen, Qingyan Peng, Xiaocong Wu, Ruiyi Zhou, Yuru Ma, Zhurong Zou
Summary: The stability-enhanced DnaJB1-tua2 can prevent the aggregation of Tau protein and maintain redox balance and protein homeostasis. In a MA-induced cognitive disorder mouse model, the expression of DnaJB1-tua2 in the hippocampus rescued the cognitive disorder and relieved the overactivated inflammatory response. Additionally, the escorting of DnaJB1-tua2 also reduced Tau neurofibrillary tangles and apoptotic neurons.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Neurosciences
Heng Zhang, Ling Zhang, Dongming Zhou, Hongfei Li, Yang Xu
Summary: The specific deletion of ErbB4 in parvalbumin neurons attenuated A beta-induced neuronal toxicity, decreased synaptic proteins levels and altered activity-related proteins. JNK pathway may mediate A beta-induced neuropathology through ErbB4, providing a potential therapeutic target in Alzheimer's disease.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
