期刊
NEUROCHEMICAL RESEARCH
卷 36, 期 7, 页码 1253-1260出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-010-0341-x
关键词
Caspase; Neural development; Apoptosis; Cell death
资金
- Japanese Ministry of Education, Science, Sports, Culture and Technology
- RIKEN Bioarchitect Research Grant
- Grants-in-Aid for Scientific Research [19109003] Funding Source: KAKEN
During neural development, massive cell death occurs in both vertebrates and invertebrates. Caspase is a central player in apoptosis that is evolutionally conserved. Genetic manipulation of the caspase activity in Drosophila and mice has revealed that caspases control cell fate through apoptotic and non-apoptotic mechanisms, to ensure appropriate cell differentiation and maturation in the developing nervous system.
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