Article
Biochemistry & Molecular Biology
Raibel Suarez, Carolina Villarreal, Yessica Nahuelpan, Claudia Jara, Carlos Oyarzun, Sebastian Alarcon, Montserrat M. Diaz-Encarnacion, Elena Guillen-Gomez, Claudia Quezada, Rody San Martin
Summary: This study highlights the importance of insulin regulation in maintaining normal adenosine levels and kidney function through controlling the activity of equilibrative nucleoside transporter-2 (ENT2). However, in diabetic patients, impaired insulin regulation of ENT2 activity leads to chronically high levels of adenosine, which further contributes to the progression of diabetic kidney disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Pharmacology & Pharmacy
Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi
Summary: Adenosine plays a complex role in various physiological and pathophysiological processes, tightly regulated in the brain, and is associated with conditions such as stroke, epilepsy, and neurodegenerative diseases. The generation and inactivation of adenosine are crucial for the development of central nervous system disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Bradley M. Roberts, Elizabeth Lambert, Jessica A. Livesey, Zhaofa Wu, Yulong Li, Stephanie J. Cragg
Summary: Activation of Y striatal adenosine A1 receptors can inhibit dopamine release, with this inhibition modulated by astrocytic ENT1 and ethanol. The release of dopamine in the nucleus accumbens core is under tonic inhibition by A1Rs and this process is regulated by adenosine tone in the striatum, suggesting a complex interplay between neurotransmitters and astrocytic transporters in the regulation of dopamine dynamics.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Lukas Cerveny, Sara Karbanova, Rona Karahoda, Hana Horackova, Lucie Jiraskova, Mohammed Naji Husaen Ali, Frantisek Staud
Summary: The nucleoside analog entecavir (ETV) is a first-line pharmacotherapy for chronic hepatitis B in adult and pediatric patients. However, insufficient data on placental transfer and pregnancy effects limit its recommended use in women after conception. This study investigated the contribution of various transporters to the placental kinetics of ETV and found that ENTs, but not CNTs, ABCB1, ABCG2, and ABCC2, significantly affect ETV transport across the placenta.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Volonte, Francesca Alberti, Giuseppe Vitale, Francesco Liguori
Summary: Fruit flies are still widely used in scientific research as a genetic model due to their simplicity, low cost, and similarity to human genes. The study aims to provide a comprehensive understanding of purinergic events in fruit flies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hui-Ling Chiang, Kuo-Chen Wu, You-Yin Chen, Chin-Jui Ho, Han-Lin Wang, Yu-Hua Fu, Wen-Yu Chen, Chun-Jung Lin
Summary: Ent2 plays a critical role in modulating cerebral collateral circulation and ameliorating pathological events of brain ischemia and reperfusion injury. Ent2 deletion reduces infarct volume, brain edema, and neuroinflammation. It also improves microvascular structure, regional cerebral blood flow, cerebral metabolic rate of oxygen, and reduces reactive oxygen species production. Furthermore, the protective effects of Ent2 deletion involve adenosine receptor A(2A)R.
PHARMACEUTICAL RESEARCH
(2023)
Article
Biology
Sunny Sharma, Jun Yang, John Favate, Premal Shah, Megerditch Kiledjian
Summary: Two methods, NADcapPro and circNC, are introduced to precisely identify NAD-capped RNAs and non-canonical caps in eukaryotes. These methods overcome the limitations of previous techniques and reveal unexpected features of NAD-capped RNAs in budding yeast. The study shows that NAD-RNAs can be full-length, polyadenylated transcripts, and that their transcription start sites can be different from canonical m(7)G-capped RNAs. Additionally, NAD caps can be added after transcription initiation, and NAD-RNAs exhibit a preference for translation in mitochondria.
COMMUNICATIONS BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Carly Jade Carter, Ahmed H. Mekkawy, David L. Morris
Summary: The prognosis of pancreatic cancer is poor with a very low 5-year survival rate, and research has shown that human nucleoside transporters play a crucial role in its development and chemoresistance mechanisms. This review summarizes the abnormal expression and function of these transporters in pancreatic cancer, as well as the importance of mucins associated with nucleoside transporters, current diagnostic techniques, and therapeutic treatments for pancreatic cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Neurosciences
Michelle Corkrum, Alfonso Araque
Summary: Astrocytes respond to dopamine signaling and modulate information processing in key brain regions. They exhibit circuit-specific modulation of neuronal networks, potentially serving as a therapeutic target for dopamine pathologies.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena V. V. Mitroshina, Mikhail I. I. Krivonosov, Alexander M. M. Pakhomov, Laysan E. E. Yarullina, Maria S. S. Gavrish, Tatiana A. A. Mishchenko, Roman S. S. Yarkov, Maria V. V. Vedunova
Summary: This study investigated the characteristics of calcium dynamics in astrocytes in physiological aging and hypoxia modeling. It was found that the number of active cells and frequency of calcium events decreased in old astrocytes. Additionally, the correlation in calcium dynamics between neighboring cells and the number of functionally connected cells decreased. However, the mRNA expression of anti-apoptotic factor Bcl-2 and connexin 43 increased in old astrocytes, indicating a compensatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrey Kropotov, Veronika Kulikova, Kirill Nerinovski, Alexander Yakimov, Maria Svetlova, Ljudmila Solovjeva, Julia Sudnitsyna, Marie E. Migaud, Mikhail Khodorkovskiy, Mathias Ziegler, Andrey Nikiforov
Summary: Nicotinamide riboside can be imported into cells by equilibrative nucleoside transporters, while nicotinic acid riboside requires active utilization in the cytosol before being taken up by HEK293 cells. Concentrative nucleoside transporters do not mediate the uptake of nicotinamide riboside.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Masayoshi Tanaka, Eiji Shigetomi, Bijay Parajuli, Hiroaki Nagatomo, Youichi Shinozaki, Yuri Hirayama, Kozo Saito, Yuto Kubota, Yosuke Danjo, Ji Hwan Lee, Sun Kwang Kim, Junichi Nabekura, Schuichi Koizumi
Summary: mGluR5 in astrocytes is regulated by ATP/adenosine signals, which helps control synapse remodeling and potentially contributes to disease pathogenesis.
Article
Neurosciences
Benton S. Purnell, Mariana Alves, Detlev Boison
Summary: The epilepsies are a group of diseases characterized by spontaneous seizures and associated comorbidities, but current understanding of the underlying mechanisms is limited. Focusing on neurons has led to the development of anti-seizure medications, but not all aspects of seizure activity can be explained. The role of astrocytes, another type of brain cell, and their implications in epilepsy are explored in this review.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Virology
Henrik Berg Rasmussen, Gesche Jurgens, Ragnar Thomsen, Olivier Taboureau, Kornelius Zeth, Poul Erik Hansen, Peter Riis Hansen
Summary: GS-441524 is a potential treatment for COVID-19 and its efficacy relies on cellular uptake and conversion processes, which may be impacted by tissue hypoxia and inflammation. This could lead to reduced therapeutic effectiveness of GS-441524 in treating COVID-19.
Review
Pharmacology & Pharmacy
Tejinder Kaur, Brenna Weadick, Thomas A. Mace, Kajal Desai, Hannah Odom, Rajgopal Govindarajan
Summary: Adenosine compartmentalization plays a significant role in suppressing immune cell function in the tumor microenvironment. Nucleoside transporters, responsible for the localization and translocation of adenosine, are crucial for adenosine disposition. Targeting nucleoside transporters could potentially attenuate the accumulation of immunosuppressive adenosine in solid tumors.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, General & Internal
Rawan Barakat, Zoran Redzic
MEDICAL PRINCIPLES AND PRACTICE
(2016)
Article
Pharmacology & Pharmacy
Maie D. Al-Bader, Sara A. Jasem, Narayana Kilarkaje
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Obstetrics & Gynecology
Mariam Alqaryyan, Narayana Kilarkaje, Abdeslam Mouihate, Maie D. Al-Bader
REPRODUCTIVE SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Ala Abdelali, Maie Al-Bader, Narayana Kilarkaje
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Endocrinology & Metabolism
Elham Ghadhanfar, Aseel Alsalem, Shaimaa Al-Kandari, Jumana Naser, Fawzi Babiker, Maie Al-Bader
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Hameed Al-Sarraf, Slava Malatiali, Mariam Al-Awadi, Zoran Redzic
NEUROCHEMISTRY INTERNATIONAL
(2018)
Article
Behavioral Sciences
Zeinab Adel Samy, Lulwa Al-Abdullah, Marian Turcani, James Craik, Zoran Redzic
BRAIN AND BEHAVIOR
(2018)
Article
Clinical Neurology
Zoran B. Redzic, Tamer Rabie, Brad A. Sutherland, Alastair M. Buchan
INTERNATIONAL JOURNAL OF STROKE
(2015)
Article
Obstetrics & Gynecology
Maie Dawoud Al-Bader, Narayana Kilarkaje, Aseel El-Farra, Abeer Adnan Al-Abdallah
REPRODUCTIVE SCIENCES
(2015)
Article
Public, Environmental & Occupational Health
Narayana Kilarkaje, Maie Al-Bader
TOXICOLOGY AND INDUSTRIAL HEALTH
(2016)
Article
Mathematical & Computational Biology
Andreas W. Henkel, Lulwa A. A. D. Al-Abdullah, Mohammed S. Al-Qallaf, Zoran B. Redzic
FRONTIERS IN NEUROINFORMATICS
(2019)
Article
Biochemistry & Molecular Biology
M. M. Alawadhi, F. Al Shammari, F. Mulla Ali, R. Almatar, A. Al-Duwaikhi, M. D. Al-Bader
Summary: Dexamethasone (DEX) induces intrauterine growth restriction (IUGR) by altering the expression of placental MTA1 and MTA3 antigens, while progesterone (P4) improves pregnancy outcome by preventing these changes in MTA expression.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Obstetrics & Gynecology
Mariam Alawadhi, Abdeslam Mouihate, Narayana Kilarkaje, Maie Al-Bader
Summary: This study aims to investigate how progesterone improves fetal outcome and changes the expression of placental glucose transporters in dexamethasone-induced intrauterine growth restriction. The results show that dexamethasone reduces maternal serum progesterone concentrations and placental and fetal weights, as well as the expression of GLUT1 and GLUT3. However, coadministration of dexamethasone and progesterone can prevent these adverse effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Multidisciplinary Sciences
Ala' Abdelali, Maie Al-Bader, Narayana Kilarkaje
Article
Neurosciences
Rawan Barakat, Zoran Redzic
FLUIDS AND BARRIERS OF THE CNS
(2015)