Article
Medicine, General & Internal
Yuexia Ding, Wei Zhu, Wei Kong, Tuo Li, Peng Zou, Hongguang Chen
Summary: Treatment with edaravone significantly alleviated neurological impairment induced by TBI and improved cognitive function outcomes. The neuroprotective effects of edaravone may be attributed to modulation of the BDNF/TrkB signaling pathway, leading to reduced apoptosis in hippocampal neurons.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Changxiang Li, Conglu Sui, Wei Wang, Juntang Yan, Nan Deng, Xin Du, Fafeng Cheng, Xiaona Ma, Xueqian Wang, Qingguo Wang
Summary: This study showed that baicalin protects neurons from oxidative stress, inflammation, and apoptosis by promoting astrocytes to release more BDNF. The neuroprotective effect is mainly mediated through the BDNF-TrkB pathway and downstream signaling regulators PI3K/Akt and MAPK/ERK1/2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Rui Han, Zhi-Qing Li, Jun-Ren Yang, Xia Yin, Yu-Qi Gao, Jin-Ming Gao
Summary: This study identified 10 secondary metabolites, including a new lanostane triterpenoid named 2 alpha-hydroxy-inotodiol (2 alpha-HI), from the edible mushroom I. obliquus. The results showed that 2 alpha-HI exhibited remarkable neuroprotective activity against oxidative stress and apoptosis induced by H2O2 in SH-SY5Y cells, mediated by the Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway. Additionally, the neuroprotective effects of 2 alpha-HI were preliminarily verified in zebrafish.
Article
Pharmacology & Pharmacy
Gulay Hacioglu, Selma Cirrik, Berna Tezcan Yavuz, Canberk Tomruk, Arif Keskin, Emel Uzunoglu, Selcuk Takir
Summary: Recent studies have shown that hydrogen sulfide (H2S) has a neuroprotective effect in neurodegenerative diseases, possibly mediated by brain-derived neurotrophic factor (BDNF). This study aimed to investigate the effects of H2S on neural damage in Parkinson's disease (PD) and the role of the BDNF-TrkB pathway. A PD model was created using 1-methyl-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It was found that H2S treatment reduced motor deficits in the PD model and the BDNF-TrkB pathway played a role in this protective effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhijian Jin, Yifan Lu, Xiongyan Wu, Tao Pan, Zhenjia Yu, Junyi Hou, Airong Wu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Chao Yan, Zhenggang Zhu, Bingya Liu, Weihua Qiu, Liping Su
Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.
Article
Neurosciences
Jongryul Hong, Yeonji Jeong, Won Do Heo
Summary: In this study, researchers found that deletion of TrkB in neurons projecting from the medial entorhinal cortex to the mPFC led to reduced remote memory recall in male mice. The deletion of TrkB also attenuated the participation of mPFC cells in the recall of remote fear memory and was associated with reduced reactivation of cells in the mPFC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Dominik Fiedler, Manju Sasi, Robert Blum, Christopher M. Klinke, Marta Andreatta, Hans-Christian Pape, Maren D. Lange
Summary: Researchers have identified that the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) is rich in brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) receptor, which interact to reduce neuronal excitability and mediate long-term depression (LTD) in ovBNST neurons. This suggests that BDNF/TrkB signaling is a critical regulator of synaptic activity in ovBNST, dampening excitability at short and long time scales, and providing a potential entry point for adaptation to stressful environmental encounters, particularly in mediating maladaptive behaviors associated with stress exposure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ji-Hyun Kim, Muhammad Irfan, Md Akil Hossain, Anne George, Seung Chung
Summary: The odontoblastic differentiation of dental pulp stem cells is affected by inflammation and can be enhanced through the activation of BDNF and TrkB receptors. This finding provides a novel therapeutic approach in dentin tissue engineering using dental pulp stem cells.
Article
Endocrinology & Metabolism
Melissa J. Marchese, Shuman Li, Bin Liu, Jun J. Zhang, Liping Feng
Summary: The study found that BDNF receptors are present in different regions of human placental villi, indicating diverse functions of BDNF signaling in placental development. While exposure to PFOS, PFOA, PFBS, and a PFAS mixture did not significantly affect the BDNF pathway in placental trophoblast cells, exposure to PFNA may affect TrkB phosphorylation. Further research is needed to understand how PFAS impacts other critical signaling pathways during fetal neurodevelopment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Sha Wang, Hua Duan, Bohan Li, Wei Hong, Xiao Li, Yiyi Wang, Zheng Chen Guo
Summary: BDNF and TrKB are closely related to dysmenorrhoea caused by endometriosis and may play an important role in the pathobiology or pathophysiology of this disease.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Md. Jakaria, Abdel A. Belaidi, Adam Southon, Krista A. Dent, Darius J. R. Lane, Ashley I. Bush, Scott Ayton
Summary: This study found that some TrkB modulators have protective effects against ferroptosis, but their mechanism is unrelated to the TrkB receptor and is instead due to their antioxidant properties. These modulators could be potential therapeutics for various diseases in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Bin Li, Yunxiang Wang, Xin Yuan, Guanting Liu, Yunpeng Diao, Jing Liu
Summary: 6-Shogaol protects against intestinal ischemia-reperfusion injury by inhibiting cell apoptosis through the BDNF/TrkB/PI3K/AKT pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Fisheries
Shupeng Zhang, Yongpei Lu, Yingzi Li, Yanling Liu, Qin Yao, Qin Kang, Shuhuang Chen, Youlian Liu, Yixiao Xiong, Defang Chen, Xin Zhang, Ni Tang, Zhiqiong Li
Summary: This study confirms the anorexigenic effect of brain-derived neurotrophic factor (BDNF) in Siberian sturgeon. Injection of BDNF suppresses feeding and affects the expression of peptide genes.
Article
Chemistry, Multidisciplinary
Shunlong Pan, Xi Nie, Xinrui Guo, Hao Hu, Biming Liu, Yongjun Zhang
Summary: Traditional treatment methods are ineffective in removing phosphonates from circulating cooling water in one step. In this study, a peroxymonosulfate/UV irradiation/hydrated zirconium oxide (PMS/UV/HZO) coupling process was designed to enhance phosphonates removal. The PMS/UV/HZO process showed significantly higher efficiency in removing nitrilotrismethylenephosphonic acid (NTMP) compared to other processes. The process achieved 97.2% degradation of NTMP and reduced the total phosphorous (TP) from 9.3 mg/L to 0.26 mg/L within 180 minutes at pH 7. The results suggest that the PMS/UV/HZO process is a promising technique for enhanced phosphonates decontamination.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Mechanical
Hongxun Zhao, Zhaojun Yang, Chuanhai Chen, Shizheng Li, Jun Ying
Summary: This paper presents a new optimization criterion that considers stress weight based on D-s-optimality to solve the low estimation accuracy problem of certain stress model parameters when optimizing the multistress accelerated degradation test scheme using existing optimization design criteria. The accelerated degradation model and constraints are determined by analyzing the test characteristics of step-stress accelerated degradation test (SSADT) with multistress. The weight of each stress is identified using fault tree analysis and potential improvement value methods. Combined with the tabu search-particle swarm optimization (TS-PSO) algorithm, the paper proposes an optimization design process for SSADT with multiple stresses. The practicality of the method is verified through the optimization design of SSADT with multistress for a motorized spindle, and the effectiveness of the method is validated by comparing the optimization results with D-optimality and D-s-optimality.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hangwei Liu, Xiaojie Sun, Zhan Shi, Xingkui An, Adel Khashaveh, Yan Li, Shaohua Gu, Yongjun Zhang
Summary: In this study, OBPs in the genome of the green bug Apolygus lucorum were identified and their expression levels in different tissues and stages were analyzed. A total of 31 OBP genes encoding 39 transcripts were found, with several OBP clusters. Comprehensive expression profiling revealed tissue-specific expression of some OBP genes. Ligand-binding assays showed that selected AlucOBPs could specifically bind to plant volatiles, nonvolatile compounds, and synthetic analogs. Additionally, Alu-cOBP19 was suggested to function in gustatory sensing to avoid deleterious plant secondary metabolites. These findings highlight the biotechnological application of plant volatiles and their analogs as ecological attractants and provide new gene targets for A. lucorum control.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agronomy
Dongbiao Lu, Yanlu Dong, Zizheng Yan, Xueying Liu, Yongjun Zhang, Daibin Yang, Kanglai He, Zhenying Wang, Ping Wang, Xiangqun Yuan, Yiping Li
Summary: This study investigated the dynamics of gut microbial community in the fall armyworm (Spodoptera frugiperda) at different developmental stages and the impact of antibiotic treatment on the gut flora. The results showed that the composition of gut bacteria played an important role in the growth, development, and feeding of S. frugiperda. Antibiotic treatment inhibited the gut flora, leading to reduced food intake and body weight gain, as well as prolonged larval stage.
PEST MANAGEMENT SCIENCE
(2023)
Correction
Engineering, Environmental
Anlin Xu, Donghong Wu, Ren Zhang, Siyan Fan, Albert T. Lebedev, Yongjun Zhang
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Software Engineering
HeLiang Yang, YongJun Zhang, ZhongWei Cui, YuJie Xu, YiTong Yang
Summary: In this paper, a dual gradient regression scheme is proposed to improve the image restoration problem of existing super-resolution methods. In the first stage of the network, the proposed scheme is used to recover the structural information of the image and learn the difference between structural maps. In the second stage, the HR gradient maps restored by the first stage are used to provide additional structural information and further constrain the structure of the SR image. Experimental results show that the proposed method outperforms the state-of-the-art SR methods in terms of SSIM and visual effects.
COMPUTERS & GRAPHICS-UK
(2023)
Article
Engineering, Chemical
Anlin Xu, Xin Sun, Siyan Fan, Ziyan Yang, Qiqi Zhang, Yunhai Zhang, Yongjun Zhang
Summary: A novel cathode was fabricated using biogenic Fe-Mn oxides and carbon black for heterogeneous electro-Fenton process. The cultivation time of the applied microbes was found to regulate the crystallinity and metal valence of the cathode, affecting the degradation efficiency of ofloxacin. The degradation kinetic constant with the novel cathode was twice that of the chemogenic peer. The cathode showed high stability and efficiency in a broad pH range and its applicability was validated with real livestock wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Immunology
Tianwen Zhu, Fei Bei, Ruoqi He, Xiaohui Gong, Yan Chen, Zhanghua Yin, Jian Wang, Yu Sun, Yongjun Zhang
Summary: This study investigated the association between genetic diseases and invasive infections in neonates or infants, and identified predictive variables and risk factors. Prenatal findings, neonatal intensive care unit admission, invasive ventilation, bacterial infections, fever, anemia, and neutrophilia were found to be associated with genetic diseases. In addition, a genetic etiology, neurological manifestations, and septic shock were associated with severe outcomes.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Letter
Pediatrics
Yan Chen, Yongjun Zhang
Summary: A full-term boy born with global hypotonia, weakness, and respiratory insufficiency was diagnosed as X-linked centronuclear myopathy by whole exome sequencing. A distinctive feature in his chest x-ray, extremely thinning ribs, was observed, which may serve as an important indicator for skeletal muscle conditions.
PEDIATRIC PULMONOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lingte Huang, Siying Zuo, Xiaofeng Gao, Zengqi Li, Shang Wang, Baiqi Chen, Xinghan Li, Liyun Zhu, Yongjun Zhang
Summary: Pumpkin peel pigments contain natural antioxidants carotenoids and can be extracted efficiently using a deep eutectic solvent (DES) alcohol two-aqueous phase system combined with ultrasound-assisted cellulase. The obtained pigments showed inhibitory effects on alpha-amylase and sucrase, prolonged the survival rate of Caenorhabditis elegans under hydrogen peroxide stress, and increased the activities of T-SOD and CAT enzymes while reducing the level of MDA. These findings indicate the potential of pumpkin peel pigments as a valuable recyclable resource for alleviating oxidative stress damage.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Food Science & Technology
Yongjun Zhang, Xinqing Xiao, Huanhuan Feng, Marina A. Nikitina, Xiaoshuan Zhang, Qinan Zhao
Summary: A non-invasive multi-sensor fusion method using enhanced gray wolf-optimized backpropagation network (EGWO-BP) and K-means++ (KMPP) algorithm is proposed to evaluate the dynamic blood glucose level (BGL) variations. The results show that KMPP-EGWO-BP can effectively acquire more accurate BGL variations compared to traditional methods. The proposed BGL fusion evaluation model can accurately assess the physiological stress states of live fish and reduce potential mortality in the fish circulation industry.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Article
Food Science & Technology
Lingte Huang, Zeen Yang, Jiankun Yuan, Siying Zuo, Zengqi Li, Kelei Yang, Shang Wang, Jia Li, Liyun Zhu, Yongjun Zhang
Summary: Pumpkin polysaccharides can improve abnormal glucose metabolism caused by oxidative stress, significantly reduce blood glucose and lipid levels. In addition, pumpkin polysaccharides can increase the activity of antioxidant enzymes and protect against oxidative stress damage in the liver.
Review
Engineering, Environmental
Chen-Shun Lu, Jin-Ming Qiu, Yang Yang, Yong Hu, Yu-You Li, Takuro Kobayashi, Yong-Jun Zhang
Summary: This paper reviews the effects of high salinity on microbial communities and granulation process in anaerobic treatment of high-salinity wastewater. Various strategies, such as inoculation of adaptive sludge, addition of exogenous substances, and conductive materials, have been adopted to improve microbial community structure, promote methane production, and enhance granulation to some extent.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Xuexue Zhang, Yongjun Zhang, Zewei Wang, Wei Long, Weihao Gao, Bob Zhang
Summary: Sparse representation is an effective data classification algorithm that relies on known training samples to categorize test samples. It has been widely used in various image classification tasks. For deformable images like human faces, extracting features and correctly classifying them is difficult due to variations in intensity and other factors. To address these challenges, the authors propose a novel image representation and classification algorithm that generates virtual samples and uses a score fusion scheme to improve performance and robustness.
CAAI TRANSACTIONS ON INTELLIGENCE TECHNOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Haoliang Zhao, Huizhou Zhou, Yongjun Zhang, Yong Zhao, Yitong Yang, Ting Ouyang
Summary: Current state-of-the-art stereo algorithms often fail to fully exploit high-frequency information, resulting in blurry disparity maps. In this paper, a refinement module is proposed to incorporate high-frequency information, enabling the network to generate detailed disparity maps with sharp edges. Additionally, an Iterative Multiscale Wide-LSTM Network is introduced to enhance data transfer efficiency across iterations. The proposed method achieves outstanding performance on various benchmarks and outperforms existing methods in cross-domain scenarios.
COMPUTER VISION - ACCV 2022, PT I
(2023)
