Article
Cell Biology
Xiao Liu, Shang-Kun Dai, Pei-Pei Liu, Chang-Mei Liu
Summary: This study demonstrates the important role of Arid1a in regulating the proliferation and differentiation of neural stem/progenitor cells during cortical development, and suggests potential gene candidates for understanding the pathological mechanisms and developing interventions for neurodevelopmental disorders caused by Arid1a mutations. Rescue experiments successfully restored the neurogenic defects in Arid1a knockout neural stem/progenitor cells.
CELL PROLIFERATION
(2021)
Review
Cell Biology
Anne Teissier, Alessandra Pierani
Summary: This review discusses the historical and recent advances in the understanding of cortical hierarchy in adults, the similarities and differences in the developmental processes underlying cortical development of primary and higher-order areas, and the potential impact of the dramatic expansion in cortical size on cognitive complexification in evolution. It also explores the alteration of cortical hierarchy in neuropsychiatric disorders and their potential developmental origins.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Clinical Neurology
Thiviya Selvanathan, Mireille Guillot, Helen M. Branson, Vann Chau, Edmond N. Kelly, Steven P. Miller
Summary: Malformations of cortical development (MCD) are a rare group of disorders caused by genetic, metabolic, infectious, or vascular factors that disrupt the development of the cerebral cortex. They are typically detected with brain MRI when symptomatic, but recent advances allow for detection during fetal or neonatal periods. This study presents neuroimaging findings and neurodevelopmental outcomes of a very preterm infant with incidentally detected MCD on neonatal research brain MRI.
Article
Multidisciplinary Sciences
Andrija Stajduhar, Tomislav Lipic, Sven Loncaric, Milos Judas, Goran Sedmak
Summary: This study presents a quantitative histology data science methodology that focuses on neuron-level representations of cortical regions, rather than image-level investigations. The methodology involves automatic segmentation of neurons and the use of engineered features to map phenotype to cortical layers. The approach offers high interpretability and can help deepen our understanding of human cortex organization.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Madeline G. Andrews, Clara Siebert, Li Wang, Matthew L. White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpanaarjun Mckinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E. Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R. Kriegstein
Summary: The differentiation of outer radial glia (oRG) cells and the production of inhibitory interneurons (INs) in the cerebral cortex are regulated by leukemia-inhibitory factor (LIF) signaling.
Article
Multidisciplinary Sciences
Christina M. Cerkevich, Jean-Alban Rathelot, Peter L. Strick
Summary: This study examines the cortical control of a laryngeal muscle, essential for vocalization in marmosets and macaques. The researchers find that the expansion of descending output from the premotor areas, particularly ventral area 6 and supplementary motor area, contributes to the enhanced vocal motor abilities in marmosets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Xiaosu Li, Guoping Liu, Lin Yang, Zhenmeiyu Li, Zhuangzhi Zhang, Zhejun Xu, Yuqun Cai, Heng Du, Zihao Su, Ziwu Wang, Yangyang Duan, Haotian Chen, Zicong Shang, Yan You, Qi Zhang, Miao He, Bin Chen, Zhengang Yang
Summary: The study elucidates the development of mouse cortical radial glial cells into intermediate progenitors and different subtypes of neural cells. It provides insights into the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Chia-Fang Wang, Jenq-Wei Yang, Zi-Hui Zhuang, Hsiang-Wei Hsing, Heiko J. Luhmann, Shen-Ju Chou
Summary: This study revealed a bottom-up feedback mechanism for regulating the development of TCAs, which involves feedback signals from L4 neurons and the regulation by Lhx2 and Sema7a.
Article
Biochemistry & Molecular Biology
Zhipeng Cao, Renata B. Cupertino, Jonatan Ottino-Gonzalez, Alistair Murphy, Devarshi Pancholi, Anthony Juliano, Bader Chaarani, Matthew Albaugh, Dekang Yuan, Nathan Schwab, James Stafford, Anna E. Goudriaan, Kent Hutchison, Chiang-Shan R. Li, Maartje Luijten, Martine Groefsema, Reza Momenan, Lianne Schmaal, Rajita Sinha, Ruth J. van Holst, Dick J. Veltman, Reinout W. Wiers, Bernice Porjesz, Tristram Lett, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Gunter Schumann, Robert Whelan, Ravi R. Bhatt, Alyssa Zhu, Patricia Conrod, Neda Jahanshad, Paul M. Thompson, Scott Mackey, Hugh Garavan
Summary: In this study, researchers identified a shared spatial pattern of cortical thickness (CT) in normative development and several psychiatric and neurological disorders. Further analysis revealed significant spatial correspondences between this pattern and widespread lower CT observed in psychiatric disorders, as well as the spatial pattern of normative maturation and aging. Transcriptional analysis also identified a set of genes closely related to this pattern, indicating disrupted neurodevelopment in the pathogenesis of psychiatric diseases emerging during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Biology
Sabrina A. Jones, Jacob H. Barfield, V. Kindler Norman, Woodrow L. Shew
Summary: Naturally occurring body movements and collective neural activity exhibit scale-free dynamics, with fractal spatiotemporal structure. Scale-free brain activity and scale-free behavior have been studied separately, without a unified explanation. We show that mouse behavior and neurons in the visual cortex exhibit strongly related scale-free dynamics, with stochastic competition among neural subsets. Our computational model incorporating cell-type-specific circuit structure provides a new explanation for these findings, establishing the neural underpinnings of scale-free behavior and the relevance of scale-free neural activity to behavior.
Article
Multidisciplinary Sciences
Mark-Phillip Pebworth, Jayden Ross, Madeline Andrews, Aparna Bhaduri, Arnold R. Kriegstein
Summary: Research on the spatiotemporal, transcriptomic, and morphological variations of neural intermediate progenitor cells (nIPCs) in the developing human brain has provided insights for future studies. The study identifies changes in spatial distribution of nIPCs around gestational week 19/20, along with five transcriptomic subtypes, one of which emerges at this transition. Additionally, a diversity of nIPC morphologies were observed, which do not correspond with specific transcriptomic subtypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Dennis van der Meer, Tobias Kaufmann, Alexey A. Shadrin, Carolina Makowski, Oleksandr Frei, Daniel Roelfs, Jennifer Monereo-Sanchez, David E. J. Linden, Jaroslav Rokicki, Dag Alnaes, Christiaan de Leeuw, Wesley K. Thompson, Robert Loughnan, Chun Chieh Fan, Lars T. Westlye, Ole A. Andreassen, Anders M. Dale
Summary: The folding of the human cerebral cortex is a highly genetically regulated process that allows for a larger surface area and optimized functional organization. Sulcal depth, a measure of localized folding, has been associated with neurodevelopmental disorders. This study, the first genome-wide association study of sulcal depth, identified multiple significant loci and highlighted genetic overlap with cortical thickness and surface area, suggesting potential insights into cortical morphology.
Review
Genetics & Heredity
Baptiste Libe-Philippot, Pierre Vanderhaeghen
Summary: The human cerebral cortex has unique developmental features, including prolonged patterns of neuronal generation and maturation, specific gene regulatory networks, and newly emerged molecular characteristics. These features are closely related to neurodevelopmental disorders, highlighting the connections between human neural development, evolution, and diseases.
ANNUAL REVIEW OF GENETICS, VOL 55
(2021)
Article
Biochemical Research Methods
Jessica L. Sevetson, Brian Theyel, Diane Hoffman-Kim
Summary: This study demonstrates network activity in three-dimensional brain cultures, showing that the networks become more complex over time and can be manipulated with various drugs. The correlations and distances between neurons within the network can be quantified with micron-scale resolution to study emergent network events.
Article
Cell Biology
Ryan M. Glanz, Greta Sokoloff, Mark S. Blumberg
Summary: This research investigates the changes in the primary motor cortex during development in rats. Using neural decoding, it was found that the complexity and uniqueness of the movement information in M1 increases as the activity becomes continuous. Additionally, the representation in M1 at this stage is more susceptible to damage.
