Changes in Expression and Activity of CD38 in Astroglial Cells after Impairment of the Neuron-Glia Relationship in the Brain Induced by Perinatal Hypoxia-Ischemia

We studied changes in the expression and activity of a bifunctional enzyme, CD38, in neurons and glia induced by perinatal hypoxia-ischemia in rats. These changes influenced reactive gliosis and functional coupling between ADP-ribosyl cyclase and connexin 43 in the development of neuron-glia interactions.