Article
Clinical Neurology
Sungyang Jo, Jungsu S. Oh, E-Nae Cheong, Hyung Ji Kim, Sunju Lee, Minyoung Oh, Jae Seung Kim, Sun Ju Chung, Chong S. Lee, Miseon Kwon, Dongwha Kang, Jae-Hong Lee
Summary: This study used FDG-PET to reveal distinct glucose hypometabolism patterns in ideomotor and imitation apraxia subtypes in CBS patients. Patients with both ideomotor and imitation apraxia were more likely to exhibit the typical features of CBS and progressive supranuclear palsy compared to those with only one type of apraxia. These findings contribute to our understanding of the brain networks underlying apraxia in relation to the clinical features of CBS.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Rehabilitation
Lizhu Liang, Min Jiang, Yajie Yang, Jingxin Wei, Qindi Zhang, Xiaoyan Liao
Summary: The Chinese version of the DILA-S classic subtests demonstrated satisfactory psychometric properties for assessing limb apraxia in Chinese patients after ischemic stroke. The study showed that the translated version had good internal consistency, test-retest reliability, dimensionality, convergent validity, divergent validity, and concurrent validity.
TOPICS IN STROKE REHABILITATION
(2023)
Article
Behavioral Sciences
Claudia C. Schmidt, Elisabeth I. S. Achilles, Gereon R. Fink, Peter H. Weiss
Summary: Apraxia is a multi-componential syndrome characterized by deficits in higher motor functions, primarily caused by left hemisphere lesions. This study analyzed different profiles of apraxia and related motor-cognitive processes following LH stroke, revealing specific lesion patterns associated with various components. The results suggest that apraxia represents impaired motor-cognitive processes that partially dissociate from language processes and are associated with distinct lesion patterns following LH stroke.
Article
Rehabilitation
Mai Yamada, Masahiko Koyanagi, Miyo Kawaguchi, Yuki Sato, Mitsuhiro Tsujihata, Toshio Higashi
Summary: This study developed a short assessment test for upper limb apraxia in stroke patients, which includes 10 items and can be completed in a short time. The test showed high reliability and validity in evaluating apraxia, making it a useful tool for assessing stroke patients from acute to chronic phases.
BRITISH JOURNAL OF OCCUPATIONAL THERAPY
(2022)
Article
Behavioral Sciences
Mitchell W. Isaacs, Laurel J. Buxbaum, Aaron L. Wong
Summary: Imitating observed actions is an efficient method for learning novel movements. This study investigated the role of proprioception in imitation and found that representing movement goals proprioceptively is crucial for successful imitation. Patients with apraxia, a neurological disorder commonly seen after left hemisphere stroke, showed deficits in representing and accessing proprioceptive goals, which contributed to their imitation impairments.
Review
Clinical Neurology
Martina Di Pietro, Mirella Russo, Fedele Dono, Claudia Carrarini, Astrid Thomas, Vincenzo Di Stefano, Roberta Telese, Laura Bonanni, Stefano L. Sensi, Marco Onofrj, Raffaella Franciotti
Summary: Consensus criteria for corticobasal degeneration (CBD) include alien limb (AL) phenomena, but the exact nature of AL behavioral features is still debated. CBD-related AL may manifest as involuntary movements, frontal release phenomena, or somatognosia. To make a proper diagnosis of AL in CBD, cognitive and language dysfunctions must be carefully examined. The term "AL" should be used in conjunction with precise descriptions of accompanying involuntary movements, sensory misperceptions, agnosia-asomatognosia contents, and utilization behavior.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Anna E. Goodheart, Joseph J. Locascio, Wesley R. Samore, Jessica A. Collins, Michael Brickhouse, Aaron Schultz, Alexandra Touroutoglou, Keith A. Johnson, Matthew P. Frosch, John H. Growdon, Bradford C. Dickerson, Stephen N. Gomperts
Summary: The study found that corticobasal syndrome patients without amyloid deposition showed higher F-18-AV-1451 retention and regional atrophy, particularly in areas associated with corticobasal degeneration pathology, while cases associated with Alzheimer's disease exhibited greater and more diffuse brain involvement on tau-PET imaging. The differences between the two groups were significant.
Review
Clinical Neurology
Rene L. Utianski, Keith A. Josephs
Summary: This article reviews recent findings regarding the clinic phenotypes of AOS, neuroimaging correlates, and the underlying disease processes. Recent studies have identified two clinical subtypes of AOS that are linked to molecular pathology. New imaging techniques have been applied to the study of progressive AOS. While there is limited data on the impact of behavioral intervention, studies suggest some benefit in speech intelligibility and maintenance for patients with AOS.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Psychology
Michele Scandola, Loredana Canzano, Renato Avesani, Mara Leder, Sara Bertagnoli, Valeria Gobbetto, Salvatore M. Aglioti, Valentina Moro
Summary: Anosognosia is a syndrome characterized by a lack of awareness of deficits in motor, cognitive, or emotional functions. This study explored the existence of a specific form of anosognosia for apraxia in patients with uni-hemispheric vascular lesions. The findings suggest that patients with bucco-facial and limb apraxia are specifically unaware of errors in corresponding actions, indicating a topographical organization of the syndrome.
JOURNAL OF NEUROPSYCHOLOGY
(2021)
Review
Geriatrics & Gerontology
Anna Dunalska, Julia Pikul, Katarzyna Schok, Katarzyna Anna Wiejak, Piotr Alster
Summary: Corticobasal syndrome (CBS) is classified as atypical Parkinsonism characterized by motor and higher cortical dysfunctions. Vascular CBS cases are associated with vascular lesions, particularly internal carotid artery stenosis and ischemic strokes, and often occur in elderly patients with cardiovascular risk factors.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Cell Biology
Federica Arienti, Giulia Lazzeri, Maria Vizziello, Edoardo Monfrini, Nereo Bresolin, Maria Cristina Saetti, Marina Picillo, Giulia Franco, Alessio Di Fonzo
Summary: CBS is a atypical parkinsonian syndrome with heterogeneous clinical features and different underlying neuropathology. The most common gene involved in CBS is GRN, followed by MAPT, C9ORF72, and PRNP. GRN-CBS patients commonly exhibit symptoms such as visuospatial impairment, behavioral changes, aphasia, and language alterations. Specific demographic, clinical, biochemical, and radiological features may suggest mutations in other genes.
Article
Clinical Neurology
Makoto Sainouchi, Mari Tada, Yusran Ady Fitrah, Norikazu Hara, Kou Tanaka, Jiro Idezuka, Izumi Aida, Takashi Nakajima, Akinori Miyashita, Kohei Akazawa, Takeshi Ikeuchi, Osamu Onodera, Akiyoshi Kakita
Summary: The presence of TDP-43 inclusions in the brains of CBD patients has been correlated with clinical phenotypes. This study investigated the relationship between TDP-43 inclusions and neuronal loss in CBD. The results suggest that TDP-43 alterations in neurons, independent of tau pathology, may contribute to neuronal degeneration in CBD.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Piotr Alster, Michal Nieciecki, Bartosz Migda, Michal Kutylowski, Natalia Madetko, Karolina Duszynska-Was, Ingeborga Charzynska, Dariusz Koziorowski, Leszek Krolicki, Andrzej Friedman
Summary: This study examined patients with MSA-P and PSP-P, two types of atypical parkinsonism that are difficult to differentiate in the early years of development. The researchers found that extended examination using MRI and perfusion SPECT, focusing on the evaluation of the mesencephalon/pons ratio, mesencephalic volume decrease, MRPI, and frontal perfusion, may be more feasible than cognitive evaluation in the 3-6-year duration of symptoms.
Article
Behavioral Sciences
Rachel Metzgar, Harrison Stoll, Scott T. Grafton, Laurel J. Buxbaum, Frank E. Garcea
Summary: This study investigates the relationship between meaningless gesture imitation and tool use pantomiming and their corresponding brain lesions. The results suggest that specific brain regions are associated with different subtypes of limb apraxia, providing important insights into the understanding of this condition.
Article
Clinical Neurology
Nina Rohrbach, Carmen Krewer, Lisa Loehnert, Annika Thierfelder, Jennifer Randerath, Klaus Jahn, Joachim Hermsdoerfer
Summary: The study showed that limb apraxia patients performed better in pantomiming tool use when using augmented reality and dynamic cues, with their performance approaching that of real tool demonstration. Good visual stimuli can enhance patients' pantomiming ability.
FRONTIERS IN NEUROLOGY
(2021)
