期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 108, 期 -, 页码 172-184出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2013.07.014
关键词
Ingestive behavior; Learning; Energy regulation; Western diet; Hippocampus; Dementia
资金
- National Institutes of Child Health and Development [P01 HD052112, R01 HD29792]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK076078]
An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regulation. Within our framework, this disruption occurs when (a) consumption of sweet-tasting, but low calorie or noncaloric, foods and beverages reduces the ability of sweet tastes to predict the postingestive caloric consequences of intake and (b) consuming diets high in saturated fat and sugar (a.k.a., Western diet) impairs hippocampal-dependent learning and memory processes that are involved with the use of interoceptive satiety signals to anticipate when food and eating are not followed by appetitive postingestive outcomes. The paper concludes with discussion of a vicious-cycle model which links obesity to cognitive decline. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据