期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 105, 期 -, 页码 63-80出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2013.06.013
关键词
Striatum; Nucleus accumbens; Basal ganglia; Long-term potentiation; Long-term depression; Instrumental learning; L-DOPA induced dyskinesia; Drug addiction; Ras-ERK signaling; Endocannabinoids
资金
- Michael J. Fox Foundation for Parkinson's Research
- Parkinson's UK
- Italian Ministry of Health
- Compagnia di San Paolo
- Fondazione Istituto Italian di Tecnologia
- Progetto Giovani Ricercatori Ministero della Salute
The striatum is the input structure of the basal ganglia system. By integrating glutamatergic signals from cortical and subcortical regions and dopaminergic signals from mesolimbic nuclei the striatum functions as an important neural substrate for procedural and motor learning as well as for reward-guided behaviors. In addition, striatal activity is significantly altered in pathological conditions in which either a loss of dopamine innervation (Parkinson's disease) or aberrant dopamine-mediated signaling (drug addiction and L-DOPA induced dyskinesia) occurs. Here we discuss cellular mechanisms of striatal synaptic plasticity and aspects of cell signaling underlying striatum-dependent behavior, with a major focus on the neuromodulatory action of the endocannabinoid system and on the role of the Ras-ERK cascade. (C) 2013 Elsevier Inc. All rights reserved.
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