期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 98, 期 4, 页码 354-360出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2012.10.004
关键词
Place cell; Long-term plasticity; Long-term stability; Memory consolidation; Attention; Behavior
资金
- University of Bordeaux 1
- France Alzheimer Foundation
- ACI: Computational and integrative neuroscience program
- Agence Nationale de la Recherche [ANR-08-MNPS-019-01]
To investigate the intriguing and paradoxical contrast between the time-limited role of the hippocampus in memory consolidation and its permanent contribution to spatial memory as revealed by place cell activity, we carefully monitored the temporal evolution of the same set of place cells in normal naive mice throughout their familiarization to a spatial context and their consolidation of memory about space. Over six daily recording sessions, despite their widely reported stability, we observed gradual changes in hippocampal place fields and cell firing patterns. These changes were interpreted in terms of both improvement and impoverishment of spatial codes: improvement due to intrinsic place cell plasticity, and impoverishment as a consequence of attentional filtering of allocentric spatial information reaching the hippocampus due to the procedural behavioral requirements of the task, or to hippocampal disengagement as learning progresses. (C) 2012 Elsevier Inc. All rights reserved.
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