Article
Neurosciences
Tania Llana, Marta Mendez, Candela Zorzo, Camino Fidalgo, M. -Carmen Juan, Magdalena Mendez-Lopez
Summary: This study investigates the acquisition and consolidation of declarative and procedural memory in long-COVID patients and explores the potential relationship between anosmia and these memory functions. The results suggest that long-COVID patients exhibit deficits in general cognition, psychomotor speed, sustained attention, and incidental learning. They also show impaired long-term retention of verbal declarative memory and procedural memory. Anosmia in long-COVID patients may be associated with dysfunction in the limbic system.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Infectious Diseases
P. D. J. Bollen, H. A. B. Prins, A. Colbers, K. Velthoven-Graafland, B. J. A. Rijnders, T. E. M. S. De Vries-Sluijs, E. van Nood, J. Nouwen, H. Bax, M. de Mendonca Melo, A. Verbon, D. M. Burger, C. Rokx
Summary: This study confirms protein displacement as the main mechanism for the dolutegravir/valproic acid drug-drug interaction, although additional mechanisms might be involved too. If dolutegravir is taken with food, this drug-drug interaction is probably not clinically relevant.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Clinical Neurology
Christina Paula Plamberger, Helen Elisabeth Van Wijk, Hubert Kerschbaum, Belinda Angela Pletzer, Georg Gruber, Karin Oberascher, Martin Dresler, Michael Andreas Hahn, Kerstin Hoedlmoser
Summary: The study found that women using OCs and naturally cycling women in the luteal phase showed higher levels of fast sleep spindle density, while women in the follicular phase of the natural cycle showed lower levels. Additionally, a positive correlation was observed between endogenous progesterone levels and fast spindle density in women during the luteal phase.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Chenwei Xie, Manson Cheuk-Man Fong, Matthew King-Hang Ma, Juliahna Wang, William Shiyuan Wang
Summary: The study reveals that both declarative and procedural memory decline with age, but declarative memory is relatively preserved compared to procedural memory. Additionally, older adults show different patterns in recognizing familiar and unfamiliar items, contradicting the retrogenesis hypothesis.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Nicolas Stefaniak, Veronique Baltazart, Christelle Declercq
Summary: The Declarative/Procedural Model suggests that lexicon relies on declarative memory while grammar depends on procedural memory. Procedural memory supports the sequential processing of language. Studies on verb processing show that semantic knowledge acquired implicitly preactivates typical patients, suggesting a link to procedural memory. The typicality effect in children's cognitive development may depend on procedural memory, as it is necessary for learning word sequences in a sentence with meaning.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ivana Kacirova, Milan Grundmann, Hana Brozmanova
Summary: The study found significant correlations between milk/maternal serum concentration ratio and infant/maternal serum concentration ratio. Valproic acid concentrations in milk and infant serum did not reach the lower limit of the reference range for the general epileptic population, indicating that routine monitoring of serum concentrations of breastfed infants is not necessary.
Review
Psychology, Multidisciplinary
Bruce Crosson
Summary: Research suggests that the thalamus plays a role in lexical-semantic processes and linguistic procedural memory, not simply distinguishing between declarative and procedural memory, but also regarding how the thalamus participates in these processes and their interaction.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Nutrition & Dietetics
Marta Moreno-Torres, Carla Guzman, Petar D. Petrov, Ramiro Jover
Summary: In this study, valproic acid (VPA) and natural short-chain fatty acids (SCFAs) were identified as novel transcriptional activators for the human VDR gene. The researchers characterized the responsive elements in the regulatory region of the hVDR gene and found that a short DNA region upstream of the transcription start site is responsible for the increase in transcriptional activity in response to VPA/SCFAs. The results suggest that VPA and SCFAs facilitate the activity of the transcription factor Sp1 in the hVDR gene, promoting VDR upregulation and signaling. These findings may have clinical relevance in epileptic pediatric patients on VPA therapy and suggest a potential role of SCFAs produced by gut microbiota in VDR upregulation.
Article
Critical Care Medicine
Alexander Balcerac, Kevin Bihan, Benedicte Lebrun-Vignes, Dominique Thabut, Joe-Elie Salem, Nicolas Weiss
Summary: This study is the first large-scale investigation into drug-associated hyperammonaemia, revealing associations between various drugs and this condition. These findings have significant implications for clinicians and trial designers.
ANNALS OF INTENSIVE CARE
(2022)
Article
Biochemistry & Molecular Biology
Jordan L. Pederick, Jessica C. Woolman, John B. Bruning
Summary: Pseudomonas aeruginosa is a major human pathogen in healthcare settings, and the emergence of drug-resistant strains necessitates the development of new antibiotics. In this study, researchers characterized two enzymes involved in cell wall biosynthesis in P. aeruginosa, and found that inhibiting their activity could be a promising approach for designing new antibiotics. The study provides important insights into potential targets for combating drug resistance in P. aeruginosa.
Article
Clinical Neurology
Esraa M. Elnahas, Sally A. Abuelezz, Magda I. Mohamad, Mai M. Nabil, Sahar M. Abdelraouf, Nevine Bahaa, Ghada A. M. Hassan, Eman A. Ibrahim, Asmaa I. Ahmed, Sawsan Aboul-Fotouh
Summary: Despite the controversy on the timing of exposure to valproic acid (VPA) in inducing autism-like changes in male Wistar rats, this study found that both prenatal and postnatal VPA exposures showed similar effects on inducing autistic-like behaviors and neuropathological changes. The prenatal VPA exposure model demonstrated significant alterations in ASD core symptoms and histopathological changes compared to the postnatal model, with lower postnatal animal mortality.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Education & Educational Research
Tan Zhang, Anqi Deng, Ang Chen
Summary: This study aimed to investigate the relationship between declarative and procedural knowledge in fitness among middle school students. The findings indicate that most students lack the procedural knowledge needed to engage in fitness-enhancing physical activities, while a few students with mastery of declarative knowledge demonstrated a high level of procedural knowledge.
JOURNAL OF TEACHING IN PHYSICAL EDUCATION
(2021)
Article
Cell Biology
Eun-Hye Jang, Jung-Ho Lee, Soon-Ae Kim
Summary: In this study, we found that treatment with valproic acid induced mitochondrial biogenesis and autophagy in the SH-SY5Y cell line by altering FOXO3a expression and posttranslational modification.
Article
Integrative & Complementary Medicine
Dongxiao Qu, Yiqin Ge, Limin Zhuo, Liji Chen, Yonghua Xue, Jiwei Cheng, Jie Tao, Guoyi Li, Yudan Zhu, Qian Xiao
Summary: In this study, the efficacy and mechanisms of combined treatment with Dingxian pill and valproic acid (VPA) on chronic pentylenetetrazol-induced epilepsy in rats were investigated. The combination therapy showed stronger inhibition of seizure-like behavior and reduction of seizure grades compared to VPA alone. In addition, it improved learning and memory ability in epileptic rats and regulated gene expression. These results highlight the antiepileptic effects of the combined treatment and provide insights into the molecular mechanisms, offering a potential approach for the treatment of epilepsy with Traditional Chinese Medicine.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Neurosciences
Akira Yoshikawa, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Motoyasu Honma, Keiko Watanabe, Satomi Kubota, Iizuka Natsuko, Masahiro Ida, Masahiko Izumizaki
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Satomi Kubota, Yuri Masaoka, Haruko Sugiyama, Masaki Yoshida, Akira Yoshikawa, Nobuyoshi Koiwa, Motoyasu Honma, Ryuta Kinno, Keiko Watanabe, Natsuko Iizuka, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Neurosciences
Motoyasu Honma, Hidetomo Murakami, Yoshiko Yabe, Takeshi Kuroda, Akinori Futamura, Azusa Sugimoto, Yasuo Terao, Yuri Masaoka, Masahiko Izumizaki, Mitsuru Kawamura, Kenjiro Ono
Summary: The study found that duration feedback training can improve cognitive task performance in patients with PD, particularly in the Go/No-go task, Stroop task, and impulsivity assessment. These results suggest that time perception is functionally linked to inhibitory systems, and that feedback training to maintain time perception could improve cognitive/psychiatric functions in patients with PD.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Medicine, Research & Experimental
Motoyasu Honma, Shoko Saito, Takeshi Atsumi, Shin-ichi Tokushige, Satomi Inomata-Terada, Atsuro Chiba, Yasuo Terao
Summary: This study aimed to manipulate subjective duration production by memory consolidation through the modulation of neural plasticity. Altered duration production returned to baseline within two hours, but with quadripulse transcranial magnetic stimulation (QPS) over the right dorsolateral prefrontal cortex, false duration production was maintained for four hours and persisted for at least one week.
Article
Behavioral Sciences
Natsuko Iizuka, Yuri Masaoka, Satomi Kubota, Haruko Sugiyama, Masaki Yoshida, Akira Yoshikawa, Nobuyoshi Koiwa, Motoyasu Honma, Keiko Watanabe, Shotaro Kamijo, Sawa Kamimura, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
Summary: This study found that volume reduction in the medial temporal regions is not directly linked to declining olfactory ability. Reduction in the left entorhinal cortex volume was correlated with reduction in the left parahippocampus and dentate gyrus volumes. However, reduction in the left parahippocampus volume had the greatest impact on olfactory decline, with the entorhinal cortex and dentate gyrus potentially contributing to the decline as well.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Yasuo Terao, Motoyasu Honma, Yuki Asahara, Shin-ichi Tokushige, Toshiaki Furubayashi, Tai Miyazaki, Satomi Inomata-Terada, Ayumi Uchibori, Shinji Miyagawa, Yaeko Ichikawa, Atsuro Chiba, Yoshikazu Ugawa, Masahiko Suzuki
Summary: The study found that time production/reproduction tasks in PD and PSP patients showed unusual time perception compared to normal subjects, while perceptual tasks showed changes in the opposite direction to motor timing tasks. This suggests that timing performance in PD may be influenced by complex interactions among time scales on the motor and sensory sides, and by their distortion in memory.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Rika Moriya, Mitsuko Kanamaru, Naoki Okuma, Akira Yoshikawa, Kenji F. Tanaka, Satoshi Hokari, Yasuyoshi Ohshima, Akihiro Yamanaka, Motoyasu Honma, Hiroshi Onimaru, Toshiaki Kikuchi, Masahiko Izumizaki
Summary: Studies have shown that 5-HT neurons in the DRN play a crucial role in regulating different waking states, with optogenetic activation of these neurons causing rapid transition from non-REM sleep to active wakefulness. Activation of medullary 5-HT neurons, on the other hand, does not seem to affect sleep/wake states or locomotor activity. Further research into the cortical functional connectivity involved in sleep/wake state regulation is encouraged based on these findings.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Sayaka Wada, Motoyasu Honma, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Haruko Sugiyama, Natsuko Iizuka, Satomi Kubota, Yumika Kokudai, Akira Yoshikawa, Shotaro Kamijo, Sawa Kamimura, Masahiro Ida, Kenjiro Ono, Hidetoshi Onda, Masahiko Izumizaki
Summary: The study found that brain atrophy associated with emotion recognition was observed in elderly participants, with education years linked to the volume of certain brain regions. Specifically, the volume of the right orbital gyrus, right inferior frontal gyrus, and right supramarginal gyrus were associated with years of education, and the volume of the right supramarginal gyrus was further linked to emotion recognition score.
Article
Neurosciences
Yuri Masaoka, Haruko Sugiyama, Masaki Yoshida, Akira Yoshikawa, Motoyasu Honma, Nobuyoshi Koiwa, Shotaro Kamijo, Keiko Watanabe, Satomi Kubota, Natsuko Iizuka, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
Summary: This study found that specific odors can evoke autobiographical memories and identified the brain regions involved, providing insights into the impact of odors on cognitive function in older adults.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yumika Kokudai, Motoyasu Honma, Yuri Masaoka, Masaki Yoshida, Haruko Sugiyama, Akira Yoshikawa, Nobuyoshi Koiwa, Satomi Kubota, Natsuko Iizuka, Sayaka Wada, Shotaro Kamijo, Yuki Uchida, Satoshi Yano, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
Summary: The study found that aging affects certain brain regions, leading to cognitive dysfunction. Specifically, a cascade process mediated by the left hippocampus and left superior frontal gyrus is involved in the relationship between aging and cognitive dysfunction.
Article
Geriatrics & Gerontology
Satoshi Matsuno, Takuya Yoshiike, Atsushi Yoshimura, Sachiyo Morita, Yusuke Fujii, Motoyasu Honma, Yuji Ozeki, Kenichi Kuriyama
Summary: This study suggests that standing plantar perception training (SPPT) can improve standing postural stability in older adults by enhancing regional cortical activity, particularly in the right parietal association area.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2021)
Article
Neurosciences
Takeshi Kuroda, Motoyasu Honma, Yukiko Mori, Akinori Futamura, Azusa Sugimoto, Hideyo Kasai, Satoshi Yano, Sotaro Hieda, Kensaku Kasuga, Takeshi Ikeuchi, Kenjiro Ono
Summary: This study compared the extent and distribution of white matter lesions (WMLs) between idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD), and found that deep WML volume was significantly larger in iNPH than in AD, while periventricular WML volume was dominant in AD. The lateral ventricular volume positively correlated with WML volume in all participants, and there was a significant negative correlation between lateral ventricular volume and Aβ(38) in iNPH.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Motoyasu Honma, Yuri Masaoka, Natsuko Iizuka, Sayaka Wada, Sawa Kamimura, Akira Yoshikawa, Rika Moriya, Shotaro Kamijo, Masahiko Izumizaki
Summary: The study investigates the reason for the decline in reading comprehension when reading on a smartphone compared to reading on paper. It is found that reading on a smartphone elicits fewer sighs, promotes brain overactivity in the prefrontal cortex, and results in reduced comprehension. The relationship between sigh inhibition and overactivity in the prefrontal cortex is believed to cause the decline in comprehension.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Multidisciplinary
Masayoshi Nagai, Motoyasu Honma, Takatsune Kumada, Yoshihisa Osada
Summary: Spontaneous behavior, influenced by social factors, plays a role in building harmonious relationships. This study found that individuals with high levels of autistic-like traits showed poorer coordination in spontaneous stepping when facing each other, potentially indicating a source of their poor social-communication abilities.
JAPANESE PSYCHOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Miku Kosuge, Motoyasu Honma, Yuri Masaoka, Shota Kosuge, Momoka Nakayama, Shotaro Kamijo, Yusuke Shikama, Masahiko Izumizaki
Summary: Change in body perception requires recalibration of sensory inputs. It is less known how other information relates to body perception recalibration. This study investigated the relationship between respiration and hand perception recalibration. Results showed that temporal and spatial congruency between respiratory rhythm and mannequin hand facilitated hand ownership transfer, while incongruency had little effect. The findings suggest that respiratory rhythms are involved in adapting the body's neural representations.
SCIENTIFIC REPORTS
(2023)