Article
Multidisciplinary Sciences
Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F. Sleiman, Joseph S. Stephan
Summary: Exercise enhances learning and memory recall and counteracts cognitive decline associated with aging. The positive effects of exercise are mediated by circulatory factors, specifically Brain Derived Neurotrophic Factor (BDNF) signaling in the hippocampus. Identifying the mechanisms behind the release of these factors and their effects on hippocampal Bdnf expression will help harness the therapeutic potential of exercise.
Article
Biochemistry & Molecular Biology
Ramon Martinez-Marmol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frederic A. Meunier
Summary: The traditional medicinal mushroom Hericium erinaceus enhances peripheral nerve regeneration through neurotrophic activity. We identified N-de phenylethyl isohericerin (NDPIH) and hericene A as biologically active compounds from this mushroom that promote neurite outgrowth in hippocampal neurons. NDPIH acts through a neurotrophic pathway independent of TrkB with ERK1/2 activation, while hericene A acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance in mice.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Ching-Chiung Wang, Yi-Shan Lee, Yi-Yan Sie, Chi- Chang, Wen-Chi Hou
Summary: Resveratrol tetramers of hopeaphenol, vitisin A, and vitisin B show potential in improving degenerative disorders.
Article
Behavioral Sciences
Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Singh
Summary: This study investigated the effects of heat stress on the hippocampus and spatial memory in rats, revealing that heat exposure can lead to oxidative damage, neuronal apoptosis and spatial memory deficits in the hippocampus. Furthermore, the dysregulation of the BDNF/ERK1/2/CREB axis was found to be associated with cognitive decline under heat stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Virendra Tiwari, Akanksha Mishra, Sonu Singh, Sandeep Kumar Mishra, Kiran Kumari Sahu, Parul, Mahesh J. Kulkarni, Rakesh Shukla, Shubha Shukla
Summary: The study demonstrated that the tricyclic antidepressant protriptyline significantly reduced neurodegeneration, oxidative stress, and glial activation, improving the learning and memory retention in streptozotocin-induced rat model of Alzheimer's disease. Protriptyline also improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFXB and GFAP expression, suggesting its potential as a multi-target molecule for the development of effective new treatments in neurodegenerative disorders.
Article
Neurosciences
Xiao-Hui Li, Cheng Xue, Meng-Qi Liu, Meng-Yu Zhang, Yang Zhou, Xu Xiao, Jia Wang, Xi-Jia Xu, Yun Shi, Wei-Ning Zhang
Summary: The introduction of a novel rat strain with a mutation in the ATRN gene reveals learning and memory impairments, as well as slight motor deficits and behavioral abnormalities in these mutant rats. These findings provide new insights into the mechanisms by which mutant ATRN induces neurodegenerative changes.
Article
Clinical Neurology
Natalia Freddo, Suelen Mendonca Soares, Milena Fortuna, Aline Pompermaier, Amanda Carolina Cole Varela, Victoria Costa Maffi, Mateus Timbola Mozzato, Heloisa Helena de Alcantara Barcellos, Gessi Koakoski, Leonardo Jose Gil Barcellos, Luciana Grazziotin Rossato-Grando
Summary: The study demonstrates that high doses of MPH and CAF negatively impact the behavior, oxidative status, and mitochondrial activity in zebrafish. MPH alone induces antisocial behavior and inhibits lipid peroxidation, while MPH+CAF combination leads to memory impairment and anxiogenic behavior. The changes in cognition, memory, oxidative, and mitochondrial status are more significant when MPH and CAF are used together.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Jongryul Hong, Yeonji Jeong, Won Do Heo
Summary: In this study, researchers found that deletion of TrkB in neurons projecting from the medial entorhinal cortex to the mPFC led to reduced remote memory recall in male mice. The deletion of TrkB also attenuated the participation of mPFC cells in the recall of remote fear memory and was associated with reduced reactivation of cells in the mPFC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Microbiology
Yulong Wu, Zhouyan Dong, Xinze Jiang, Lei Qu, Wei Zhou, Xu Sun, Jiangshan Hou, Hongmei Xu, Mei Cheng
Summary: This study reveals that Methamphetamine (METH) exposure causes cognitive impairment and alters the gut microbiota. The disruption of gut microbiota triggers the transformation of microglial M2 to M1, leading to changes in hippocampal neural processes and impairments in spatial learning and memory. Understanding the interaction between the gut microbiota and microglia has important implications for the treatment of cognitive deterioration after chronic METH exposure.
MICROBIOLOGY SPECTRUM
(2023)
Article
Endocrinology & Metabolism
Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao
Summary: The results of the study suggest that isofraxidin can improve cognitive and memory impairments induced by scopolamine through multiple mechanisms, including regulating AChE activity, antioxidant stress, and inhibiting inflammatory response.
METABOLIC BRAIN DISEASE
(2022)
Article
Pharmacology & Pharmacy
Sayna Bagheri, Kamyar Moradi, Elnaz Ehghaghi, Abolfazl Badripour, Mohammad Keykhaei, Amir Ashraf-Ganjouei, Mana Moassefi, Shahriar Faghani, Ahmad Reza Dehpour
Summary: Chronic social isolation stress can impair learning and memory-related behaviors, while melatonin treatment can alleviate memory impairment by modulating the BDNF/TrkB/CREB signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Ding Quan Ng, Daniella Chan, Parisa Agrawal, Weian Zhao, Xiangmin Xu, Munjal Acharya, Alexandre Chan
Summary: This systematic review assessed the relationship between BDNF biomarkers and neurocognitive outcomes in cancer patients and survivors. The results suggest that BDNF is a potential monitoring biomarker and druggable target for CRCI.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Plant Sciences
Razvan Stefan Boiangiu, Eyup Bagci, Gabriela Dumitru, Lucian Hritcu, Elena Todirascu-Ciornea
Summary: This study investigates the protective effect of Angelica purpurascens essential oil (APO) on memory impairments induced by scopolamine in zebrafish. The results show that APO can restore cholinergic system function and improve brain antioxidant state, thereby alleviating the memory deficits.
Article
Plant Sciences
Jorelle Linda Kamda Damo, Razvan Stefan Boiangiu, Ion Brinza, Lea Blondelle Kenko Djoumessi, Roland Nhouma Rebe, Balbine Nkwingwa Kamleu, Simon Desire Nyayi Guedang, Guillaume Woumitna Camdi, Parfait Bouvourne, Eglantine Wado Keugong, Herve Herve Abaissou Ngatanko, Oana Cioanca, Monica Hancianu, Harquin Simplice Foyet, Lucian Hritcu
Summary: The present study investigated the potential benefits of Guiera senegalensis in improving scopolamine-induced memory impairment and brain oxidative stress in zebrafish. The results showed that Guiera senegalensis treatment reduced oxidative stress and acetylcholinesterase activity. These findings suggest that Guiera senegalensis could be a natural alternative treatment for cognitive disorders associated with Alzheimer's disease.
Article
Cell Biology
Larissa Daniele Bobermin, Fernanda Becker Weber, Tiago Marcon dos Santos, Adriane Bello-Klein, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: Sulforaphane, a natural compound, has anti-inflammatory and antioxidant properties. This study found that sulforaphane protects astroglial cells by inhibiting inflammation and oxidative stress, through modulation of multiple molecular mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Tiago Marcon dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, Andre Quincozes-Santos, Angela T. S. Wyse
Summary: The study revealed that mild hyperhomocysteinemia may lead to anxiety-like behavior and alterations in locomotion/exploration in rats. Glutamate uptake remained unchanged, but the activities of glutamine synthetase and ATPases were increased. Cell viability was not affected.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Larissa Daniele Bobermin, Romulo Rodrigo de Souza Almeida, Fernanda Becker Weber, Lara Scopel Medeiros, Livia Medeiros, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: The study showed that resveratrol can protect aged astrocytes from LPS-induced toxicity, reduce inflammatory response, and improve astroglial functions. The glioprotective effects of resveratrol on aged astrocytes may be associated with molecular mechanisms such as SIRT1, Nrf2, and HO-1.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Robson Coutinho Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: Supplementing with 4 mg/kg of folic acid during pregnancy can negatively affect the behavior and biochemical indicators of offspring.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Osmar Vieira Ramires Junior, Tiago Marcon dos Santos, Josiane Silva Silveira, Raissa Leite-Aguiar, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: This study evaluated the effects of mild hyperhomocysteinemia on behavior and neurochemical parameters in male rats, and investigated the therapeutic effects of ibuprofen and rivastigmine. The results showed that mild hyperhomocysteinemia caused cognitive deficits and impaired motor coordination, but treatment with ibuprofen and rivastigmine reduced these damages.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Fernanda Silva Ferreira, Tiago Marcon Dos Santos, Osmar Vieira Ramires Junior, Josiane Silva Silveira, Felipe Schmitz, Angela T. S. Wyse
Summary: Quinolinic acid (QUIN) is an important agonist of NMDA receptors that are found at high levels in cases of brain injury and neuroinflammation. This study found that coenzyme Q(10) (CoQ(10)) can mitigate the toxicity caused by QUIN in the brain, including reducing the generation of reactive oxygen species, alleviating oxidative stress, preserving the activity of antioxidant enzymes, maintaining glutathione levels, reducing protein and lipid damage, and preventing alterations in electron transport chain complex activity and ATP levels. CoQ(10) may be a promising therapeutic alternative for neuroprotection against QUIN neurotoxicity.
NEUROTOXICITY RESEARCH
(2022)
Article
Clinical Neurology
Luiza N. Foschiera, Felipe Schmitz, Angela T. S. Wyse
Summary: Methylphenidate (MPH) is effective in treating Attention Deficit Hyperactivity Disorder (ADHD), but its unrestricted use can have neurological and psychiatric consequences. Animal studies show that MPH alters brain energy homeostasis, induces oxidative stress, causes inflammation, and alters the apoptosis pathway. Age, treatment time, administration route, and dose are important factors that influence the effects of MPH.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Alessandra S. Rieder, Bruna F. Deniz, Carlos Alexandre Netto, Angela T. S. Wyse
Summary: Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, there has been a growing interest in using in silico approaches to identify potential therapeutic molecules for this disease. Molecular docking, a commonly used method, has been employed to find inhibitors for viral proteins of SARS-CoV-2, including the papain-like protease (PLpro). This systematic review focuses on in silico research of PLpro inhibitors and their potential therapeutic effects on COVID-19. Additionally, the neurological problems associated with COVID-19, particularly the similarities to neuroinflammation in Alzheimer's disease, are briefly discussed.
NEUROTOXICITY RESEARCH
(2022)
Article
Developmental Biology
Janaina Zang, Anna Clara Machado Colucci, Isadora D'Avila Tassinari, Ricardo Ribeiro Nunes, Mirella Kielek Galvan Andrade, Francielle Fernandes Spies, Maikel Rosa de Oliveira, Luz Elena Duran-Carabali, Paula Rigon, Carlos Alexandre Netto, Ana Helena Paz, Luciano Sturmer de Fraga
Summary: Currently, therapeutic hypothermia (TH) is the only treatment for hypoxia-ischemia (HI) in human babies. This study evaluated the short-term effects of TH on brain injury and behavioral outcomes in neonatal rats subjected to neonatal HI. The findings suggest that TH has a sex-dependent effect, with a reduction in brain injury only observed in males. These results highlight the importance of assessing sex differences in newborns with HI and developing sex-specific treatment strategies.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Marion Deon, Graziella Ribas, Robson Coutinho-Silva, Carmen Regla Vargas, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: This study investigated the effects of a high-protein diet consumed during pregnancy on neurobiochemistry and behavioral performance in the offspring. The results showed that maternal consumption of a high-protein diet led to increased levels of homocysteine and neuroinflammatory mediators in the offspring's cerebral cortex, as well as decreased histidine levels in their serum. It also resulted in impaired memory and motricity, and increased anxiety-like behavior in the offspring.
Correction
Endocrinology & Metabolism
Felipe Schmitz, Paula Pierozan, Helena Biasibetti-Brendler, Fernanda Silva Ferreira, Fernanda dos Santos Petry, Vera Maria Treis Trindade, Regina Pessoa-Pureur, Angela T. S. Wyse
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Rafael Teixeira Ribeiro, Andrey Vinicios Soares Carvalho, Rafael Palavro, Luz Elena Duran-Carabali, Angela Beatris Zemniacak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajner
Summary: L-2-Hydroxyglutaric aciduria (L-2-HGA) is a genetic disorder characterized by deficient activity of l-2-hydroxyglutarate dehydrogenase, leading to the accumulation of l-2-hydroxyglutaric acid (L-2-HG) in the brain and biological fluids. This results in neurological symptoms and brain abnormalities, particularly in the cerebral cortex, basal ganglia, and cerebellum. A study using neonatal rats showed that intracerebroventricular injection of L-2-HG caused oxidative stress in the cerebellum, leading to neuronal loss, demyelination, astrocyte reactivity, and increased inflammatory response in the cerebral cortex and striatum. L-2-HG administration also resulted in a delay in neuromotor development and cognitive deficits in adult animals, which were prevented by the antioxidant melatonin.
NEUROTOXICITY RESEARCH
(2023)
Editorial Material
Education, Scientific Disciplines
Natali Valim Oliver Bento-Torres, Joao Bento-Torres, Andrea Camaz Deslandes, Carlos Alexandre Netto, Luiz Fernando Freire Royes, Felipe Schuch, Ionara Rodrigues Siqueira, Pamela Billig Mello-Carpes
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Cell Biology
Julia Pramio, Mateus Grings, Amanda Gasparin da Rosa, Rafael Teixeira Ribeiro, Nicolas Manzke Glanzel, Marian Flores Signori, Manuela Bianchin Marcuzzo, Larissa Daniele Bobermin, Angela T. S. Wyse, Andre Quincozes-Santos, Moacir Wajner, Guilhian Leipnitz
Summary: Isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases characterized by the accumulation of toxic sulfite in the brain tissues, leading to neurological dysfunction and brain abnormalities in newborns. This study found that sulfite administration caused redox imbalance, mitochondrial dysfunction, and altered signaling proteins in the cerebral cortex of rat pups, which may contribute to the neuropathology of ISOD and MoCD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Lucas Ferreira Teixeira, Gustavo R. Krupp Prauchner, Darlan Gusso, Angela T. S. Wyse
Summary: Classic galactosemia is a rare inborn error of metabolism caused by gene variants leading to absent or misfolded enzyme, resulting in galactose metabolite accumulation and cell damage. Its symptoms vary and prevalence differs among populations. Dairy restriction is a common treatment, but recent studies suggest its reconsideration in certain cases. Further preclinical trials are needed to understand the disease and propose new treatments.
METABOLIC BRAIN DISEASE
(2023)
