Article
Biochemistry & Molecular Biology
Marco Rinaudo, Francesca Natale, Francesco La Greca, Matteo Spinelli, Antonella Farsetti, Fabiola Paciello, Salvatore Fusco, Claudio Grassi
Summary: This study found that male mice are more susceptible to memory loss induced by retroactive interference than females. Estrogen signaling involving estrogen receptor alpha activation in the dorsal hippocampus mediates the resistance of female mice to retroactive interference. Female mice showed higher phosphorylation levels of ERK1/2 in the hippocampus following retroactive interference. Inhibition of ERK1/2 made female mice more prone to retroactive interference.
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Endocrinology & Metabolism
Cheryl A. Frye, Vincent F. Lembo, Alicia A. Walf
Summary: The study found that progesterone can enhance cognitive performance in male mice by increasing allopregnanolone concentrations, BDNF levels, and GABA(A) activity. These effects may be independent of traditional progestin receptors' trophic actions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Laura C. Fox, Jamie L. Scholl, Geralyn M. Palmer, Gina L. Forster, Michael J. Watt
Summary: Mild traumatic brain injuries (mild TBIs) commonly occur in young adults in high-stress environments. Sex differences have been observed in the development of post-concussive anxiety and PTSD-like behaviors. Progesterone, which has neuroprotective properties, does not effectively prevent psychological symptoms associated with mild TBI in male and female rats. Overall, both sex and estrous cycle contribute to psychological outcomes following mild TBI, and sex steroids may play a role as a moderator rather than a treatment for these symptoms.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jolanta H. Kotlinska, Pawel Grochecki, Agnieszka Michalak, Anna Pankowska, Katarzyna Kochalska, Piotr Suder, Joanna Ner-Kluza, Dariusz Matosiuk, Marta Marszalek-Grabska
Summary: Repeated maternal separation has long-term effects on the neurophysiology of the rodent brain, specifically in the regions responsible for memory. These effects vary depending on the sex of the rats, and enhancing glutamate neurotransmission can improve memory deficits.
Article
Behavioral Sciences
Haiyan Zeng, Zijia Yu, Qingjun Huang, Haiyun Xu
Summary: This study identified attachment insecurity behaviors in rats subjected to maternal separation and early weaning, and found significant gender differences in their performances in open-field, social interaction, and elevated-plus maze tests.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
Summary: The hippocampal formation is vulnerable to normal aging, and Long-Evans rats serve as a valuable model to study aging. This study found individual differences in spatial navigation and episodic-like memory abilities in aged rats, similar to age-related cognitive decline observed in humans. These findings suggest that aged Long-Evans rats can be used to explore the changes in cognitive function during aging.
Article
Behavioral Sciences
Martina Canatelli-Mallat, Priscila Chiavellini, Marianne Lehmann, Rodolfo Gustavo Goya, Gustavo Ramon Morel
Summary: Ageing is associated with impaired recognition memory. This study aimed to evaluate the ability of female rats at different ages to retain long-term recognition memory. The results showed that spatial discrimination capacity could be affected earlier than feature discrimination capacity. Furthermore, neurogenesis depletion in the Dentate Gyrus and microglial disruption in the perirhinal cortex were associated with memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Behavioral Sciences
Marta Mendez-Couz, Denise Manahan-Vaughan, Ana Paula Silva, Hector Gonzalez-Pardo, Jorge Luis Arias, Nelida Maria Conejo
Summary: The neuropeptide Y2 receptors play a significant role in hippocampus-dependent spatial memory, with receptor expression dynamically regulated by learning experiences. Antagonism of the receptors in the dorsal intrahippocampal area improves spatial reference memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Claudia Barth, Stener Nerland, Kjetil N. Jorgensen, Beathe Haatveit, Laura A. Wortinger, Ingrid Melle, Unn K. Haukvik, Torill Ueland, Ole A. Andreassen, Ingrid Agartz
Summary: This study examined sex and diagnostic group differences in hippocampal subfield volumes in individuals with schizophrenia spectrum disorder, bipolar disorders, and healthy controls. The results showed a larger volumetric deficit in male patients compared to female patients when compared with same-sex controls. There were no significant sex differences in the associations between hippocampal volumes and clinical or cognitive measures in schizophrenia and bipolar disorder.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Joel G. Hashimoto, Mo L. Singer, Calla M. Goeke, Fuming Zhang, Yuefan Song, Ke Xia, Robert J. Linhardt, Marina Guizzetti
Summary: This study investigated the effects of a neonatal handling protocol on dendritic arborization and glycosaminoglycan (GAG) levels in the developing brain. Sex differences were found in both dendritic arborization and HS-GAG levels, with an increase observed in females but not males. Additionally, neonatal handling led to changes in GAG levels in the hippocampus in both males and females, indicating a similar stress response in both sexes.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Computer Science, Artificial Intelligence
S. H. Shabbeer Basha, Sravan Kumar Vinakota, Shiv Ram Dubey, Viswanath Pulabaigari, Snehasis Mukherjee
Summary: The proposed AutoFCL model automatically learns the structure of FC layers of a CNN using Bayesian Optimization, achieving good performance in image classification tasks, particularly outperforming existing methods on CalTech-101 and Oxford-102 Flowers datasets.
NEURAL COMPUTING & APPLICATIONS
(2021)
Article
Physiology
Caitlin S. Mitchell, Elisabeth K. Goodman, Caitlin R. Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P. Begg
Summary: This study investigated the effect of disrupted insulin signaling in NPY neurons on diet-induced deficits in hippocampal-dependent memory. The results showed that obesogenic diets can lead to hippocampal insulin resistance and impairments to hippocampal-dependent cognition. However, chronic sucrose intake did not have adverse effects on metabolic outcomes or hippocampal-dependent memory. These findings suggest that the effects of high-fat diet on hippocampal-dependent memory may depend on insulin signaling in hippocampal NPY cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Steve Mabry, E. Nicole Wilson, Jessica L. Bradshaw, Jennifer J. Gardner, Oluwadarasimi Fadeyibi, Edward Vera Jr, Oluwatobiloba Osikoya, Spencer C. Cushen, Dimitrios Karamichos, Styliani Goulopoulou, Rebecca L. Cunningham
Summary: Gestational sleep apnea may lead to social and cognitive impairments in offspring, and these effects may be modified by sex and age.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Veterinary Sciences
Chad W. Schmiedt, Robert M. Gogal, Stephen B. Harvey, Amanda K. Torres, Carla L. Jarrett, Elizabeth W. Uhl, David J. Hurley
COMPARATIVE MEDICINE
(2011)