Article
Behavioral Sciences
B. K. B. Murthy, S. Somatakis, A. F. Ulivi, H. Klimmt, T. P. Castello-Waldow, N. Haynes, R. E. Huettl, A. Chen, Alessio Attardo
Summary: Subpopulations of neurons with increased activity during memory encoding are considered as cellular engrams. Correlated synaptic activity between these engram neurons is thought to strengthen their connections, increasing the likelihood of recalling neural activity patterns. Labeling synaptic engrams using a transsynaptic GFP reconstitution system can highlight the synaptic connections between engram neurons.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Anne Albrecht, Elisa Redavide, Stav Regev-Tsur, Oliver Stork, Gal Richter-Levin
Summary: Studies show that the hippocampal formation plays a crucial role in cognition, emotion, and adaptation to stressful events. Different types of inhibitory interneurons in the hippocampus have distinct roles in anxiety, fear, and stress adaptation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Nicholas A. Heroux, Colin J. Horgan, Mark E. Stanton
Summary: The CPFE is a variant of contextual fear conditioning where prefrontal inactivation disrupts retention test freezing in adolescent rats, and the mPFC shows robust learning-related gene expression during immediate-shock training. NMDA receptor plasticity in the prefrontal cortex is important for the acquisition and/or consolidation of incidental context learning, but not required for context retrieval or acquisition of a context-shock association during immediate-shock training in the CPFE.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Tao Bai, Lijie Zhan, Na Zhang, Feikai Lin, Dieter Saur, Chun Xu
Summary: Temporal associative learning binds discontiguous conditional stimuli (CSs) and unconditional stimuli (USs) by maintaining CS information in the hippocampus after its offset. This study investigates how learning regulates the maintenance of CS information in hippocampal circuits during auditory trace fear conditioning (TFC) paradigm. Results show that plasticity in stimulus information maintenance occurs in the CA1 area during learning, while CS and US memories are primarily stored in the CA1 area.
Article
Neurosciences
Xiaoxiao Lin, Neeyaz Cyrus, Brenda Avila, Todd C. Holmes, Xiangmin Xu
Summary: Traditionally, hippocampal CA3 is thought to be part of a unidirectional feedforward trisynaptic pathway. However, recent studies using genomic and viral tracing techniques have revealed that the anatomical connectivity of CA3 and the trisynaptic pathway is more complex than expected, with cell type-specific input gradients throughout the hippocampal structure. These studies also identified noncanonical circuit connections between CA3 inhibitory neurons and ventral CA1, subiculum complex, and other brain regions, suggesting a more intricate network than previously thought. Understanding these novel connections provides a basis for further investigating the function of CA3 inhibitory neurons.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Anabel M. M. Miguelez Fernandez, Hanna M. Molla, Daniel R. Thomases, Kuei Y. Tseng
Summary: The study shows that disruption of prefrontal cortex (PFC) alpha 7nAChR signaling impacts hippocampal and amygdalar transmission, with significant effects observed in adult rats. Prefrontal infusion of MLA affects trace fear-conditioning and extinction in an age-dependent manner, potentially due to the late-adolescent maturation of ventral hippocampal-PFC functional connectivity and its modulation by alpha 7nAChR signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Olivia A. Shipton, Clara S. Tang, Ole Paulsen, Mariana Vargas-Caballero
Summary: The study shows that both A beta and tau protein play a role in the development of Alzheimer's disease. A beta affects synaptic deficits in wild-type mice, but not in mice without tau protein. Additionally, CA3-CA1 synapses in the hippocampus with presynaptic axons from the left CA3 are more vulnerable to A beta.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Seung-Woo Jin, Inah Lee
Summary: The study found that in goal-directed tasks, the intermediate region of the hippocampus plays a key role in representing changes in the motivational significance of a place, especially when the motivational significance decreases, place cells remap and dynamically shift towards high-value locations.
Review
Behavioral Sciences
Ilgang Hong, Bong-Kiun Kaang
Summary: The hippocampus, especially the ventral CA1 (vCA1) region, plays a significant role in emotional behaviors. With the help of latest technologies, researchers are able to study the specific neural circuit and complex connectivity of the ventral hippocampus in-depth.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Behavioral Sciences
L. R. Seemiller, T. J. Gould
Summary: Genetic background plays a role in determining the effect of ethanol and MK-801 on learning outcomes, with adult mice and male adolescents being more susceptible to ethanol, while MK-801 has a greater impact on contextual learning. Additionally, age, sex, and genetic background interact to influence learning impairments after exposure to ethanol or MK-801.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Jalina Graham, Alexa F. D'Ambra, Se Jung Jung, Yusuke Teratani-Ota, Nina Vishwakarma, Rasika Venkatesh, Abhijna Parigi, Evan G. Antzoulatos, Diasynou Fioravante, Brian J. Wiltgen
Summary: The hippocampus can be divided into distinct segments with unique contributions to learning and memory; while the dorsal segment supports cognitive processes like spatial learning and navigation, the ventral regulates emotional behaviors related to fear, anxiety, and reward. CA1 neurons in both segments appear to make similar contributions to context fear conditioning, despite some differences in response patterns.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Brunno Rocha Levone, John F. Cryan, Olivia F. O'Leary
Summary: Studies have shown that different sub-regions of the hippocampus play distinct roles in stress responses, with the intermediate hippocampus playing a predominant role in stress-induced social avoidance, and the ventral sub-region having a predominant role in active coping behaviors and antidepressant-like behavior.
Editorial Material
Biochemistry & Molecular Biology
Kaue Machado Costa, Geoffrey Schoenbaum
Summary: Hippocampal place cells represent spatial locations, and a recent study shows that place cells in the intermediate hippocampus remap their fields following changes in reward, shedding light on how they incorporate associations between locations and specific outcomes.
Article
Neurosciences
Xin Li, Zhuo-Jun Du, Jun-Nan Xu, Zhi-Man Liang, Song Lin, Hao Chen, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: Pharmacological manipulation of mGluR5 suggests its involvement in anxiety disorders, but the mechanism behind its role in stress-induced anxiety-like behavior is unclear. This study found that chronic restraint stress and mGluR5 knockdown lead to anxiety-like behavior and impaired inhibitory synaptic inputs in hippocampal CA1 pyramidal neurons. However, positive allosteric modulator of mGluR5 can rescue anxiety-like behavior and restore inhibitory synaptic inputs. These findings highlight the essential role of mGluR5 in mediating stress-induced anxiety-like behavior in hippocampal CA1 pyramidal neurons.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Julia A. Scott, Naomi Goodrich-Hunsaker, Kristopher Kalish, Aaron Lee, Michael R. Hunsaker, Cynthia M. Schumann, Owen T. Carmichael, Tony J. Simon
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2016)
Article
Behavioral Sciences
Michael R. Hunsaker, Genevieve K. Smith, Raymond P. Kesner
JOURNAL OF COMPARATIVE PSYCHOLOGY
(2017)
Article
Neurosciences
Erik W. Schluter, Michael R. Hunsaker, Claudia M. Greco, Rob Willemsen, Robert F. Berman
Article
Clinical Neurology
Robert F. Berman, Karl D. Murray, Gloria Arque, Michael R. Hunsaker, H. Juergen Wenzel
Article
Behavioral Sciences
F. Tassone, C. M. Greco, M. R. Hunsaker, A. L. Seritan, R. F. Berman, L. W. Gane, S. Jacquemont, K. Basuta, L. -W. Jin, P. J. Hagerman, R. J. Hagerman
GENES BRAIN AND BEHAVIOR
(2012)
Article
Neurosciences
Michael R. Hunsaker, Kyoungmi Kim, Rob Willemsen, Robert F. Berman
Article
Neurosciences
Michael R. Hunsaker, Victoria Chen, Giang T. Tran, Raymond P. Kesner
Article
Neurosciences
Michael R. Hunsaker, Julia A. Scott, Melissa D. Bauman, Cynthia M. Schumann, David G. Amaral
Article
Critical Care Medicine
Gene G. Gurkoff, Jennifer D. Gahan, Rahil T. Ghiasvand, Michael R. Hunsaker, Ken Van, Jun-feng Feng, Kiarash Shahlaie, Robert F. Berman, Bruce G. Lyeth, Michael M. Folkerts
JOURNAL OF NEUROTRAUMA
(2013)
Article
Behavioral Sciences
Amanda A. Diep, Michael R. Hunsaker, Richard Kwock, Kyoungmi Kim, Rob Willemsen, Robert F. Berman
NEUROBIOLOGY OF LEARNING AND MEMORY
(2012)
Article
Behavioral Sciences
Ramona E. von Leden, Lindsey C. Curley, Gian D. Greenberg, Michael R. Hunsaker, Rob Willemsen, Robert F. Berman
NEUROBIOLOGY OF LEARNING AND MEMORY
(2014)
Review
Behavioral Sciences
Michael R. Hunsaker, Raymond P. Kesner
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2013)
Article
Multidisciplinary Sciences
Michael R. Hunsaker, David G. Amaral
Review
Neurosciences
Michael R. Hunsaker
PROGRESS IN NEUROBIOLOGY
(2012)
Article
Neurosciences
Dalyir I. Pretto, Michael R. Hunsaker, Christopher L. Cunningham, Claudia M. Greco, Randi J. Hagerman, Stephen C. Noctor, Deborah A. Hall, Paul J. Hagerman, Flora Tassone
TRANSLATIONAL NEURODEGENERATION
(2013)