Article
Clinical Neurology
Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Muhlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth Francois, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rueber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Summary: Neuronal dysfunction caused by iron accumulation and reactive oxygen species may play a significant role in the epileptogenic process, while alterations in iron metabolism in the epileptic brain have not been extensively studied. Through clinical and animal experiments, as well as in vitro cell culture, the study revealed the mechanisms of iron in epilepsy pathology and antioxidant metabolism.
ACTA NEUROPATHOLOGICA
(2021)
Article
Endocrinology & Metabolism
Rick H. G. J. van Lanen, Roel H. L. Haeren, Julie Staals, Jim T. A. Dings, Olaf E. M. G. Schijns, Govert Hoogland, Sander M. J. van Kuijk, Dimitris Kapsokalyvas, Marc A. M. J. van Zandvoort, Hans Vink, Kim Rijkers
Summary: This study investigated the association between blood-brain barrier dysfunction, microvascular alterations and temporal lobe epilepsy. The results showed impaired neurovascular coupling mechanisms and reduced glycocalyx integrity in patients with drug-resistant TLE. These findings may provide new therapeutic targets for drug-resistant epilepsy.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Behavioral Sciences
Marco de Curtis, Andrea O. Rossetti, Diogo Vila Verde, Erwin A. van Vliet, Christine T. Ekdahl
Summary: Status Epilepticus (SE) is a neurological emergency characterized by abnormally sustained seizures, which can result in long-term consequences for the brain. However, the specific effects of different types of SE on brain pathology and long-term deficits in patients are still not clearly understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Anna Maria Costa, Mohammad Gol, Chiara Lucchi, Giuseppe Biagini
Summary: This study found that increasing the levels of the anticonvulsant neurosteroid allopregnanolone may delay the development of epileptic seizures. By using the inhibitor trilostane to increase allopregnanolone levels, researchers observed a delay in seizure onset in rats. These findings have important implications for the development of new treatment methods.
Article
Medicine, Research & Experimental
Kewei Liu, Juan Zhu, Yuan Chang, Zhenzhou Lin, Zhu Shi, Xing Li, Xing Chen, Chuman Lin, Suyue Pan, Kaibin Huang
Summary: The study suggests that post-seizure cerebral edema may impair glymphatic system function, making the brain vulnerable to p-tau aggregation and neurocognitive impairment.
Article
Clinical Neurology
Silvana Sarria-Estrada, Estevo Santamarina, Manuel Quintana, Deborah Pareto, Maria Sueiras, Cristina Auger, Manuel Toledo, Alex Rovira
Summary: This study analyzed MRI features in patients with status epilepticus (SE), finding abnormalities in over half of the patients. Longer SE duration and the presence of lateralized periodic discharges (LPDs) on EEG were associated with SE-related MRI abnormalities and the development of mesial temporal sclerosis (MTS).
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Genetics & Heredity
Yishu Wang, Jing Peng, Shuwei Bai, Haojun Yu, Hong He, Chunxiang Fan, Yong Hao, Yangtai Guan
Summary: Temporal lobe epilepsy (TLE), the most common form of refractory epilepsy in adults, may require surgery to alleviate seizures. Research suggests that a mutation in the PIK3R2 gene may play a significant role in the development of TLE.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Chengru Song, Xiaonan Zhang, Shaoqiang Han, Keran Ma, Kefan Wang, Xinyue Mao, Yajun Lian, Xianchang Zhang, Jinxia Zhu, Yong Zhang, Jingliang Cheng
Summary: This study comprehensively explored the potential brain activity abnormalities affected by temporal lobe epilepsy (TLE) and found significant differences in several brain regions between TLE patients and healthy volunteers. These abnormalities were associated with cognitive impairment and correlated with epilepsy duration and cognitive scale scores.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ayushe A. Sharma, Rodolphe Nenert, Adam Goodman, Jerzy P. Szaflarski
Summary: This study investigated abnormal brain temperature elevations (T-CRE) in patients with temporal lobe epilepsy (TLE) and found spatial concordance between T-CRE and edema, supporting the use of brain thermometry as a biomarker for identifying seizure-producing tissue.
Review
Clinical Neurology
J. Y. Zeng, X. Q. Hu, J. F. Xu, W. J. Zhu, H. Y. Wu, F. J. Dong
Summary: Arterial spin-labeling shows moderate accuracy in localizing epileptic foci, with relatively low specificity. Blood perfusion changes may be closely related to seizure time and patterns, suggesting potential for assessing and monitoring epilepsy postoperatively.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Fatemeh Fadaie, Hyo M. Lee, Benoit Caldairou, Ravnoor S. Gill, Viviane Sziklas, Joelle Crane, Boris C. Bernhardt, Seok-Jun Hong, Andrea Bernasconi, Neda Bernasconi
Summary: The study revealed bidirectional disruptions of sensory-paralimbic functional organization in TLE patients, which might contribute to cognitive impairments in multiple domains. Associations with paralimbic microstructure and sensorimotor atrophy suggest that system-level imbalance likely reflects complementary structural processes, ultimately leading to a broad spectrum of cognitive impairments.
Article
Medicine, General & Internal
Song Lu, Min Chu, Xian Wang, Yating Wu, Yue Hou, Aihua Liu
Summary: This study evaluated changes in cognitive function, mood status, and quality of life in patients who underwent anterior temporal lobectomy. The results showed that the surgery significantly reduced epileptiform discharges, improved anxiety and depression symptoms, and enhanced quality of life without causing significant changes in cognitive function.
CHINESE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Fengjun Zhu, Hanwen Wang, Lin Li, Anatol Bragin, Dezhi Cao, Yuan Cheng
Summary: This study tested the feasibility and reliability of intracranial electrophysiological recordings in a pig model of acute status epilepticus. The results showed that the model successfully induced status epilepticus and the high-frequency oscillations (HFOs) rate was a sensitive and reliable measurement. This model is of great significance for studying the mechanisms of epileptogenesis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Veterinary Sciences
Patrick Roynard, Ann Bilderback, Curtis Wells Dewey
Summary: Ketamine 5 mg/kg IV bolus may be successful in treating RSE in dogs, but its efficacy in handling CS is limited. The incidence of adverse effects is low, but timing of administration should be carefully considered.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Pavel Yanev, Geralda A. F. van Tilborg, Annette van der Toorn, Xiangmei Kong, Ann M. Stowe, Rick M. Dijkhuizen
Summary: In this study, a slow-releasing hydrogel loaded with pro-angiogenic factors was injected into the stroke lesion of rats to promote recovery. The hydrogel showed prolonged release of the factors and resulted in significant sensorimotor recovery and increased vascularization in the perilesional cortex. This method supports brain tissue regeneration and functional recovery in the chronic phase post-stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Clinical Neurology
Aladdin Taha, Joaquim Bobi, Ruben Dammers, Rick M. Dijkhuizen, Antje Y. Dreyer, Adriaan C. G. M. van Es, Fabienne Ferrara, Matthew J. Gounis, Bjoern Nitzsche, Simon Platt, Michael H. Stoffel, Victor Volovici, Gregory J. del Zoppo, Dirk J. Duncker, Diederik W. J. Dippel, Johannes Boltze, Heleen M. M. van Beusekom
Summary: Translation of acute ischemic stroke research to the clinical setting remains limited, with only one drug successfully completing the path from experimental study to clinical practice. Large gyrencephalic animal models, such as dogs, swine, sheep, and nonhuman primates, have been recommended to improve the selection of experimental treatments before testing in clinical studies. This review discusses the characteristics of these animal models and aims to facilitate the selection of appropriate models for studying acute ischemic stroke.
Review
Clinical Neurology
Erwin A. van Vliet, Nicola Marchi
Summary: The neurovascular unit (NVU) is a complex network involving different cells in the brain, including specialized brain endothelium, glial and mural cells, and neurons. Research suggests that dysfunction of the NVU is a common mechanism underlying late-onset seizures or epilepsy, neurological and neurodegenerative disorders associated with aging. Further studies also indicate that seizure activity may contribute to brain aging by causing regional NVU dysfunction, while cerebrovascular pathology may be linked to comorbidities. Diagnostic approaches tailored to seizure conditions in the elderly and disease-modifying strategies focusing on NVU restoration and control of inflammation are being explored. However, there are still knowledge gaps and clinical challenges in understanding seizure onset and conditions in an aging population.
Article
Clinical Neurology
Cato M. Drion, Lieneke Kooijman, Derek Chan, Janna Berkhout, Erwin A. van Vliet, Wytse J. Wadman, Jan A. Gorter
Summary: The study found that curcumin can delay the development of epilepsy, but cannot prevent full kindling. The effects of curcumin on neuropathology were not significant, highlighting the need for further research into its potential as an anti-epileptic agent.
Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Arister N. J. Yew, Marijn Schraagen, Willem M. M. Otte, Eric van Diessen
Summary: Despite advancements in ancillary investigations for epilepsy care, patient narratives remain crucial for diagnosis and treatment monitoring. However, these narratives are often stored in an unstructured manner, hindering their complete utilization in clinical decision-making. To address this, researchers have turned to natural language processing (NLP), a branch of artificial intelligence, to extract meaningful information from free-text clinical records. This systematic review provides an overview of current NLP applications in epilepsy and discusses the challenges and opportunities for its future use in improving patient care and research outcomes.
Article
Health Care Sciences & Services
Johanna A. Damen, Pauline Heus, Herm J. Lamberink, Joeri K. Tijdink, Lex Bouter, Paul Glasziou, David Moher, Willem M. Otte, Christiaan H. Vinkers, Lotty Hooft
Summary: This study explores indicators of questionable research practices in randomized controlled trials, including bias risk, selective reporting bias, sample size, and statistical discrepancy. The findings suggest that more recent publication year, trial registration, mentioning of reporting standards, and higher journal impact factor are associated with a lower risk of questionable research practices.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Clinical Neurology
Noa van der Knaap, Bart A. A. Franx, Charles B. L. M. Majoie, Aad van der Lugt, Rick M. Dijkhuizen
Summary: The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel. However, successful recanalization does not always result in favorable clinical outcome. Post-recanalization perfusion deficits (PRPDs), constituted by cerebral hypo- or hyperperfusion, may contribute to lagging patient recovery rates, but its clinical significance remains unclear.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Samuel W. Terman, Renate van Griethuysen, Carole E. Rheaume, Geertruida Slinger, Anisa S. Haque, Shawna N. Smith, Wesley T. Kerr, Charlotte van Asch, Willem M. Otte, Carolina Ferreira-Atuesta, Marian Galovic, James F. Burke, Kees P. J. Braun
Summary: This study evaluated the ability of neurologists to predict the risk of seizure recurrence after antiseizure medication withdrawal in well-controlled epilepsy. It also examined the barriers and influences of using risk calculation tools. The results showed a moderate correlation between clinician predictions and calculated predictions, but there was wide variation in clinician predictions. Calculated predictions had an impact on the clinicians' recommendations, particularly for cases without epileptiform abnormalities, leading to a more cautious approach. The main barrier to using risk calculation tools was doubting their accuracy.
Review
Clinical Neurology
Samuel W. W. Terman, Geertruida Slinger, Adriana Koek, Jeremy Skvarce, Mellanie V. V. Springer, Julie M. M. Ziobro, James F. F. Burke, Willem M. M. Otte, Roland D. D. Thijs, Kees P. J. Braun
Summary: Only about half of patients with epilepsy who have been seizure-free for a long time have discussions about discontinuing antiseizure medication. Discontinuation is still relatively rare, even for low-risk patients. Future research should explore the barriers and facilitators of counseling and discontinuation attempts.
Article
Biochemistry & Molecular Biology
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkanen
Summary: Traumatic brain injury (TBI) is responsible for a significant percentage of structural and all epilepsies, but there is currently a lack of prognostic biomarkers for post-traumatic epilepsy (PTE). This study investigated the potential of plasma microRNAs (miRNAs) as biomarkers for brain damage severity and the development of PTE. The results showed that acutely altered plasma miRNA levels could reflect the extent of cortical injury, but they were not able to predict PTE development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jord J. T. Vink, Eline C. C. van Lieshout, Willem M. M. Otte, Ruben P. A. van Eijk, Mirjam Kouwenhoven, Sebastiaan F. W. Neggers, H. Bart van der Worp, Johanna M. A. Visser-Meily, Rick M. M. Dijkhuizen
Summary: Inhibitory repetitive transcranial magnetic stimulation treatment started within 3 weeks after stroke onset promotes upper limb motor recovery, reduces disability and dependence, and leads to earlier discharge from the rehabilitation center.
Article
Endocrinology & Metabolism
Bart A. A. Franx, Geralda A. F. Van Tilborg, Aladdin Taha, Joaquim Bobi, Annette Van der Toorn, Caroline L. Van Heijningen, Heleen M. M. Van Beusekom, Ona Wu, Rick M. Dijkhuizen, CONTRAST Consortium
Summary: In this study, we investigated the effects of recanalization on disease outcome after experimental cerebral ischemia-reperfusion. We found that recanalization resulted in acute-to-subacute lesion volume reductions, particularly in females. Post-ischemic hyperperfusion developed differently in males and females, and had varying effects on disease outcome, depending on the perfusion parameter used.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Education & Educational Research
Damien S. Fleur, Max Marshall, Miguel Pieters, Natasa Brouwer, Gerrit Oomens, Angelos Konstantinidis, Koos Winnips, Sylvia Moes, Wouter van den Bos, Bert Bredeweg, Erwin A. van Vliet
Summary: Personalized peer-comparison feedback can be used to improve self-regulated learning and academic achievement. Providing meaningful feedback and peer comparison through a learning analytics dashboard offers a solution.
JOURNAL OF LEARNING ANALYTICS
(2023)
Article
Clinical Neurology
Samuel W. Terman, Geertruida Slinger, Adriana Koek, Jeremy Skvarce, Mellanie V. Springer, Julie M. Ziobro, James F. Burke, Willem M. Otte, Roland D. Thijs, Morten I. Lossius, Anthony G. Marson, Laura J. Bonnett, Kees P. J. Braun
Summary: This study evaluated the influence of antiseizure medication discontinuation on seizure risk and found that there are variations in the increase of risk among different patients. Based on the results, decisions should be made based on individualized risk calculation and understanding of patient preferences.
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)