期刊
NEUROBIOLOGY OF DISEASE
卷 53, 期 -, 页码 36-48出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2012.11.013
关键词
Schizophrenia; Interneurons; Cortex; Inhibition; GABA; NMDA; Gamma oscillations; Parvalbumin; Somatostatin; Neuregulin
资金
- [R01 MH066912]
- [K02 MH070031]
GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of cortical function. The diverse types of cINs are classified into subgroups according to their morphology, intrinsic physiology, neurochemical markers and synaptic targeting. Recent advances in mouse genetics, imaging and electrophysiology techniques have greatly advanced our efforts to understand the role of normal cIN function and its dysfunction in neuropsychiatric disorders. In schizophrenia (SCZ), a wealth of data suggests that cIN function is perturbed, and that interneuron dysfunction may underlie key symptoms of the disease. In this review, we discuss the link between cINs and SCZ, focusing on the evidence for GABAergic signaling deficits from both SCZ patients and mouse models. (C) 2013 Elsevier Inc. All rights reserved.
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