Review
Clinical Neurology
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen
Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Mahsa Motavaf, Xianhua Piao
Summary: Perinatal white matter injury is common in premature infants and can lead to lifelong neurological deficits. The immaturity of oligodendrocytes and failure of myelination are the key factors in the etiology of this condition. Currently, there are no clinical treatment options available, leading to increased interest in cell transplantation and promoting endogenous oligodendrocyte function as potential therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Zhou Zhou, Xiaogai Li, Yuzhe Liu, Madelen Fahlstedt, Marios Georgiadis, Xianghao Zhan, Samuel J. Raymond, Gerald Grant, Svein Kleiven, David Camarillo, Michael Zeineh
Summary: Finite element models of the human head are valuable tools for exploring the mechanobiological pathway of external loading, localized brain response, and injury risks. New tract-related strains proposed in this study show superior performance in predicting brain injury compared to traditional strain indicators. This comprehensive quantification of WM tract-related deformation may improve the computational predictability of brain injury.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Cell Biology
Yuexian Cui, Xuelian Jin, Jun Young Choi, Byung Gon Kim
Summary: Subcortical ischemic white matter injury (SIWMI) is a common cause of cognitive decline in the elderly, but the degeneration process of various white matter components in response to chronic ischemia is not fully understood. Different types of animal models exist, including chemically induced, vascular occlusive, and models with comorbid vascular risk factors.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Li, George Fadoul, Milos Ikonomovic, Tuo Yang, Feng Zhang
Summary: The activation of Nrf2 reduces neuronal loss, white matter injury, and neurobehavioral deficits in a mouse model of PSCI. The Nrf2 activator, sulforaphane, improved long-term sensorimotor and cognitive deficits after ischemic stroke in wildtype mice. This neuroprotective effect was dependent on Nrf2 activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Guillaume Sarfati, Ananyo Maitra, Raphael Voituriez, Jean-Christophe Galas, Andre Estevez-Torres
Summary: This study observed four instabilities in an active gel and found that they are controlled by the concentrations of ATP and depletion agent. The results show that as the ATP concentration decreases, the gel undergoes a gelation transition, and buckling is selected against bending while global contraction is favored over local ones.
Article
Neurosciences
Margaret A. Hamner, Ashley McDonough, Davin C. Gong, Levi J. Todd, German Rojas, Sibylle Hodecker, Christopher B. Ransom, Thomas A. Reh, Bruce R. Ransom, Jonathan R. Weinstein
Summary: Ischemic preconditioning (IPC) is a phenomenon where exposure to non-injurious ischemia enhances tolerance to subsequent ischemic challenges. In a study testing the hypothesis that microglia are necessary for IPC in white matter (WM), researchers found that depletion of microglia eliminated IPC-mediated protection, highlighting the critical role of preconditioned microglia in WM IPC.
Article
Clinical Neurology
Juho Dahl, Olli Tenovuo, Jussi P. Posti, Jussi Hirvonen, Ari J. Katila, Janek Frantzen, Henna-Riikka Maanpaa, Riikka Takala, Eliisa Loyttyniemi, Jussi Tallus, Virginia Newcombe, David K. Menon, Peter J. Hutchinson, Mehrbod Mohammadian
Summary: Cerebral microbleeds are associated with the clinical severity of traumatic brain injury but have a weaker association with white matter integrity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Chiara Maffei, Natalie Gilmore, Samuel B. Snider, Andrea S. Foulkes, Yelena G. Bodien, Anastasia Yendiki, Brian L. Edlow
Summary: New techniques are needed to assess white matter integrity in individual patients with traumatic brain injury (TBI). Diffusion MRI tractography has been used to quantify white matter microstructure, but it is not commonly used in clinical settings due to the presence of focal lesions. In this study, we propose an automated tractography pipeline that successfully detected and quantified TAI in patients with acute severe TBI.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Ryo Ueda, Hiroyoshi Hara, Junichi Hata, Atsushi Senoo
Summary: This study aimed to clarify the characteristics of white matter tract degeneration in patients with diffuse axonal injury (DAI) and mild traumatic brain injury (MTBI) using automated tractography. Both DAI and MTBI were found to exhibit axonal degeneration in a scattered manner. DAI patients showed more pronounced axonal degeneration in the ampulla of the corpus callosum compared to MTBI patients, and the two conditions could be accurately distinguished using DTI.
Article
Engineering, Biomedical
Mohit Agarwal, Parameshwaran Pasupathy, Assimina A. Pelegri
Summary: A novel finite element model is developed to study the mechanical response of axons under non-affine kinematic conditions. The results suggest that oligodendrocytes play an important role in determining axonal stiffness and stress distribution.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Clinical Neurology
A. W. van der Eerden, T. L. van den Heuvel, V. Perlbarg, P. Vart, P. E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing, B. M. Goraj
Summary: In patients with moderate to severe traumatic brain injury, microbleed concentration in the subacute phase is associated with the integrity of normal-appearing white matter in the chronic phase. DTI findings reflect white matter integrity in the chronic phase, but interpretation in the subacute phase is more complex. SWI evaluation for microbleeds is straightforward in both phases.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Neurosciences
Qing Lin, Ling Lin, Li Li, Yu-fen Zheng, Ding-wang Hu, Geng Zhang
Summary: Selective vulnerability of oligodendrocytes is closely related to white matter injury in premature infants. This study revealed the long-term dynamic effect of endogenous oligodendrogenesis after hypoxic-ischemic white matter injury, with the proliferation of oligodendrocyte precursor cells inhibited from postoperative day 3 to 14, which may be a potential target for early intervention.
Article
Clinical Neurology
Pietro Maggi, Jens Kuhle, Sabine Schadelin, Franziska van der Meer, Matthias Weigel, Riccardo Galbusera, Amandine Mathias, Po-Jui Lu, Reza Rahmanzadeh, Pascal Benkert, Francesco La Rosa, Meritxell Bach Cuadra, Pascal Sati, Marie Theaudin, Caroline Pot, Vincent van Pesch, David Leppert, Christine Stadelmann, Ludwig Kappos, Renaud Du Pasquier, Daniel S. Reich, Martina Absinta, Cristina Granziera
Summary: Chronic white matter inflammation was found to be associated with elevated levels of sNfL and increased disease severity.
Article
Cell Biology
Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhang
Summary: Ischemic stroke leads to white matter damage and neurological deficits. In this study, the characteristics of white matter injury and repair after stroke were investigated using a mouse stroke model. The researchers found that white matter damage was most severe on Day 7 after the stroke, and gradually recovered from Day 7 to Day 30. They also discovered that CD11c(+) microglia play critical roles in white matter repair and functional recovery after stroke. These findings suggest that spontaneous white matter repair occurs after ischemic stroke, with CD11c(+) microglia being key players in this restorative process.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Amanda Dirickson, Sonja E. Stutzman, Mark J. Alberts, Roberta L. Novakovic, Ann M. Stowe, Claudia C. Beal, Mark P. Goldberg, DaiWai M. Olson
JOURNAL OF NEUROSCIENCE NURSING
(2017)
Article
Cell Biology
Meifan Chen, Cedric G. Geoffroy, Jessica M. Meves, Aarti Narang, Yunbo Li, Mallorie T. Nguyen, Vung S. Khai, Xiangmei Kong, Christopher L. Steinke, Krislyn I. Carolino, Lucie Elziere, Mark P. Goldberg, Yishi Jin, Binhai Zheng
Article
Biology
Patrick D. Ganzer, Michael J. Darrow, Eric C. Meyers, Bleyda R. Solorzano, Andrea D. Ruiz, Nicole M. Robertson, Katherine S. Adcock, Justin T. James, Han S. Jeong, April M. Becker, Mark P. Goldberg, David T. Pruitt, Seth A. Hays, Michael P. Kilgard, Robert L. Rennaker
Article
Neurosciences
Katherine Poinsatte, Dene Betz, Vanessa O. Torres, Apoorva D. Ajay, Shazia Mirza, Uma M. Selvaraj, Erik J. Plautz, Xiangmei Kong, Sankalp Gokhale, Julian P. Meeks, Denise M. O. Ramirez, Mark P. Goldberg, Ann M. Stowe
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Rebecca Sadler, Julia V. Cramer, Steffanie Heindl, Sarantos Kostidis, Dene Betz, Kielen R. Zuurbier, Bernd H. Northoff, Marieke Heijink, Mark P. Goldberg, Erik J. Plautz, Stefan Roth, Rainer Malik, Martin Dichgans, Lesca M. Holdt, Corinne Benakis, Martin Giera, Ann M. Stowe, Arthur Liesz
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Sterling B. Ortega, Vanessa O. Torres, Sarah E. Latchney, Cody W. Whoolery, Ibrahim Z. Noorbhai, Katie Poinsatte, Uma M. Selvaraj, Monica A. Benson, Anouk J. M. Meeuwissen, Erik J. Plautz, Xiangmei Kong, Denise M. Ramirez, Apoorva D. Ajay, Julian P. Meeks, Mark P. Goldberg, Nancy L. Monson, Amelia J. Eisch, Ann M. Stowe
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Clinical Neurology
Merit Cudkowicz, Marianne K. Chase, Christopher S. Coffey, Dixie J. Ecklund, Brenda J. Thornell, Codrin Lungu, Katy Mahoney, Laurie Gutmann, Jeremy M. Shefner, Kevin J. Staley, Michael Bosch, Eric Foster, Jeffrey D. Long, Emine O. Bayman, James Torner, Jon Yankey, Richard Peters, Trevis Huff, Robin A. Conwit
Article
Clinical Neurology
James C. Grotta, Jane A. Anderson, Robin L. Brey, Thomas A. Kent, Patricia D. Hurn, Mark P. Goldberg, Sean I. Savitz, Salvador Cruz-Flores, Steven J. Warach
Article
Neurosciences
Tzu-Ching Wu, Christy Ankrom, Michele Joseph, Alyssa Trevino, Liang Zhu, Steven Warach, Roberta R. Novakovic, Mark P. Goldberg, Lee A. Birnbaum, Osman Mir, Gustavo J. Rodriguez, Yazan J. Alderazi, Ameer E. Hassan, Sean Savitz
Summary: This study aimed to report intra-arterial thrombectomy transfer metrics for ischemic stroke patients transferred to hub hospitals for possible intra-arterial thrombectomy in different regions of Texas. Data from 103 patients showed that transfer of intra-arterial thrombectomy patients in Texas may take over 4 hours, but earlier transfer initiation and acceptance could help shorten this time.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Immunology
Uma Maheswari Selvaraj, Thomas A. Ujas, Xiangmei Kong, Ashwani Kumar, Erik J. Plautz, Shanrong Zhang, Chao Xing, Tiffany L. Sudduth, Donna M. Wilcock, Jadwiga Turchan-Cholewo, Mark P. Goldberg, Ann M. Stowe
Summary: The study shows that CD8 T cells persist in the ischemic brain and have a long-term impact on functional recovery. Depletion of CD8 T cells can improve motor recovery, reduce leukocyte infiltration, as well as decrease the numbers of macrophages, neutrophils, and CD4 T cells in the injured brain.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Emergency Medicine
DaiWai M. Olson, Michelle Provencher, Sonja E. Stutzman, Linda S. Hynan, Sava Novakovic, Sandeep Guttikonda, Stephen Figueroa, Roberta Novakovic-White, Julian P. Yang, Mark P. Goldberg
Summary: This study explored the impact of a nurse-led workflow on acute ischemic stroke care. The results showed that implementing the nurse-driven protocol significantly reduced the time patients waited for providers and CT scans, but had limited effects on other time metrics. Additionally, the study emphasized the importance of well-outlined workflows and standardized stroke code protocols in every aspect of acute ischemic stroke care.
JOURNAL OF EMERGENCY NURSING
(2022)
Article
Medicine, General & Internal
Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Leora I. Horwitz, Andrea S. Foulkes
Summary: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, known as postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID. This study developed a definition of PASC based on self-reported symptoms and described the frequencies of PASC across cohorts, vaccination status, and number of infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Tanayott R. Thaweethai, Sarah E. Jolley, Elizabeth Karlson, Emily M. Levitan, Bruce Levy, Grace McComsey, Lisa S. McCorkell, Girish D. Nadkarni, Sairam E. Parthasarathy, Upinder J. Singh, Tiffany Walker, Caitlin W. Selvaggi, Daniel Shinnick, Carolin C. M. P. Schulte, Rachel M. Atchley-Challenner, Leora Horwitz, Andrea Foulkes
Summary: This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) using self-reported symptoms and analyze the frequencies of PASC across different cohorts, vaccination status, and number of infections. The results show that PASC is associated with various symptoms and around 10% of participants were PASC positive at 6 months after infection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Clinical Neurology
April M. Becker, Dene M. Betz, Mark P. Goldberg
NEUROREHABILITATION AND NEURAL REPAIR
(2020)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)