Review
Chemistry, Multidisciplinary
Chuankai Dai, Xiaoming Liu, Rongyu Tang, Jiping He, Tatsuo Arai
Summary: In recent years, microfluidics has been crucial to the advancement of nerve regeneration research. Microfluidic devices accurately simulate the in vivo microenvironment for various research purposes such as analyzing growth inhibitory factors, screening drugs, evaluating nerve growth factors, and investigating neural injury and regeneration mechanisms. The platform enables precise control of cell behavior, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance, providing technical support for nerve regeneration.
APPLIED SCIENCES-BASEL
(2022)
Article
Endocrinology & Metabolism
Mohamad-Reza Aghanoori, Vicky Margulets, Darrell R. Smith, Lorrie A. Kirshenbaum, Daniel Gitler, Paul Fernyhough
Summary: The study demonstrated decreased glycolytic capacity and impaired mitochondrial respiration in DRG neurons from type 1 diabetic rats. IGF-1 was found to protect against ATP depletion in DRG neurons from diabetic rats by enhancing glycolysis and mitochondrial respiration parameters.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Anthony G. Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William C. Kwan, Tobias D. Merson, Susan K. Nilsson, Nenad Sestan, Stephen M. Strittmatter, James A. Bourne
Summary: This study characterizes marmoset astrocytes following brain injury using single nuclei transcriptomics and finds that NogoA-expressing astrocytes can limit macrophage infiltration, thus mediating an anti-inflammatory response.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Arthur Sefiani, Ivan Rusyn, Cedric G. Geoffroy
Summary: Neurodegenerative diseases and neurotraumatic injuries can lead to the loss of neurological functions. Using current screening methods with neurons that do not match the age and sex of the target population is a barrier for translational success. By modifying the processing method of adult neurons, we have developed age- and sex-appropriate models for in vitro screening, which greatly increases the relevance of finding neuroprotective compounds.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Cheng Qian, Bryan Dong, Xu-Yang Wang, Feng-Quan Zhou
Summary: This article summarizes the challenges of neuron replacement in the adult mammalian CNS and discusses promising strategies for glia-to-neuron conversion. It compares regeneration capabilities in zebrafish and mammals, highlighting differences in signaling transductions and regulatory mechanisms. The article also presents evidence from mouse studies on glia-to-neuron conversion and emphasizes the importance of addressing technical concerns to achieve successful neural function recovery.
Article
Multidisciplinary Sciences
Lili Xie, Ling-Ping Cen, Yiqing Li, Hui-Ya Gilbert, Oleksandr Strelko, Cynthia Berlinicke, Mihaela A. Stavarache, Madeline Ma, Yongting Wang, Qi Cui, Michael G. Kaplitt, Donald J. Zack, Larry I. Benowitz, Yuqin Yin
Summary: Sterile inflammation in the eye can partially reverse the failure of mammalian retinal ganglion cells (RGCs) to regenerate axons and survive after optic nerve injury. This reversal is mediated by the expression of axogenic protein oncomodulin (Ocm) by infiltrative myeloid cells. Additionally, stromal cell-derived factor 1 (SDF1) expressed by infiltrative macrophages plays a central role in enhancing Ocm activity and promoting inflammation-induced regeneration and RGC survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Sharif Alhajlah, Adam M. Thompson, Zubair Ahmed
Summary: The study shows that RTN3 may play a critical role in promoting axon regeneration in the central nervous system, especially after spinal cord and optic nerve injuries. Overexpression of RTN3 can enhance neurite outgrowth in cell culture and promote survival and axon regeneration in vivo.
Article
Neurosciences
Nayeon Lee, Mi-Young Lee, Junghun Lee, Sang Ho Kwon, Hana Seung, Jaegook Lim, Sunyoung Kim
Summary: The study found that HGF might promote neurite outgrowth by controlling mitochondrial activity through the HGF/Erk/STAT3 axis.
Article
Cell & Tissue Engineering
Ngan Pan Bennett Au, Gajendra Kumar, Pallavi Asthana, Fuying Gao, Riki Kawaguchi, Raymond Chuen Chung Chang, Kwok Fai So, Yang Hu, Daniel H. Geschwind, Giovanni Coppola, Chi Him Eddie Ma
Summary: In this study, researchers demonstrated that Lycium barbarum polysaccharides (LBP) extracted from Wolfberry can accelerate axon regeneration after severe nerve injury. They also identified a small-molecule glycopyrrolate approved by the FDA that promotes nerve regeneration and visual function recovery.
NPJ REGENERATIVE MEDICINE
(2022)
Review
Cell Biology
Mary L. Tapia, Gabriel Nascimento-dos-Santos, Kevin K. Park
Summary: This review discusses the heterogeneity of retinal ganglion cells (RGCs) and their differential resilience to injury and regeneration. By identifying molecular features and studying different regeneration models, specific RGC types that exhibit preferential survival and regeneration have been discovered. Cellular characteristics and the selective expression of certain genes may contribute to their reparative capacity. These studies lay an important groundwork for identifying factors that promote neural regeneration and developing targeted therapy for RGC degeneration and neurodegenerative diseases in general.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Jahnke, Souska Zandi, Ahmed Elhelbawi, Federica Maria Conedera, Volker Enzmann
Summary: Reactive gliosis, characterized by increased expression of S100 beta and intermediate filaments (GFAP, vimentin, and nestin), plays a significant role in tissue repair during retinal degeneration. The expression of gliotic markers was elevated in the damaged area of both mouse and human retinal samples. In zebrafish, the expression of S100 beta was detected earlier than GFAP and nestin. The different expression patterns of intermediate filaments suggest that targeting S100 beta may help suppress chronic gliosis in retinal degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Georgina Palomes-Borrajo, Xavier Navarro, Clara Penas
Summary: This study demonstrates that inhibiting BET proteins in macrophages can enhance axonal outgrowth and promote peripheral nerve regeneration. However, specific targeting of BET proteins to macrophages is needed for efficient functional recovery after nerve injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jacen Emerson, Thomas Delgado, Peter Girardi, Gail V. W. Johnson
Summary: Astrocytes are important support cells in the central nervous system that affect the function and recovery of neurons. Reactive astrocytes can have both beneficial and harmful effects on injured neurons, and understanding the factors and pathways that determine their reactive phenotypes is still a developing field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jia-Jian Liang, Yu-Fen Liu, TszKin Ng, Ci-Yan Xu, Mingzhi Zhang, ChiPui Pang, Ling-Ping Cen
Summary: Inflammation plays a crucial role in regulating neuronal survival in the central nervous system, and this study showed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth, with further exacerbation by macrophage activation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Vance P. Lemmon
Summary: Published in 1981, a study on the receptive field properties of neurons in the reeler mouse visual cortex revealed robust systems ensuring proper formation of connections in mouse cortex. This study transformed the author from an electrophysiologist into a molecular neuroscientist studying cell adhesion molecules and axon growth regulation mechanisms. It highlights the importance of collaboration and available technologies in driving scientific discoveries.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Emergency Medicine
Jaden Tollman, Zubair Ahmed
Summary: Tracheal tube introducers and stylets are effective aids for intubation in the prehospital environment, with bougies having a statistical advantage in first pass ETI success when video technology is available, while stylets lead to shorter intubation times and are easier to use. There is no statistical difference in success rates and complication rates between different devices, and device selection may ultimately depend on the clinical scenario, practitioner expertise, and personal preference.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Andrew J. Carrod, Francesco Graglia, Louise Male, Cecile Le Duff, Peter Simpson, Mohamed Elsherif, Zubair Ahmed, Haider Butt, Guang-Xi Xu, Kenneth Kam-Wing Lo, Paolo Bertoncello, Zoe Pikramenou
Summary: Dual detection systems are beneficial for rapid and accurate data collection in sensing systems and in vitro testing. The newly introduced Ir-III complex with a boronic acid receptor site attached to a 2-phenylpyridine ligand serves as an ideal probe for sensitive detection of monosaccharide binding, showing potential for integration into devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Biographical-Item
Neurosciences
Zubair Ahmed, Ann Logan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Ophthalmology
Inesa Lelyte, Zubair Ahmed, Simon Kaja, Giedrius Kalesnykas
Summary: This systematic review investigated the most useful readouts of STZ-induced DR and found that electroretinography (ERG) represents the most consistent functional readout. However, caution must be used when interpreting these studies due to the high risk of bias.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Carolina Alva, Ivan Vidakovic, Barbara Lorber, Anna-Laurence Schachner-Nedherer, Manuel Zettl, Johannes Khinast, Ruth Prassl, Wen-Kai Hsiao
Summary: This study aims to verify the suitability of inkjet printing technology for liposomes. The results show that the concentration and size distribution of liposomes are largely unaffected by the shear forces during the jetting process.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Review
Cell Biology
Andrew R. Stevens, Clarissa A. Stickland, Georgia Harris, Zubair Ahmed, Pola Goldberg Oppenheimer, Antonio Belli, David J. Davies
Summary: Traumatic brain injury (TBI) is a global health problem, and there is currently a lack of therapeutics to improve survival and outcomes. Current neuromonitoring methods cannot accurately reflect the complex pathophysiological processes occurring after TBI. Raman spectroscopy (RS) is a powerful optical tool that can provide detailed biochemical data in vivo. This systematic review evaluates the evidence for the use of RS in TBI and highlights its potential in identifying injury severity and metabolic dysfunction.
Review
Neurosciences
Zubair Ahmed
Summary: Traumatic brain injury (TBI) is a major cause of morbidity, disability, and mortality globally. Experimental treatments targeting biochemical and cellular changes after TBI are currently being evaluated in clinical trials, but the results vary. This study aims to identify the drugs currently being evaluated for TBI in clinical trials.
Article
Oncology
Zubair Ahmed, Sharif Alhajlah, Adam M. Thompson, Rebecca J. Fairclough
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Emergency Medicine
Jaden Tollman, Zubair Ahmed
Summary: Ventilation strategies for primary blast lung injury (PBLI) should aim to minimize lung injury by utilizing conventional low tidal volume ventilation, airway pressure release ventilation, and high frequency oscillatory ventilation. Conventional low tidal volume ventilation with variable positive end-expiratory pressure and permissive hypercapnia has shown to reduce inflammation and mortality. Airway pressure release ventilation has the potential to reduce dynamic strain and extravascular lung water while encouraging spontaneous breathing. High frequency oscillatory ventilation is able to effectively avoid lung injury but may not necessarily reduce mortality.
Review
Critical Care Medicine
Andrew Robert Stevens, Mohammed Hadis, Michael Milward, Zubair Ahmed, Antonio Belli, William Palin, David James Davies
Summary: Photobiomodulation (PBM) is a therapeutic modality that has shown promise in improving outcomes in acute traumatic brain injury (TBI), with its antiapoptotic and anti-inflammatory effects. This systematic review provides evidence of the benefits of PBM on functional and histological outcomes of TBI in in vivo mammalian models, supporting its safety and feasibility in acute moderate TBI in human patients.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Oncology
Zubair Ahmed, Richard I. Tuxworth
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Yuanjie Xia, Mohamed Khamis, F. Anibal Fernandez, Hadi Heidari, Haider Butt, Zubair Ahmed, Tim Wilkinson, Rami Ghannam
Summary: Recent advances in microelectronics and nanofabrication on flexible substrates have enabled contact lenses to be used for a range of human-machine interaction applications. A systematic review reveals that smart contact lenses can display information, detect eye movements, restore vision, and detect biomarkers in tear fluid. The study also classifies literature on smart contact lenses and speculates on their challenges and opportunities for HMI, providing guidelines for future design.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Review
Cell Biology
Zunira Areeba Bhuiyan, Oluwasemilore Adebayo, Zubair Ahmed
Summary: This study aimed to explore the efficacy and safety of localised insulin administration on wound healing in non-diabetic adults. The findings showed a significant improvement in wound healing rate in the insulin treated group, but other parameters were not statistically significant. Therefore, larger prospective studies are needed to fully investigate the effects of insulin on different wounds.
WOUND REPAIR AND REGENERATION
(2023)
Review
Medicine, General & Internal
Sheikh Azka Zaheer, Zubair Ahmed
Summary: Carpal tunnel syndrome (CTS) is a common condition that causes numbness and weakness in the hand and arm. Neurodynamic modulation techniques have been used as a non-surgical treatment for CTS, but their effectiveness has been unclear. This systematic review found that neurodynamic techniques significantly reduced symptom severity, pain, and motor latency in CTS patients, while improving nerve conduction velocities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. H. Backes, Robert J. J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sebastien Foulquier
Summary: Cerebral small vessel disease is characterized by decreased cerebral blood flow and blood-brain barrier impairments, leading to the development of white matter lesions. Cerebral hypoperfusion induces hypoxia and affects the signaling between oligodendrocyte precursor cells and endothelial cells, resulting in blood-brain barrier dysfunction. In this study, a mouse model of cerebral hypoperfusion was used to investigate the role of hypoxia-induced VEGFA expression in the development of white matter lesions. The results suggest that VEGFA upregulation in hypoxic oligodendrocyte precursor cells mediates blood-brain barrier permeability, which is associated with increased VEGFA plasma levels in cerebral small vessel disease patients.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)
