Article
Behavioral Sciences
Radharani Benvenutti, Matheus Marcon, Matheus Gallas-Lopes, Anna Julie de Mello, Ana Paula Herrmann, Angelo Piato
Summary: Zebrafish is emerging as an alternative model organism for studying neurobiological mechanisms of various behaviors, including anxiety, preference, learning, and memory, relevant to neuropsychiatric disorders. However, the wide variation in protocols and apparatus shapes and dimensions for maze studies in zebrafish literature poses challenges to reproducibility across institutions. This review aims to provide an overview of the behavioral paradigms assessed in different types of mazes in zebrafish and contribute to a better characterization of multi-behavioral assessment in zebrafish.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Computer Science, Information Systems
Francisco Jose Lobato-Camacho, Juan Carlos Lopez, Juan Pedro Vargas
Summary: This study demonstrates the potential of virtual reality tools for evaluating and enhancing attention and memory processes. The researchers developed a virtual water maze to assess search strategies in gamers and analyzed how spatial memory strategies evolve with gaming experience.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Neurosciences
Roisin Deery, Sean Commins
Summary: This study investigated overshadowing in human spatial learning using a virtual water maze task. The results showed that the near cue had a stronger influence on learning compared to the far cue, which appeared to be completely ignored.
Article
Multidisciplinary Sciences
S. Bianchi, I. Munoz-Martin, E. Covi, A. Bricalli, G. Piccolboni, A. Regev, G. Molas, J. F. Nodin, F. Andrieu, D. Ielmini
Summary: Authors propose a bio-inspired recurrent neural network based on resistive-switching synaptic arrays for autonomous exploration. The network utilizes homeostatic Hebbian learning for improved efficiency in reinforcement learning tasks. Experimental and theoretical discussions are presented to benchmark the accuracy and resilience of the proposed architecture.
NATURE COMMUNICATIONS
(2023)
Review
Veterinary Sciences
Muhammad Zulfadhli Othman, Zurina Hassan, Ahmad Tarmizi Che Has
Summary: The Morris water maze has been a popular tool for assessing spatial learning and memory for about 40 years, with advantages such as effectiveness, reliability, and adaptability. Despite some experimental and analysis loopholes, improvements and adaptations have ensured its relevance as a tool for understanding spatial learning and memory mechanisms.
EXPERIMENTAL ANIMALS
(2021)
Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Ying
Summary: The study found that ginsenosides can ameliorate memory impairment in rats caused by propofol anesthesia by increasing the expression levels of NGF and BDNF. Therefore, ginsenosides have the potential to serve as a novel therapeutic agent for postoperative cognitive dysfunction caused by propofol anesthesia.
Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Yeseul Lee, Zuner A. Bortolotto, Clarrisa A. Bradley, Thomas M. Sanderson, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Inhibition of GSK-3 improves learning speed in behavioral tasks and enhances the accuracy of long-term spatial memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychology, Biological
F. Avila-Gamiz, A. M. Perez-Cano, J. M. Perez-Berlanga, R. M. Mullor-Vigo, E. N. Zambrana-Infantes, L. J. Santin, D. Ladron de Guevara-Miranda
Summary: Combining physical and cognitive training can potentially have synergistic effects on adult hippocampal neurogenesis, leading to improved cognition. This study showed that treadmill exercise followed by working memory training resulted in increased cell proliferation/survival and better performance in a water maze compared to either treatment alone. These findings suggest that the combination of physical and cognitive stimulation can enhance neurogenesis and may be beneficial for cognition in healthy individuals and those with neurological impairments.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Marta Balietti, Arianna Pugliese, Fiorenzo Conti
Summary: It has been demonstrated that cognitive stimulation in late life can prevent cognitive decline in still cognitively preserved animals and improve cognitive compromised animals. Future research should focus on individually tailored stimulation protocols to enhance their effectiveness.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Critical Care Medicine
Laura B. Tucker, Amanda H. Fu, Joseph T. McCabe
Summary: Cognitive dysfunction is a common complaint following acquired traumatic brain injuries, with hippocampal circuits often implicated in resulting deficits. The study aimed to phenotype cognitive deficits in male and female mice following TBI induced by the CHIMERA device, showing significant impairment in spatial learning and memory skills. Differences in injury-induced deficits between male and female mice were observed, with cognitive impairment assessment potentially confounded by motor and visual impairments post-injury.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Hiroki Fujiwara, Tsukasa Osaki, Satoshi Fujii, Junichi Fujii
Summary: This study investigated the learning and memory abilities of Prdx4 knockout mice and found that Prdx4-KO mice performed poorly in spatial memory tasks. In contrast, their locomotor activity was significantly increased. Molecular analysis revealed increased expression of genes related to ER-associated degradation mechanisms and aberrant expression of proteins associated with calcium homeostasis and synaptogenesis in the brains of Prdx4-KO mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
IbDanelo Cortez, Caterina M. Hernandez, Kelly T. Dineley
Summary: The study found that the insulin-sensitizing drug rosiglitazone can improve age- and AD-related learning and memory deficits, particularly in cognitive domains that rely on the dorsal hippocampus.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Leigh N. Sepeta, Madison M. Berl, Marko Wilke, Xiaozhen You, Meera Mehta, Benjamin Xu, Sara Inati, Irene Dustin, Omar Khan, Alison Austermuehle, William H. Theodore, William D. Gaillard
Letter
Biophysics
M. E. Gatti-Mays, M. Manion, L. N. Bowen, G. T. Brown, R. L. Danner, O. Khan, A. Nath, M. Battiwalla, A. J. Barrett, S. Ito
BONE MARROW TRANSPLANTATION
(2016)
Article
Immunology
Anil A. Panackal, Mika Komori, Peter Kosa, Omar Khan, Dima A. Hammoud, Lindsey B. Rosen, Sarah K. Browne, Yen-Chih Lin, Elena Romm, Charu Ramaprasad, Bettina C. Fries, John E. Bennett, Bibiana Bielekova, Peter R. Williamson
CLINICAL INFECTIOUS DISEASES
(2017)
Article
Clinical Neurology
Daniel M. Goldenholz, Alexander Jow, Omar I. Khan, Anto Bagic, Susumu Sato, Sungyoung Auh, Conrad Kufta, Sara Inati, William H. Theodore
Article
Behavioral Sciences
Omar I. Khan, Xiangping Zhou, Jill Leon, Riley Kessler, Thomas Gaughan, Precilla D'Souza, Andrea Gropman, Ninette Cohen, Owen Rennert, Ashura Buckley, Sara Inati, Audrey Thurm
EPILEPSY & BEHAVIOR
(2018)
Article
Clinical Neurology
Madison M. Berl, Lauren A. Zimmaro, Omar I. Khan, Irene Dustin, Eva Ritzl, Elizabeth S. Duke, Leigh N. Sepeta, Susumu Sato, William H. Theodore, William D. Gaillard
ANNALS OF NEUROLOGY
(2014)
Article
Clinical Neurology
Shmuel Appel, Elizabeth S. Duke, Ashley R. Martinez, Omar I. Khan, Irene M. Dustin, Patricia Reeves-Tyer, Madison B. Berl, Susumu Sato, William D. Gaillard, William H. Theodore
Article
Radiology, Nuclear Medicine & Medical Imaging
William H. Theodore, Ashley R. Martinez, Omar I. Khan, Clarissa J. Liew, Sungyoung Auh, Irene M. Dustin, John Heiss, Susumu Sato
JOURNAL OF NUCLEAR MEDICINE
(2012)
Article
Clinical Neurology
Sondra W. Levin, Eva H. Baker, Wadih M. Zein, Zhongjian Zhang, Zenaide M. N. Quezado, Ning Miao, Andrea Gropman, Kurt J. Griffin, Simona Bianconi, Goutam Chandra, Omar I. Khan, Rafael C. Caruso, Aiyi Liu, Anil B. Mukherjee
Article
Clinical Neurology
Wyatt P. Bensken, Alexandra K. Hansen, Gina Norato, John D. Heiss, Avindra Nath, Omar I. Khan
Article
Clinical Neurology
John D. Heiss, Davis P. Argersinger, William H. Theodore, John A. Butman, Susumu Sato, Omar Khan
Article
Education, Scientific Disciplines
Wyatt P. Bensken, Avindra Nath, John D. Heiss, Omar Khan
Article
Clinical Neurology
Lauren Bowen Reoma, Christopher Julius Trindade, Maria Chiara Monaco, Jamie Solis, Marta Garcia Montojo, Phuong Vu, Kory Johnson, Erin Beck, Govind Nair, Omar Khan, Marta Quezado, Stephen M. Hewitt, Daniel S. Reich, Richard Childs, Avindra Nath
ANNALS OF NEUROLOGY
(2019)
Review
Medicine, General & Internal
Lisa M. Cordes, Nicole N. Davarpanah, Lauren B. Reoma, Billel Gasmi, Martha Quezado, Omar I. Khan, Avindra Nath, Andrea B. Apolo
CLINICAL CASE REPORTS
(2020)
Article
Clinical Neurology
Omar I. Khan, Christina J. Azevedo, Alendia L. Hartshorn, Justin T. Montanye, Juan C. Gonzalez, Mark A. Natola, Stephen D. Surgenor, Richard P. Morse, Richard E. Nordgren, Krzysztof A. Bujarski, Gregory L. Holmes, Barbara C. Jobst, Rod C. Scott, Vijay M. Thadani
EPILEPTIC DISORDERS
(2014)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)