Review
Peripheral Vascular Disease
Andrianto, Makhyan Jibril Al-Farabi, Ricardo Adrian Nugraha, Bagas Adhimurda Marsudi, Yusuf Azmi
Summary: Biomarkers of endothelial dysfunction, including VWF antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19, indicating the importance of endothelial dysfunction in COVID-19 patients.
MICROVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Editorial Material
Hematology
Ravi K. Alluri, Keith R. McCrae
Summary: The study found a novel variant of thrombophilia independent of circulating coagulation proteins or their inhibitors, which is associated with deficient annexin A2 expression. This variant may play an important role in maintaining blood fluidity, suggesting a potential therapeutic target for thrombosis.
Article
Endocrinology & Metabolism
Ariel Diaz, Yena Woo, Cynthia Martin-Jimenez, Paola Merino, Enrique Torre, Manuel Yepes
Summary: Ischemic tolerance is a phenomenon where exposure to a non-injurious preconditioning stimulus triggers resistance to a subsequent lethal ischemic insult. Tissue-type plasminogen activator (tPA) released from astrocytes plays a crucial role in inducing ischemic tolerance in the blood-brain barrier.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Environmental Sciences
Kai Wang, Wanzhou Wang, Lei Lei, Yang Lan, Qisijing Liu, Lihua Ren, Shaowei Wu
Summary: This study conducted a systematic review and meta-analysis of existing epidemiological research to examine the associations between ambient air pollution and coagulation biomarkers. The results showed that short-term exposures to PM2.5 and O3 were associated with significant increases in coagulation biomarkers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Plant Sciences
Shu-Qi Yao, Yang Ye, Quan Li, Xiao-Yi Wang, Li Yan, Xin-Mei Huo, Chun-Shui Pan, Yu Fu, Jian Liu, Jing-Yan Han
Summary: This research aimed to investigate the mechanism of YangXueQingNaoWan (YXQNW), a compound Chinese medicine, in protecting the blood-brain barrier (BBB) after tissue plasminogen activator (tPA) induced cerebral microvascular damage. The results showed that YXQNW could attenuate cerebral microvascular exudation and hemorrhage, improve cerebral blood flow and neurological function.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
David Karasek, Jaromira Spurna, Dominika Macakova, Ondrej Krystynik, Veronika Kucerova
Summary: This study compared vascular damage indicators in different age groups of patients with type 2 diabetes (T2D) and determined their relationship to glycometabolic control. The results showed that older patients had higher arterial stiffness parameters, while markers of endothelial damage were unrelated to glycometabolic control. Age and systolic blood pressure were major determinants of arterial stiffness in T2D patients.
Review
Nutrition & Dietetics
Anna Ungvari, Rafal Gulej, Boglarka Csik, Peter Mukli, Sharon Negri, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Benyo, Anna Csiszar, Zoltan Ungvari
Summary: This review examines the impact of a diet rich in methionine on cognitive impairment and its potential role in accelerating cerebrovascular and brain aging. The study highlights the links between high methionine intake, hyperhomocysteinemia, oxidative stress, mitochondrial dysfunction, inflammation, accelerated epigenetic aging, and microvascular determinants of cognitive deterioration.
Article
Biochemistry & Molecular Biology
Christiane D. Much, Barbara S. Sendtner, Konrad Schwefel, Eric Freund, Sander Bekeschus, Oliver Otto, Axel Pagenstecher, Ute Felbor, Matthias Rath, Stefanie Spiegler
Summary: "The study explores the use of CRISPR/Cas9 technology to model cerebral cavernous malformations, showing that CCM1 inactivation induces high-level expression of VWF and redistribution of Weibel-Palade bodies within endothelial cells. This research provides insights into the cellular and molecular mechanisms underlying the dysfunction in cavernous malformations."
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Max Liu, Khalequz Zaman, Yolanda M. Fortenberry
Summary: Aptamers are single-stranded DNA or RNA sequences that exhibit high specificity and affinity in binding target molecules. They are non-immunogenic, easier to synthesize and modify, and can bind targets with greater affinity, making them a promising therapeutic candidate for treating various conditions. Active research is ongoing in developing aptamers to target blood coagulation factors, with potential applications in treating cardiovascular diseases, blood disorders, and cancers. Although no aptamers targeting blood coagulation factors have been approved for clinical use, several have shown promise in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Nikolett Wohner, Silvie Sebastian, Vincent Muczynski, Dana Huskens, Bas de Laat, Philip G. de Groot, Peter J. Lenting
Summary: The study reveals that VWF strings secreted from endothelial cells are only partially covered with platelets, and osteoprotegerin plays a role in regulating platelet adhesion to VWF. This regulatory mechanism may be more relevant under inflammatory conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Neurosciences
Hua Teng, Chao Li, Yi Zhang, Mei Lu, Michael Chopp, Zheng Gang Zhang, Melanie Melcher-Mourgas, Burkhard Fleckenstein
Summary: This study demonstrates that Cerebrolysin can mitigate and reverse the effects of tPA and fibrin on cerebral endothelial cell permeability by reducing proinflammatory and procoagulant proteins, and by elevating tight junction proteins.
Article
Hematology
Ferdows Atiq, Jens van de Wouw, Oana Sorop, Ilkka Heinonen, Moniek P. M. de Maatl, Daphne Merkus, Dirk J. Duncker, Frank W. G. Leebeek
Summary: The levels of von Willebrand factor (VWF) and factor VIII (FVIII) are associated with an increased risk of cardiovascular disease. Short-term hyperglycemia and dyslipidemia increase FVIII levels independently of VWF, while long-term diabetes and hypercholesterolemia increase VWF levels through endothelial dysfunction and atherosclerosis, indicating VWF as a biomarker for advanced cardiovascular disease.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Helena Bleken Ostergaard, Steven H. J. Hageman, Stephanie H. Read, Owen Taylor, Lisa Pennells, Stephen Kaptoge, Carmen Petitjean, Zhe Xu, Fanchao Shi, John William McEvoy, William Herrington, Frank L. J. Visseren, Angela Wood, Bjorn Eliasson, Naveed Sattar, Sarah Wild, Emanuele Di Angelantonio, Jannick A. N. Dorresteijn
Summary: This study aimed to update and calibrate the DIAbetes Lifetime perspective model (DIAL model) using contemporary and representative registry data. The DIAL2 model was derived from the Swedish National Diabetes Register and validated using data from the Scottish Care Information-Diabetes and Clinical Practice Research Datalink. The results showed that the recalibrated DIAL2 model provides an accurate prediction of cardiovascular disease risk in individuals with Type 2 diabetes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Subodh Verma, Nitish K. Dhingra, Javed Butler, Stefan D. Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L. Januzzi, Carolyn S. P. Lam, Naveed Sattar, Egon Pfarr, Matias Nordaby, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad, Milton Packer
Editorial Material
Medical Laboratory Technology
Paul Welsh, Naveed Sattar
CLINICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Naomi Holman, Emma Barron, Bob Young, Edward W. Gregg, Kamlesh Khunti, Jonathan Valabhji, Naveed Sattar
Summary: This study aimed to investigate whether COVID-19 increases the incidence of diabetes. The results showed that COVID-19 did not have a significant impact on the incidence of diabetes compared to people hospitalized with pneumonia.
Article
Endocrinology & Metabolism
Naomi Holman, Kamlesh Khunti, Sarah H. Wild, Naveed Sattar, Peter Knighton, Bob Young, Edward W. Gregg, Chirag Bakhai, Jonathan Valabhji
Summary: This study examines whether people with remission from type 2 diabetes continue to receive recommended care processes and the potential impacts of formal recognition of remission. The results show that individuals with a remission diagnosis were less likely to receive care processes compared to those without such coding, while those with evidence of remission had only a slightly reduced likelihood of receiving care processes.
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Cardiac & Cardiovascular Systems
Adam G. Tabak, Naveed Sattar, Mika Kivimaki
Article
Cardiac & Cardiovascular Systems
Naveed Sattar, John McMurray, Jan Boren, Araz Rawshani, Elmir Omerovic, Niklas Berg, Janita Halminen, Kristoffer Skoglund, Bjorn Eliasson, Hertzel C. Gerstein, Darren K. McGuire, Deepak Bhatt, Aidin Rawshani
Summary: The goal of this study was to analyze the trends in cardiovascular events and cardiometabolic risk factor levels in individuals with type 2 diabetes (T2D) and matched control subjects. The results showed a decreasing trend in the risk and rates of atherosclerotic complications and heart failure in individuals with T2D, although the incidence of heart failure has plateaued in recent years. Modifiable risk factors within target levels were associated with lower risks for outcomes.
Article
Endocrinology & Metabolism
Sanskar Ranglani, Joey Ward, Naveed Sattar, Rona J. J. Strawbridge, Donald M. M. Lyall
Summary: This study aimed to investigate the association between continuous HbA1c levels and HbA1c-polygenic risk scores (HbA1c-PRS) with brain health, independent of type 2 diabetes (T2D) diagnosis. Results showed that higher HbA1c levels were associated with poorer cognitive health and worse brain MRI phenotypes. However, HbA1c-PRS did not add significant information to this association when adjusted for HbA1c levels.
DIABETES OBESITY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Francesco Cosentino, Subodh Verma, Philip Ambery, Marianne Bach Treppendahl, Martin van Eickels, Stefan D. Anker, Michele Cecchini, Paola Fioretto, Per-Henrik Groop, David Hess, Kamlesh Khunti, Carolyn S. P. Lam, Isabelle Richard-Lordereau, Lars H. Lund, Paul McGreavy, Philip N. Newsome, Naveed Sattar, Scott Solomon, Franz Weidinger, Faiez Zannad, Andreas Zeiher
Summary: Metabolic comorbidities are common in cardiorenal disease and are associated with increased risk of poor outcomes of COVID-19 infection. Recognition and treatment of cardiometabolic diseases, as well as improving lifestyle and developing new biomarkers, are essential for prevention and management.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
L. Malin Overmars, Sanne Kuipers, Bram van Es, Jeroen de Bresser, Esther E. Bron, Imo E. Hoefer, Wouter W. Van Solinge, L. Jaap Kappelle, Matthias J. P. van Osch, Charlotte E. Teunissen, Geert Jan Biessels, Saskia Haitjema
Summary: The biological processes causing decreased cerebral blood flow in cardiovascular disease patients are not well understood. Identifying protein clusters associated with lower cerebral blood flow may provide insight into these underlying processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Dong, Kirsten Koolstra, Ziyu Li, Malte Riedel, Matthias J. P. van Osch, Peter Boernert
Summary: The proposed algorithm effectively eliminates shot-to-shot phase variations and separates water/fat images, providing a promising solution for future DWI on different anatomies.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kaitlin H. Wade, Fergus W. Hamilton, David Carslake, Naveed Sattar, George Davey Smith, Nicholas J. Timpson
Summary: Mendelian randomization (MR) is a commonly used method for strengthening causal inference by utilizing the properties of genetic variation. Nonlinear MR allows estimation of the shape of such relationships. In this study, the authors explore the utility and biases of these nonlinear MR methods using a negative control design.
Article
Oncology
Barbara Schmitz-Abecassis, Linda Dirven, Janey Jiang, Jasmin A. Keller, Robert J. Croese, Danielle van Dorth, Rashid Ghaznawi, Ilse M. J. Kant, Martin J. B. Taphoorn, Matthias J. P. van Osch, Johan A. F. Koekkoek, Jeroen de Bresser
Summary: This study establishes different MRI phenotypes of glioblastomas at 3 months after radiotherapy through combined analysis of structural and perfusion tumor characteristics, and finds that one of the phenotypes is significantly associated with increased mortality risk.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
