Article
Geriatrics & Gerontology
Caitlin F. Fowler, Dan Madularu, Masoumeh Dehghani, Gabriel A. Devenyi, Jamie Near
Summary: By using magnetic resonance spectroscopy, it is possible to quantify brain metabolites and macromolecules in aging individuals, revealing age- and sex-related neurochemical changes. These findings contribute to a better understanding of the neurobiological processes associated with healthy aging, critical for identifying and managing pathological aging trajectories accurately.
NEUROBIOLOGY OF AGING
(2021)
Review
Biochemistry & Molecular Biology
Sonja Elsaid, Dafna S. Rubin-Kahana, Stefan Kloiber, Sidney H. Kennedy, Sofia Chavez, Bernard Le Foll
Summary: This systematic review examines the molecular pathogenesis of Social Anxiety Disorder (SAD) by evaluating data from proton magnetic resonance spectroscopic (H-1 MRS) studies. The study finds regional abnormalities in the fear neurocircuitry of patients with SAD, suggesting impairments in neuronal and glial cell function. Further cross-sectional studies with larger sample sizes are needed to validate these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Geraldine Rodriguez-Nieto, Oron Levin, Lize Hermans, Akila Weerasekera, Anca Croitor Sava, Astrid Haghebaert, Astrid Huybrechts, Koen Cuypers, Dante Mantini, Uwe Himmelreich, Stephan P. Swinnen
Summary: Aging is associated with structural and metabolic changes in the brain. Previous research has focused on individual brain regions, but the relationship among metabolites across the brain has been less studied. Using 1H-MRS, this study investigated the relationship among metabolite concentrations in different brain regions in young and older adults. The results showed age-related differences in metabolite concentrations and revealed associative patterns between metabolites across brain regions, which differed between age groups.
Article
Neurosciences
Yu Veronica Sui, Arjun V. Masurkar, Henry Rusinek, Barry Reisberg, Mariana Lazar
Summary: Demyelination is observed in both healthy aging and age-related neurodegenerative disorders. This study focuses on intracortical demyelination and depth-specific structural alterations in normal aging using the T1w/T2w ratio. The nonlinearity index (NLI) showed a steep decline in aging, independent of local cortical thinning. Lower T1w/T2w near the gray-white matter boundary and superficial cortical depths were major contributors to the apparent NLI variations with age.
Article
Clinical Neurology
Ji-tian Guan, Xin Zheng, Lingfeng Lai, Shuyi Sun, Yiqun Geng, Xiaolei Zhang, Teng Zhou, Huan-ze Wu, Jia-qing Chen, Zhong-xian Yang, Xiao-hong Zheng, Jia-xu Wang, Wei Chen, You-qiao Zhang
Summary: This study investigated the alteration of metabolites in patients with Parkinson's disease (PD) and non-motor symptoms using 1H-MRS. The results suggest that Cr, NAA/Cr, and mI/Cr may serve as potential biomarkers for the progression of PD. Furthermore, MRS of the thalamus may be a sensitive region for the detection of cognitive decline in PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Physiology
Nicholas A. Brennan, Kenneth W. Fishbein, David A. Reiter, Luigi Ferrucci, Richard G. Spencer
Summary: Research has shown that muscle density decreases with age, and this decline is associated with the accumulation of intramyocellular lipid (IMCL). In a study involving 314 healthy participants, higher IMCL concentrations were correlated with lower muscle density in older individuals, independent of age, sex, race, and obesity-related factors. These findings suggest that IMCL accumulation may be a potential therapeutic target for age-associated decreased muscle function.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jing Lu, Ying Li, Yong Ai Li, Li Wang, An Rong Zeng, Xiao Liang Ma, Jin Wei Qiang
Summary: This study investigated the metabolic alterations and dysregulated metabolic pathways in paclitaxel-resistant epithelial ovarian cancer (EOC) using in vivo proton-magnetic resonance spectroscopy (H-1-MRS), metabolomics, and proteomics. The findings suggest that dysregulated choline metabolism is associated with paclitaxel resistance in EOC, and the elevated total choline (tCho) observed on in vivo H-1-MRS may serve as an indicator for paclitaxel resistance in EOC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Amirhossein Rasooli, Hamed Zivari Adab, Peter Van Ruitenbeek, Akila Weerasekera, Sima Chalavi, Koen Cuypers, Oron Levin, Thijs Dhollander, Ronald Peeters, Stefan Sunaert, Dante Mantini, Stephan P. Swinnen
Summary: Aging is associated with changes in the central nervous system and leads to reduced life quality. Magnetic resonance spectroscopy and diffusion MRI were used to investigate the age-related differences in the CNS underlying motor performance deficits. The study found that aging was associated with increased reaction time, reduced fiber density (FD), and N-acetyl aspartate (NAA) concentration in the sensorimotor voxel. Both FD and NAA mediated the association between age and reaction time, and NAA concentration mediated the association between age and FD in the sensorimotor voxel. The decrease in NAA concentration may result in reduced axonal fiber density, which ultimately accounts for the response slowness of older participants.
Article
Neurosciences
Josh Allen, Louise Pham, Simon T. T. Bond, William T. T. O'Brien, Gershon Spitz, Sandy R. R. Shultz, Brian G. G. Drew, David K. K. Wright, Stuart J. J. McDonald
Summary: This study investigated the effects of repetitive mild traumatic brain injuries (mTBIs) on neurometabolism and lipid levels. The results showed that multiple mTBIs in short succession led to behavioral deficits and neurometabolic abnormalities, while a single injury had no effect. This suggests that repeated mTBIs can have cumulative effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biology
Pietro Bontempi, Maria Jimena Ricatti, Marco Sandri, Elena Nicolato, Carla Mucignat-Caretta, Carlo Zancanaro
Summary: This study found that elderly mice are less scared of new environments and their olfactory bulb differs in structure compared to young mice, which is related to their anxious behavior. These findings provide a foundation for studying normal and pathological aging in mice and open up new opportunities for in vivo human aging studies.
Article
Cardiac & Cardiovascular Systems
Ana Natalia Ribeiro Batista, Thais Garcia, Robson Prudente, Mauricio F. Barbosa, Pamela Modesto, Estefania Franco, Irma de Godoy, Sergio Paiva, Paula Azevedo, Suzana Erico Tanni
Summary: The study found associations between cardiac morphometric characteristics, myocardial fat deposition, smoking cessation, and lipid profile in young smokers. Significant differences were observed in cardiac features and lipid levels in the smoking group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jean-Charles Picaud, Anna De Magistris, Michele Mussap, Sara Corbu, Angelica Dessi, Antonio Noto, Vassilios Fanos, Flaminia Cesare Marincola
Summary: The study investigated changes in the urine metabolome of very low birth weight preterm newborns with NEC and feed intolerance. Differences in metabolites were found in different conditions, contributing to the discussion of nutritional and clinical managements of patients and gut microbiota.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wonjeong Yang, Ji Eun Kim, Ho Cheol Choi, Mi Jung Park, Hye Young Choi, Hwa Seon Shin, Jeong Ho Won, Fei Han, Marcel Dominik Nickel, Hyun Chin Cho
Summary: T2 mapping in liver MRI can predict decompensation and death in cirrhotic patients. Risk models combining T2(Liver), serum albumin level, and MELD score were created for predicting outcomes.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Athina C. Tsili, Loukas Astrakas, Nikolaos Sofikitis, Maria I. Argyropoulou
Summary: Proton magnetic resonance spectroscopy provides information on testicular metabolism and pathological changes. It has been used in conjunction with scrotal MRI to gain insights into the biochemical environment of normal and abnormal testes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Pauline Mouches, Matthias Wilms, Deepthi Rajashekar, Sonke Langner, Nils D. Forkert
Summary: This study aimed to develop deep learning models to predict biological brain age using multimodal imaging data. The results showed that combining T1-weighted and angiography MRI data significantly improved prediction accuracy, while also identifying the most contributing brain regions and arteries.
HUMAN BRAIN MAPPING
(2022)
Letter
Obstetrics & Gynecology
Fu-Sheng Chou, Vishal Pandey, Hung-Wen Yeh
JOURNAL OF PERINATOLOGY
(2021)
Article
Neurosciences
Evan J. White, Rayus Kuplicki, Jennifer L. Stewart, Namik Kirlic, Hung-Wen Yeh, Martin P. Paulus, Robin L. Aupperle
Summary: The study used a latent variable approach to analyze activation patterns during anticipatory reward processes, identifying factors related to general arousal, valence, and region-specific activation in a transdiagnostic clinical sample. The results suggest that multiview techniques offer a novel approach for differentiating brain activation patterns and may provide insight into neural processing patterns and individual differences.
Correction
Psychology, Clinical
Jonathan Savitz, Bart N. Ford, Hung-Wen Yeh, Elisabeth Akeman, Kelly Cosgrove, Ashley N. Clausen, Christopher Martell, Namik Kirlic, Jessica Santiago, T. Kent Teague, Michael R. Irwin, Martin P. Paulus, Robin L. Aupperle
PSYCHOLOGICAL MEDICINE
(2022)
Article
Education & Educational Research
Namik Kirlic, Elisabeth Akeman, Danielle C. DeVille, Hung-Wen Yeh, Kelly T. Cosgrove, Timothy J. McDermott, James Touthang, Ashley Clausen, Martin P. Paulus, Robin L. Aupperle
Summary: The objective of this study was to identify stable and reliable factors associated with suicidal thoughts and behaviors in college students. The findings revealed that depression severity, social isolation, meaning and purpose in life, and positive affect were the most important contributing factors. Additionally, there was a significant reduction in suicidal thoughts and behaviors by the end of the academic year.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Urology & Nephrology
Michael Grasing, Palash Sharma, Rebecca J. Lepping, Robyn Honea, Jeffrey M. Burns, William M. Brooks, Aditi Gupta
Summary: This study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to investigate the association between estimated glomerular filtration rate (eGFR) and brain volumes. The results indicate that mild to moderate kidney dysfunction is not associated with brain atrophy.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Letter
Allergy
Sean Stout, Helen Murphy, Aarti Pandya, Hung-Wen Yeh, Jay Portnoy
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Pediatrics
Alison L. Fowler, Megan E. Mann, Francisco J. Martinez, Hung-Wen Yeh, John D. Cowden
Summary: The survey found that many Hispanic parents believe in folk illnesses and use cultural remedies to treat their children, but only a small percentage have discussed these practices with their child's healthcare provider. Demographic factors do not predict the use of cultural remedies by Hispanic parents.
CLINICAL PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Robin P. Shook, Hung-Wen Yeh, Gregory J. Welk, Ann M. Davis, Daniel Ries
Summary: This study evaluated the validity, repeatability, and measurement error of consumer devices when estimating energy balance in free-living adults. Results showed that estimates of energy expenditure were relatively accurate, while estimates of energy storage were poor.
JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Natalie S. Shwaish, Lindsey Malloy-Walton, Keith Feldman, Kelli M. Teson, Jessica S. Watson, Hung-Wen Yeh, David A. White
Summary: This study compared the HRR patterns in children and adolescents with repaired acyanotic CHD (raCHD) and those without CHD. The results suggest that HRR in pediatric raCHD patients should not vary significantly from their healthy peers, and an attenuated HRR may not be directly attributed to underlying raCHD.
PEDIATRIC CARDIOLOGY
(2022)
Review
Pediatrics
Vijaya R. Dasari, Steven M. Shapiro, Hung-Wen Yeh, Rose Gelineau-Morel
Summary: The KSD-TK is a reliable screening tool for predicting Kernicterus Spectrum Disorders, with high sensitivity and specificity in determining the likelihood of KSDs. Abnormal auditory processing, exam findings, and MRI results were the most specific indicators for the diagnosis of KSDs.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
John D. D. Lantos, Hung-Wen Yeh, Fajar Raza, Mark Connelly, Kathy Goggin, Shayla A. A. Sullivant
Summary: During the early months of the pandemic, rates of suicidal ideation among adolescent patients rose. Rates of screening and of positive screens were lower in telehealth visits.
Article
Neurosciences
Sahib S. Khalsa, Teresa A. Victor, Rayus Kuplicki, Hung-Wen Yeh, Kimberly E. Vanover, Martin P. Paulus, Robert E. Davis
Summary: This study investigated the effects of a PDE1 inhibitor called lenrispodun on healthy volunteers using behavioral and neuroimaging approaches. The results showed that lenrispodun selectively improved neural inhibitory control without altering fear extinction processing. Further research is needed to explore the application of lenrispodun in target populations such as individuals with attention deficit hyperactivity disorder.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Health Policy & Services
Shayla Sullivant, Hung-Wen Yeh, Alexandra Hartwig, Mark Connelly
Summary: This study investigated the impact of an education program on safe storage practices for lethal means among parents. The results showed that education combined with tools for behavior change motivated parents to enact safe storage measures.
JOURNAL OF COMMUNITY HEALTH
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
